aDepartment of Pharmacology and Department of Anesthesiology of the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China

bKey Laboratory of Neuropharmacology and Translational Medicine of Zhejiang Province, College of Pharmaceutical Sciences, Zhejiang Chinese Medical University, Hangzhou, China

*Corresponding author. Address: Department of Pharmacology and Department of Anesthesiology of the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310058 China. Tel.: (86)571-88208227. E-mail address: [email protected] (S.-H. Zhang).

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F. Guo, S.-D. Lin, and Y. Du contributed equally to the article.