Trefts E, Gannon M, Wasserman DH. The liver. Curr Biol. 2017;27(21):R1147–51.
Article CAS PubMed PubMed Central Google Scholar
Moreira PR, Maioli MA, Medeiros HCD, Guelfi M, Pereira FTV, Mingatto FE. Protective effect of bixin on carbon tetrachloride-induced hepatotoxicity in rats. Biol Res. 2014;47(1):49.
Article PubMed PubMed Central Google Scholar
Zhao M, Ma J, Li M, Zhang Y, Jiang B, Zhao X, et al. Cytochrome P450 enzymes and drug metabolism in humans. Int J Mol Sci. 2021. https://doi.org/10.3390/ijms222312808.
Article PubMed PubMed Central Google Scholar
Harjumäki R, Pridgeon CS, Ingelman-Sundberg M. CYP2E1 in alcoholic and non-alcoholic liver injury. Roles of ROS, reactive intermediates and lipid overload. Int J Mol Sci. 2021. https://doi.org/10.3390/ijms22158221.
Article PubMed PubMed Central Google Scholar
Massart J, Begriche K, Hartman JH, Fromenty B. Role of mitochondrial cytochrome P450 2E1 in healthy and diseased liver. Cells. 2022. https://doi.org/10.3390/cells11020288.
Article PubMed PubMed Central Google Scholar
Roehlen N, Crouchet E, Baumert TF. Liver fibrosis: mechanistic concepts and therapeutic perspectives. Cells. 2020. https://doi.org/10.3390/cells9040875.
Article PubMed PubMed Central Google Scholar
Tsuchida T, Friedman SL. Mechanisms of hepatic stellate cell activation. Nat Rev Gastroenterol Hepatol. 2017;14(7):397–411.
Article CAS PubMed Google Scholar
Glick D, Barth S, Macleod KF. Autophagy: cellular and molecular mechanisms. J Pathol. 2010;221(1):3–12.
Article CAS PubMed PubMed Central Google Scholar
Zhang Y, Hua L, Lin C, Yuan M, Xu W, Raj DA, et al. Pien-Tze-Huang alleviates CCl4-induced liver fibrosis through the inhibition of HSC autophagy and the TGF-β1/Smad2 pathway. Front Pharmacol. 2022. https://doi.org/10.3389/fphar.2022.937484.
Article PubMed PubMed Central Google Scholar
Allaire M, Rautou PE, Codogno P, Lotersztajn S. Autophagy in liver diseases: time for translation? J Hepatol. 2019;70(5):985–98.
Gao J, Wei B, de Assuncao TM, Liu Z, Hu X, Ibrahim S, et al. Hepatic stellate cell autophagy inhibits extracellular vesicle release to attenuate liver fibrosis. J Hepatol. 2020;73(5):1144–54.
Article CAS PubMed PubMed Central Google Scholar
Peng X, Dai C, Liu Q, Li J, Qiu J. Curcumin attenuates on carbon tetrachloride-induced acute liver injury in mice via modulation of the Nrf2/HO-1 and TGF-β1/Smad3 pathway. Molecules. 2018;23(1):215.
Article PubMed PubMed Central Google Scholar
Chang SN, Kim SH, Dey DK, Park SM, Nasif O, Bajpai VK, et al. 5-O-Demethylnobiletin alleviates CCl(4)-induced acute liver injury by equilibrating ROS-mediated apoptosis and autophagy induction. Int J Mol Sci. 2021. https://doi.org/10.3390/ijms22031083.
Article PubMed PubMed Central Google Scholar
Weber LW, Boll M, Stampfl A. Hepatotoxicity and mechanism of action of haloalkanes: carbon tetrachloride as a toxicological model. Crit Rev Toxicol. 2003;33(2):105–36.
Article CAS PubMed Google Scholar
Laleu B, Rubiano K, Yeo T, Hallyburton I, Anderson M, Crespo-Fernandez B, et al. Exploring a tetrahydroquinoline antimalarial hit from the medicines for malaria pathogen box and identification of its mode of resistance as PfeEF2. ChemMedChem. 2022;17(22): e202200393.
Article CAS PubMed PubMed Central Google Scholar
Méndez-Luna D, Morelos-Garnica LA, García-Vázquez JB, Bello M, Padilla M II, Fragoso-Vázquez MJ, et al. Modifications on the tetrahydroquinoline scaffold targeting a phenylalanine cluster on GPER as antiproliferative compounds against renal liver and pancreatic cancer cells. Pharmaceuticals. 2021. https://doi.org/10.3390/ph14010049.
Article PubMed PubMed Central Google Scholar
Park I, Lee W, Yoo Y, Shin H, Oh J, Kim H, et al. Protective effect of tetrahydroquinolines from the edible insect allomyrina dichotoma on LPS-induced vascular inflammatory responses. Int J Mol Sci. 2020. https://doi.org/10.3390/ijms21103406.
Article PubMed PubMed Central Google Scholar
Ragab HM, Ashour HMA, Galal A, Ghoneim AI, Haidar HR. Synthesis and biological evaluation of some tacrine analogs: study of the effect of the chloro substituent on the acetylcholinesterase inhibitory activity. Monatshefte für Chemie - Chemical Monthly. 2016;147(3):539–52.
Vesga LC, Kronenberger T, Tonduru AK, Kita DH, Zattoni IF, Bernal CC, et al. Tetrahydroquinoline/4,5-dihydroisoxazole molecular hybrids as inhibitors of breast cancer resistance protein (BCRP/ABCG2). ChemMedChem. 2021;16(17):2686–94.
Article CAS PubMed PubMed Central Google Scholar
Zykova S, Shurov S, Savinkov A, Gugushvili N, Talismanov V, editors. Pharmacoprophylaxis of liver diseases: creating a new hepatoprotector. BIO Web of Conferences. EDP Sciences; 2020.
Ragab HM, Teleb M, Haidar HR, Gouda N. Chlorinated tacrine analogs: design, synthesis and biological evaluation of their anti-cholinesterase activity as potential treatment for Alzheimer’s disease. Bioorg Chem. 2019;86:557–68.
Article CAS PubMed Google Scholar
Mroueh M, Faour WH, Shebaby WN, Daher CF, Ibrahim TM, Ragab HM. Synthesis, biological evaluation and modeling of hybrids from tetrahydro-1H-pyrazolo [3, 4-b] quinolines as dual cholinestrase and COX-2 inhibitors. Bioorg Chem. 2020;100: 103895.
Article CAS PubMed Google Scholar
Shang X-F, Morris-Natschke SL, Liu Y-Q, Li X-H, Zhang J-Y, Lee K-H. Biology of quinoline and quinazoline alkaloids. Alkaloids Chem Biol. 2022;88:1–47.
Article CAS PubMed Google Scholar
Sorour AA, Aly RG, Ragab HM, Wahid A. Structure modification converts the hepatotoxic tacrine into novel hepatoprotective analogs. ACS Omega. 2024;9(2):2491–503.
Article CAS PubMed PubMed Central Google Scholar
Raslan RR, Hessein SA, Fouad SA, Shmiess NA. Synthesis and antitumor evaluation of some new thiazolopyridine, nicotinonitrile, pyrazolopyridine, and polyhydroquinoline derivatives using ceric ammonium nitrate as a green catalyst. J Heterocycl Chem. 2022;59(5):832–46.
Asadbegi S, Bodaghifard MA, Mobinikhaledi A. Poly N,N-dimethylaniline-formaldehyde supported on silica-coated magnetic nanoparticles: a novel and retrievable catalyst for green synthesis of 2-amino-3-cyanopyridines. Res Chem Intermed. 2020;46:1629–43.
Mosmann T. Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J Immunol Methods. 1983;65(1–2):55–63.
Article CAS PubMed Google Scholar
Zeashan H, Amresh G, Singh S, Rao CV. Hepatoprotective activity of Amaranthus spinosus in experimental animals. Food Chem Toxicol. 2008;46(11):3417–21.
Article CAS PubMed Google Scholar
Rao GM, Rao CV, Pushpangadan P, Shirwaikar A. Hepatoprotective effects of rubiadin, a major constituent of Rubia Cordifolia Linn. J Ethnopharmacol. 2006;103(3):484–90.
Article CAS PubMed Google Scholar
Goh CW, Aw CC, Lee JH, Chen CP, Browne ER. Pharmacokinetic and pharmacodynamic properties of cholinesterase inhibitors donepezil, tacrine, and galantamine in aged and young lister hooded rats. Drug Metab Dispos. 2011;39(3):402–11.
Article CAS PubMed Google Scholar
Shomer NH, Allen-Worthington KH, Hickman DL, Jonnalagadda M, Newsome JT, Slate AR, et al. Review of rodent euthanasia methods. J Am Assoc Lab Animal Sci. 2020;59(3):242–53.
Brown RE, Jarvis KL, Hyland KJ. Protein measurement using bicinchoninic acid: elimination of interfering substances. Anal Biochem. 1989;180(1):136–9.
Article CAS PubMed Google Scholar
Draper HH, Hadley M. Malondialdehyde determination as index of lipid peroxidation. Methods Enzymol. 1990;186:421–31.
Article CAS PubMed Google Scholar
Bedossa P, Poynard T. An algorithm for the grading of activity in chronic hepatitis C. The METAVIR Cooperative Study Group. Hepatology. 1996. https://doi.org/10.1002/hep.510240201.
Hamza AA, Lashin FM, Gamel M, Hassanin SO, Abdalla Y, Amin A. Hawthorn herbal preparation from crataegus oxyacantha attenuates in vivo carbon tetrachloride-induced hepatic fibrosis via modulating oxidative stress and inflammation. Antioxidants. 2020;9(12):1173.
Article CAS PubMed PubMed Central Google Scholar
Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods (San Diego, Calif). 2001;25(4):402–8.
留言 (0)