Kaya M, Ahishali B. Basic physiology of the blood-brain barrier in health and disease: a brief overview. Tissue Barriers. 2021;9:1840913. https://doi.org/10.1080/21688370.2020.1840913

Article  CAS  PubMed  Google Scholar 

Zhao Y, Gan L, Ren L, Lin Y, Ma C, Lin X. Factors influencing the blood-brain barrier permeability. Brain Res. 2022;1788:147937. https://doi.org/10.1016/j.brainres.2022.147937

Article  CAS  PubMed  Google Scholar 

Rawal SU, Patel BM, Patel MM. New drug delivery systems developed for brain targeting. Drugs. 2022;82:749–92. https://doi.org/10.1007/s40265-022-01717-z

Article  CAS  PubMed  Google Scholar 

Khalil A, Barras A, Boukherroub R, Tseng CL, Devos D, Burnouf T, et al. Enhancing paracellular and transcellular permeability using nanotechnological approaches for the treatment of brain and retinal diseases. Nanoscale Horiz. 2023;9:14–43. https://doi.org/10.1039/d3nh00306j

Article  CAS  PubMed  Google Scholar 

Bhunia S, Kolishetti N, Vashist A, Yndart Arias A, Brooks D, Nair M. Drug delivery to the brain: recent advances and unmet challenges. Pharmaceutics. 2023;15:2658. https://doi.org/10.3390/pharmaceutics15122658

Article  CAS  PubMed  PubMed Central  Google Scholar 

Baghirov H. Receptor-mediated transcytosis of macromolecules across the blood-brain barrier. Expert Opin Drug Deliv. 2023;20:1699–711. https://doi.org/10.1080/17425247.2023.2255138

Article  CAS  PubMed  Google Scholar 

Tashima T. Smart strategies for therapeutic agent delivery into brain across the blood-brain barrier using receptor-mediated transcytosis. Chem Pharm Bull. 2020;68:316–325. https://doi.org/10.1248/cpb.c19-00854

Article  Google Scholar 

Terstappen GC, Meyer AH, Bell RD, Zhang W. Strategies for delivering therapeutics across the blood-brain barrier. Nat Rev Drug Discov. 2021;20:362–83. https://doi.org/10.1038/s41573-021-00139-y

Article  CAS  PubMed  Google Scholar 

Arvanitis CD, Ferraro GB, Jain RK. The blood-brain barrier and blood-tumour barrier in brain tumours and metastases. Nat Rev Cancer. 2020;20:26–41. https://doi.org/10.1038/s41568-019-0205-x

Article  CAS  PubMed  Google Scholar 

Galea I. The blood-brain barrier in systemic infection and inflammation. Cell Mol Immunol. 2021;18:2489–501. https://doi.org/10.1038/s41423-021-00757-x

Article  CAS  PubMed  PubMed Central  Google Scholar 

Liao J, Fan L, Li Y, Xu QQ, Xiong LY, Zhang SS, et al. Recent advances in biomimetic nanodelivery systems: new brain-targeting strategies. J Control Release. 2023;358:439–64. https://doi.org/10.1016/j.jconrel.2023.05.009

Article  CAS  PubMed  Google Scholar 

Marcello E, Chiono V. Biomaterials-enhanced intranasal delivery of drugs as a direct route for brain targeting. Int J Mol Sci. 2023;24:27 https://doi.org/10.3390/ijms24043390

Article  CAS  Google Scholar 

Gao H. Progress and perspectives on targeting nanoparticles for brain drug delivery. Acta Pharm Sin B. 2016;6:268–86. https://doi.org/10.1016/j.apsb.2016.05.013

Article  PubMed  PubMed Central  Google Scholar 

Jain KK. Nanobiotechnology-based strategies for crossing the blood-brain barrier. Nanomedicine. 2012;7:1225–33. https://doi.org/10.2217/nnm.12.86

Article  CAS  PubMed  Google Scholar 

Masserini M. Nanoparticles for brain drug delivery. ISRN Biochem. 2013;2013:238428 https://doi.org/10.1155/2013/238428

Article  CAS  PubMed  PubMed Central  Google Scholar 

Alotaibi BS, Buabeid M, Ibrahim NA, Kharaba ZJ, Ijaz M, Noreen S, et al. Potential of nanocarrier-based drug delivery systems for brain targeting: a current review of literature. Int J Nanomed. 2021;16:7517–33. https://doi.org/10.2147/IJN.S333657

Article  CAS  Google Scholar 

Agrawal M, Saraf S, Saraf S, Dubey SK, Puri A, Patel RJ, et al. Recent strategies and advances in the fabrication of nano lipid carriers and their application towards brain targeting. J Control Release. 2020;321:372–415. https://doi.org/10.1016/j.jconrel.2020.02.020

Article  CAS  PubMed  Google Scholar 

Patching SG. Glucose transporters at the blood-brain barrier: function, regulation and gateways for drug delivery. Mol Neurobiol. 2017;54:1046–77. https://doi.org/10.1007/s12035-015-9672-6

Article  CAS  PubMed  Google Scholar 

Thomsen MS, Johnsen KB, Kucharz K, Lauritzen M, Moos T. Blood-brain barrier transport of transferrin receptor-targeted nanoparticles. Pharmaceutics. 2022;14:2237. https://doi.org/10.3390/pharmaceutics14102237

Article  CAS  PubMed  PubMed Central  Google Scholar 

Johnsen KB, Burkhart A, Thomsen LB, Andresen TL, Moos T. Targeting the transferrin receptor for brain drug delivery. Prog Neurobiol. 2019;181:101665. https://doi.org/10.1016/j.pneurobio.2019.101665

Article  CAS  PubMed  Google Scholar 

Falanga AP, Melone P, Cagliani R, Borbone N, D’Errico S, Piccialli G, et al. Design, synthesis and characterization of novel co-polymers decorated with peptides for the selective nanoparticle transport across the cerebral endothelium. Molecules. 2018;23:1655. https://doi.org/10.3390/molecules23071655

Article  CAS  PubMed  PubMed Central  Google Scholar 

Friden PM, Walus LR, Musso GF, Taylor MA, Malfroy B, Starzyk RM. Anti-transferrin receptor antibody and antibody-drug conjugates cross the blood-brain barrier. Proc Natl Acad Sci USA. 1991;88:4771–5. https://doi.org/10.1073/pnas.88.11.4771

Article  CAS  PubMed  PubMed Central  Google Scholar 

Huwyler J, Wu D, Pardridge WM. Brain drug delivery of small molecules using immunoliposomes. Proc Natl Acad Sci USA. 1996;93:14164–9. https://doi.org/10.1073/pnas.93.24.14164

Article  CAS  PubMed  PubMed Central  Google Scholar 

Dufes C, Gaillard F, Uchegbu IF, Schatzlein AG, Olivier JC, Muller JM. Glucose-targeted niosomes deliver vasoactive intestinal peptide (VIP) to the brain. Int J Pharm. 2004;285:77–85. https://doi.org/10.1016/j.ijpharm.2004.07.020

Article  CAS  PubMed  Google Scholar 

Alyautdin RN, Petrov VE, Langer K, Berthold A, Kharkevich DA, Kreuter J. Delivery of loperamide across the blood-brain barrier with polysorbate 80-coated polybutylcyanoacrylate nanoparticles. Pharm Res. 1997;14:325–8. https://doi.org/10.1023/a:1012098005098

Article  CAS  PubMed  Google Scholar 

Pawar S, Koneru T, McCord E, Tatiparti K, Sau S, Iyer AK. LDL receptors and their role in targeted therapy for glioma: a review. Drug Discov Today. 2021;26:1212–25. https://doi.org/10.1016/j.drudis.2021.02.008

Article  CAS  PubMed  Google Scholar 

Wang AJJ, Li CH, Li SD, Lin YF, Liu SJ (Inventor) Wang AJ, Jian SJ. (assignee) Gluthione-based delivery system. TW patent 2007/0141133A1. 2007.

Aoyama K, Nakaki T. Impaired glutathione synthesis in neurodegeneration. Int J Mol Sci. 2013;14:21021–44. https://doi.org/10.3390/ijms141021021

Article  CAS  PubMed  PubMed Central  Google Scholar