Semkovska M, Quinlivan L, O’Grady T, Johnson R, Collins A, O’Connor J et al (2019) Cognitive function following a major depressive episode: a systematic review and meta-analysis. Lancet Psychiatry 6:851–861

Article  PubMed  Google Scholar 

Murrough JW, Iacoviello B, Neumeister A, Charney DS, Iosifescu DV (2011) Cognitive dysfunction in depression: neurocircuitry and new therapeutic strategies. Neurobiol Learn Mem 96:553–563

Article  CAS  PubMed  Google Scholar 

Hasselbalch BJ, Knorr U, Hasselbalch SG, Gade A, Kessing LV (2012) Cognitive deficits in the remitted state of unipolar depressive disorder. Neuropsychology 26:642–651

Article  PubMed  Google Scholar 

Marx EM, Williams JM, Claridge GC (1992) Depression and social problem solving. J Abnorm Psychol 101:78–86

Article  CAS  PubMed  Google Scholar 

Disner SG, Beevers CG, Haigh EA, Beck AT (2011) Neural mechanisms of the cognitive model of depression. Nat Rev Neurosci 12:467–477

Article  CAS  PubMed  Google Scholar 

Yang XH, Huang J, Zhu CY, Wang YF, Cheung EF, Chan RC et al (2014) Motivational deficits in effort-based decision making in individuals with subsyndromal depression, first-episode and remitted depression patients. Psychiatry Res 220:874–882

Article  PubMed  Google Scholar 

Prévot T, Sibille E (2021) Altered GABA-mediated information processing and cognitive dysfunctions in depression and other brain disorders. Mol Psychiatry 26(1):151–167

Article  PubMed  Google Scholar 

Haroon E, Miller AH, Sanacora G (2017) Inflammation, glutamate, and glia: a trio of trouble in mood disorders. Neuropsychopharmacol 42:193–215

Article  CAS  Google Scholar 

Capuron L, Miller AH (2011) Immune system to brain signaling: neuropsychopharmacological implications. Pharm Ther 130:226–238

Article  CAS  Google Scholar 

Neto FL, Borges G, Torres-Sanchez S, Mico JA, Berrocoso E (2011) Neurotrophins role in depression neurobiology: a review of basic and clinical evidence. Curr Neuropharmacol 9:530–552

Article  CAS  PubMed  PubMed Central  Google Scholar 

Fee C, Banasr M, Sibille E (2017) Somatostatin-positive gamma-aminobutyric acid interneuron deficits in depression: cortical microcircuit and therapeutic perspectives. Biol Psychiatry 82:549–559

Article  CAS  PubMed  PubMed Central  Google Scholar 

Martinowich K, Lu B (2008) Interaction between BDNF and serotonin: role in mood disorders. Neuropsychopharmacol 33:73–83

Article  CAS  Google Scholar 

Diehl DJ, Gershon S (1992) The role of dopamine in mood disorders. Compr Psychiatry 33:115–120

Article  CAS  PubMed  Google Scholar 

Bender DA (1983) Effects of a dietary excess of leucine on the metabolism of tryptophan in the rat: a mechanism for the pellagragenic action of leucine. Br J Nutr 50(1):25–32

Article  CAS  PubMed  Google Scholar 

Savitz J (2020) The kynurenine pathway: a finger in every pie. Mol Psychiatry 25(1):131–147

Article  PubMed  Google Scholar 

Kanai M, Funakoshi H, Takahashi H, Hayakawa T, Mizuno S, Matsumoto K et al (2009) Tryptophan 2,3-dioxygenase is a key modulator of physiological neurogenesis and anxiety-related behavior in mice. Mol Brain 2:8

Article  PubMed  PubMed Central  Google Scholar 

Fukunaga M, Yamamoto Y, Kawasoe M, Arioka Y, Murakami Y, Hoshi M et al (2012) Studies on tissue and cellular distribution of indoleamine 2,3-dioxygenase 2: the absence of IDO1 upregulates IDO2 expression in the epididymis. J Histochem Cytochem 60(11):854–860

Article  PubMed  PubMed Central  Google Scholar 

Connor TJ, Starr N, O’Sullivan JB, Harkin A (2008) Induction of indolamine 2,3-dioxygenase and kynurenine 3-monooxygenase in rat brain following a systemic inflammatory challenge: a role for IFN-gamma? Neurosci Lett 441(1):29–34

Article  CAS  PubMed  Google Scholar 

Molteni R, Macchi F, Zecchillo C, Dell’agli M, Colombo E, Calabrese F et al (2013) Modulation of the inflammatory response in rats chronically treated with the antidepressant agomelatine. Eur Neuropsychopharmacol 23(11):1645–1655

Article  CAS  PubMed  Google Scholar 

Cervenka I, Agudelo LZ, Ruas JL (2017) Kynurenines: tryptophan’s metabolites in exercise, inflammation, and mental health. Science 357(6349):eaaf9794

Article  PubMed  Google Scholar 

Foster AC, Vezzani A, French ED, Schwarcz R (1984) Kynurenic acid blocks neurotoxicity and seizures induced in rats by the related brain metabolite quinolinic acid. Neurosci Lett 48(3):273–278

Article  CAS  PubMed  Google Scholar 

Guillemin GJ (2012) Quinolinic acid, the inescapable neurotoxin. Febs J 279(8):1356–1365

Article  CAS  PubMed  Google Scholar 

Kaindl AM, Degos V, Peineau S, Gouadon E, Chhor V, Loron G et al (2012) Activation of microglial N-methyl-D-aspartate receptors triggers inflammation and neuronal cell death in the developing and mature brain. Ann Neurol 72(4):536–549

Article  CAS  PubMed  Google Scholar 

Stone TW, Perkins MN (1981) Quinolinic acid: a potent endogenous excitant at amino acid receptors in CNS. Eur J Pharmacol 72(4):411–412

Article  CAS  PubMed  Google Scholar 

Guillemin GJ, Croitoru-Lamoury J, Dormont D, Armati PJ, Brew BJ (2003) Quinolinic acid upregulates chemokine production and chemokine receptor expression in astrocytes. Glia 41(4):371–381

Article  PubMed  Google Scholar 

Kita T, Morrison PF, Heyes MP, Markey SP (2002) Effects of systemic and central nervous system localized inflammation on the contributions of metabolic precursors to the L-kynurenine and quinolinic acid pools in brain. J Neurochem 82(2):258–268

Article  CAS  PubMed  Google Scholar 

Moffett JR, Namboodiri MA (2003) Tryptophan and the immune response. Immunol Cell Biol 81(4):247–265

Article  CAS  PubMed  Google Scholar 

Tufvesson-Alm M, Imbeault S, Liu XC, Zheng Y, Faka A, Choi DS, Schwieler L, Engberg G, Erhardt S (2020) Repeated administration of LPS exaggerates amphetamine-induced locomotor response and causes learning deficits in mice. J Neuroimmunol 349:577401

Article  CAS  PubMed  Google Scholar 

Schwarcz R, Bruno JP, Muchowski PJ, Wu H-Q (2012) Kynurenines in the mammalian brain: when physiology meets pathology. Nat Rev Neurosci 13(7):465–477

Article  CAS  PubMed  PubMed Central  Google Scholar 

Oliveros A, Wininger K, Sens J, Larsson MK, Liu XC, Choi S et al (2017) LPS-induced cortical kynurenic acid and neurogranin-NFAT signaling is associated with deficits in stimulus processing during pavlovian conditioning. J Neuroimmunol 313:1–9

Article  CAS  PubMed  PubMed Central  Google Scholar 

Imbeault S, Goiny M, Liu X, Erhardt S (2020) Effects of IDO1 and TDO2 inhibition on cognitive deficits and anxiety following LPS-induced neuroinflammation. Acta Neuropsychiatr 32(1):43–53

Article  PubMed  Google Scholar 

Gulaj E, Pawlak K, Bien B et al (2010) Kynurenine and its metabolites in Alzheimer’s disease patients. Adv Med Sci 55(2):204–211. https://doi.org/10.2478/v10039-010-0023-6

Article  CAS  PubMed  Google Scholar 

Bonda DJ, Mailankot M, Stone JG et al (2010) Indoleamine 2,3-dioxygenase and 3- hydroxykynurenine modifications are found in the neuropathology of Alzheimer’s disease. Redox Rep 15(4):161–168. https://doi.org/10.1179/174329210X12650506623645

Article  CAS  PubMed  Google Scholar 

Guillemin GJ, Brew B, Noonan C et al (2005) Indoleamine 2, 3 dioxygenase and QUIN immunoreactivity in Alzheimer’s disease hippocampus. Neuropathol App Neurobiol 31(4):395–404

Article  CAS  Google Scholar 

Marcinkowska M, Mordyl B, Fajkis-Zajaczkowska N, Siwek A, Karcz T, Gawalska A, Bucki A, Żmudzki P, Partyka A, Jastrzębska-Więsek M, Pomierny B, Walczak M, Smolik M, Pytka K, Mika K, Kotańska M, Kolaczkowski M (2023) Hybrid molecules combining GABA-A and serotonin 5-HT6 receptors activity designed to tackle neuroinflammation associated with depression. Eur J Med Chem 247:115071

Article  CAS  PubMed  Google Scholar 

Rao SK, Andrade C, Reddy K, Madappa KN, Thyagarajan S, Chandra S (2002) Memory protective effect of indomethacin against electroconvulsive shock-induced retrograde amnesia in rats. Biol Psychiatry 51:770–773

Article  CAS  PubMed  Google Scholar 

Kumar A, Rani A, Scheinert RB, Ormerod BK, Foster TC (2018) Nonsteroidal anti-inflammatory drug, indomethacin improves spatial memory and NMDA receptor function in aged animals. Neurobiol Aging 70:184

Article  CAS