Pastuszak Z, Kozniewska E, Stepien A, Piusinska-Macoch A, Czernicki Z, Koszewski W. Importance rating of risk factors of ischemic stroke in patients over 85 years old in the polish population. Neurol Neurochir Pol. 2018;52:88–93. https://doi.org/10.1016/j.pjnns.2017.11.007.

Article  PubMed  Google Scholar 

Navar-Boggan AM, Peterson ED, D’Agostino RB, Neely B, Sniderman AD, Pencina MJ. Hyperlipidemia in Early Adulthood Increases Long-Term Risk of Coronary Heart Disease. Circulation. 2015;131:451–8. https://doi.org/10.1161/CIRCULATIONAHA.114.012477.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chevli PA, Freedman BI, Hsu FC, Xu JZ, Rudock ME, Ma LJ, et al. Plasma metabolomic profiling in subclinical atherosclerosis: the Diabetes Heart Study. Cardiovasc Diabetol. 2021;20:215. https://doi.org/10.1186/s12933-021-01419-y.

Article  CAS  Google Scholar 

Nomura S, Takahashi N, Inami N, Kajiura T, Yamada K, Nakamori H, et al. Probucol and ticlopidine: effect on platelet and monocyte activation markers in hyperlipidemic patients with and without type 2 diabetes. Atherosclerosis. 2004;174:329–35. https://doi.org/10.1016/j.atherosclerosis.2004.01.027.

Article  CAS  PubMed  Google Scholar 

Zhang YP, Wang YX, Zhou JQ, Wang Q, Yan YN, Yang X, et al. The Influence of Diabetes, Hypertension, and Hyperlipidemia on the Onset of Age-Related Macular Degeneration in North China: The Kailuan Eye Study. Biomed Environ Sci. 2022;35:613–21. https://doi.org/10.3967/bes2022.081.

Article  PubMed  Google Scholar 

Kim E, Yang JW, Park KW, Cho SH. Preventative, but not post-stroke, inhibition of CD36 attenuates brain swelling in hyperlipidemic stroke. J Cereb Blood Flow Metab. 2020;40:885–94. https://doi.org/10.1177/0271678X19850004.

Article  CAS  PubMed  Google Scholar 

Sahebkar A, Simental-Mendía LE, Watts GF, Serban MC, Banach M, Lipid Blood Pressure M-A. Comparison of the effects of fibrates versus statins on plasma lipoprotein(a) concentrations: a systematic review and meta-analysis of head-to-head randomized controlled trials. BMC Med. 2017;15:22. https://doi.org/10.1186/s12916-017-0787-7.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Thompson PD, Panza G, Zaleski A, Taylor B. Statin-Associated Side Effects. J Am Coll Cardiol. 2016;67:2395–410. https://doi.org/10.1016/j.jacc.2016.02.071.

Article  CAS  PubMed  Google Scholar 

Barkas F, Adamidis P, Koutsogianni A-D, Liamis G, Liberopoulos E. Statin-associated side effects in patients attending a lipid clinic: evidence from a 6-year study. Arch Med Sci Atheroscler Dis. 2021;6:e182–e187. https://doi.org/10.5114/amsad.2021.111313.

Article  PubMed  PubMed Central  Google Scholar 

Demyen M, Alkhalloufi K, Pyrsopoulos NT. Lipid-Lowering Agents and Hepatotoxicity. Clin Liver Dis. 2013;17:699–714. https://doi.org/10.1016/j.cld.2013.07.016.

Article  PubMed  Google Scholar 

Liu HT, Zhang PP, Ge XX, Wu Q, Han CC, Zhang LY, et al. Optimization of clofibrate with O-desmethyl anetholtrithione lead to a novel hypolipidemia compound with hepatoprotective effect. Bioorg Med Chem Lett. 2022;72:128844 https://doi.org/10.1016/j.bmcl.2022.128844.

Article  CAS  PubMed  Google Scholar 

Hedrington MS, Davis SN. Peroxisome proliferator-activated receptor alpha-mediated drug toxicity in the liver. Expert Opin Drug Metab Toxicol. 2018;14:671–7. https://doi.org/10.1080/17425255.2018.1483337.

Article  CAS  PubMed  Google Scholar 

Guo ZR. The modification of natural products for medical use. ACTA Pharm Sin B. 2017;7:119–36. https://doi.org/10.1016/j.apsb.2016.06.003.

Article  PubMed  Google Scholar 

Najmi A, Javed SA, Al Bratty M, Alhazmi HA. Modern Approaches in the Discovery and Development of Plant-Based Natural Products and Their Analogues as Potential Therapeutic Agents. Molecules. 2022;27:349. https://doi.org/10.3390/molecules27020349.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Narasimhulu CA, Selvarajan K, Litvinov D, Parthasarathy S. Anti-Atherosclerotic and Anti-Inflammatory Actions of Sesame Oil. J Med Food. 2015;18:11–20. https://doi.org/10.1089/jmf.2014.0138.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhang RJ, Yu Y, Hu SK, Zhang JH, Yang HX, Han B, et al. Sesamin ameliorates hepatic steatosis and inflammation in rats on a high-fat diet via LXRα and PPARα. Nutr Res. 2016;36:1022–30. https://doi.org/10.1016/j.nutres.2016.06.015.

Article  CAS  PubMed  Google Scholar 

Xie Y, Liu J, Shi Y, Wang B, Wang X, Wang W, et al. Structural simplification and bioisostere principle lead to Bis-benzodioxole-fibrate derivatives as potential hypolipidemic and hepatoprotective agents. Bioorg Chem. 2021;117:105454. https://doi.org/10.1016/j.bioorg.2021.105454.

Article  CAS  PubMed  Google Scholar 

Garg G, Patil A, Singh J, Kaushik N, Praksah A, Pal A, et al. Pharmacological evaluation of Convolvulus pluricaulis as hypolipidaemic agent in Triton WR-1339-induced hyperlipidaemia in rats. J Pharm Pharmacol. 2018;70:1572–80. https://doi.org/10.1111/jphp.13004.

Article  CAS  PubMed  Google Scholar 

Bouhlali EDT, Hmidani A, Bourkhis B, Khouya T, Harnafi H, Filali-Zegzouti Y, et al. Effect of Phoenix dactylifera seeds (dates) extract in triton WR-1339 and high fat diet induced hyperlipidaemia in rats: A comparison with simvastatin. J Ethnopharmacol. 2020;259:112961. https://doi.org/10.1016/j.jep.2020.112961.

Article  CAS  PubMed  Google Scholar 

Todisco S, Santarsiero A, Convertini P, De Stefano G, Gilio M, Iacobazzi V, et al. PPAR Alpha as a Metabolic Modulator of the Liver: Role in the Pathogenesis of Nonalcoholic Steatohepatitis (NASH). Biol Basel. 2022;11:792. https://doi.org/10.3390/biology11050792.

Article  CAS  Google Scholar 

Wang H, Sun ZO, Ur-Rehman R, Riaz S, Shen TT, Fan ZC, et al. Apple phlorizin reduce plasma cholesterol by down-regulating hepatic HMG-CoA reductase and enhancing the excretion of fecal sterols. J Funct Foods. 2019;62:103548. https://doi.org/10.1016/j.jff.2019.103548.

Article  CAS  Google Scholar 

Yang RL, Shi YH, Hao G, Li W, Le GW. Increasing Oxidative Stress with Progressive Hyperlipidemia in Human: Relation between Malondialdehyde and Atherogenic Index. J Clin Biochem Nutr. 2008;43:154–8. https://doi.org/10.3164/jcbn.2008044.

Article  PubMed  PubMed Central  Google Scholar 

He DQ, Zhang JW, Chen YQ, Li ZL. Tanshinone IIA Alleviates Atherosclerosis Through Inhibition of NF-κB and PPARαE/ABCA1 Signaling Pathways. J Biomed Nanotechnol. 2023;19:1824–31. https://doi.org/10.1166/jbn.2023.3689.

Article  CAS  Google Scholar 

Kuo DH, Yeh CH, Shieh PC, Cheng KC, Chen FA, Cheng JT. Effect of ShanZha, a Chinese herbal product, on obesity and dyslipidemia in hamsters receiving high-fat diet. J Ethnopharmacol. 2009;124:544–50. https://doi.org/10.1016/j.jep.2009.05.005.

Article  PubMed  Google Scholar 

Song KH, Lee SH, Kim BY, Park AY, Kim JY. Extracts of Scutellaria baicalensis Reduced Body Weight and Blood Triglyceride in db/db Mice. Phytother Res. 2013;27:244–50. https://doi.org/10.1002/ptr.4691.

Article  PubMed  Google Scholar 

Chang ST, Chu CM, Hsu TE, Pan KL, Lin PG, Chung CM. Role of ankle-brachial pressure index as a predictor of coronary artery disease severity in patients with diabetes mellitus. Can J Cardiol. 2009;25:E301–E305. https://doi.org/10.1016/S0828-282X(09)70140-0.

Article  PubMed  PubMed Central  Google Scholar 

Alvarez-Jimenez L, Moreno-Cabañas A, Ramirez-Jimenez M, Morales-Palomo F, Ortega JF, Mora-Rodriguez R. Effectiveness of statins vs. exercise on reducing postprandial hypertriglyceridemia in dyslipidemic population: A systematic review and network meta-analysis. J Sport Health Sci. 2022;11:567–77. https://doi.org/10.1016/j.jshs.2021.07.006.

Article  PubMed  Google Scholar 

Higashi K, Shige H, Ito T, Nakajima K, Ishikawa T, Nakamura H, et al. Impaired glucose tolerance without hypertriglyceridemia does not enhance postprandial lipemia. Horm Metab Res. 2001;33:101–5. https://doi.org/10.1055/s-2001-12400.

Article  CAS  PubMed  Google Scholar 

Zhang YW, Xu K, Zhang YQ. Ginsenoside-Mc1 reduces ischemia/reperfusion-induced cardiac arrhythmias through activating JAK2/STAT3 pathway and attenuating oxidative/endoplasmic reticulum stress in hyperlipidemic rats. Turkish J Biochem Turk Biyokimya Derg. 2022;47:491–500. https://doi.org/10.1515/tjb-2021-0171.

Article  CAS  Google Scholar 

Amrita J, Mahajan M, Bhanwer AJS, Mohan G. Oxidative Stress: An Effective Prognostic Tool for an Early Detection of Cardiovascular Disease in Menopausal Women. Biochem Res Int. 2016;2016:6157605–6157605. https://doi.org/10.1155/2016/6157605.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Farah R, Jubran F, Khamisy-Farah R. Effects of statins on oxidative stress and primed polymorphonuclear leukocytes in hyperlipidemic patients. Biotech Histochem. 2012;87:519–25. https://doi.org/10.3109/10520295.2012.719243.

Article  CAS  PubMed  Google Scholar 

Shen YC, Yang T, Guo SJ, Li XO, Chen L, Wang T, et al. Increased Serum ox-LDL Levels Correlated with Lung Function, Inflammation, and Oxidative Stress in COPD. Mediat Inflam. 2013;2013. https://doi.org/10.1155/2013/972347.

Teppner M, Böss F, Ernst B, Pähler A. Application of lipid peroxidation products as biomarkers for flutamide-induced oxidative stress in vitro. Toxicol Lett. 2015;238:53–59. https://doi.org/10.1016/j.toxlet.2015.08.005.

Article  CAS  PubMed  Google Scholar 

Hasanein P, Ghafari-Vahed M, Khodadadi I. Effects of isoquinoline alkaloid berberine on lipid peroxidation, antioxidant defense system, and liver damage induced by