Excess of body weight is associated with accelerated T-cell senescence in hospitalized COVID-19 patients

Wang D, Hu B, Hu C, Zhu F, Liu X, Zhang J, et al. Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus-infected pneumonia in Wuhan, China. JAMA. 2020;323:1061–9.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Gao M, Piernas C, Astbury NM, Hippisley-Cox J, O’Rahilly S, Aveyard P, et al. Associations between body-mass index and COVID-19 severity in 6·9 million people in England: a prospective, community-based, cohort study. Lancet Diabetes Endocrinol. 2021;9:350–9.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ho FK, Petermann-Rocha F, Gray SR, Jani BD, Katikireddi SV, Niedzwiedz CL, et al. Is older age associated with COVID-19 mortality in the absence of other risk factors? General population cohort study of 470,034 participants. PLoS ONE. 2020;15:e0241824.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hunsche C, Hernandez O, De La Fuente M. Impaired immune response in old mice suffering from obesity and premature immunosenescence in adulthood. Journals Gerontol - Ser Biol Sci Med Sci. 2016;71:983–91.

Article  CAS  Google Scholar 

Yan T, Xiao R, Wang N, Shang R, Lin G. Obesity and severe coronavirus disease 2019: molecular mechanisms, paths forward, and therapeutic opportunities. Theranostics. 2021;11:8234–53.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Discacciati MG, Siani S, Campa A, Nakaya HI. Why should obese youth be prioritized in COVID-19 vaccination programs? A nationwide retrospective study. The Lancet Regional Health – Americas. 2022 [cited 2023 Dec 20];7. Available from: https://www.thelancet.com/journals/lanam/article/PIIS2667193X(21)00163-0/fulltext.

Barbé-Tuana F, Funchal G, Schmitz CRR, Maurmann RM, Bauer ME. The interplay between immunosenescence and age-related diseases. Semin Immunopathol. 2020;42:545–57.

Article  PubMed  PubMed Central  Google Scholar 

Spielmann G, Johnston CA, O’Connor DP, Foreyt JP, Simpson RJ. Excess body mass is associated with T cell differentiation indicative of immune ageing in children. Clin Exp Immunol. 2014;176:246–54.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Merad M, Blish CA, Sallusto F, Iwasaki A. The immunology and immunopathology of COVID-19. Science (New York, NY). 2022;375:1122–7.

Evangelou K, Veroutis D, Paschalaki K, Foukas PG, Lagopati N, Dimitriou M, et al. Pulmonary infection by SARS-CoV-2 induces senescence accompanied by an inflammatory phenotype in severe COVID-19: possible implications for viral mutagenesis. Eur Respir J. 2022;60:2102951.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Tsuji S, Minami S, Hashimoto R, Konishi Y, Suzuki T, Kondo T, et al. SARS-CoV-2 infection triggers paracrine senescence and leads to a sustained senescence-associated inflammatory response. Nat Aging. 2022;2:115–24.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hoel H, Heggelund L, Reikvam DH, Stiksrud B, Ueland T, Michelsen AE et al. Elevated markers of gut leakage and inflammasome activation in COVID-19 patients with cardiac involvement. J Intern Med. 2021;289.

Teixeira PC, Dorneles GP, Santana Filho PC, Da Silva IM, Schipper LL, Postiga IAL, et al. Increased LPS levels coexist with systemic inflammation and result in monocyte activation in severe COVID-19 patients. Int Immunopharmacol. 2021;100:108125.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zheng M, Gao Y, Wang G, Song G, Liu S, Sun D, et al. Functional exhaustion of antiviral lymphocytes in COVID-19 patients. Cell Mol Immunol. 2020;17:533–5.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Gil-Manso S, Herrero-Quevedo D, Carbonell D, Martínez-Bonet M, Bernaldo-de-Quirós E, Kennedy-Batalla R, et al. Multidimensional analysis of immune cells from COVID-19 patients identified cell subsets associated with the severity at hospital admission. PLoS Pathog. 2023;19:e1011432.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Mathew D, Giles JR, Baxter AE, Oldridge DA, Greenplate AR, Wu JE, et al. Deep immune profiling of COVID-19 patients reveals distinct immunotypes with therapeutic implications. Science. 2020;369:eabc8511.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Gil-Manso S, Miguens Blanco I, López-Esteban R, Carbonell D, López-Fernández LA, West L, et al. Comprehensive flow cytometry profiling of the immune system in COVID-19 convalescent individuals. Front Immunol. 2021;12:793142.

Article  CAS  PubMed  Google Scholar 

Antonioli L, Fornai M, Pellegrini C, Blandizzi C. NKG2A and COVID-19: another brick in the wall. Cell Mol Immunol. 2020;17:672–4.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yang J, Chang T, Tang L, Deng H, Chen D, Luo J, et al. Increased expression of Tim-3 is associated with depletion of NKT cells in SARS-CoV-2 infection. Front Immunol. 2022;13:796682.

Article  CAS  PubMed  PubMed Central  Google Scholar 

De Barros J-PP, Gautier T, Sali W, Adrie C, Choubley H, Charron E, et al. Quantitative lipopolysaccharide analysis using HPLC/MS/MS and its combination with the limulus amebocyte lysate assay. J Lipid Res. 2015;56:1363–9.

Article  Google Scholar 

Ziegler-Heitbrock L, Ancuta P, Crowe S, Dalod M, Grau V, Hart DN, et al. Nomenclature of monocytes and dendritic cells in blood. Blood. 2010;116:e74–80.

Article  CAS  PubMed  Google Scholar 

Michel T, Poli A, Cuapio A, Briquemont B, Iserentant G, Ollert M, et al. Human CD56bright NK cells: an update. J Immunol. 2016;196:2923–31.

Article  CAS  PubMed  Google Scholar 

Arana Echarri A, Struszczak L, Beresford M, Campbell JP, Jones RH, Thompson D, et al. Immune cell status, cardiorespiratory fitness and body composition among breast cancer survivors and healthy women: a cross sectional study. Front Physiol. 2023;14:1107070.

Article  PubMed  PubMed Central  Google Scholar 

Liu W, Putnam AL, Xu-Yu Z, Szot GL, Lee MR, Zhu S, et al. CD127 expression inversely correlates with FoxP3 and suppressive function of human CD4 + T reg cells. J Exp Med. 2006;203:1701–11.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Appay V, Dunbar PR, Callan M, Klenerman P, Gillespie GMA, Papagno L, et al. Memory CD8 + T cells vary in differentiation phenotype in different persistent virus infections. Nat Med. 2002;8:379–85.

Article  CAS  PubMed  Google Scholar 

Soto-Heredero G, De Gómez MM, Escrig-Larena JI, Mittelbrunn M. Extremely differentiated T cell subsets contribute to tissue deterioration during aging. Annu Rev Immunol. 2023;41:181–205.

Article  CAS  PubMed  Google Scholar 

Tarazona R, DelaRosa O, Alonso C, Ostos B, Espejo J, Pea J, et al. Increased expression of NK cell markers on T lymphocytes in aging and chronic activation of the immune system reflects the accumulation of effector/senescent T cells. Mech Ageing Dev. 2001;121:77–88.

Article  Google Scholar 

Laatifi M, Douzi S, Bouklouz A, Ezzine H, Jaafari J, Zaid Y, et al. Machine learning approaches in Covid-19 severity risk prediction in Morocco. J Big Data. 2022;9:5.

Article  PubMed  PubMed Central  Google Scholar 

McInnes L, Healy J, Melville JUMAP. Uniform manifold approximation and projection for dimension reduction. arXiv; 2020 [cited 2024 Feb 8]. Available from: http://arxiv.org/abs/1802.03426

Frontiers | Mass cytometry study on hepatic fibrosis and its drug-induced recovery. Using mouse peripheral blood mononuclear cells. [cited 2024 Feb 8]. Available from: https://www.frontiersin.org/journals/immunology/articles/https://doi.org/10.3389/fimmu.2022.814030/full

Levine JH, Simonds EF, Bendall SC, Davis KL, Amir ED, Tadmor MD, et al. Data-driven phenotypic dissection of AML reveals progenitor-like cells that correlate with prognosis. Cell. 2015;162:184–97.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yu L, Zhang X, Ye S, Lian H, Wang H, Ye J. Obesity and COVID-19: mechanistic insights from adipose tissue. J Clin Endocrinol Metab. 2022;107:1799–811.

Article  PubMed  Google Scholar 

Zuo T, Zhang F, Lui GCY, Yeoh YK, Li AYL, Zhan H, et al. Alterations in gut microbiota of patients with COVID-19 during time of hospitalization. Gastroenterology. 2020;159:944–955e8.

Article  CAS  PubMed  Google Scholar 

Dorneles GP, Teixeira PC, Peres A, Rodrigues Júnior LC, da Fonseca SG, Monteiro MC, et al. Endotoxin tolerance and low activation of TLR-4/NF-κB axis in monocytes of COVID-19 patients. J Mol Med. 2023;101:183–95.

Article  CAS  PubMed  Google Scholar 

Ahlawat S, Asha null, Sharma KK. Immunological co-ordination between gut and lungs in SARS-CoV-2 infection. Virus Res. 2020;286:198103.

Article  CAS  PubMed  Google Scholar 

Su GL, Simmons RL, Wang SC. Lipopolysaccharide binding protein participation in cellular activation by LPS. Crit Rev Immunol. 1995;15:201–14.

Article  CAS  PubMed  Google Scholar 

Cani PD, Amar J, Iglesias MA, Poggi M, Knauf C, Bastelica D, et al. Metabolic endotoxemia initiates obesity and insulin resistance. Diabetes. 2007;56:1761–72.

Article  CAS  PubMed  Google Scholar 

Tilg H, Zmora N, Adolph TE, Elinav E. The intestinal microbiota fuelling metabolic inflammation. Nat Rev Immunol. 2020;20:40–54.

留言 (0)

沒有登入
gif