Zhou P, Yang XL, Wang XG, Hu B, Zhang L, Zhang W, et al. A pneumonia outbreak associated with a new coronavirus of probable bat origin. Nature. 2020;579:270–3.
Article PubMed PubMed Central Google Scholar
Peckham H, de Gruijter NM, Raine C, Radziszewska A, Ciurtin C, Wedderburn LR, et al. Male sex identified by global COVID-19 meta-analysis as a risk factor for death and ITU admission. Nat Commun. 2020;11:6317.
Article PubMed PubMed Central Google Scholar
Wiersinga WJ, Rhodes A, Cheng AC, Peacock SJ, Prescott HC. Pathophysiology, Transmission, Diagnosis, and Treatment of Coronavirus Disease 2019 (COVID-19): A Review. JAMA. 2020;324:782–93.
Gallo Marin B, Aghagoli G, Lavine K, Yang L, Siff EJ, Chiang SS, et al. Predictors of COVID-19 severity: A literature review. Rev Med Virol. 2021;31:1–10.
Velavan TP, Pallerla SR, Rüter J, Augustin Y, Kremsner PG, Krishna S, Meyer CG. Host genetic factors determining COVID-19 susceptibility and severity. EBioMedicine. 2021;72:103629.
Article PubMed PubMed Central Google Scholar
Bigdelou B, Sepand MR, Najafikhoshnoo S, Negrete JAT, Sharaf M, Ho JQ, et al. COVID-19 and Preexisting Comorbidities: Risks, Synergies, and Clinical Outcomes. Front Immunol. 2022;13:890517.
Article PubMed PubMed Central Google Scholar
Maynou L, Owen R, Konstant-Hambling R, Imam T, Arkill S, Bertfield D, et al. The association between frailty risk and COVID-19-associated all-mortality in hospitalised older people: a national cohort study. Eur Geriatr Med. 2022;13:1149–57.
Article PubMed PubMed Central Google Scholar
Santesmasses D, Castro JP, Zenin AA, Shindyapina AV, Gerashchenko MV, Zhang B, et al. COVID-19 is an emergent disease of aging. Aging Cell. 2020;19:e13230.
Article PubMed PubMed Central Google Scholar
Bajaj V, Gadi N, Spihlman AP, Wu SC, Choi CH, Moulton VR. Aging, Immunity, and COVID-19: How Age Influences the Host Immune Response to Coronavirus Infections? Front Physiol. 2021;11:571416.
Article PubMed PubMed Central Google Scholar
Koduri G, Gokaraju S, Darda M, Warrier V, Duta I, Hayes F, et al. Clinical frailty score as an independent predictor of outcome in COVID-19 hospitalised patients. Eur Geriatr Med. 2021;12:1065–73.
Article PubMed PubMed Central Google Scholar
Elbadawy HM, Khattab A, El-Agamy DS, Eltahir HM, Alhaddad A, Aljohani FD, Almuzaini TM, Abouzied MM, Aldhafiri A. IL-6 at the center of cytokine storm: Circulating inflammation mediators as biomarkers in hospitalized COVID-19 patients. J Clin Lab Anal. 2023;37(7):e24881. https://doi.org/10.1002/jcla.24881.
Article PubMed PubMed Central Google Scholar
Hu B, Huang S, Yin L. The cytokine storm and COVID-19. J Med Virol. 2021;93(1):250–6. https://doi.org/10.1002/jmv.26232. (Epub 2020 Sep 3).
Mihaljevic O, Zivancevic-Simonovic S, Cupurdija V, Marinkovic M, Tubic Vukajlovic J, Markovic A, Stanojevic-Pirkovic M, Milosevic-Djordjevic O. DNA damage in peripheral blood lymphocytes of severely ill COVID-19 patients in relation to inflammatory markers and parameters of hemostasis. Mutagenesis. 2022;37(3–4):203–12. https://doi.org/10.1093/mutage/geac011.
Haller O, Kochs G, Weber F. The interferon response circuit: induction and suppression by pathogenic viruses. Virology. 2006;344(1):119–30. https://doi.org/10.1016/j.virol.2005.09.024.
Sun Y, Wang G, Wang R, Ren L, Yuan Z, Liu Y, Wu Y, Chen R, Chen Y, Diao B. Serum levels of type I interferon (IFN-I) is associated with the severity of COVID-19. J Med Microbiol. 2023;72(8).
Trifonova I, Ngoc K, Nikolova M, Todorova Y, Gladnishka T, Christova I. Patterns of cytokine and chemokine expression in peripheral blood of patients with COVID-19 associated with disease severity. Int J Immunopathol Pharmacol. 2023;37:3946320231163681. https://doi.org/10.1177/03946320231163681.
Ho HE, Radigan L, Bongers G, El-Shamy A, Cunningham-Rundles C. Circulating bioactive bacterial DNA is associated with immune activation and complications in common variable immunodeficiency. JCI Insight. 2021;6(19):e144777. https://doi.org/10.1172/jci.insight.144777.
Article PubMed PubMed Central Google Scholar
D’Aquila P, Giacconi R, Malavolta M, Piacenza F, Bürkle A, Villanueva MM, et al. Microbiome in Blood Samples From the General Population Recruited in the MARK-AGE Project: A Pilot Study. Front Microbiol. 2021;12:707515.
Article PubMed PubMed Central Google Scholar
Gargari G, Mantegazza G, Taverniti V, Del Bo’ C, Bernardi S, Andres-Lacueva C, et al. Bacterial DNAemia is associated with serum zonulin levels in older subjects. Sci Rep. 2021;11:11054.
Mutignani M, Penagini R, Gargari G, Guglielmetti S, Cintolo M, Airoldi A, et al. Blood Bacterial DNA Load and Profiling Differ in Colorectal Cancer Patients Compared to Tumor-Free Controls. Cancers (Basel). 2021;13:6363.
Giacconi R, D’Aquila P, Malavolta M, Piacenza F, Bürkle A, Moreno Villanueva M, et al. Bacterial DNAemia in older subjects and nonagenarian offspring and association with redox biomarkers: results from MARK-AGE Study. J Gerontol A Biol Sci Med Sci. 2023;78:42–50.
Giacconi R, D’Aquila P, Balietti M, Giuli C, Malavolta M, Piacenza F, et al. Bacterial DNAemia in Alzheimer’s Disease and Mild Cognitive Impairment: Association with Cognitive Decline, Plasma BDNF Levels, and Inflammatory Response. Int J Mol Sci. 2022;24:78.
Sirivongrangson P, Kulvichit W, Payungporn S, Pisitkun T, Chindamporn A, Peerapornratana S, et al. Endotoxemia and circulating bacteriome in severe COVID-19 patients. Intensive Care Med Exp. 2020;8:72.
Article PubMed PubMed Central Google Scholar
Kitsios GD, Bain W, Al-Yousif N, Duttagupta R, Ahmed AA, McVerry BJ, Morris A. Plasma microbial cell-free DNA load is associated with mortality in patients with COVID-19. Respir Res. 2021;22:24.
Article PubMed PubMed Central Google Scholar
Hanada S, Pirzadeh M, Carver KY, Deng JC. Respiratory Viral Infection-Induced Microbiome Alterations and Secondary Bacterial Pneumonia. Front Immunol. 2018;9:2640.
Article PubMed PubMed Central Google Scholar
Johansson MA, Quandelacy TM, Kada S, Prasad PV, Steele M, Brooks JT, et al. SARS-CoV-2 Transmission From People Without COVID-19 Symptoms. JAMA Netw Open. 2021;4:e2035057.
Article PubMed PubMed Central Google Scholar
Boyton RJ, Altmann DM. The immunology of asymptomatic SARS-CoV-2 infection: what are the key questions? Nat Rev Immunol. 2021;21:762–8.
Article PubMed PubMed Central Google Scholar
Pshenichnaya N, Lizinfeld I, Zhuravlev G. Factors influencing on hospitalization of COVID-19 patients with comorbidity. Int J Infect Dis. 2022;116:S39.
Article PubMed Central Google Scholar
Chen Y, Klein SL, Garibaldi BT, Li H, Wu C, Osevala NM, et al. Aging in COVID-19: Vulnerability, immunity and intervention. Ageing Res Rev. 2021;65:101205.
Martin-Loeches I, Schultz MJ, Vincent JL, Alvarez-Lerma F, Bos LD, Solé-Violán J, et al. Increased incidence of co-infection in critically ill patients with influenza. Intensive Care Med. 2017;43:48–58.
Garcia-Vidal C, Sanjuan G, Moreno-García E, Puerta-Alcalde P, Garcia-Pouton N, Chumbita M, et al. COVID-19 Researchers Group. Incidence of co-infections and superinfections in hospitalized patients with COVID-19: a retrospective cohort study. Clin Microbiol Infect. 2021;27:83–8.
Davies NG, Jarvis CI, CMMID COVID-19 Working Group, Edmunds WJ, Jewell NP, Diaz-Ordaz K, Keogh RH. Increased mortality in community-tested cases of SARS-CoV-2 lineage B.1.1.7. Nature. 2021;593(7858):270–4. https://doi.org/10.1038/s41586-021-03426-1.
Article PubMed PubMed Central Google Scholar
Capozzi L, Simone D, Bianco A, Del Sambro L, Rondinone V, Pace L, Manzulli V, Iacobellis M, Parisi A. Emerging Mutations Potentially Related to SARS-CoV-2 Immune Escape: The Case of a Long-Term Patient. Life (Basel). 2021;11(11):1259. https://doi.org/10.3390/life11111259.
Spinicci M, Graziani L, Tilli M, Nkurunziza J, Vellere I, Borchi B, Mencarini J, Campolmi I, Gori L, Giovannoni L, Amato C, Livi L, Rasero L, Fattirolli F, Marcucci R, Giusti B, Olivotto I, Tomassetti S, Lavorini F, Maggi L, Annunziato F, Marchionni N, Zammarchi L, Bartoloni A. Infection with SARS-CoV-2 Variants Is Associated with Different Long COVID Phenotypes. Viruses. 2022;14(11):2367. https://doi.org/10.3390/v14112367.
Article PubMed PubMed Central Google Scholar
Liu Y, Du X, Chen J, Jin Y, Peng L, Wang HHX, et al. Neutrophil-to-lymphocyte ratio as an independent risk factor for mortality in hospitalized patients with COVID-19. J Infect. 2020;81:e6–12.
PubMed PubMed Central Google Scholar
Pardhan S, Wood S, Vaughan M, Trott M. The Risk Of COVID-19 The Risk of COVID-19 Related Hospitalsation, Intensive Care Unit Admission and Mortality in People With Underlying Asthma or COPD: A Systematic Review and Meta-Analysis. Front Med (Lausanne). 2021;8:668808.
Contoli M, Papi A, Tomassetti L, Rizzo P, Vieceli Dalla Sega F, Fortini F, et al. Blood Interferon-α Levels and Severity, Outcomes, and Inflammatory Profiles in Hospitalized COVID-19 Patients. Front Immunol. 2021;12:648004.
Article PubMed PubMed Central Google Scholar
Hadjadj J, Yatim N, Barnabei L, Corneau A, Boussier J, Smith N, et al. Impaired type I interferon activity and inflammatory responses in severe COVID-19 patients. Science. 2020;369:718–24.
Article PubMed PubMed Central Google Scholar
Magalhães NS, Savino W, Silva PMR, Martins MA, Carvalho VF. Gut Microbiota Dysbiosis Is a Crucial Player for the Poor Outcomes for COVID-19 in Elderly, Diabetic and Hypertensive Patients. Front Med (Lausanne). 2021;8:644751.
Al-Emran HM, Rahman S, Hasan MS, Ul Alam R, Islam OK, Anwar A, et al. Microbiome analysis revealing microbial interactions and secondary bacterial infections in COVID-19 patients comorbidly affected by Type 2 diabetes. J Med Virol. 2023;95:e28234.
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