Microvascular Dysfunction in Obesity-Hypertension

Collaboration NCDRF. Trends in adult body-mass index in 200 countries from 1975 to 2014: a pooled analysis of 1698 population-based measurement studies with 19.2 million participants. Lancet. 2016;387(10026):1377–1396.

Tsai AG, Williamson DF, Glick HA. Direct medical cost of overweight and obesity in the USA: a quantitative systematic review. Obes Rev. 2011;12(1):50–61.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Forman JP, Stampfer MJ, Curhan GC. Diet and lifestyle risk factors associated with incident hypertension in women. JAMA. 2009;302(4):401–11.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Stamler R, Stamler J, Riedlinger WF, Algera G, Roberts RH. Weight and blood pressure. Findings in hypertension screening of 1 million Americans. JAMA. 1978;240(15):1607–1610.

• Xu C, Sellke FW, Abid MR. Assessments of microvascular function in organ systems. Am J Physiol Heart Circ Physiol. 2022;322(6):H891–905. This review discusses the extensive direct and indirect modalities currently available to assess microvascular function in different organ systems and their clinical utility.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Rizzoni D, Mengozzi A, Masi S, AgabitiRosei C, De Ciuceis C, Virdis A. New noninvasive methods to evaluate microvascular structure and function. Hypertension. 2022;79(5):874–86.

Article  CAS  PubMed  Google Scholar 

Mathew RC, Bourque JM, Salerno M, Kramer CM. Cardiovascular imaging techniques to assess microvascular dysfunction. JACC Cardiovasc Imaging. 2020;13(7):1577–90.

Article  PubMed  Google Scholar 

Layland J, MacIsaac AI, Burns AT, et al. When collateral supply is accounted for epicardial stenosis does not increase microvascular resistance. Circ Cardiovasc Interv. 2012;5(1):97–102.

Article  PubMed  Google Scholar 

Ng MK, Yeung AC, Fearon WF. Invasive assessment of the coronary microcirculation: superior reproducibility and less hemodynamic dependence of index of microcirculatory resistance compared with coronary flow reserve. Circulation. 2006;113(17):2054–61.

Article  PubMed  Google Scholar 

Park SD, Baek YS, Lee MJ, et al. Comprehensive assessment of microcirculation after primary percutaneous intervention in ST-segment elevation myocardial infarction: insight from thermodilution-derived index of microcirculatory resistance and coronary flow reserve. Coron Artery Dis. 2016;27(1):34–9.

Article  PubMed  Google Scholar 

Murthy VL, Bateman TM, Beanlands RS, et al. Clinical quantification of myocardial blood flow using PET: Joint Position Paper of the SNMMI Cardiovascular Council and the ASNC. J Nucl Cardiol. 2018;25(1):269–97.

Article  PubMed  Google Scholar 

Shimizu I, Aprahamian T, Kikuchi R, et al. Vascular rarefaction mediates whitening of brown fat in obesity. J Clin Invest. 2014;124(5):2099–112.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Gealekman O, Guseva N, Hartigan C, et al. Depot-specific differences and insufficient subcutaneous adipose tissue angiogenesis in human obesity. Circulation. 2011;123(2):186–94.

Article  PubMed  PubMed Central  Google Scholar 

Nakadate K, Motojima K, Tanaka-Nakadate S. Dilatation of sinusoidal capillary and swelling of sinusoidal fenestration in obesity: an ultrastructural study. Ultrastruct Pathol. 2015;39(1):30–7.

Article  PubMed  Google Scholar 

Zhi Z, Chao JR, Wietecha T, Hudkins KL, Alpers CE, Wang RK. Noninvasive imaging of retinal morphology and microvasculature in obese mice using optical coherence tomography and optical microangiography. Invest Ophthalmol Vis Sci. 2014;55(2):1024–30.

Article  PubMed  PubMed Central  Google Scholar 

De Ciuceis C, Porteri E, Rizzoni D, et al. Effects of weight loss on structural and functional alterations of subcutaneous small arteries in obese patients. Hypertension. 2011;58(1):29–36.

Article  PubMed  Google Scholar 

Steinberg HO, Chaker H, Leaming R, Johnson A, Brechtel G, Baron AD. Obesity/insulin resistance is associated with endothelial dysfunction. Implications for the syndrome of insulin resistance. J Clin Invest. 1996;97(11):2601–2610.

Grassi G, Seravalle G, Scopelliti F, et al. Structural and functional alterations of subcutaneous small resistance arteries in severe human obesity. Obesity (Silver Spring). 2010;18(1):92–8.

Article  CAS  PubMed  Google Scholar 

Virdis A, Duranti E, Rossi C, et al. Tumour necrosis factor-alpha participates on the endothelin-1/nitric oxide imbalance in small arteries from obese patients: role of perivascular adipose tissue. Eur Heart J. 2015;36(13):784–94.

Article  CAS  PubMed  Google Scholar 

Shimomura I, Funahashi T, Takahashi M, et al. Enhanced expression of PAI-1 in visceral fat: possible contributor to vascular disease in obesity. Nat Med. 1996;2(7):800–3.

Article  CAS  PubMed  Google Scholar 

Massiera F, Bloch-Faure M, Ceiler D, et al. Adipose angiotensinogen is involved in adipose tissue growth and blood pressure regulation. FASEB J. 2001;15(14):2727–9.

Article  CAS  PubMed  Google Scholar 

Soares AG, de Carvalho MHC, Akamine E. Obesity induces artery-specific alterations: evaluation of vascular function and inflammatory and smooth muscle phenotypic markers. Biomed Res Int. 2017;2017:5038602.

Article  PubMed  PubMed Central  Google Scholar 

Maury E, Navez B, Brichard SM. Circadian clock dysfunction in human omental fat links obesity to metabolic inflammation. Nat Commun. 2021;12(1):2388.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hsu CY, McCulloch CE, Iribarren C, Darbinian J, Go AS. Body mass index and risk for end-stage renal disease. Ann Intern Med. 2006;144(1):21–8. Epub 2006/01/04. https://doi.org/10.7326/0003-4819-144-1-200601030-00006. PubMed PMID: 16389251.

Zhu P, Herrington WG, Haynes R, Emberson J, Landray MJ, Sudlow CLM, Woodward M, Baigent C, Lewington S, Staplin N. Conventional and genetic evidence on the association between adiposity and CKD. J Am Soc Nephrol. 2021;32(1):127–37. Epub 2020/11/01. https://doi.org/10.1681/ASN.2020050679. PubMed PMID: 33127858; PMCID: PMC7894659.

Xu X, Eales JM, Jiang X, Sanderson E, Drzal M, Saluja S, Scannali D, Williams B, Morris AP, Guzik TJ, Charchar FJ, Holmes MV, Tomaszewski M. Contributions of obesity to kidney health and disease: insights from Mendelian randomization and the human kidney transcriptomics. Cardiovasc Res. 2022;118(15):3151–61. Epub 2021/12/12. https://doi.org/10.1093/cvr/cvab357. PubMed PMID: 34893803; PMCID: PMC9732514.

Iliescu R, Chade AR. Progressive renal vascular proliferation and injury in obese Zucker rats. Microcirculation. 2010;17(4):250–8. Epub 2010/06/12. https://doi.org/10.1111/j.1549-8719.2010.00020.x. PubMed PMID: 20536738; PMCID: PMC2924614.

Ngo DT, Farb MG, Kikuchi R, Karki S, Tiwari S, Bigornia SJ, Bates DO, LaValley MP, Hamburg NM, Vita JA, Hess DT, Walsh K, Gokce N. Antiangiogenic actions of vascular endothelial growth factor-A165b, an inhibitory isoform of vascular endothelial growth factor-A, in human obesity. Circulation. 2014;130(13):1072–80. Epub 2014/08/15. https://doi.org/10.1161/CIRCULATIONAHA.113.008171. PubMed PMID: 25116954; PMCID: PMC4175289.

Yong J, Tian J, Yang X, Xing H, He Y, Song X. Effects of oral drugs on coronary microvascular function in patients without significant stenosis of epicardial coronary arteries: a systematic review and meta-analysis of coronary flow reserve. Front Cardiovasc Med. 2020;7:580419.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Baller D, Notohamiprodjo G, Gleichmann U, Holzinger J, Weise R, Lehmann J. Improvement in coronary flow reserve determined by positron emission tomography after 6 months of cholesterol-lowering therapy in patients with early stages of coronary atherosclerosis. Circulation. 1999;99(22):2871–5.

Article  CAS  PubMed  Google Scholar 

Pizzi C, Manfrini O, Fontana F, Bugiardini R. Angiotensin-converting enzyme inhibitors and 3-hydroxy-3-methylglutaryl coenzyme A reductase in cardiac Syndrome X: role of superoxide dismutase activity. Circulation. 2004;109(1):53–8.

Article  CAS  PubMed  Google Scholar 

Zhang X, Li Q, Zhao J, et al. Effects of combination of statin and calcium channel blocker in patients with cardiac syndrome X. Coron Artery Dis. 2014;25(1):40–4.

Article  PubMed  Google Scholar 

Ishida K, Geshi T, Nakano A, et al. Beneficial effects of statin treatment on coronary microvascular dysfunction and left ventricular remodeling in patients with acute myocardial infarction. Int J Cardiol. 2012;155(3):442–7.

Article  PubMed  Google Scholar 

Rehan R, Yong A, Ng M, Weaver J, Puranik R. Coronary microvascular dysfunction: a review of recent progress and clinical implications. Front Cardiovasc Med. 2023;10:1111721.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wittfeldt A, Emanuelsson H, Brandrup-Wognsen G, et al. Ticagrelor enhances adenosine-induced coronary vasodilatory responses in humans. J Am Coll Cardiol. 2013;61(7):723–7.

Article  CAS  PubMed  Google Scholar 

Liu Y, Ding LY, Li XZ. Therapy with ticagrelor for ST-elevated acute coronary syndrome accompanied by diabetes mellitus. Eur Rev Med Pharmacol Sci. 2019;23(3 Suppl):312–8.

CAS  PubMed  Google Scholar 

Gong C, Shen SC, Zhang K, et al. Association of sodium-glucose cotransporter 2 inhibitors with cardiovascular outcome and safety events: a meta-analysis of randomized controlled clinical trials. Front Cardiovasc Med. 2022;9:926979.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Sattar N, Lee MMY, Kristensen SL, et al. Cardiovascular, mortality, and kidney outcomes with GLP-1 receptor agonists in patients with type 2 diabetes: a systematic review and meta-analysis of randomised trials. Lancet Diabetes Endocrinol. 2021;9(10):653–62.

Article  CAS  PubMed  Google Scholar 

Delgado-Aros S, Kim DY, Burton DD, et al. Effect of GLP-1 on gastric volume, emptying, maximum volume ingested, and postprandial symptoms in humans. Am J Physiol Gastrointest Liver Physiol. 2002;282(3):G424–431.

Article  CAS  PubMed  Google Scholar 

Jastreboff AM, Aronne LJ, Ahmad NN, et al. Tirzepatide once weekly for the treatment of obesity. N Engl J Med. 2022;387(3):205–16.

Article  CAS  PubMed  Google Scholar 

Rosenstock J, Frias J, Jastreboff AM, et al. Retatrutide, a GIP, GLP-1 and glucagon receptor agonist, for people with type 2 diabetes: a randomised, double-blind, placebo and active-controlled, parallel-group, phase 2 trial conducted in the USA. Lancet. 2023.

Sukumaran V, Tsuchimochi H, Sonobe T, Waddingham MT, Shirai M, Pearson JT. Liraglutide treatment improves the coronary microcirculation in insulin resistant Zucker obese rats on a high salt diet. Cardiovasc Diabetol. 2020;19(1):24.

Article  CAS  PubMed 

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