Association of leptin–melanocortin gene polymorphisms with the risk of obesity in northwest Indian population

Chooi YC, Ding C, Magkos F (2019) The epidemiology of obesity. Metabolism 92:6–10

Article  CAS  PubMed  Google Scholar 

Bray MS, Loos RJ, McCaffery JM, Ling C, Franks PW, Weinstock GM et al (2016) NIH working group report—using genomic information to guide weight management: From universal to precision treatment. Obesity 24(1):14–22

Article  PubMed  Google Scholar 

Heymsfield SB, Wadden TA (2017) Mechanisms, pathophysiology, and management of obesity. N Engl J Med 376(3):254–266

Article  CAS  PubMed  Google Scholar 

Wang YC, McPherson K, Marsh T, Gortmaker SL, Brown M (2011) Health and economic burden of the projected obesity trends in the USA and the UK. Lancet 378:815–825. https://doi.org/10.1016/S0140-6736(11)60814-

Article  PubMed  Google Scholar 

World Health Organization (2020) WHO guidelines on physical activity and sedentary behaviour: web annex: evidence profiles. https://doi.org/10.1136/bjsports-2020-102955

Rizzo NS, Jaceldo-Siegl K, Sabate J, Fraser GE (2013) Nutrient profiles of vegetarian and nonvegetarian dietary patterns. J Acad Nutr Diet 113(12):1610–1619

Article  PubMed  PubMed Central  Google Scholar 

Luhar S, Timæus IM, Jones R, Cunningham S, Patel SA, Kinra S et al (2020) Forecasting the prevalence of overweight and obesity in India to 2040. PLoS ONE 15(2):e0229438

Article  CAS  PubMed  PubMed Central  Google Scholar 

Tao YX (2010) The melanocortin-4 receptor: physiology, pharmacology, and pathophysiology. Endocr Rev 31(4):506–543

Article  CAS  PubMed  PubMed Central  Google Scholar 

Delhanty PJ, Bouw E, Huisman M, Vervenne RM, Themmen AP, van der Lely AJ et al (2014) Functional characterization of a new human melanocortin-4 receptor homozygous mutation (N72K) that is associated with early-onset obesity. Mol Biol Rep 41(12):7967–7972

Article  CAS  PubMed  Google Scholar 

Münzberg H, Morrison CD (2015) Structure, production and signaling of leptin. Metabolism 64(1):13–23

Article  PubMed  Google Scholar 

Rovite V, Petrovska R, Vaivade I, Kalnina I, Fridmanis D, Zaharenko L et al (2014) The role of common and rare MC4R variants and FTO polymorphisms in extreme form of obesity. Mol Biol Rep 41:1491–1500

Article  CAS  PubMed  Google Scholar 

Albuquerque D, Nóbrega C, Rodríguez-López R, Manco L (2014) Association study of common polymorphisms in MSRA, TFAP2B, MC4R, NRXN3, PPARGC1A, TMEM18, SEC16B, HOXB5 and OLFM4 genes with obesity-related traits among Portuguese children. J Hum Genet 59(6):307–313

Article  CAS  PubMed  Google Scholar 

Been LF, Nath SK, Ralhan SK, Wander GS, Mehra NK, Singh J et al (2010) Replication of association between a common variant near melanocortin-4 receptor gene and obesity-related traits in Asian Sikhs. Obesity 18(2):425–429

Article  CAS  PubMed  Google Scholar 

Xi B, Chandak GR, Shen Y, Wang Q, Zhou D (2012) Association between common polymorphism near the MC4R gene and obesity risk: a systematic review and meta-analysis. PLoS ONE 7(9):e45731

Article  CAS  PubMed  PubMed Central  Google Scholar 

Dusatkova L, Zamrazilová H, Sedlackova B, Vcelak J, Hlavatý P, Hainerová IA et al (2013) Association of obesity susceptibility gene variants with metabolic syndrome and related traits in 1,443 Czech adolescents. Folia Biol 59(3):123–133

CAS  Google Scholar 

Apalasamy YD, Ming MF, Rampal S, Bulgiba A, Mohamed Z (2013) Association of melanocortin-4 receptor gene polymorphisms with obesity-related parameters in Malaysian Malays. Ann Hum Biol 40(1):102–106

Article  PubMed  Google Scholar 

Kochetova OV, Korytina GF, Akhmadishina LZ, Semenov EE, Viktorova TV (2014) Association of polymorphic variants of FTO and MC4R genes with obesity in a Tatar population. Genetika 51(2):248–255

Google Scholar 

Wei BL, Yin RX, Liu CX, Deng GX, Guan YZ, Zheng PF (2020) The MC4R SNPs, their haplotypes and gene-environment interactions on the risk of obesity. Mol Med 26(1):1–10

Article  Google Scholar 

Moazzam-Jazi M, Zahedi AS, Akbarzadeh M, Azizi F, Daneshpour MS (2022) Diverse effect of MC4R risk alleles on obesity-related traits over a lifetime: evidence from a well-designed cohort study. Gene 807:145950

Article  CAS  PubMed  Google Scholar 

Ferreira-Julio MA, Pinhel MS, Quinhoneiro DCG, Nicoletti CF, Brandão AC, Nonino CB et al (2015) LEP-2548G> A polymorphism of the leptin gene and its influence on the lipid profile in obese individuals. Lifestyle Genom 7(4–6):225–231

Google Scholar 

Saqlain M, Khalid M, Fiaz M, Saeed S, Mehmood Raja A, Mobeen Zafar M et al (2022) Risk variants of obesity associated genes demonstrate BMI raising effect in a large cohort. PLoS ONE 17(9):e0274904

Article  CAS  PubMed  PubMed Central  Google Scholar 

Fan SH, Say YH (2014) Leptin and leptin receptor gene polymorphisms and their association with plasma leptin levels and obesity in a multi-ethnic Malaysian suburban population. J Physiol Anthropol 33(1):1–10

Article  CAS  Google Scholar 

Hinuy HM, Hirata MH, Sampaio MF, Armaganijan D, Arazi SS, Salazar LA et al (2010) Relationship between variants of the leptin gene and obesity and metabolic biomarkers in Brazilian individuals. Arq Bras Endocrinol Metabol 54(3):282–288

Article  PubMed  Google Scholar 

Fourati M, Mnif M, Kharrat N, Charfi N, Kammoun M, Fendri N et al (2013) Association between Leptin gene polymorphisms and plasma leptin level in three consanguineous families with obesity. Gene 527(1):75–81

Article  CAS  PubMed  Google Scholar 

Dasgupta S, Salman M, Siddalingaiah LB, Lakshmi GL, Xaviour D, Sreenath J (2015) Genetic variants in leptin: determinants of obesity and leptin levels in South Indian population. Adipocyte 4(2):135–140

Article  CAS  PubMed  Google Scholar 

Snehalatha C, Viswanathan V, Ramachandran A (2003) Cutoff values for normal anthropometric variables in Asian Indian adults. Diabetes Care 26(5):1380–1384

Article  PubMed  Google Scholar 

Yang WS, Chuang LM (2006) Human genetics of adiponectin in the metabolic syndrome. J Mol Med 84:112–121

Article  CAS  PubMed  Google Scholar 

Friedewald WT, Levy RI, Fredrickson DS (1972) Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin Chem 18(6):499–502

Article  CAS  PubMed  Google Scholar 

Menezes CA, Alves Junior ER, Costa GNO, Dombroski TCD, Mattos RT, Gomes JAS et al (2022) Genetic polymorphisms and plasma concentrations of leptin (rs7799039) and adiponectin (rs17300539) are associated with obesity in children and adolescents. Rev Paul Pediatr 10(40):e2021030

Google Scholar 

Duan DM, Jhang JY, Wu S, Teng MS, Hsu LA, Ko YL (2020) Modification effect of sex and obesity on the correlation of LEP polymorphisms with leptin levels in Taiwanese obese women. Mol Genet Genomic Med 8(3):e1113

Article  CAS  PubMed  PubMed Central  Google Scholar 

Shamsuddin AA, Ahmad A, Taib WRW (2018) Haplotype analysis of leptin gene polymorphisms in obesity among Malays in Terengganu, Malaysia population. Med J Malays 73(5):281–285

Google Scholar 

Wang Y, Pan L, Wan S, Yihuo W, Yang F, He H et al (2022) MC4R Gene Polymorphisms Interact with the Urbanized Living Environment on Obesity: Results From the Yi Migrant Study. Front Genet 13(849138):1–10

Google Scholar 

Hong KW, Oh B (2012) Recapitulation of genome-wide association studies on body mass index in the Korean population. Int J Obes 36(8):1127–1130

Article  CAS  Google Scholar 

Dwivedi O, Tabassum R, Chauhan G, Kaur I, Ghosh S, Marwaha RK et al (2013) Strong influence of variants near MC4R on adiposity in children and adults: a cross-sectional study in Indian population. J Hum Genet 58(1):27–32

Article  PubMed  Google Scholar 

Yang Y, Gao X, Tao X, Gao Q, Zhang Y, Yang J (2019) Combined effect of FTO and MC4R gene polymorphisms on obesity in children and adolescents in Northwest China: a case-control study. Asia Pac J Clin Nutr 28(1):177–182

CAS  PubMed  Google Scholar 

Chehadeh SEH, Osman W, Nazar S, Jerman L, Alghafri A, Sajwani A et al (2020) Implication of genetic variants in overweight and obesity susceptibility among the young Arab population of the United Arab Emirates. Gene 739:144509

Article  Google Scholar 

Jääskeläinen T, Paananen J, Lindström J, Eriksson JG, Tuomilehto J, Uusitupa M et al (2013) Genetic predisposition to obesity and lifestyle factors–the combined analyses of twenty-six known BMI-and fourteen known waist: hip ratio (WHR)-associated variants in the Finnish Diabetes Prevention Study. Br J Nutr 110(10):1856–1865

Article  PubMed  Google Scholar 

Angeli CB, Kimura L, Auricchio MT, Vicente JP, Mattevi VS, Zembrzuski VM et al (2011) Multilocus analyses of seven candidate genes suggest interacting pathways for obesity-related traits in Brazilian populations. Obesity 19(6):1244–1251

Article  CAS  PubMed  Google Scholar 

Dorajoo R, Blakemore AIF, Sim X, Ong RT, Ng DPK, Seielstad M et al (2012) Replication of 13 obesity loci among Singaporean Chinese, Malay and Asian-Indian populations. Int J Obes 36(1):159–163

Article  CAS  Google Scholar 

Alharbi KK, Richardson TG, Khan IA, Syed R, Mohammed AK, Boustred CR et al (2014) Influence of adiposity-related genetic markers in a population of Saudi Arabians where other variables influencing obesity may be reduced. Dis Mark. https://doi.org/10.1155/2014/758232

Article 

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