Armstrong DG, Tan TW, Boulton AJM, Bus SA. Diabetic Foot Ulcers: a review. JAMA. 2023;330(1):62–75.

Article  CAS  PubMed  Google Scholar 

Walker AF, Graham S, Maple-Brown L, Egede LE, Campbell JA, Walker RJ, Wade AN, Mbanya JC, Long JA, Yajnik C, et al. Interventions to address global inequity in diabetes: international progress. Lancet. 2023;402(10397):250–64.

Article  PubMed  PubMed Central  Google Scholar 

Jones RE, Foster DS, Longaker MT. Management of chronic Wounds-2018. JAMA. 2018;320(14):1481–2.

Article  PubMed  Google Scholar 

McDermott K, Fang M, Boulton AJM, Selvin E, Hicks CW. Etiology, epidemiology, and disparities in the Burden of Diabetic Foot Ulcers. Diabetes Care. 2023;46(1):209–21.

Article  PubMed  Google Scholar 

Gordois A, Scuffham P, Shearer A, Oglesby A, Tobian JA. The health care costs of diabetic peripheral neuropathy in the US. Diabetes Care. 2003;26(6):1790–5.

Article  PubMed  Google Scholar 

Sargen MR, Hoffstad O, Margolis DJ. Geographic variation in Medicare spending and mortality for diabetic patients with foot ulcers and amputations. J Diabetes Complications. 2013;27(2):128–33.

Article  PubMed  Google Scholar 

Sen CK. Human wound and its Burden: updated 2022 Compendium of estimates. Adv Wound Care (New Rochelle). 2023;12(12):657–70.

Article  PubMed  Google Scholar 

Zou J, Zhang W, Chen X, Su W, Yu D. Data mining reveal the association between diabetic foot ulcer and peripheral artery disease. Front Public Health. 2022;10:963426.

Article  PubMed  PubMed Central  Google Scholar 

Mishra SC, Chhatbar KC, Kashikar A, Mehndiratta A. Diabetic foot. BMJ. 2017;359:j5064.

Article  PubMed  PubMed Central  Google Scholar 

Sloan G, Selvarajah D, Tesfaye S. Pathogenesis, diagnosis and clinical management of diabetic sensorimotor peripheral neuropathy. Nat Rev Endocrinol. 2021;17(7):400–20.

Article  PubMed  Google Scholar 

Everett E, Mathioudakis N. Update on management of diabetic foot ulcers. Ann N Y Acad Sci. 2018;1411(1):153–65.

Article  PubMed  PubMed Central  Google Scholar 

McIllhatton A, Lanting S, Lambkin D, Leigh L, Casey S, Chuter V. Reliability of recommended non-invasive chairside screening tests for diabetes-related peripheral neuropathy: a systematic review with meta-analyses. BMJ Open Diabetes Res Care 2021, 9(2).

Orlando G, Prior Y, Reeves ND, Vileikyte L. Patient and provider perspective of Smart Wearable Technology in Diabetic Foot Ulcer Prevention: a systematic review. Med (Kaunas) 2021, 57(12).

Wang X, Jiang G, Zong J, Lv D, Lu M, Qu X, Wang S. Revealing the novel ferroptosis-related therapeutic targets for diabetic foot ulcer based on the machine learning. Front Genet. 2022;13:944425.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Perera RM, Zoncu R. The lysosome as a Regulatory Hub. Annu Rev Cell Dev Biol. 2016;32:223–53.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lamming DW, Bar-Peled L. Lysosome: the metabolic signaling hub. Traffic. 2019;20(1):27–38.

Article  CAS  PubMed  Google Scholar 

Gros F, Muller S. The role of lysosomes in metabolic and autoimmune diseases. Nat Rev Nephrol. 2023;19(6):366–83.

Article  CAS  PubMed  Google Scholar 

Greenhalgh DG. Wound healing and diabetes mellitus. Clin Plast Surg. 2003;30(1):37–45.

Article  PubMed  Google Scholar 

Leek JT, Johnson WE, Parker HS, Jaffe AE, Storey JD. The sva package for removing batch effects and other unwanted variation in high-throughput experiments. Bioinformatics. 2012;28(6):882–3.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Theocharidis G, Thomas BE, Sarkar D, Mumme HL, Pilcher WJR, Dwivedi B, Sandoval-Schaefer T, Sîrbulescu RF, Kafanas A, Mezghani I, et al. Single cell transcriptomic landscape of diabetic foot ulcers. Nat Commun. 2022;13(1):181.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Langfelder P, Horvath S. WGCNA: an R package for weighted correlation network analysis. BMC Bioinformatics. 2008;9:559.

Article  PubMed  PubMed Central  Google Scholar 

Szklarczyk D, Gable AL, Lyon D, Junge A, Wyder S, Huerta-Cepas J, Simonovic M, Doncheva NT, Morris JH, Bork P, et al. STRING v11: protein-protein association networks with increased coverage, supporting functional discovery in genome-wide experimental datasets. Nucleic Acids Res. 2019;47(D1):D607–13.

Article  CAS  PubMed  Google Scholar 

Yu G, Wang LG, Han Y, He QY. clusterProfiler: an R package for comparing biological themes among gene clusters. Omics. 2012;16(5):284–7.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chen Y, Li Y, Narayan R, Subramanian A, Xie X. Gene expression inference with deep learning. Bioinformatics. 2016;32(12):1832–9.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Noble WS. What is a support vector machine? Nat Biotechnol. 2006;24(12):1565–7.

Article  CAS  PubMed  Google Scholar 

Paul A, Mukherjee DP, Das P, Gangopadhyay A, Chintha AR, Kundu S. Improved Random Forest for classification. IEEE Trans Image Process. 2018;27(8):4012–24.

Article  PubMed  Google Scholar 

Vasquez MM, Hu C, Roe DJ, Chen Z, Halonen M, Guerra S. Least absolute shrinkage and selection operator type methods for the identification of serum biomarkers of overweight and obesity: simulation and application. BMC Med Res Methodol. 2016;16(1):154.

Article  PubMed  PubMed Central  Google Scholar 

Hänzelmann S, Castelo R, Guinney J. GSVA: gene set variation analysis for microarray and RNA-seq data. BMC Bioinformatics. 2013;14:7.

Article  PubMed  PubMed Central  Google Scholar 

Satija R, Farrell JA, Gennert D, Schier AF, Regev A. Spatial reconstruction of single-cell gene expression data. Nat Biotechnol. 2015;33(5):495–502.

Article  CAS  PubMed  PubMed Central  Google Scholar 

He H, Suryawanshi H, Morozov P, Gay-Mimbrera J, Del Duca E, Kim HJ, Kameyama N, Estrada Y, Der E, Krueger JG, et al. Single-cell transcriptome analysis of human skin identifies novel fibroblast subpopulation and enrichment of immune subsets in atopic dermatitis. J Allergy Clin Immunol. 2020;145(6):1615–28.

Article  CAS  PubMed  Google Scholar 

Lu Y, Liu X, Zhao J, Bie F, Liu Y, Xie J, Wang P, Zhu J, Xiong Y, Qin S, et al. Single-cell profiling reveals transcriptomic signatures of vascular endothelial cells in non-healing diabetic foot ulcers. Front Endocrinol (Lausanne). 2023;14:1275612.

Article  PubMed  Google Scholar 

Reynolds G, Vegh P, Fletcher J, Poyner EFM, Stephenson E, Goh I, Botting RA, Huang N, Olabi B, Dubois A et al. Developmental cell programs are co-opted in inflammatory skin disease. Science 2021, 371(6527).

Tan JX, Finkel T. A phosphoinositide signalling pathway mediates rapid lysosomal repair. Nature. 2022;609(7928):815–21.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ren H, Zhao F, Zhang Q, Huang X, Wang Z. Autophagy and skin wound healing. Burns Trauma. 2022;10:tkac003.