A genome-wide association study identifies candidate genes for sleep disturbances in depressed individuals

Howard DM, Adams MJ, Clarke TK, Hafferty JD, Gibson J, Shirali M, et al. Genome-wide meta-analysis of depression identifies 102 independent variants and highlights the importance of the prefrontal brain regions. Nat Neurosci. 2019;22(3):343–52.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Herrman H, Kieling C, McGorry P, Horton R, Sargent J, Patel V. Reducing the global burden of depression: a Lancet-World Psychiatric Association Commission. Lancet (London England). 2019;393(10189):e42–3.

Article  PubMed  Google Scholar 

Riemann D. Insomnia and comorbid psychiatric disorders. Sleep Med. 2007;8(Suppl 4):S15–20.

Article  PubMed  Google Scholar 

Goldstone A, Javitz HS, Claudatos SA, Buysse DJ, Hasler BP, de Zambotti M, et al. Sleep disturbance predicts Depression symptoms in early adolescence: initial findings from the adolescent brain Cognitive Development Study. J Adolesc Health: Official Publication Soc Adolesc Med. 2020;66(5):567–74.

Article  Google Scholar 

Cho HJ, Lavretsky H, Olmstead R, Levin MJ, Oxman MN, Irwin MR. Sleep disturbance and depression recurrence in community-dwelling older adults: a prospective study. Am J Psychiatry. 2008;165(12):1543–50.

Article  PubMed  PubMed Central  Google Scholar 

Troxel WM, Kupfer DJ, Reynolds CF 3rd, Frank E, Thase ME, Miewald JM, et al. Insomnia and objectively measured sleep disturbances predict treatment outcome in depressed patients treated with psychotherapy or psychotherapy-pharmacotherapy combinations. J Clin Psychiatry. 2012;73(4):478–85.

Article  PubMed  Google Scholar 

Park SC, Kim JM, Jun TY, Lee MS, Kim JB, Jeong SH, et al. Prevalence and clinical correlates of Insomnia in Depressive disorders: the CRESCEND Study. Psychiatry Invest. 2013;10(4):373–81.

Article  Google Scholar 

Nutt D, Wilson S, Paterson L. Sleep disorders as core symptoms of depression. Dialog Clin Neurosci. 2008;10(3):329–36.

Article  Google Scholar 

Aschbrenner KA, Naslund JA, Salwen-Deremer JK, Browne J, Bartels SJ, Wolfe RS et al. Sleep quality and its relationship to mental health, physical health and health behaviours among young adults with serious mental illness enrolled in a lifestyle intervention trial. Early Interv Psychiat. 2022;16(1):106–10.

Anna Karin H, Hössjer O, Bellocco R, Ye W, Trolle LY, Åkerstedt T. Insomnia in the context of short sleep increases suicide risk. Sleep. 2021;44(4):zsaa245.

Article  Google Scholar 

Baglioni C, Battagliese G, Feige B, Spiegelhalder K, Nissen C, Voderholzer U, et al. Insomnia as a predictor of depression: a meta-analytic evaluation of longitudinal epidemiological studies. J Affect Disord. 2011;135(1–3):10–9.

Article  PubMed  Google Scholar 

Hertenstein E, Feige B, Gmeiner T, Kienzler C, Spiegelhalder K, Johann A, et al. Insomnia as a predictor of mental disorders: a systematic review and meta-analysis. Sleep Med Rev. 2019;43:96–105.

Article  PubMed  Google Scholar 

Roman V, Walstra I, Luiten PG, Meerlo P. Too little sleep gradually desensitizes the serotonin 1A receptor system. Sleep. 2005;28(12):1505–10.

PubMed  Google Scholar 

Hu Y, Shmygelska A, Tran D, Eriksson N, Tung JY, Hinds DA. GWAS of 89,283 individuals identifies genetic variants associated with self-reporting of being a morning person. Nat Commun. 2016;7:10448.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Sullivan PF, Neale MC, Kendler KS. Genetic epidemiology of major depression: review and meta-analysis. Am J Psychiatry. 2000;157(10):1552–62.

Article  CAS  PubMed  Google Scholar 

Lane JM, Liang J, Vlasac I, Anderson SG, Bechtold DA, Bowden J, et al. Genome-wide association analyses of sleep disturbance traits identify new loci and highlight shared genetics with neuropsychiatric and metabolic traits. Nat Genet. 2017;49(2):274–81.

Article  CAS  PubMed  Google Scholar 

Wing YK, Zhang J, Lam SP, Li SX, Tang NL, Lai KY, et al. Familial aggregation and heritability of insomnia in a community-based study. Sleep Med. 2012;13(8):985–90.

Article  CAS  PubMed  Google Scholar 

Howard DM, Adams MJ, Shirali M, Clarke TK, Marioni RE, Davies G, et al. Genome-wide association study of depression phenotypes in UK Biobank identifies variants in excitatory synaptic pathways. Nat Commun. 2018;9(1):1470.

Article  PubMed  PubMed Central  Google Scholar 

Sudlow C, Gallacher J, Allen N, Beral V, Burton P, Danesh J, et al. UK biobank: an open access resource for identifying the causes of a wide range of complex diseases of middle and old age. PLoS Med. 2015;12(3):e1001779.

Article  PubMed  PubMed Central  Google Scholar 

Kroenke K, Spitzer RL, Williams JB. The PHQ-9: validity of a brief depression severity measure. J Gen Intern Med. 2001;16(9):606–13.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ye J, Wen Y, Sun X, Chu X, Li P, Cheng B, et al. Socioeconomic deprivation index is Associated with Psychiatric disorders: an observational and genome-wide Gene-by-Environment Interaction Analysis in the UK Biobank Cohort. Biol Psychiatry. 2021;89(9):888–95.

Article  CAS  PubMed  Google Scholar 

Jones SE, Lane JM, Wood AR, van Hees VT, Tyrrell J, Beaumont RN, et al. Genome-wide association analyses of chronotype in 697,828 individuals provides insights into circadian rhythms. Nat Commun. 2019;10(1):343.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Michalek-Zrabkowska M, Wieckiewicz M, Macek P, Gac P, Smardz J, Wojakowska A, et al. The relationship between simple snoring and sleep bruxism: a Polysomnographic Study. Int J Environ Res Public Health. 2020;17(23):8960.

Article  PubMed  PubMed Central  Google Scholar 

Lessov-Schlaggar CN, Bliwise DL, Krasnow RE, Swan GE, Reed T. Genetic association of daytime sleepiness and depressive symptoms in elderly men. Sleep. 2008;31(8):1111–7.

PubMed  PubMed Central  Google Scholar 

Bycroft C, Freeman C, Petkova D, Band G, Elliott LT, Sharp K, et al. The UK Biobank resource with deep phenotyping and genomic data. Nature. 2018;562(7726):203–9.

Article  CAS  PubMed  PubMed Central  Google Scholar 

McCarthy S, Das S, Kretzschmar W, Delaneau O, Wood AR, Teumer A, et al. A reference panel of 64,976 haplotypes for genotype imputation. Nat Genet. 2016;48(10):1279–83.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bycroft C, Freeman C, Petkova D, Band G, Elliott LT, Sharp K et al. Genome-wide genetic data on ~ 500,000 UK Biobank participants. 2017:166298.

Manichaikul A, Mychaleckyj JC, Rich SS, Daly K, Sale M, Chen WM. Robust relationship inference in genome-wide association studies. Bioinformatics. 2010;26(22):2867–73.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Manichaikul A, Palmas W, Rodriguez CJ, Peralta CA, Divers J, Guo X, et al. Population structure of hispanics in the United States: the multi-ethnic study of atherosclerosis. PLoS Genet. 2012;8(4):e1002640.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Purcell S, Neale B, Todd-Brown K, Thomas L, Ferreira MA, Bender D, et al. PLINK: a tool set for whole-genome association and population-based linkage analyses. Am J Hum Genet. 2007;81(3):559–75.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wang J, Huang D, Zhou Y, Yao H, Liu H, Zhai S, et al. CAUSALdb: a database for disease/trait causal variants identified using summary statistics of genome-wide association studies. Nucleic Acids Res. 2020;48(D1):D807–16.

CAS  PubMed  Google Scholar 

Jones SE, Tyrrell J, Wood AR, Beaumont RN, Ruth KS, Tuke MA, et al. Genome-Wide Association Analyses in 128,266 individuals identifies new morningness and sleep duration loci. PLoS Genet. 2016;12(8):e1006125.

Article  PubMed  PubMed Central  Google Scholar 

Lane JM, Vlasac I, Anderson SG, Kyle SD, Dixon WG, Bechtold DA, et al. Genome-wide association analysis identifies novel loci for chronotype in 100,420 individuals from the UK Biobank. Nat Commun. 2016;7:10889.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Watanabe K, Stringer S, Frei O, Umićević Mirkov M, de Leeuw C, Polderman TJC, et al. A global overview of pleiotropy and genetic architecture in complex traits. Nat Genet. 2019;51(9):1339–48.

Article  CAS  PubMed  Google Scholar 

Lee JJ, Wedow R, Okbay A, Kong E, Maghzian O, Zacher M, et al. Gene discovery and polygenic prediction from a genome-wide association study of educational attainment in 1.1 million individuals. Nat Genet. 2018;50(8):1112–21.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Luciano M, Hagenaars SP, Davies G, Hill WD, Clarke TK, Shirali M, et al. Association analysis in over 329,000 individuals identifies 116 independent variants influencing neuroticism. Nat Genet. 2018;50(1):6–11.

Article  CAS  PubMed  Google Scholar 

Xu P, Morrison JP, Foley JF, Stumpo DJ, Ward T, Zeldin DC, et al. Conditional ablation of the RFX4 isoform 1 transcription factor: allele dosage effects on brain phenotype. PLoS ONE. 2018;13(1):e0190561.

Article  PubMed  PubMed Central  Google Scholar 

Araki R, Takahashi H, Fukumura R, Sun F, Umeda N, Sujino M, et al. Restricted expression and photic induction of a novel mouse regulatory factor X4 transcript in the suprachiasmatic nucleus. J Biol Chem. 2004;279(11):10237–42.

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