Colonna M, Butovsky O. Microglia function in the Central Nervous System during Health and Neurodegeneration. Annu Rev Immunol. 2017;35:441–68.
Article CAS PubMed PubMed Central Google Scholar
Thompson D, Brissette CA, Watt JA. The choroid plexus and its role in the pathogenesis of neurological Infections. Fluids Barriers CNS. 2022;19(1):75.
Article PubMed PubMed Central Google Scholar
Lehtinen MK, Bjornsson CS, Dymecki SM, Gilbertson RJ, Holtzman DM, Monuki ES. The choroid plexus and cerebrospinal fluid: emerging roles in development, Disease, and therapy. J Neurosci. 2013;33(45):17553–9.
Article CAS PubMed PubMed Central Google Scholar
Telano LN, Baker S, Physiology. Cerebral Spinal Fluid. StatPearls. Treasure Island (FL)2023.
Derk J, Jones HE, Como C, Pawlikowski B, Siegenthaler JA. Living on the Edge of the CNS: Meninges Cell Diversity in Health and Disease. Front Cell Neurosci. 2021;15:703944.
Article CAS PubMed PubMed Central Google Scholar
DeSisto J, O’Rourke R, Jones HE, Pawlikowski B, Malek AD, Bonney S, et al. Single-cell transcriptomic analyses of the developing meninges reveal meningeal fibroblast diversity and function. Dev Cell. 2020;54(1):43–59 e4.
Article CAS PubMed PubMed Central Google Scholar
Jessen NA, Munk AS, Lundgaard I, Nedergaard M. The Glymphatic System: a beginner’s guide. Neurochem Res. 2015;40(12):2583–99.
Article CAS PubMed PubMed Central Google Scholar
Louveau A, Smirnov I, Keyes TJ, Eccles JD, Rouhani SJ, Peske JD, et al. Structural and functional features of central nervous system lymphatic vessels. Nature. 2015;523(7560):337–41.
Article CAS PubMed PubMed Central Google Scholar
Aspelund A, Antila S, Proulx ST, Karlsen TV, Karaman S, Detmar M, et al. A dural lymphatic vascular system that drains brain interstitial fluid and macromolecules. J Exp Med. 2015;212(7):991–9.
Article CAS PubMed PubMed Central Google Scholar
Louveau A, Herz J, Alme MN, Salvador AF, Dong MQ, Viar KE, et al. CNS lymphatic drainage and neuroinflammation are regulated by meningeal lymphatic vasculature. Nat Neurosci. 2018;21(10):1380–91.
Article CAS PubMed PubMed Central Google Scholar
Ma Q, Ineichen BV, Detmar M, Proulx ST. Outflow of cerebrospinal fluid is predominantly through lymphatic vessels and is reduced in aged mice. Nat Commun. 2017;8(1):1434.
Article PubMed PubMed Central Google Scholar
Korin B, Ben-Shaanan TL, Schiller M, Dubovik T, Azulay-Debby H, Boshnak NT, et al. High-dimensional, single-cell characterization of the brain’s immune compartment. Nat Neurosci. 2017;20(9):1300–9.
Article CAS PubMed Google Scholar
Mrdjen D, Pavlovic A, Hartmann FJ, Schreiner B, Utz SG, Leung BP, et al. High-dimensional single-cell mapping of Central Nervous System Immune cells reveals distinct myeloid subsets in Health, Aging, and Disease. Immunity. 2018;48(2):380–95 e6.
Article CAS PubMed Google Scholar
Jordao MJC, Sankowski R, Brendecke SM, Sagar, Locatelli G, Tai YH et al. Single-cell profiling identifies myeloid cell subsets with distinct fates during neuroinflammation. Science. 2019;363(6425).
Wang Y, Chen D, Xu D, Huang C, Xing R, He D, et al. Early developing B cells undergo negative selection by central nervous system-specific antigens in the meninges. Immunity. 2021;54(12):2784–94 e6.
Article CAS PubMed Google Scholar
Brioschi S, Wang WL, Peng V, Wang M, Shchukina I, Greenberg ZJ et al. Heterogeneity of meningeal B cells reveals a lymphopoietic niche at the CNS borders. Science. 2021;373(6553).
Rustenhoven J, Drieu A, Mamuladze T, de Lima KA, Dykstra T, Wall M et al. Functional characterization of the dural sinuses as a neuroimmune interface. Cell. 2021;184(4):1000-16 e27.
Schafflick D, Wolbert J, Heming M, Thomas C, Hartlehnert M, Borsch AL, et al. Single-cell profiling of CNS border compartment leukocytes reveals that B cells and their progenitors reside in non-diseased meninges. Nat Neurosci. 2021;24(9):1225–34.
Article CAS PubMed Google Scholar
Rebejac J, Eme-Scolan E, Arnaud Paroutaud L, Kharbouche S, Teleman M, Spinelli L, et al. Meningeal macrophages protect against viral neuroinfection. Immunity. 2022;55(11):2103–17 e10.
Article CAS PubMed Google Scholar
Kim YC, Ahn JH, Jin H, Yang MJ, Hong SP, Yoon JH, et al. Immaturity of immune cells around the dural venous sinuses contributes to viral meningoencephalitis in neonates. Sci Immunol. 2023;8(88):eadg6155.
Article CAS PubMed Google Scholar
Van Hove H, Martens L, Scheyltjens I, De Vlaminck K, Pombo Antunes AR, De Prijck S, et al. A single-cell atlas of mouse brain macrophages reveals unique transcriptional identities shaped by ontogeny and tissue environment. Nat Neurosci. 2019;22(6):1021–35.
Radjavi A, Smirnov I, Kipnis J. Brain antigen-reactive CD4 + T cells are sufficient to support learning behavior in mice with limited T cell repertoire. Brain Behav Immun. 2014;35:58–63.
Article CAS PubMed Google Scholar
Fitzpatrick Z, Frazer G, Ferro A, Clare S, Bouladoux N, Ferdinand J, et al. Gut-educated IgA plasma cells defend the meningeal venous sinuses. Nature. 2020;587(7834):472–6.
Article CAS PubMed PubMed Central Google Scholar
Abbaoui A, Fatoba O, Yamashita T. Meningeal T cells function in the central nervous system homeostasis and neurodegenerative Diseases. Front Cell Neurosci. 2023;17:1181071.
Article PubMed PubMed Central Google Scholar
Mazzitelli JA, Smyth LCD, Cross KA, Dykstra T, Sun J, Du S, et al. Cerebrospinal fluid regulates skull bone marrow niches via direct access through dural channels. Nat Neurosci. 2022;25(5):555–60.
Article CAS PubMed PubMed Central Google Scholar
Pulous FE, Cruz-Hernandez JC, Yang C, Kaya Z, Paccalet A, Wojtkiewicz G, et al. Cerebrospinal fluid can exit into the skull bone marrow and instruct cranial hematopoiesis in mice with bacterial Meningitis. Nat Neurosci. 2022;25(5):567–76.
Article CAS PubMed PubMed Central Google Scholar
Herisson F, Frodermann V, Courties G, Rohde D, Sun Y, Vandoorne K, et al. Direct vascular channels connect skull bone marrow and the brain surface enabling myeloid cell migration. Nat Neurosci. 2018;21(9):1209–17.
Article CAS PubMed PubMed Central Google Scholar
Cai R, Pan C, Ghasemigharagoz A, Todorov MI, Forstera B, Zhao S, et al. Panoptic imaging of transparent mice reveals whole-body neuronal projections and skull-meninges connections. Nat Neurosci. 2019;22(2):317–27.
Article CAS PubMed Google Scholar
Garofalo S, Cocozza G, Mormino A, Bernardini G, Russo E, Ielpo D, et al. Natural killer cells and innate lymphoid cells 1 tune anxiety-like behavior and memory in mice via Interferon-Gamma and acetylcholine. Nat Commun. 2023;14(1):3103.
Article CAS PubMed PubMed Central Google Scholar
Zhang Y, Bailey JT, Xu E, Singh K, Lavaert M, Link VM, et al. Mucosal-associated invariant T cells restrict reactive oxidative damage and preserve meningeal barrier integrity and cognitive function. Nat Immunol. 2022;23(12):1714–25.
Article CAS PubMed PubMed Central Google Scholar
Ribeiro M, Brigas HC, Temido-Ferreira M, Pousinha PA, Regen T, Santa C et al. Meningeal gammadelta T cell-derived IL-17 controls synaptic plasticity and short-term memory. Sci Immunol. 2019;4(40).
Alves de Lima K, Rustenhoven J, Da Mesquita S, Wall M, Salvador AF, Smirnov I, et al. Meningeal gammadelta T cells regulate anxiety-like behavior via IL-17a signaling in neurons. Nat Immunol. 2020;21(11):1421–9.
Article CAS PubMed Google Scholar
Ziv Y, Ron N, Butovsky O, Landa G, Sudai E, Greenberg N, et al. Immune cells contribute to the maintenance of neurogenesis and spatial learning abilities in adulthood. Nat Neurosci. 2006;9(2):268–75.
Article CAS PubMed Google Scholar
Wolf SA, Steiner B, Akpinarli A, Kammertoens T, Nassenstein C, Braun A, et al. CD4-positive T lymphocytes provide a neuroimmunological link in the control of adult hippocampal neurogenesis. J Immunol. 2009;182(7):3979–84.
Article CAS PubMed Google Scholar
Derecki NC, Cardani AN, Yang CH, Quinnies KM, Crihfield A, Lynch KR, et al. Regulation of learning and memory by meningeal immunity: a key role for IL-4. J Exp Med. 2010;207(5):1067–80.
Article CAS PubMed PubMed Central Google Scholar
Herz J, Fu Z, Kim K, Dykstra T, Wall M, Li H, et al. GABAergic neuronal IL-4R mediates T cell effect on memory. Neuron. 2021;109(22):3609–18 e9.
Article CAS PubMed PubMed Central Google Scholar
Filiano AJ, Xu Y, Tustison NJ, Marsh RL, Baker W, Smirnov I, et al. Unexpected role of interferon-gamma in regulating neuronal connectivity and social behaviour. Nature. 2016;535(7612):425–9.
留言 (0)