Li Q, Barres BA. Microglia and macrophages in brain homeostasis and disease. Nat Rev Immunol. 2018;18:225–42.
Article CAS PubMed Google Scholar
Prinz M, Jung S, Priller J. Microglia biology: one century of evolving concepts. Cell. 2019;179:292–311.
Article CAS PubMed Google Scholar
Keren-Shaul H, Spinrad A, Weiner A, Matcovitch-Natan O, Dvir-Szternfeld R, Ulland TK, David E, Baruch K, Lara-Astaiso D, Toth B, et al. A unique microglia type associated with restricting development of alzheimer’s disease. Cell. 2017;169:1276–e12901217.
Article CAS PubMed Google Scholar
Masuda T, Sankowski R, Staszewski O, Bottcher C, Amann L, Sagar; Scheiwe C, Nessler S, Kunz P, van Loo G, et al. Spatial and temporal heterogeneity of mouse and human microglia at single-cell resolution. Nature. 2019;566:388–92.
Article CAS PubMed Google Scholar
Masuda T, Sankowski R, Staszewski O, Prinz M. Microglia heterogeneity in the single-cell era. Cell Rep. 2020;30:1271–81.
Article CAS PubMed Google Scholar
Li Q, Cheng Z, Zhou L, Darmanis S, Neff NF, Okamoto J, Gulati G, Bennett ML, Sun LO, Clarke LE, et al. Developmental heterogeneity of microglia and brain myeloid cells revealed by deep single-cell rna sequencing. Neuron. 2019;101:207–e223210.
Article CAS PubMed Google Scholar
Hammond TR, Dufort C, Dissing-Olesen L, Giera S, Young A, Wysoker A, Walker AJ, Gergits F, Segel M, Nemesh J, et al. Single-cell rna sequencing of microglia throughout the mouse lifespan and in the injured brain reveals complex cell-state changes. Immunity. 2019;50:253–e271256.
Article CAS PubMed Google Scholar
Stratoulias V, Venero JL, Tremblay ME, Joseph B. Microglial subtypes: diversity within the microglial community. EMBO J. 2019;38:e101997.
Article PubMed PubMed Central Google Scholar
Krasemann S, Madore C, Cialic R, Baufeld C, Calcagno N, El Fatimy R, Beckers L, O’Loughlin E, Xu Y, Fanek Z, et al. The trem2-apoe pathway drives the transcriptional phenotype of dysfunctional microglia in neurodegenerative diseases. Immunity. 2017;47:566–e581569.
Article CAS PubMed PubMed Central Google Scholar
Mrdjen D, Pavlovic A, Hartmann FJ, Schreiner B, Utz SG, Leung BP, Lelios I, Heppner FL, Kipnis J, Merkler D, et al. High-dimensional single-cell mapping of central nervous system immune cells reveals distinct myeloid subsets in health, aging, and disease. Immunity. 2018;48:380–e395386.
Article CAS PubMed Google Scholar
Benmamar-Badel A, Owens T, Wlodarczyk A. Protective microglial subset in development, aging, and disease: lessons from transcriptomic studies. Front Immunol. 2020;11:430.
Article CAS PubMed PubMed Central Google Scholar
Wlodarczyk A, Holtman IR, Krueger M, Yogev N, Bruttger J, Khorooshi R, Benmamar-Badel A, de Boer-Bergsma JJ, Martin NA, Karram K, et al. A novel microglial subset plays a key role in myelinogenesis in developing brain. EMBO J. 2017;36:3292–308.
Article CAS PubMed PubMed Central Google Scholar
Shen X, Qiu Y, Wight AE, Kim HJ, Cantor H. Definition of a mouse microglial subset that regulates neuronal development and proinflammatory responses in the brain. Proc. Natl. Acad. Sci 2022, 119.
Qiu Y, Shen X, Ravid O, Atrakchi D, Rand D, Wight AE, Kim HJ, Liraz-Zaltsman S, Cooper I, Schnaider Beeri M et al. Definition of the contribution of an osteopontin-producing cd11c+ microglial subset to alzheimer’s disease. Proc. Natl. Acad. Sci. 2023;120:e2218915120.
Lawrence AR, Canzi A, Bridlance C, Olivie N, Lansonneur C, Catale C, Pizzamiglio L, Kloeckner B, Silvin A, Munro DAD, et al. Microglia maintain structural integrity during fetal brain morphogenesis. Cell. 2024;187:962–e980919.
Article CAS PubMed PubMed Central Google Scholar
Silvin A, Uderhardt S, Piot C, Da Mesquita S, Yang K, Geirsdottir L, Mulder K, Eyal D, Liu Z, Bridlance C, et al. Dual ontogeny of disease-associated microglia and disease inflammatory macrophages in aging and neurodegeneration. Immunity. 2022;55:1448–e14651446.
Article CAS PubMed Google Scholar
Stratoulias V, Ruiz R, Kanatani S, Osman AM, Keane L, Armengol JA, Rodríguez-Moreno A, Murgoci A-N, García-Domínguez I, Alonso-Bellido I, et al. Arg1-expressing microglia show a distinct molecular signature and modulate postnatal development and function of the mouse brain. Nat Neurosci. 2023;26:1008–20.
Article CAS PubMed PubMed Central Google Scholar
Hagemeyer N, Hanft KM, Akriditou MA, Unger N, Park ES, Stanley ER, Staszewski O, Dimou L, Prinz M. Microglia contribute to normal myelinogenesis and to oligodendrocyte progenitor maintenance during adulthood. Acta Neuropathol. 2017;134:441–58.
Article PubMed PubMed Central Google Scholar
Butovsky O, Koronyo-Hamaoui M, Kunis G, Ophir E, Landa G, Cohen H, Schwartz M. Glatiramer acetate fights against Alzheimer’s disease by inducing dendritic-like microglia expressing insulin-like growth factor 1. Proc Natl Acad Sci. 2006;103:11784–9.
Article CAS PubMed PubMed Central Google Scholar
Sato-Hashimoto M, Nozu T, Toriba R, Horikoshi A, Akaike M, Kawamoto K, Hirose A, Hayashi Y, Nagai H, Shimizu W et al. Microglial sirpa a regulates the emergence of cd11c+ microglia and demyelination damage in white matter. eLife. 2019;8.
Kohno K, Shirasaka R, Yoshihara K, Mikuriya S, Tanaka K, Takanami K, Inoue K, Sakamoto H, Ohkawa Y, Masuda T, et al. A spinal microglia population involved in remitting and relapsing neuropathic pain. Science. 2022;376:86–90.
Article CAS PubMed Google Scholar
Tsuda M, Masuda T, Kohno K. Microglial diversity in neuropathic pain. Trends Neurosci. 2023;46:597–610.
Article CAS PubMed Google Scholar
Bulloch K, Miller MM, Gal-Toth J, Milner TA, Gottfried-Blackmore A, Waters EM, Kaunzner UW, Liu K, Lindquist R, Nussenzweig MC, et al. Cd11c/eyfp transgene illuminates a discrete network of dendritic cells within the embryonic, neonatal, adult, and injured mouse brain. J Comp Neurol. 2008;508:687–710.
Cossart R, Garel S. Step by step: cells with multiple functions in cortical circuit assembly. Nat Rev Neurosci. 2022;23:395–410.
Article CAS PubMed Google Scholar
Anandasabapathy N, Victora GD, Meredith M, Feder R, Dong B, Kluger C, Yao K, Dustin ML, Nussenzweig MC, Steinman RM, et al. Flt3l controls the development of radiosensitive dendritic cells in the meninges and choroid plexus of the steady-state mouse brain. J Exp Med. 2011;208:1695–705.
Article CAS PubMed PubMed Central Google Scholar
Remington LT, Babcock AA, Zehntner SP, Owens T. Microglial recruitment, activation, and proliferation in response to primary demyelination. Am J Pathol. 2007;170:1713–24.
Article PubMed PubMed Central Google Scholar
Wlodarczyk A, Løbner M, Cédile O, Owens T. Comparison of microglia and infiltrating cd11c+ cells as antigen presenting cells for t cell proliferation and cytokine response. J Neuroinflamm. 2014;11:57.
Wlodarczyk A, Cedile O, Jensen KN, Jasson A, Mony JT, Khorooshi R, Owens T. Pathologic and protective roles for microglial subsets and bone marrow- and blood-derived myeloid cells in central nervous system inflammation. Front Immunol. 2015;6:463.
Article PubMed PubMed Central Google Scholar
Jia J, Zheng L, Ye L, Chen J, Shu S, Xu S, Bao X, Xia S, Liu R, Xu Y, et al. Cd11c+ microglia promote white matter repair after ischemic stroke. Cell Death Dis. 2023;14:156.
Article PubMed PubMed Central Google Scholar
Weinger JG, Brosnan CF, Loudig O, Goldberg MF, Macian F, Arnett HA, Prieto AL, Tsiperson V, Shafit-Zagardo B. Loss of the receptor tyrosine kinase axl leads to enhanced inflammation in the cns and delayed removal of myelin debris during experimental autoimmune encephalomyelitis. J Neuroinflamm. 2011;8:49.
Nishiyama A, Shimizu T, Sherafat A, Richardson WD. Life-long oligodendrocyte development and plasticity. Semin Cell Dev Biol. 2021;116:25–37.
Article CAS PubMed PubMed Central Google Scholar
Hattori Y, Kato D, Murayama F, Koike S, Asai H, Yamasaki A, Naito Y, Kawaguchi A, Konishi H, Prinz M, et al. Cd206(+) macrophages transventricularly infiltrate the early embryonic cerebral wall to differentiate into microglia. Cell Rep. 2023;42:112092.
Article CAS PubMed Google Scholar
Bottcher C, Schlickeiser S, Sneeboer MAM, Kunkel D, Knop A, Paza E, Fidzinski P, Kraus L, Snijders GJL, Kahn RS, et al. Human microglia regional heterogeneity and phenotypes determined by multiplexed single-cell mass cytometry. Nat Neurosci. 2019;22:78–90.
Lindquist RL, Shakhar G, Dudziak D, Wardemann H, Eisenreich T, Dustin ML, Nussenzweig MC. Visualizing dendritic cell networks in vivo. Nat Immunol. 2004;5:1243–50.
Article CAS PubMed Google Scholar
Masuda T, Amann L, Sankowski R, Staszewski O, Lenz M, P DE, Snaidero N, Costa Jordao MJ, Bottcher C, Kierdorf K, et al. Novel hexb-based tools for studying microglia in the cns. Nat Immunol. 2020;21:802–15.
Article CAS PubMed Google Scholar
Silvin A, Qian J, Ginhoux F. Brain macrophage development, diversity and dysregulation in health and disease. Cell Mol Immunol. 2023;20:1277–89.
留言 (0)