Castro-Rodríguez M, Carnicero J, Garcia-Garcia F, et al. Frailty as a major factor in the increased risk of death and disability in older people with Diabetes. J Am Med Dir Assoc. 2016;17:949–55. https://doi.org/10.1016/j.jamda.2016.07.013

Article  PubMed  Google Scholar 

Angulo J, El Assar M, Rodríguez-Mañas L. Frailty and Sarcopenia as the basis for the phenotypic manifestation of chronic Diseases in older adults. Mol Aspects Med. 2016;50:1–32. https://doi.org/10.1016/j.mam.2016.06.001

Article  PubMed  Google Scholar 

Cesari M, Prince M, Thiyagarajan J, et al. Frailty: an emerging Public Health Priority. J Am Med Dir Assoc. 2016;17:188–92. https://doi.org/10.1016/j.jamda.2015.12.016

Article  PubMed  Google Scholar 

Ferrucci L, Fabbri E. Inflammageing: chronic inflammation in ageing, Cardiovascular Disease, and frailty. Nat Reviews Cardiol. 2018;15:505–22. https://doi.org/10.1038/s41569-018-0064-2

Article  Google Scholar 

Wu I, Lin C, Hsiung C. Emerging roles of frailty and inflammaging in risk assessment of age-related chronic Diseases in older adults: the intersection between aging biology and personalized medicine. BioMedicine. 2015;5:1. https://doi.org/10.7603/s40681-015-0001-1

Article  PubMed  PubMed Central  Google Scholar 

Walker K, Walston J, Gottesman R, Kucharska-Newton A, Palta P, Windham B. Midlife systemic inflammation is Associated with Frailty in later life: the ARIC Study. The Journals of Gerontology Series A Biological Sciences and Medical Sciences. 2019;74:343–9. https://doi.org/10.1093/gerona/gly045

Article  PubMed  Google Scholar 

López-Otín C, Blasco M, Partridge L, Serrano M, Kroemer G. Hallmarks of aging: an expanding universe. Cell. 2023;186:243–78. https://doi.org/10.1016/j.cell.2022.11.001

Article  PubMed  Google Scholar 

Calçada D, Vianello D, Giampieri E, et al. The role of low-grade inflammation and metabolic flexibility in aging and nutritional modulation thereof: a systems biology approach. Mech Ageing Dev. 2014;138–47. https://doi.org/10.1016/j.mad.2014.01.004

Furman D, Campisi J, Verdin E, et al. Chronic inflammation in the etiology of Disease across the life span. Nat Med. 2019;25:1822–32. https://doi.org/10.1038/s41591-019-0675-0

Article  PubMed  PubMed Central  Google Scholar 

Bellumkonda L, Tyrrell D, Hummel S, Goldstein D. Pathophysiology of Heart Failure and frailty: a common inflammatory origin? Aging Cell. 2017;16:444–50. https://doi.org/10.1111/acel.12581

Article  PubMed  PubMed Central  Google Scholar 

Martinez-Lopez N, Athonvarangkul D, Singh R. Autophagy and aging. Adv Exp Med Biol. 2015;847:73–87. https://doi.org/10.1007/978-1-4939-2404-2_3

Article  PubMed  PubMed Central  Google Scholar 

Michaud M, Balardy L, Moulis G, et al. Proinflammatory cytokines, aging, and age-related Diseases. J Am Med Dir Assoc. 2013;14:877–82. https://doi.org/10.1016/j.jamda.2013.05.009

Article  PubMed  Google Scholar 

Fridovich I. Mitochondria: are they the seat of senescence? Aging Cell. 2004;3:13–6. https://doi.org/10.1046/j.1474-9728.2003.00075.x

Article  PubMed  Google Scholar 

Soysal P, Arik F, Smith L, Jackson S, Isik A. Inflammation, Frailty and Cardiovascular Disease. Adv Exp Med Biol. 2020;1216:55–64. https://doi.org/10.1007/978-3-030-33330-0_7

Article  PubMed  Google Scholar 

Zanini G, Selleri V, Lopez Domenech S, et al. Mitochondrial DNA as inflammatory DAMP: a warning of an aging immune system? Biochem Soc Trans. 2023;51:735–45. https://doi.org/10.1042/bst20221010

Article  PubMed  Google Scholar 

Conway J, Duggal A. Ageing of the gut microbiome: potential influences on immune senescence and inflammageing. Ageing Res Rev. 2021;68:101323. https://doi.org/10.1016/j.arr.2021.101323

Article  PubMed  Google Scholar 

Meyers A, Zhu X. The NLRP3 inflammasome: metabolic regulation and contribution to Inflammaging. Cells. 2020;9. https://doi.org/10.3390/cells9081808

Barroso-Vilares M, Logarinho E. Chromosomal instability and pro-inflammatory response in aging. Mech Ageing Dev. 2019;182:111118doi. https://doi.org/10.1016/j.mad.2019.111118

Article  Google Scholar 

Sendama W. The effect of ageing on the resolution of inflammation. Ageing Res Rev. 2020;57:101000. https://doi.org/10.1016/j.arr.2019.101000

Article  PubMed  PubMed Central  Google Scholar 

Salminen A. Increased immunosuppression impairs tissue homeostasis with aging and age-related Diseases. J Mol Med. 2021;99:1–20. https://doi.org/10.1007/s00109-020-01988-7

Article  PubMed  Google Scholar 

Bhusal A, Rahman M, Suk K. Hypothalamic inflammation in metabolic disorders and aging. Cell Mol Life Sci. 2021;79:32. https://doi.org/10.1007/s00018-021-04019-x

Article  PubMed  Google Scholar 

Mancuso P, Bouchard B. The impact of aging on adipose function and Adipokine Synthesis. Front Endocrinol. 2019;10:137. https://doi.org/10.3389/fendo.2019.00137

Article  Google Scholar 

Dugué P, Hodge A, Ulvik A, et al. Association of Markers of Inflammation, the Kynurenine Pathway and B vitamins with Age and Mortality, and a signature of inflammaging. The Journals of Gerontology Series A Biological Sciences and Medical Sciences. 2022;77:826–36. https://doi.org/10.1093/gerona/glab163

Article  PubMed  Google Scholar 

Barbé-Tuana F, Funchal G, Schmitz C, Maurmann R, Bauer M. The interplay between immunosenescence and age-related Diseases. Semin Immunopathol. 2020;42:545–57. https://doi.org/10.1007/s00281-020-00806-z

Article  PubMed  PubMed Central  Google Scholar 

Martemucci G, Portincasa P, Di Ciaula A, Mariano M, Centonze V, D’Alessandro A. Oxidative stress, aging, antioxidant supplementation and their impact on human health: an overview. Mech Ageing Dev. 2022;206:111707. https://doi.org/10.1016/j.mad.2022.111707

Article  PubMed  Google Scholar 

Royce G, Brown-Borg H, Deepa S. The potential role of necroptosis in inflammaging and aging. GeroScience. 2019;41:795–811. https://doi.org/10.1007/s11357-019-00131-w

Article  PubMed  PubMed Central  Google Scholar 

Cardoso A, Fernandes A, Aguilar-Pimentel J, et al. Towards frailty biomarkers: candidates from genes and pathways regulated in aging and age-related Diseases. Ageing Res Rev. 2018;47:214–77. https://doi.org/10.1016/j.arr.2018.07.004

Article  PubMed  Google Scholar 

Deretic V. Autophagy in inflammation, Infection, and immunometabolism. Immunity. 2021;54:437–53. https://doi.org/10.1016/j.immuni.2021.01.018

Article  PubMed  PubMed Central  Google Scholar 

Robb M, McInnes P, Califf R. Biomarkers and surrogate endpoints: developing common terminology and definitions. JAMA. 2016;315:1107–8. https://doi.org/10.1001/jama.2016.2240

Article  PubMed  Google Scholar 

Van Epps P, Oswald D, Higgins P, et al. Frailty has a stronger association with inflammation than age in older veterans. Immun Ageing: I a. 2016;13:27. https://doi.org/10.1186/s12979-016-0082-z

Article  PubMed  PubMed Central  Google Scholar 

Xia S, Zhang X, Zheng S, et al. An update on Inflamm-Aging: mechanisms, Prevention, and treatment. J Immunol Res. 2016;2016:8426874. https://doi.org/10.1155/2016/8426874

Article  PubMed  PubMed Central  Google Scholar 

Fried L, Tangen C, Walston J, et al. Frailty in older adults: evidence for a phenotype. The Journals of Gerontology Series A Biological Sciences and Medical Sciences. 2001;56:M146–156. https://doi.org/10.1093/gerona/56.3.m146

Article  PubMed  Google Scholar 

Buta B, Walston J, Godino J, et al. Frailty assessment instruments: systematic characterization of the uses and contexts of highly-cited instruments. Ageing Res Rev. 2016;26:53–61. https://doi.org/10.1016/j.arr.2015.12.003

Article  PubMed  Google Scholar 

Rockwood K, Mitnitski A. Frailty in relation to the accumulation of deficits. The Journals of Gerontology Series A Biological Sciences and Medical Sciences. 2007;62:722–7. https://doi.org/10.1093/gerona/62.7.722

Article  PubMed  Google Scholar 

Walston J, Bandeen-Roche K. Frailty: a tale of two concepts. BMC Med. 2015;13:185. https://doi.org/10.1186/s12916-015-0420-6

Article  PubMed  PubMed Central  Google Scholar 

Morley J, Malmstrom T, Miller D. A simple frailty questionnaire (FRAIL) predicts outcomes in middle aged African americans. J Nutr Health Aging. 2012;16:601–8. https://doi.org/10.1007/s12603-012-0084-2

Article  PubMed  PubMed Central  Google Scholar 

Ma L, Tang Z, Chan P, Walston J. Novel Frailty Screening Questionnaire (FSQ) predicts 8-year Mortality in older adults in China. J Frailty Aging. 2019;8:33–8. https://doi.org/10.14283/jfa.2018.38

Article  PubMed  Google Scholar 

Fabrício-Wehbe S, Schiaveto F, Vendrusculo T, Haas V, Dantas R, Rodrigues R. Cross-cultural adaptation and validity of the ‘Edmonton Frail Scale - EFS’ in a Brazilian elderly sample. Rev Latinoam Enferm. 2009;17:1043–9. https://doi.org/10.1590/s0104-11692009000600018

Article  Google Scholar 

Peters L, Boter H, Burgerhof J, Slaets J, Buskens E. Construct validity of the Groningen Frailty Indicator established in a large sample of home-dwelling elderly persons: evidence of stability across age and gender. Exp Gerontol. 2015;69:129–41. https://doi.org/10.1016/j.exger.2015.05.006

Article