PFOS Elicits Cytotoxicity in Neuron Through Astrocyte-Derived CaMKII-DLG1 Signaling In Vitro Rat Hippocampal Model

Ge JB, Wang C, Nie XK, Yang JB, Lu HJ, Song XJ, Su K, Li T, Han JL, Zhang Y, Mao JM, Gu YY, Zhao JY, Jiang SY, Wu QY (2016) ROS-mediated apoptosis of HAPI microglia through p53 signaling following PFOS exposure. Environ Toxicol Phar 46:9–16

Article  CAS  Google Scholar 

Salgado R, Lopez-Doval S, Pereiro N, Lafuente A (2016) Perfluorooctane sulfonate (PFOS) exposure could modify the dopaminergic system in several limbic brain regions. Toxicol Lett 240:226–235

Article  CAS  PubMed  Google Scholar 

Choi GH, Lee DY, Jeong DK, Kuppusamy S, Lee YB, Park BJ, Kim JH (2017) Perfluorooctanoic acid (PFOA) and perfluorooctanesulfonic acid (PFOS) concentrations in the South Korean agricultural environment: a national survey. J Integr Agr 16:1841–1851

Article  CAS  Google Scholar 

Augustsson A, Lennqvist T, Osbeck CMG, Tibblin P, Glynn A, Nguyen MA, Westberg E, Vestergren R (2021) Consumption of freshwater fish: a variable but significant risk factor for PFOS exposure. Environ Res 192:110284

Article  CAS  PubMed  Google Scholar 

Olsen GW, Burris JM, Ehresman DJ, Froehlich JW, Seacat AM, Butenhoff JL, Zobel LR (2007) Half-life of serum elimination of perfluorooctanesulfonate, perfluorohexanesulfonate, and perfluorooctanoate in retired fluorochemical production workers. Environ Health Persp 115:1298–1305

Article  CAS  Google Scholar 

van Asselt ED, Kowalczyk J, van Eijkeren JCH, Zeilmaker MJ, Ehlers S, Furst P, Lahrssen-Wiederholt M, van der Fels-Klerx HJ (2013) Transfer of perfluorooctane sulfonic acid (PFOS) from contaminated feed to dairy milk. Food Chem 141:1489–1495

Article  PubMed  Google Scholar 

Wang Y, Rogan WJ, Chen HY, Chen PC, Su PH, Chen HY, Wang SL (2015) Prenatal exposure to perfluroalkyl substances and children’s IQ: The Taiwan maternal and infant cohort study. Int J Hyg Envir Heal 218:639–644

Article  CAS  Google Scholar 

Long Y, Wang YB, Ji GX, Yan LF, Hu F, Gu AH (2013) Neurotoxicity of perfluorooctane sulfonate to hippocampal cells in adult mice. PLoS ONE 8:e54176

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chen N, Li J, Li D, Yang YS, He DF (2014) Chronic exposure to perfluorooctane sulfonate induces behavior defects and neurotoxicity through oxidative damages, in vivo and in vitro. PLoS ONE 9:e113453

Article  PubMed  PubMed Central  Google Scholar 

Wang X, Li B, Zhao WD, Liu YJ, Shang DS, Fang WG, Chen YH (2011) Perfluorooctane sulfonate triggers tight junction “opening” in brain endothelial cells via phosphatidylinositol 3-kinase. Biochem Bioph Res Co 410:258–263

Article  CAS  Google Scholar 

Greaves AK, Letcher RJ, Sonne C, Dietz R (2013) Brain region distribution and patterns of bioaccumulative perfluoroalkyl carboxylates and sulfonates in east greenland polar bears (Ursus maritimus). Environ Toxicol Chem 32:713–722

Article  CAS  PubMed  Google Scholar 

Mariussen E (2012) Neurotoxic effects of perfluoroalkylated compounds: mechanisms of action and environmental relevance. Arch Toxicol 86:1349–1367

Article  CAS  PubMed  Google Scholar 

Liu X, Ying J, Wang X, Zheng Q, Zhao T, Yoon S, Yu W, Yang D, Fang Y, Hua F (2021) Astrocytes in neural circuits: key factors in synaptic regulation and potential targets for neurodevelopmental disorders. Front Mol Neurosci 14:729273

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kwon HS, Koh SH (2020) Neuroinflammation in neurodegenerative disorders: the roles of microglia and astrocytes. Transl Neurodegener 9:42

Article  PubMed  PubMed Central  Google Scholar 

Chen X, Nie X, Mao J, Zhang Y, Yin K, Sun P, Luo J, Liu Y, Jiang S, Sun L (2018) Perfluorooctane sulfonate mediates secretion of IL-1beta through PI3K/AKT NF-small ka, CyrillicB pathway in astrocytes. Neurotoxicol Teratol 67:65–75

Article  CAS  PubMed  Google Scholar 

Chen X, Nie X, Mao J, Zhang Y, Yin K, Jiang S (2018) Per fl uorooctanesulfonate induces neuroinflammation through the secretion of TNF-alpha mediated by the JAK2/STAT3 pathway. Neurotoxicology 66:32–42

Article  CAS  PubMed  Google Scholar 

Wang R, Wang R, Niu X, Cheng Y, Shang X, Li Y, Li S, Liu X, Shao J (2019) Role of astrocytes-derived d-serine in PFOS-induced neurotoxicity through NMDARs in the rat primary hippocampal neurons. Toxicology 422:14–24

Article  CAS  PubMed  Google Scholar 

Wang R, Reddy PH (2017) Role of Glutamate and NMDA Receptors in Alzheimer’s Disease. J Alzheimers Dis 57:1041–1048

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lau A, Tymianski M (2010) Glutamate receptors, neurotoxicity and neurodegeneration. Pflugers Arch 460:525–542

Article  CAS  PubMed  Google Scholar 

Li Z, Liu Q, Liu C, Li C, Li Y, Li S, Liu X, Shao J (2017) Evaluation of PFOS-mediated neurotoxicity in rat primary neurons and astrocytes cultured separately or in co-culture. Toxicol In Vitro 38:77–90

Article  PubMed  Google Scholar 

Lee E, Sidoryk-Wegrzynowicz M, Wang N, Webb A, Son DS, Lee K, Aschner M (2012) GPR30 regulates glutamate transporter GLT-1 expression in rat primary astrocytes. J Biol Chem 287:26817–26828

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhang B, Su D, Song Y, Li H, Chen C, Liao L, Zhang H, Luo J, Yang M, Zhu G, Ai Z (2023) Yueju volatile oil plays an integral role in the antidepressant effect by up-regulating ERK/AKT-mediated GLT-1 expression to clear glutamate. Fitoterapia 169:105583

Article  CAS  PubMed  Google Scholar 

Ibanez I, Bartolome-Martin D, Piniella D, Gimenez C, Zafra F (2019) Activity dependent internalization of the glutamate transporter GLT-1 requires calcium entry through the NCX sodium/calcium exchanger. Neurochem Int 123:125–132

Article  CAS  PubMed  Google Scholar 

Shah D, Gsell W, Wahis J, Luckett ES, Jamoulle T, Vermaercke B, Preman P, Moechars D, Hendrickx V, Jaspers T, Craessaerts K, Horre K, Wolfs L, Fiers M, Holt M, Thal DR, Callaerts-Vegh Z, D’Hooge R, Vandenberghe R, Himmelreich U, Bonin V, De Strooper B (2022) Astrocyte calcium dysfunction causes early network hyperactivity in Alzheimer’s disease. Cell Rep 40:111280

Article  CAS  PubMed  PubMed Central  Google Scholar 

Li GZ, Hu YH, Lu YN, Yang QY, Fu D, Chen F, Li YM (2023) CaMKII and Ca(V)3.2 T-type calcium channel mediate connexin-43-dependent inflammation by activating astrocytes in vincristine-induced neuropathic pain. Cell Biol Toxicol 39:679–702

Article  CAS  PubMed  Google Scholar 

Lee ESY, Yin ZB, Milatovic D, Jiang HY, Aschner M (2009) Estrogen and tamoxifen protect against mn-induced toxicity in rat cortical primary cultures of neurons and astrocytes. Toxicol Sci 110:156–167

Article  CAS  PubMed  PubMed Central  Google Scholar 

Cho WS, Messing A (2009) Properties of astrocytes cultured from GFAP over-expressing and GFAP mutant mice. Exp Cell Res 315:1260–1272

Article  CAS  PubMed  Google Scholar 

Buosi AS, Matias I, Araujo APB, Batista C, Gomes FCA (2018) Heterogeneity in synaptogenic profile of astrocytes from different brain regions. Mol Neurobiol 55:751–762

Article  CAS  PubMed  Google Scholar 

Yang QL, Wang WS, Liu C, Wang Y, Sun K (2016) Effect of PFOS on glucocorticoid-induced changes in human decidual stromal cells in the first trimester of pregnancy. Reprod Toxicol 63:142–150

Article  CAS  PubMed  Google Scholar 

Popova D, Jacobsson SOP (2014) A fluorescence microplate screen assay for the detection of neurite outgrowth and neurotoxicity using an antibody against βIII-tubulin. Toxicol in Vitro 28:411–418

Article  CAS  PubMed  Google Scholar 

Sultan N, Amin LE, Zaher AR, Grawish ME, Scheven B (2020) Neurotrophic effects of dental pulp stem cells on trigeminal neuronal cells. Sci Rep-Uk. https://doi.org/10.1038/s41598-020-76684-0

Article  Google Scholar 

Tang J, Bair M, Descalzi G (2021) Reactive astrocytes: critical players in the development of chronic pain. Front Psychiatry 12:682056

Article  PubMed  PubMed Central  Google Scholar 

Shan L, Zhang T, Fan K, Cai W, Liu H (2021) Astrocyte-neuron signaling in synaptogenesis. Front Cell Dev Biol 9:680301

Article  PubMed  PubMed Central  Google Scholar 

Brown-Leung JM, Cannon JR (2022) Neurotransmission targets of per- and polyfluoroalkyl substance neurotoxicity: mechanisms and potential implications for adverse neurological Outcomes. Chem Res Toxicol 35:1312–1333

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bajrektarevic D, Nistri A (2017) Ceftriaxone-mediated upregulation of the glutamate transporter GLT-1 contrasts neurotoxicity evoked by kainate in rat organotypic spinal cord cultures. Neurotoxicology 60:34–41

Article  CAS  PubMed 

留言 (0)

沒有登入
gif