Beyer EC, Berthoud VM. Gap junction gene and protein families: Connexins, innexins, and pannexins. Biochim Biophys Acta Biomembr. 2018;1860:5–8.
Article CAS PubMed Google Scholar
Laird DW, Lampe PD. Cellular mechanisms of connexin-based inherited diseases. Trends Cell Biol. 2022;32:58–69.
Article CAS PubMed Google Scholar
Dobrowolski R, Willecke K. Connexin-caused genetic diseases and corresponding mouse models. Antioxid Redox Signal. 2009;11:283–95.
Article CAS PubMed Google Scholar
Maeda S, Nakagawa S, Suga M, Yamashita E, Oshima A, Fujiyoshi Y, Tsukihara T. Structure of the connexin 26 gap junction channel at 3.5 Å resolution. Nature. 2009;458:597–602.
Article CAS PubMed Google Scholar
Brotherton DH, Savva CG, Ragan TJ, Dale N, Cameron AD. Conformational changes and CO2-induced channel gating in connexin26. Structure. 2022;30:697–706.
Article CAS PubMed PubMed Central Google Scholar
Myers JB, Haddad BG, O’Neill SE, Chorev DS, Yoshioka CC, Robinson CV, et al. Structure of native lens connexin 46/50 intercellular channels by cryo-EM. Nature. 2018;564:372–7.
Article CAS PubMed PubMed Central Google Scholar
Flores JA, Haddad BG, Dolan KA, Myers JB, Yoshioka CC, Copperman J, et al. Connexin-46/50 in a dynamic lipid environment resolved by CryoEM at 1.9 Å. Nat Commun. 2020;11:4331.
Article CAS PubMed PubMed Central Google Scholar
Lee HJ, Jeong H, Hyun J, Ryu B, Park K, Lim HH, et al. Cryo-EM structure of human Cx31.3/GJC3 connexin hemichannel. Sci Adv. 2020;6: eaba4996.
Article CAS PubMed PubMed Central Google Scholar
Altevogt BM, Kleopa KA, Postma FR, Scherer SS, Paul DL. Connexin29 is uniquely distributed within myelinating glial cells of the central and peripheral nervous systems. J Neurosci. 2002;22:6458–70.
Article CAS PubMed PubMed Central Google Scholar
Sargiannidou I, Ahn M, Enriquez AD, Peinado A, Reynolds R, Abrams C, et al. Human oligodendrocytes express Cx31.3: function and interactions with Cx32 mutants. Neurobiol Dis. 2008;30:221–33.
Article CAS PubMed PubMed Central Google Scholar
Araya-Secchi R, Perez-Acle T, Kang S-G, Huynh T, Bernardin A, Escalona Y, et al. Characterization of a novel water pocket inside the human Cx26 hemichannel structure. Biophys J. 2014;107:599–612.
Article CAS PubMed PubMed Central Google Scholar
Brennan MJ, Karcz J, Vaughn NR, Woolwine-Cunningham Y, DePriest AD, Escalona Y, et al. Tryptophan scanning reveals dense packing of connexin transmembrane domains in gap junction channels composed of connexin32. J Biol Chem. 2015;290:17074–84.
Article CAS PubMed PubMed Central Google Scholar
García IE, Villanelo F, Contreras GF, Pupo A, Pinto BI, Contreras JE, et al. The syndromic deafness mutation G12R impairs fast and slow gating in Cx26 hemichannels. J Gen Physiol. 2018;150:697–711.
Article PubMed PubMed Central Google Scholar
Nielsen BS, Zonta F, Farkas T, Litman T, Nielsen MS, MacAulay N. Structural determinants underlying permeant discrimination of the Cx43 hemichannel. J Biol Chem. 2019;294:16789–803.
Article CAS PubMed PubMed Central Google Scholar
Schadzek P, Stahl Y, Preller M, Ngezahayo A. Analysis of the dominant mutation N188T of human connexin46 (hCx46) using concatenation and molecular dynamics simulation. FEBS Open Bio. 2019;9:840–50.
Article CAS PubMed PubMed Central Google Scholar
Héja L, Simon Á, Szabó Z, Kardos J. Connexons coupling to gap junction channel: potential role for extracellular protein stabilization centers. Biomolecules. 2021;12:49
Article PubMed PubMed Central Google Scholar
Tong JJ, Khan U, Haddad BG, Minogue PJ, Beyer EC, Berthoud VM, et al. Molecular mechanisms underlying enhanced hemichannel function of a cataract-associated Cx50 mutant. Biophys J. 2021;120:5644–56.
Article CAS PubMed PubMed Central Google Scholar
Yue B, Haddad BG, Khan U, Chen H, Atalla M, Zhang Z, et al. Connexin 46 and connexin 50 gap junction channel properties are shaped by structural and dynamic features of their N-terminal domains. J Physiol. 2021;599:3313–35.
Article CAS PubMed Google Scholar
Oliveira MC, Cordeiro RM, Bogaerts A. Effect of lipid oxidation on the channel properties of Cx26 hemichannels: a molecular dynamics study. Arch Biochem Biophys. 2023;746: 109741.
Article CAS PubMed Google Scholar
Tsai CY, Lu YC, Chan YH, Radhakrishnan N, Chang YY, Lin SW, et al. Simulation-predicted and -explained inheritance model of pathogenicity confirmed by transgenic mice models. Comput Struct Biotechnol J. 2023;21:5698–711.
Article CAS PubMed PubMed Central Google Scholar
García IE, Prado P, Pupo A, Jara O, Rojas-Gómez D, Mujica P, et al. Connexinopathies: a structural and functional glimpse. BMC Cell Biol. 2016;17(Suppl 1):S17.
Beahm DL, Hall JE. Hemichannel and junctional properties of connexin 50. Biophys J. 2002;82:2016–31.
Article CAS PubMed PubMed Central Google Scholar
Srinivas M, Kronengold J, Bukauskas FF, Bargiello TA, Verselis VK. Correlative studies of gating in Cx46 and Cx50 hemichannels and gap junction channels. Biophys J. 2005;88:1725–39.
Article CAS PubMed Google Scholar
Contreras JE, Sáez JC, Bukauskas FF, Bennett MVL. Gating and regulation of connexin 43 (Cx43) hemichannels. Proc Natl Acad Sci USA. 2003;100:11388–93.
Article CAS PubMed PubMed Central Google Scholar
Jara O, Acuña R, García IE, Maripillán J, Figueroa V, Sáez JC, et al. Critical role of the first transmembrane domain of Cx26 in regulating oligomerization and function. Mol Biol Cell. 2012;23:3299–311.
Article CAS PubMed PubMed Central Google Scholar
García IE, Maripillán J, Jara O, Ceriani R, Palacios-Muňoz A, Ramachandran J, et al. Keratitis-ichthyosis-deafness syndrome-associated Cx26 mutants produce nonfunctional gap junctions but hyperactive hemichannels when co-expressed with wild type Cx43. J Invest Dermatol. 2015;135:1338–47.
Article PubMed PubMed Central Google Scholar
Beyer EC, Berthoud VM. The family of connexin genes. In: Harris AL, Locke D, editors. Connexins. A guide. New York: Humana Press; 2009. p. 3–26. https://doi.org/10.1007/978-1-59745-489-6_1.
Contreras JE, Sánchez HA, Eugenin EA, Speidel D, Theis M, Willecke K, et al. Metabolic inhibition induces opening of unapposed connexin 43 gap junction hemichannels and reduces gap junctional communication in cortical astrocytes in culture. Proc Natl Acad Sci USA. 2002;99:495–500.
Article CAS PubMed Google Scholar
Anselmi F, Hernandez VH, Crispino G, Seydel A, Ortolano S, Roper SD, et al. ATP release through connexin hemichannels and gap junction transfer of second messengers propagate Ca2+ signals across the inner ear. Proc Natl Acad Sci USA. 2008;105:18770–5.
Article CAS PubMed PubMed Central Google Scholar
Sánchez HA, Orellana JA, Verselis VK, Sáez JC. Metabolic inhibition increases activity of connexin-32 hemichannels permeable to Ca2+ in transfected HeLa cells. Am J Physiol Cell Physiol. 2009;297:C665–78.
Article PubMed PubMed Central Google Scholar
Orellana JA, Sáez PJ, Cortés-Campos C, Elizondo RJ, Shoji KF, Contreras-Duarte S, et al. Glucose increases intracellular free Ca2+ in tanycytes via ATP released through connexin 43 hemichannels. Glia. 2012;60:53–68.
Kang J, Kang N, Lovatt D, Torres A, Zhao Z, Lin J, et al. Connexin 43 hemichannels are permeable to ATP. J Neurosci. 2008;28:4702–11.
Article CAS PubMed PubMed Central Google Scholar
Zhang X, Zou T, Liu Y, Qi Y. The gating effect of calmodulin and calcium on the connexin50 hemichannel. Biol Chem. 2006;387:595–601.
Article CAS PubMed Google Scholar
Laird DW, Jordan K, Thomas T, Qin H, Fistouris P, Shao Q. Comparative analysis and application of fluorescent protein-tagged connexins. Microsc Res Tech. 2001;52:263–72.
留言 (0)