Sadighi Akha AA. Aging and the immune system: an overview. J Immunol Methods. 2018;463:21–6.

Article  CAS  PubMed  Google Scholar 

Siegel RL, Miller KD, Fuchs HE, Jemal A. Cancer statistics, 2022. CA Cancer J Clin. 2022;72(1):7–33.

Article  PubMed  Google Scholar 

Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA, Jemal A. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2018;68(6):394–424.

Article  PubMed  Google Scholar 

Wei W, Zeng H, Zheng R, Zhang S, An L, Chen R, et al. Cancer registration in China and its role in cancer prevention and control. Lancet Oncol. 2020;21(7):e342–e9.

Article  PubMed  Google Scholar 

Rheinlander A, Schraven B, Bommhardt U. CD45 in human physiology and clinical medicine. Immunol Lett. 2018;196:22–32.

Article  PubMed  Google Scholar 

Mitchison NA, O’Malley C. Three-cell-type clusters of T cells with antigen-presenting cells best explain the epitope linkage and noncognate requirements of the in vivo cytolytic response. Eur J Immunol. 1987;17(11):1579–83.

Article  CAS  PubMed  Google Scholar 

Im SJ, Hashimoto M, Gerner MY, Lee J, Kissick HT, Burger MC, et al. Defining CD8 + T cells that provide the proliferative burst after PD-1 therapy. Nature. 2016;537(7620):417–21.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Huang AC, Postow MA, Orlowski RJ, Mick R, Bengsch B, Manne S, et al. T-cell invigoration to tumour burden ratio associated with anti-PD-1 response. Nature. 2017;545(7652):60–5.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Frasca D, Blomberg BB. Aging induces B cell defects and decreased antibody responses to Influenza Infection and vaccination. Immun Ageing. 2020;17(1):37.

Article  CAS  PubMed  PubMed Central  Google Scholar 

de Mol J, Kuiper J, Tsiantoulas D, Foks AC. The dynamics of B Cell Aging in Health and Disease. Front Immunol. 2021;12:733566.

Article  PubMed  PubMed Central  Google Scholar 

Paul S, Lal G. The molecular mechanism of natural killer cells function and its importance in Cancer Immunotherapy. Front Immunol. 2017;8:1124.

Article  PubMed  PubMed Central  Google Scholar 

Zingoni A, Sornasse T, Cocks BG, Tanaka Y, Santoni A, Lanier LL. Cross-talk between activated human NK cells and CD4 + T cells via OX40-OX40 ligand interactions. J Immunol. 2004;173(6):3716–24.

Article  CAS  PubMed  Google Scholar 

Martin-Fontecha A, Thomsen LL, Brett S, Gerard C, Lipp M, Lanzavecchia A, et al. Induced recruitment of NK cells to lymph nodes provides IFN-gamma for T(H)1 priming. Nat Immunol. 2004;5(12):1260–5.

Article  CAS  PubMed  Google Scholar 

Ademokun A, Wu YC, Dunn-Walters D. The ageing B cell population: composition and function. Biogerontology. 2010;11(2):125–37.

Article  PubMed  Google Scholar 

Martinet KZ, Bloquet S, Bourgeois C. Ageing combines CD4 T cell lymphopenia in secondary lymphoid organs and T cell accumulation in gut associated lymphoid tissue. Immun Ageing. 2014;11:8.

Article  PubMed  PubMed Central  Google Scholar 

Lazuardi L, Jenewein B, Wolf AM, Pfister G, Tzankov A, Grubeck-Loebenstein B. Age-related loss of naive T cells and dysregulation of T-cell/B-cell interactions in human lymph nodes. Immunology. 2005;114(1):37–43.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Panda A, Arjona A, Sapey E, Bai F, Fikrig E, Montgomery RR, et al. Human innate immunosenescence: causes and consequences for immunity in old age. Trends Immunol. 2009;30(7):325–33.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Manser AR, Uhrberg M. Age-related changes in natural killer cell repertoires: impact on NK cell function and immune surveillance. Cancer Immunol Immunother. 2016;65(4):417–26.

Article  CAS  PubMed  Google Scholar 

Bulut O, Kilic G, Dominguez-Andres J, Netea MG. Overcoming immune dysfunction in the elderly: trained immunity as a novel approach. Int Immunol. 2020;32(12):741–53.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Mittelbrunn M, Kroemer G. Hallmarks of T cell aging. Nat Immunol. 2021;22(6):687–98.

Article  CAS  PubMed  Google Scholar 

Hui E, Cheung J, Zhu J, Su X, Taylor MJ, Wallweber HA, et al. T cell costimulatory receptor CD28 is a primary target for PD-1-mediated inhibition. Science. 2017;355(6332):1428–33.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Aksoylar HI, Boussiotis VA. PD-1(+) T(reg) cells: a foe in cancer immunotherapy? Nat Immunol. 2020;21(11):1311–2.

Article  CAS  PubMed  Google Scholar 

Fane M, Weeraratna AT. How the ageing microenvironment influences tumour progression. Nat Rev Cancer. 2020;20(2):89–106.

Article  CAS  PubMed  Google Scholar 

Waki K, Yamada T, Yoshiyama K, Terazaki Y, Sakamoto S, Matsueda S, et al. PD-1 expression on peripheral blood T-cell subsets correlates with prognosis in non-small cell Lung cancer. Cancer Sci. 2014;105(10):1229–35.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Inomata M, Kado T, Okazawa S, Imanishi S, Taka C, Kambara K, et al. Peripheral PD1-positive CD4 T-Lymphocyte Count can predict progression-free survival in patients with non-small cell Lung Cancer receiving Immune checkpoint inhibitor. Anticancer Res. 2019;39(12):6887–93.

Article  CAS  PubMed  Google Scholar 

Li P, Qin P, Fu X, Zhang G, Yan X, Zhang M, et al. Associations between peripheral blood lymphocyte subsets and clinical outcomes in patients with Lung cancer treated with immune checkpoint inhibitor. Ann Palliat Med. 2021;10(3):3039–49.

Article  PubMed  Google Scholar 

Yuan S, Liu Y, Till B, Song Y, Wang Z. Pretreatment peripheral B cells are Associated with Tumor response to Anti-PD-1-Based immunotherapy. Front Immunol. 2020;11:563653.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Xu X, Wang D, Chen W, Li N, Suwinski R, Rossi A, et al. A nomogram model based on peripheral blood lymphocyte subsets to assess the prognosis of non-small cell Lung cancer patients treated with immune checkpoint inhibitors. Transl Lung Cancer Res. 2021;10(12):4511–25.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Fulop T, Larbi A, Dupuis G, Le Page A, Frost EH, Cohen AA, et al. Immunosenescence and Inflamm-Aging as two sides of the same Coin: friends or foes? Front Immunol. 2017;8:1960.

Article  PubMed  Google Scholar 

Goronzy JJ, Weyand CM. Mechanisms underlying T cell ageing. Nat Rev Immunol. 2019;19(9):573–83.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhang H, Weyand CM, Goronzy JJ. Hallmarks of the aging T-cell system. FEBS J. 2021;288(24):7123–42.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yanes RE, Gustafson CE, Weyand CM, Goronzy JJ. Lymphocyte generation and population homeostasis throughout life. Semin Hematol. 2017;54(1):33–8.

Article  PubMed  Google Scholar 

Johnson JL, Scholz JL, Marshak-Rothstein A, Cancro MP. Molecular pattern recognition in peripheral B cell tolerance: lessons from age-associated B cells. Curr Opin Immunol. 2019;61:33–8.

Article  CAS  PubMed  Google Scholar 

Kaiser M, Semeraro MD, Herrmann M, Absenger G, Gerger A, Renner W. Immune Aging and Immunotherapy in Cancer. Int J Mol Sci. 2021;22(13).

Zhao Y, Shao Q, Peng G. Exhaustion and senescence: two crucial dysfunctional states of T cells in the Tumor microenvironment. Cell Mol Immunol. 2020;17(1):27–35.

Article  CAS  PubMed  Google Scholar 

Zheng Y, Liu Q, Goronzy JJ, Weyand CM. Immune aging - a mechanism in autoimmune Disease. Semin Immunol. 2023;69:101814.

Article  CAS  PubMed  Google Scholar 

Grivennikov SI, Greten FR, Karin M. Immunity, inflammation, and cancer. Cell. 2010;140(6):883–99.

Article  CAS  PubMed