Lynge E, Vejborg I, Lillholm M, Nielsen M, Napolitano G, von Euler‐Chelpin M. Breast density and risk of breast cancer. Int J Cancer. 2023;152:1150–8.

Article  CAS  PubMed  Google Scholar 

Sharma GN, Dave R, Sanadya J, Sharma P, Sharma KK. Various types and management of breast cancer: an overview. J Adv Pharmaceut Technol Res. 2010;1:109–26.

Article  Google Scholar 

Sathishkumar K, Sankarapillai J, Mathew A, Nair RA, Gangane N, Khuraijam S, Deshmane V. Breast cancer survival in India across 11 geographic areas under the National Cancer Registry Programme. Cancer. 2024;130:1816–25.

Article  PubMed  Google Scholar 

Eliyatkin N, Yalcin E, Zengel B, Aktaş S, Vardar E. Molecular classification of breast carcinoma: from traditional, old-fashioned way to a new age, and a new way. J Breast Health. 2015;11:59–66.

Article  PubMed  PubMed Central  Google Scholar 

Imaginis, What is breast cancer? 2010. https://www.imaginis.com/breast-health-news/breast-health-news.

Robertson FM, Bondy M, Yang W, Yamauchi H, Wiggins S, Kamrudin S, et al. Inflammatory breast cancer: the disease, the biology, the treatment. CA: a cancer journal for clinicians. 2010;60:351–75.

Soliman HH, Minton SE, Han HS, Ismail-Khan R, Neuger A, Khambati F, Roberts JD. A phase I study of indoximod in patients with advanced malignancies. Oncotarget. 2016;7:22928–38.

Article  PubMed  PubMed Central  Google Scholar 

Hoeltje DT. 3-(2-Aminoethyl)indole and -indoline derivatives, processes for their preparation and pharmaceutical compositions containing them, Vol. EP0233413A2 (Ed.: EP Office), SmithKline Beecham Pharma GmbH and Co KG, Europe, 1993.

Ali I, Lone MNadeem, Al-Othman Z, Al-Warthan A, Sanagi MMarsin. Heterocyclic scaffolds: centrality in anticancer drug development. Curr Drug Targets. 2015;16:711–34.

Article  CAS  PubMed  Google Scholar 

Tantawy MA, Nafie MS, Elmegeed GA, Ali IAI. Auspicious role of the steroidal heterocyclic derivatives as a platform for anti-cancer drugs. Bioorg Chem. 2017;73:128–46.

Article  CAS  PubMed  Google Scholar 

Jaglin M, Rhimi M, Philippe C, Pons N, Bruneau A, Goustard B, Rabot S. Indole, a signaling molecule produced by the gut microbiota, negatively impacts emotional behaviors in rats. Front Neurosci. 2018;12:216.

Article  PubMed  PubMed Central  Google Scholar 

Gao J, Xu K, Liu H, Liu G, Bai M, Peng C, Yin Y. Impact of the gut microbiota on intestinal immunity mediated by tryptophan metabolism. Front Cell Infect Microbiol. 2018;8:13.

Article  PubMed  PubMed Central  Google Scholar 

Flannigan KL, Nieves KM, Szczepanski HE, Serra A, Lee JW, Alston LA, Hirota SA. The pregnane X receptor and indole-3-propionic acid shape the intestinal mesenchyme to restrain inflammation and fibrosis. Cell Mol Gastroenterol Hepatol. 2023;15:765–95.

Article  CAS  PubMed  Google Scholar 

Sheshadri SA, Nishanth MJ, Simon B. Melatonin influences terpenoid indole alkaloids biosynthesis and 5′ upstream-mediated regulation of cell wall invertase in Catharanthus roseus. J Plant Growth Regul. 2023;42:4688–706.

Lee J-H, Lee J. Indole as an intercellular signal in microbial communities. FEMS Microbiol Rev. 2010;34:426–44.

Article  CAS  PubMed  Google Scholar 

Lehninger AL, Nelson DL, Cox MM. Lehninger principles of biochemistry, Macmillan; 2005.

Hornedo‐Ortega R, Da Costa G, Cerezo AB, Troncoso AM, Richard T, Garcia‐Parrilla MC. In vitro effects ofserotonin, melatonin, and other related indole compounds on amyloid‐β kinetics and neuroprotection. Mol Nutr Food Res. 2018;62:1700383.

Sharma S, Hashmi MF, Alhajjaj MS. StatPearls [Internet] StatPearls Publishing. Treasure Island (FL): 2021;4.

Ji Y, Yin W, Liang Y, Sun L, Yin Y, Zhang W. Anti-inflammatory and anti-oxidative activity of indole-3-acetic acid involves induction of HO-1 and neutralization of free radicals in RAW264.7 cells. Int J Mol Sci. 2020;21:1579.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Vyhlídalová B, Krasulová K, Pečinková P, Marcalíková A, Vrzal R, Zemánková L, Karasová M. Gut microbial catabolites of tryptophan are ligands and agonists of the aryl hydrocarbon receptor: a detailed characterization. Int J Mol Sci. 2020;21:2614.

Article  PubMed  PubMed Central  Google Scholar 

Sogawa K, Fujii-Kuriyama Y. Ah receptor, a novel ligand-activated transcription factor. J Biochem. 1997;122:1075–9.

Article  CAS  PubMed  Google Scholar 

Chimerel C, Emery E, Summers DK, Keyser U, Gribble FM, Reimann F. Bacterial metabolite indole modulates incretin secretion from intestinal enteroendocrine L cells. Cell Reports. 2014;9:1202–8.

Article  CAS  PubMed  Google Scholar 

Venu VKP, Saifeddine M, Mihara K, Tsai YC, Nieves K, Alston L, Mani S, McCoy KD, Hollenberg MD, Hirota SA. The pregnane X receptor and its microbiota-derived ligand indole 3-propionic acid regulate endothelium-dependent vasodilation. Am J Physiol Endocrinol Metab 2019.

Choi Y, Abdelmegeed MA, Song B-J. Preventive effects of indole-3-carbinol against alcohol-induced liver injury in mice via antioxidant, anti-inflammatory, and anti-apoptotic mechanisms: Role of gut-liver-adipose tissue axis. J Nutr Biochem. 2018;55:12–25.

Article  CAS  PubMed  Google Scholar 

Banoglu E. Hepatic microsomal metabolism of indole to indoxyl, a precursor of indoxyl sulfate. Eur J Drug Metab Pharmacokinet. 2001;26:235–40.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhang X, Gan M, Li J, Li H, Su M, Tan D, Chen G. Endogenous indole pyruvate pathway for tryptophan metabolism mediated by IL4I1. J Agric Food Chem. 2020;68:10678–84.

Article  CAS  PubMed  Google Scholar 

Kumar S, Ritika. A brief review of the biological potential of indole derivatives. Future J Pharm Sci. 2020;6:1–9.

Taliani S, Da Settimo F, Martini C, Laneri S, Novellino E, Greco G. Exploiting the indole scaffold to design compounds binding to different pharmacological targets. Molecules. 2020;25:2331.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bianucci AM, Da Settimo A, Da Settimo F, Primofiore G, Martini C, Giannaccini G, Lucacchini A. Benzodiazepine receptor affinity and interaction of some N-(indol-3-ylglyoxylyl) amine derivatives. J Med Chem. 1992;35:2214–20.

Da Settimo A, Primofiore G, Da Settimo F, Marini AM, Novellino E, Greco G, Lucacchini A. Synthesis, structure-activity relationships, and molecular modeling studies of N-(indol-3-ylglyoxylyl)benzylamine derivatives acting at the benzodiazepine receptor. J Med Chem. 1996;39:5083–91.

Article  PubMed  Google Scholar 

Giordani A, Menziani MC, Moresco RM, Matarrese M, Paolino M, Saletti M, Cappelli A. Exploring Translocator Protein (TSPO) Medicinal chemistry: an approach for targeting radionuclides and boron atoms to mitochondria. J Med Chem. 2021;64:9649–76.

Article  CAS  PubMed  Google Scholar 

Barresi E, Robello M, Baglini E, Poggetti V, Viviano M, Salerno S, Da Settimo F, Taliani S. Indol-3-ylglyoxylamide as Privileged Scaffold in Medicinal Chemistry. Pharmaceuticals. 2023;16:997.

Cosimelli B, Greco G, Laneri S, Novellino E, Sacchi A, Amendola G, Viola G. Identification of novel indole derivatives acting as inhibitors of the Keap1-Nrf2 interaction. J Enzyme Inhib Med Chem. 2019;34:1152–7.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Qin R, You FM, Zhao Q, Xie X, Peng C, Zhan G, Han B. Naturally derived indole alkaloids targeting regulated cell death (RCD) for cancer therapy: from molecular mechanisms to potential therapeutic targets. J Hematol Oncol. 2022;15:133.

Article  PubMed  PubMed Central  Google Scholar 

Xu D, Xu Z. Indole alkaloids with potential anticancer activity. Curr Top Med Chem. 2020;20:1938–49.

Article  CAS  PubMed  Google Scholar 

Singh Sidhu J, Singla R, Jaitak V. Indole derivatives as anticancer agents for breast cancer therapy: a review.Anti-Cancer Agents in Medicinal Chemistry (Formerly Current Medicinal Chemistry-Anti-Cancer Agents). 2016;16:160–73.

Chadha N, Silakari O. Indoles as therapeutics of interest in medicinal chemistry: Bird’s eye view. Eur J Med Chem. 2017;134:159–84.

Article  CAS  PubMed  Google Scholar 

Moghadamtousi SZ, Nikzad S, Abdul Kadir H, Abubakar S, Zandi K. Potential antiviral agents from marine fungi: an overview. Marine Drugs. 2015;13:4520–38.

Article  CAS  PubMed  Google Scholar 

Xu L, Meng W, Cao C, Wang J, Shan W, Wang Q. Antibacterial and antifungal compounds from marine fungi. Marine Drugs. 2015;13:3479–513.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Du FY, Li X, Li XM, Zhu LW, Wang BG. Indolediketopiperazine Alkaloids from Eurotium cristatum EN-220, an Endophytic Fungus Isolated from the Marine Alga Sargassum thunbergii. Marine Drugs. 2017;15:24.

Article  PubMed