Andreadou I, Iliodromitis EK, Lazou A, Görbe A, Giricz Z, Schulz R, Ferdinandy P (2017) Effect of hypercholesterolaemia on myocardial function, ischaemia-reperfusion injury and cardioprotection by preconditioning, postconditioning and remote conditioning. Br J Pharmacol 174:1555–1569. https://doi.org/10.1111/bph.13704
Article CAS PubMed PubMed Central Google Scholar
Anuka E, Yivgi-Ohana N, Eimerl S, Garfinkel B, Melamed-Book N, Chepurkol E, Aravot D, Zinman T, Shainberg A, Hochhauser E, Orly J (2013) Infarct-induced steroidogenic acute regulatory protein: a survival role in cardiac fibroblasts. Mol Endocrinol 27:1502–1517. https://doi.org/10.1210/me.2013-1006
Article CAS PubMed PubMed Central Google Scholar
Artemenko IP, Zhao D, Hales DB, Hales KH, Jefcoate CR (2001) Mitochondrial processing of newly synthesized steroidogenic acute regulatory protein (StAR), but not total StAR, mediates cholesterol transfer to cytochrome P450 side chain cleavage enzyme in adrenal cells. J Biol Chem 276:46583–46596. https://doi.org/10.1074/jbc.M107815200
Article CAS PubMed Google Scholar
Babiker A, Andersson O, Lund E, Xiu RJ, Deeb S, Reshef A, Leitersdorf E, Diczfalusy U, Björkhem I (1997) Elimination of cholesterol in macrophages and endothelial cells by the sterol 27-hydroxylase mechanism. Comparison with high density lipoprotein-mediated reverse cholesterol transport. J Biol Chem 272:26253–26261. https://doi.org/10.1074/jbc.272.42.26253
Article CAS PubMed Google Scholar
Banati RB, Middleton RJ, Chan R, Hatty CR, Kam WW, Quin C, Graeber MB, Parmar A, Zahra D, Callaghan P, Fok S, Howell NR, Gregoire M, Szabo A, Pham T, Davis E, Liu GJ (2014) Positron emission tomography and functional characterization of a complete PBR/TSPO knockout. Nat Commun 5:5452. https://doi.org/10.1038/ncomms6452
Bao N, Minatoguchi S, Kobayashi H, Yasuda S, Kawamura I, Iwasa M, Yamaki T, Sumi S, Misao Y, Arai M, Nishigaki K, Takemura G, Fujiwara T, Fujiwara H (2007) Pravastatin reduces myocardial infarct size via increasing protein kinase C-dependent nitric oxide, decreasing oxyradicals and opening the mitochondrial adenosine triphosphate-sensitive potassium channels in rabbits. Circ J 71:1622–1628. https://doi.org/10.1253/circj.71.1622
Article CAS PubMed Google Scholar
Barau C, Ghaleh B, Berdeaux A, Morin D (2015) Cytochrome P450 and myocardial ischemia: potential pharmacological implication for cardioprotection. Fundam Clin Pharmacol 29:1–9. https://doi.org/10.1111/fcp.12087
Article CAS PubMed Google Scholar
Batoko H, Veljanovski V, Jurkiewicz P (2015) Enigmatic Translocator protein (TSPO) and cellular stress regulation. Trends Biochem Sci 40:497–503. https://doi.org/10.1016/j.tibs.2015.07.001
Article CAS PubMed Google Scholar
Bøtker HE, Cabrera-Fuentes HA, Ruiz-Meana M, Heusch G, Ovize M (2020) Translational issues for mitoprotective agents as adjunct to reperfusion therapy in patients with ST-segment elevation myocardial infarction. J Cell Mol Med 24:2717–2729. https://doi.org/10.1111/jcmm.14953
Article PubMed PubMed Central Google Scholar
Chang CW, Chiu CH, Lin MH, Wu HM, Yu TH, Wang PY, Kuo YY, Huang YY, Shiue CY, Huang WS, Yeh SH (2021) GMP-compliant fully automated radiosynthesis of [18F]FEPPA for PET/MRI imaging of regional brain TSPO expression. EJNMMI Res 11:26. https://doi.org/10.1186/s13550-021-00768-9
Article CAS PubMed PubMed Central Google Scholar
Chen C, Kuo J, Wong A, Micevych P (2014) Estradiol modulates translocator protein (TSPO) and steroid acute regulatory protein (StAR) via protein kinase A (PKA) signaling in hypothalamic astrocytes. Endocrinology 155:2976–2985. https://doi.org/10.1210/en.2013-1844
Article CAS PubMed PubMed Central Google Scholar
Chen Y, Ohmori K, Mizukawa M, Yoshida J, Zeng Y, Zhang L, Shinomiya K, Kosaka H, Kohno M (2007) Differential impact of atorvastatin vs pravastatin on progressive insulin resistance and left ventricular diastolic dysfunction in a rat model of type II diabetes. Circ J 71:144–152. https://doi.org/10.1253/circj.71.144
Article CAS PubMed Google Scholar
Chung YW, Lagranha C, Chen Y, Sun J, Tong G, Hockman SC, Ahmad F, Esfahani SG, Bae DH, Polidovitch N, Wu J, Rhee DK, Lee BS, Gucek M, Daniels MP, Brantner CA, Backx PH, Murphy E, Manganiello VC (2015) Targeted disruption of PDE3B, but not PDE3A, protects murine heart from ischemia/reperfusion injury. Proc Natl Acad Sci USA 112:E2253–E2262. https://doi.org/10.1073/pnas.1416230112
Article CAS PubMed PubMed Central Google Scholar
Desai R, East DA, Hardy L, Faccenda D, Rigon M, Crosby J, Alvarez MS, Singh A, Mainenti M, Hussey LK, Bentham R, Szabadkai G, Zappulli V, Dhoot GK, Romano LE, Xia D, Coppens I, Hamacher-Brady A, Chapple JP, Abeti R, Fleck RA, Vizcay-Barrena G, Smith K, Campanella M (2020) Mitochondria form contact sites with the nucleus to couple prosurvival retrograde response. Sci Adv. https://doi.org/10.1126/sciadv.abc9955
Egashira K, Ni W, Inoue S, Kataoka C, Kitamoto S, Koyanagi M, Takeshita A (2000) Pravastatin attenuates cardiovascular inflammatory and proliferative changes in a rat model of chronic inhibition of nitric oxide synthesis by its cholesterol-lowering independent actions. Hypertens Res 23:353–358. https://doi.org/10.1291/hypres.23.353
Article CAS PubMed Google Scholar
Fan J, Campioli E, Midzak A, Culty M, Papadopoulos V (2015) Conditional steroidogenic cell-targeted deletion of TSPO unveils a crucial role in viability and hormone-dependent steroid formation. Proc Natl Acad Sci USA 112:7261–7266. https://doi.org/10.1073/pnas.1502670112
Article CAS PubMed PubMed Central Google Scholar
Favre J, Gao J, Henry JP, Remy-Jouet I, Fourquaux I, Billon-Gales A, Thuillez C, Arnal JF, Lenfant F, Richard V (2010) Endothelial estrogen receptor alpha plays an essential role in the coronary and myocardial protective effects of estradiol in ischemia/reperfusion. Arterioscler Thromb Vasc Biol 30:2562–2567. https://doi.org/10.1161/ATVBAHA.110.213637
Article CAS PubMed Google Scholar
Fontaine D, Fontaine J, Dupont I, Dessy C, Piech A, Carpentier Y, Berkenboom G (2002) Chronic hydroxymethylglutaryl coenzyme a reductase inhibition and endothelial function of the normocholesterolemic rat: comparison with angiotensin-converting enzyme inhibition. J Cardiovasc Pharmacol 40:172–180. https://doi.org/10.1097/00005344-200208000-00002
Article CAS PubMed Google Scholar
Galano M, Li Y, Li L, Sottas C, Papadopoulos V (2021) Role of Constitutive STAR in Leydig Cells. Int J Mol Sci. https://doi.org/10.3390/ijms22042021
Article PubMed PubMed Central Google Scholar
Gatliff J, East D, Crosby J, Abeti R, Harvey R, Craigen W, Parker P, Campanella M (2014) TSPO interacts with VDAC1 and triggers a ROS-mediated inhibition of mitochondrial quality control. Autophagy 10:2279–2296. https://doi.org/10.4161/15548627.2014.991665
Article CAS PubMed Google Scholar
Gatliff J, East DA, Singh A, Alvarez MS, Frison M, Matic I, Ferraina C, Sampson N, Turkheimer F, Campanella M (2017) A role for TSPO in mitochondrial Ca2+ homeostasis and redox stress signaling. Cell Death Dis. https://doi.org/10.1038/cddis.2017.186
Article PubMed PubMed Central Google Scholar
Gliozzi M, Scarano F, Musolino V, Carresi C, Scicchitano M, Ruga S, Zito MC, Nucera S, Bosco F, Maiuolo J, Macrì R, Guarnieri L, Mollace R, Coppoletta AR, Nicita C, Tavernese A, Palma E, Muscoli C, Mollace V (2020) Role of TSPO/VDAC1 Upregulation and Matrix Metalloproteinase-2 Localization in the Dysfunctional Myocardium of Hyperglycaemic Rats. Int J Mol Sci 21:7432. https://doi.org/10.3390/ijms21207432
Article CAS PubMed PubMed Central Google Scholar
Gomez-Sanchez EP, Gomez-Sanchez CE (2021) 11β-hydroxysteroid dehydrogenases: A growing multi-tasking family. Mol Cell Endocrinol. https://doi.org/10.1016/j.mce.2021.111210
Article PubMed PubMed Central Google Scholar
Griffiths EJ, Halestrap AP (1995) Mitochondrial non-specific pores remain closed during cardiac ischaemia, but open upon reperfusion. Biochem J 307:939–948. https://doi.org/10.1042/bj3070093
Halestrap AP, Richardson AP (2015) The mitochondrial permeability transition: a current perspective on its identity and role in ischaemia/reperfusion injury. J Mol Cell Cardiol 78:129–141. https://doi.org/10.1016/j.yjmcc.2014.08.018
Article CAS PubMed Google Scholar
Hans G, Wislet-Gendebien S, Lallemend F, Robe P, Rogister B, Belachew S, Nguyen L, Malgrange B, Moonen G, Rigo JM (2005) Peripheral benzodiazepine receptor (PBR) ligand cytotoxicity unrelated to PBR expression. Biochem Pharmacol 69:819–830. https://doi.org/10.1016/j.bcp.2004.11.029
Article CAS PubMed Google Scholar
Hauet T, Yao ZX, Bose HS, Wall CT, Han Z, Li W, Hales DB, Miller WL, Culty M, Papadopoulos V (2005) Peripheral-type benzodiazepine receptor-mediated action of steroidogenic acute regulatory protein on cholesterol entry into leydig cell mitochondria. Mol Endocrinol 19:540–554. https://doi.org/10.1210/me.2004-0307
Article CAS PubMed Google Scholar
Heusch G (2020) Myocardial ischaemia-reperfusion injury and cardioprotection in perspective. Nat Rev Cardiol 17:773–789. https://doi.org/10.1038/s41569-020-0403-y
Heusch G (2024) Myocardial ischemia/reperfusion: Translational pathophysiology of ischemic heart disease. Med 5:10–31. https://doi.org/10.1016/j.medj.2023.12.007
Article CAS PubMed Google Scholar
Huang Y, Walker KE, Hanley F, Narula J, Houser SR, Tulenko TN (2004) Cardiac systolic and diastolic dysfunction after a cholesterol-rich diet. Circulation 109:97–102. https://doi.org/10.1161/01.CIR.0000109213.10461.F6
留言 (0)