Abrami L, Brandi L, Moayeri M, Brown MJ, Krantz BA, Leppla SH, van der Goot FG. Hijacking multivesicular bodies enables long-term and exosome-mediated long-distance action of anthrax toxin. Cell Rep. 2013;5:986–96.

Article  CAS  PubMed  Google Scholar 

Adamski Z, Bufo SA, Milella L, Scrano L. Identification and functional characterization of plant toxins. Toxins (Basel). 2021;13:228.

Alexander M, Hu R, Runtsch MC, Kagele DA, Mosbruger TL, Tolmachova T, Seabra MC, Round JL, Ward DM, O’Connell RM. Exosome-delivered microRNAs modulate the inflammatory response to endotoxin. Nat Commun. 2015;6:7321.

Article  CAS  PubMed  Google Scholar 

Alshannaq A, Yu JH. Occurrence, toxicity, and analysis of major mycotoxins in food. Int J Environ Res Pub Health. 2017;14(6):632.

Bignell DRD, Cheng Z, Bown L. The coronafacoyl phytotoxins: structure, biosynthesis, regulation and biological activities. Antonie Van Leeuwenhoek. 2018;111:649–66.

Article  CAS  PubMed  Google Scholar 

Boeckler GA, Gershenzon J, Unsicker SB. Phenolic glycosides of the salicaceae and their role as anti-herbivore defenses. Phytochemistry. 2011;72:1497–509.

Article  CAS  PubMed  Google Scholar 

Brahmbhatt M, Gundala SR, Asif G, Shamsi SA, Aneja R. Ginger phytochemicals exhibit synergy to inhibit prostate cancer cell proliferation. Nutr Cancer. 2013;65:263–72.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bucheli TD. Phytotoxins: environmental micropollutants of concern? Environ Sci Technol. 2014;48:13027–33.

Article  CAS  PubMed  Google Scholar 

Cao M, Diao N, Cai X, Chen X, Xiao Y, Guo C, Chen D, Zhang X. Plant exosome nanovesicles (PENs): green delivery platforms. Mater Horiz. 2023;10:3879–94.

Article  CAS  PubMed  Google Scholar 

Clark GC, Casewell NR, Elliott CT, Harvey AL, Jamieson AG, Strong PN, Turner AD. Friends or foes? emerging Impacts of biological toxins. Trends Biochem Sci. 2019;44:365–79.

Article  CAS  PubMed  Google Scholar 

Cun Y, Jin Y, Wu D, Zhou L, Zhang C, Zhang S, Yang X, Zuhong W, Zhang P. Exosome in crosstalk between inflammation and angiogenesis: a potential therapeutic strategy for stroke. Mediators Inflamm. 2022;2022:7006281.

Article  PubMed  PubMed Central  Google Scholar 

David G, Zimmermann P. Heparanase involvement in exosome formation. Adv Exp Med Biol. 2020;1221:285–307.

Article  CAS  PubMed  Google Scholar 

Deng CJ, Liu L, Liu LZ, Wang QQ, Guo XL, Lee WH, Li SA, Zhang Y. A secreted pore-forming protein modulates cellular endolysosomes to augment antigen presentation. FASEB J: Off Pub Fed Amer Soc Exp Biol. 2020;34:13609–25.

Article  CAS  Google Scholar 

Doyle LM, Wang MZ. Overview of extracellular vesicles, their origin, composition, purpose, and methods for exosome isolation and analysis.Cells. 2019;8(7):727.

Duan L, Xu L, Xu X, Qin Z, Zhou X, Xiao Y, Liang Y, Xia J. Exosome-mediated delivery of gene vectors for gene therapy. Nanoscale. 2021;13:1387–97.

Article  CAS  PubMed  Google Scholar 

Duan T, Wang X, Dong X, Wang C, Wang L, Yang X, Li T. Broccoli-derived exosome-like nanoparticles alleviate loperamide-induced constipation, in correlation with regulation on gut microbiota and tryptophan metabolism. J Agric Food Chem. 2023;71:16568–80.

Article  CAS  PubMed  Google Scholar 

Faïs T, Delmas J, Barnich N, Bonnet R, Dalmasso G. Colibactin: more than a new bacterial toxin. Toxins (Basel). 2018;10(4):151.

Finkelstein Y, Aks SE, Hutson JR, Juurlink DN, Nguyen P, Dubnov-Raz G, Pollak U, Koren G, Bentur Y. Colchicine poisoning: the dark side of an ancient drug. Clin Toxicol. 2010;48:407–14.

Article  CAS  Google Scholar 

Fuchs A, Samovski D, Smith GI, Cifarelli V, Farabi SS, Yoshino J, Pietka T, Chang S-W, Ghosh S, Myckatyn TM, Klein S. Associations among adipose tissue immunology, inflammation, exosomes and insulin sensitivity in people with obesity and nonalcoholic fatty liver disease. Gastroenterology. 2021;161:968-981.e912.

Article  CAS  PubMed  Google Scholar 

Gao HN, Hu H, Wen PC, Lian S, Xie XL, Song HL, Yang ZN, Ren FZ. Yak milk-derived exosomes alleviate lipopolysaccharide-induced intestinal inflammation by inhibiting PI3K/AKT/C3 pathway activation. J Dairy Sci. 2021;104:8411–24.

Article  CAS  PubMed  Google Scholar 

Gurung S, Perocheau D, Touramanidou L, Baruteau J. The exosome journey: from biogenesis to uptake and intracellular signalling. Cell Commun Signal. 2021;19:47.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hade MD, Suire CN, Suo Z. Mesenchymal stem cell-derived exosomes: applications in regenerative medicine. Cells. 2021;10(8):1959.

Halstead BW. Current status of marine biotoxicology—an overview. Clin Toxicol. 1981;18:1–24.

Article  CAS  PubMed  Google Scholar 

Hamzah RN, Alghazali KM, Biris AS, Griffin RJ. Exosome traceability and cell source dependence on composition and cell-cell cross talk. Int J Molec Sci. 2021;22(10):5346.

Hariharan H, Kesavan Y, Raja NS. Impact of native and external factors on exosome release: understanding reactive exosome secretion and its biogenesis. Mol Biol Rep. 2021;48:7559–73.

Article  CAS  PubMed  Google Scholar 

He C, Zheng S, Luo Y, Wang B. Exosome theranostics: biology and translational medicine. Theranostics. 2018;8:237–55.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Herzig V, Cristofori-Armstrong B, Israel MR, Nixon SA, Vetter I, King GF. Animal toxins - Nature’s evolutionary-refined toolkit for basic research and drug discovery. Biochem Pharmacol. 2020;181:114096.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Huang C, Yu W, Wang Q, Huang T, Ding Y. CircANTXR1 Contributes to the malignant progression of hepatocellular carcinoma by promoting proliferation and metastasis. J Hepatocell Carcinoma. 2021;8:1339–53.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Huang Y, Zhu Z, Luo C, Ma C, Zhu L, Kong L, Li R, Wu J, Yuan Z, Yi J. Betulinic acid attenuates cognitive dysfunction, oxidative stress, and inflammation in a model of T-2 toxin-induced brain damage. Environ Sci Pollut Res Int. 2022;29:52098–110.

Article  CAS  PubMed  Google Scholar 

Jerschke E, Barkovsky M, Jung N, Neuberger H, Stenzel J, Eyer F, Skerra A, Geith S. In vivo neutralization of colchicine toxicity by a PASylated anticalin in a rat model. Toxicology. 2023;492:153526.

Article  CAS  PubMed  Google Scholar 

Johannes L. Application of protein toxins as cell biological and pharmacological tools. Toxins. 2022;14.

Joyce DP, Kerin MJ, Dwyer RM. Exosome-encapsulated microRNAs as circulating biomarkers for breast cancer. Int J Cancer. 2016;139:1443–8.

Article  CAS  PubMed  Google Scholar 

Ju S, Mu J, Dokland T, Zhuang X, Wang Q, Jiang H, Xiang X, Deng ZB, Wang B, Zhang L, Roth M, Welti R, Mobley J, Jun Y, Miller D, Zhang HG. Grape exosome-like nanoparticles induce intestinal stem cells and protect mice from DSS-induced colitis. Molec Ther: J Amer Soc Gene Ther. 2013;21:1345–57.

Article  CAS  Google Scholar 

Kalluri R, LeBleu VS. The biology, function, and biomedical applications of exosomes. Science. 2020;367(6478).

Keller MD, Ching KL, Liang F-X, Dhabaria A, Tam K, Ueberheide BM, Unutmaz D, Torres VJ, Cadwell K. Decoy exosomes provide protection against bacterial toxins. Nature. 2020;579:260–4.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Khayambashi P, Iyer J, Pillai S, Upadhyay A, Zhang Y, Tran SD. Hydrogel encapsulation of mesenchymal stem cells and their derived exosomes for tissue engineering. Int J Molec Sci. 2021;22(2):684.

Kimiz-Gebologlu I, Oncel SS. Exosomes: large-scale production, isolation, drug loading efficiency, and biodistribution and uptake. J Control Release: Off J Control Release Soc. 2022;347:533–43.

Article  CAS  Google Scholar 

Kordiš D, Gubenšek F. Adaptive evolution of animal toxin multigene families. Gene. 2000;261:43–52.

Article  PubMed  Google Scholar 

Kozlov S. Animal toxins for channelopathy treatment. Neuropharmacol. 2018;132:83–97.

Article  CAS  Google Scholar 

Lai, JJ, Chau ZL, Chen SY, Hill JJ, Korpany KV, Liang NW, Lin LH, Lin YH, Liu JK, Liu YC, Lunde R, Shen WT. Exosome processing and characterization approaches for research and technology development. Adv Sci. 2022;9:e2103222.

Leal JF, Cristiano MLS. Marine paralytic shellfish toxins: chemical properties, mode of action, newer analogues, and structure-toxicity relationship. Nat Prod Rep. 2022;39:33–57.

Article  CAS  PubMed  Google Scholar 

Lee KS, Lee J, Lee P, et al. Exosomes released from Shiga toxin 2a-treated human macrophages modulate inflammatory responses and induce cell death in toxin receptor expressing human cells. Cell Microbiol. 2020;22(11):e13249.

Lemichez E, Popoff MR, Satchell KJF. Cellular microbiology: Bacterial toxin interference drives understanding of eukaryotic cell function. Cell Microbiol. 2020;22:e13178.

Article  CAS  PubMed  Google Scholar 

Li B, Cao Y, Sun M, Feng H. Expression, regulation, and function of exosome-derived miRNAs in cancer progression and therapy. FASEB J: Off Pub Fed Amer Soc Exp Biol. 2021;35:e21916.

Article  CAS  Google Scholar 

Liang Y, Duan L, Lu J, Xia J. Engineering exosomes for targeted drug delivery. Theranostics. 2021;11:3183–95.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Liu C, Xu X, Li B, Situ B, Pan W, Hu Y, An T, Yao S, Zheng L. Single-exosome-counting immunoassays for cancer diagnostics. Nano Lett. 2018;18:4226–32.

Article  CAS