Genetic Appraisal of RAAS-Associated SNPs: REN (rs16853055), AGT (rs3789678) and ACE (rs4305) in Preeclamptic Women Living with HIV Infection

Lumbers ER, et al. Causes and consequences of the dysregulated maternal renin-angiotensin system in preeclampsia. Front Endocrinol. 2019;10:563.

Article  Google Scholar 

Irani RA, Xia Y. Renin angiotensin signaling in normal pregnancy and preeclampsia. In: Seminars in nephrology. Elsevier; 2011.

Irani RA, Xia Y. The functional role of the renin–angiotensin system in pregnancy and preeclampsia. Placenta. 2008;29(9):763–71.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Herse F, et al. AT1-receptor autoantibodies and uteroplacental RAS in pregnancy and pre-eclampsia. J Mol Med. 2008;86:697–703.

Article  CAS  PubMed  Google Scholar 

Magee LA, Nicolaides KH, von Dadelszen P. Preeclampsia. N Engl J Med. 2022;386(19):1817–32.

Article  CAS  PubMed  Google Scholar 

Aouache R, et al. Oxidative stress in preeclampsia and placental diseases. Int J Mol Sci. 2018;19(5):1496.

Article  PubMed  PubMed Central  Google Scholar 

Lambert G, et al. Preeclampsia: an update. Acta Anaesthesiol Belg. 2014;65(4):137–49.

CAS  PubMed  Google Scholar 

Tejera E, et al. A population-based study of preeclampsia and eclampsia in Ecuador: ethnic, geographical and altitudes differences. BMC Pregnancy Childbirth. 2021;21(1):1–10.

Article  Google Scholar 

WHO. Maternal mortality. 2023 [15 May 2023]. Available from https://www.who.int/news-room/fact-sheets/detail/maternal-mortality#:~:text=Overview,most%20could%20have%20been%20prevented.

W.H. Organization. Geographic variation in the incidence of hypertension in pregnancy. World Health Organization International Collaborative Study of Hypertensive Disorders of Pregnancy. Am J Obstet Gynecol. 1988;158:80.

Mou AD, et al. Prevalence of preeclampsia and the associated risk factors among pregnant women in Bangladesh. Sci Rep. 2021;11(1):21339.

Article  ADS  CAS  PubMed  PubMed Central  Google Scholar 

Peters A, et al. Home deliveries in limited resource environments. Elsevier; 2020. p. 859–61.

WHO. HIV and AIDS. 2023. Available from https://www.who.int/news-room/fact-sheets/detail/hiv-aids.

Preventable maternal deaths from eclampsia in South Africa. [15 May 2023]. Available from https://www.dsclaw.co.za/articles/preventable-maternal-deaths-from-eclampsia-in-south-africa/.

Saving mothers and babies 2017–2019: Executive summary. 2017–2019.

Woldesenbet S, et al. The 2017 national antenatal sentinel HIV survey. National Department of Health: South Africa. 2019.

Moodley D, et al. High prevalence and incidence of asymptomatic sexually transmitted infections during pregnancy and postdelivery in KwaZulu Natal, South Africa. Sex Transm Dis. 2015;42(1):43–7.

Murugan M, et al. SNP′ s and its correlation with hypertension: a comprehensive review. Dent Medical Res. 2013;1(1):3–6.

• Alwi ZB. The use of SNPs in pharmacogenomics studies. Malays J Med Sci. 2005;12(2):4. This article discusses the use of SNPs in Pharmacogenomics. Further, these authors elaborate on techniques for identifying SNPs.

•• Yako YY, et al. Genetic factors contributing to hypertension in African-based populations: a systematic review and meta-analysis. J Clin Hypertens. 2018;20(3):485–95. This is a systematic review and meta-analysis of essential hypertension in African Individuals. They expanded on certain polymorphisms that are associated with hypertension in these African individuals.

•• Li X, et al. Renin–angiotensin–aldosterone system gene polymorphisms in gestational hypertension and preeclampsia: a case–control gene-association study. Sci Rep. 2016;6(1):38030. This article represented a case-control-gene-association study which included 6 candidate RAAS-associated SNPs. Maternal age affects the effect of different SNPs on pregnancy-induced hypertension.

Article  ADS  MathSciNet  CAS  PubMed  PubMed Central  Google Scholar 

• Zaporowska-Stachowiak I, et al. State of the art paper Aliskiren–an alternative to angiotensin-converting enzyme inhibitors or angiotensin receptor blockers in the therapy of arterial hypertension. Arch Med Sci. 2014;10(4):830–6. This review article explores the role of Aliskiren in treating arterial hypertension.

Article  PubMed  Google Scholar 

•• Verdonk K, et al. The renin–angiotensin–aldosterone system in pre-eclampsia: the delicate balance between good and bad. Clin Sci. 2014;126(8):537–44. This review provides a synopsis on current findings relating to RAAS-regulation in preeclampsia compared to normotensive pregnancies. There is a probability that there are non-parallel adjustments in both circulating and renal RAAS in preeclamptic events, reflected by renin levels in urine.

Article  CAS  Google Scholar 

• Roberts JM, Hubel CA. The two stage model of preeclampsia: variations on the theme. Placenta. 2009;30:32–7. These authors extensively elaborate on the two-stage model of preeclampsia. By understanding this model, the pathophysiology of preeclampsia can be well-understood and therapeutic interventions could be invented.

Article  Google Scholar 

Lubel J, Garg M. Renin-angiotensin-aldosterone system inhibitors in Covid-19. N Engl J Med. 2020;382(24):e92.

Population health research and disease management – the frontier (Part 4). 2015 [15 May 2023]. Available from https://clinicalscientist.wordpress.com/2015/05/10/population-health-research-and-disease-management-the-frontier-part-4/.

Papazisi O, Palmen M, Danser AJ. The use of angiotensin II for the treatment of post-cardiopulmonary bypass vasoplegia. Cardiovasc Drugs Ther. 2020;1–10.

Wilkinson-Berka JL. Prorenin and the (pro) renin receptor in ocular pathology. Am J Pathol. 2008;173(6):1591–4.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Imai T, et al. Cloning and sequence analysis of cDNA for human renin precursor. Proc Natl Acad Sci. 1983;80(24):7405–9.

Article  ADS  CAS  PubMed  PubMed Central  Google Scholar 

Cohen-Haguenauer O. Regional mapping of the human renin gene to 1q32 by in situ hybridization. In: Annales de genetique. 1989.

Hobart PM, et al. Human renin gene: structure and sequence analysis. Proc Natl Acad Sci. 1984;81(16):5026–30.

Article  ADS  CAS  PubMed  PubMed Central  Google Scholar 

Morganti A. Renin and prorenin. 2019.

Manrique C, et al. The renin angiotensin aldosterone system in hypertension: roles of insulin resistance and oxidative stress. Med Clin North Am. 2009;93(3):569–82.

Article  MathSciNet  CAS  PubMed  PubMed Central  Google Scholar 

Timmerans PBW. Angiotensin II receptors and angiotensin II receptor antagonists. Pharmacol Rev. 1993;45:205–51.

Google Scholar 

Feldmann H, Geisbert TW. Ebola haemorrhagic fever. Lancet. 2011;377(9768):849–62.

Patel S, et al. Renin-angiotensin-aldosterone (RAAS): the ubiquitous system for homeostasis and pathologies. Biomed Pharmacother. 2017;94:317–25.

Article  CAS  PubMed  Google Scholar 

Hubert C, et al. Structure of the angiotensin I-converting enzyme gene. Two alternate promoters correspond to evolutionary steps of a duplicated gene. J Biol Chem. 1991;266(23):15377–83.

Nguyen G. Renin/prorenin receptors. Kidney Int. 2006;69(9):1503–6.

Article  CAS  PubMed  Google Scholar 

Živná M, et al. Dominant renin gene mutations associated with early-onset hyperuricemia, anemia, and chronic kidney failure. Am J Hum Gen. 2009;85(2):204–13.

Lu H, Cassis LA, Vander Kooi CW, Daugherty A. Structure and functions of angiotensinogen. Hypertens Res. 2016;39:492–500.

Sands JM, Layton HE. The physiology of urinary concentration: an update. In: Seminars in nephrology. Elsevier; 2009.

Verdecchia P, et al. The renin angiotensin system in the development of cardiovascular disease: role of aliskiren in risk reduction. Vasc Health Risk Manag. 2008;4(5):971–81.

Heit C, et al. Update of the human and mouse SERPINgene superfamily. Hum Genomics. 2013;7(1):1–14.

Article  Google Scholar 

Tikellis C, Thomas M. Angiotensin-converting enzyme 2 (ACE2) is a key modulator of the renin angiotensin system in health and disease. Int J Pept. 2012;2012.

Weir MR, Dzau VJ. The renin-angiotensin-aldosterone system: a specific target for hypertension management. Am J Hypertens. 1999;12(S9):205S–13S.

Yatabe J, et al. Angiotensin III stimulates aldosterone secretion from adrenal gland partially via angiotensin II type 2 receptor but not angiotensin II type 1 receptor. Endocrinology. 2011;152(4):1582–8.

Article  CAS  PubMed  Google Scholar 

Cuadra AE, et al. A current view of brain renin–angiotensin system: is the (pro) renin receptor the missing link? Pharmacol Ther. 2010;125(1):27–38.

Article  CAS  PubMed  Google Scholar 

Crisan D, Carr J. Angiotensin I-converting enzyme: genotype and disease associations. J Mol Diagn. 2000;2(3):105–15.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Thornton SN. Thirst and hydration: physiology and consequences of dysfunction. Physiol Behav. 2010;100(1):15–21.

Article  CAS  PubMed  Google Scholar 

Chung O, et al. Physiological and pharmacological implications of AT1 versus AT2 receptors. Kidney Int. 1998;54:S95–9.

Article  Google Scholar 

Vanderheyden PM. From angiotensin IV binding site to AT4 receptor. Mol Cell Endocrinol. 2009;302(2):159–66.

Article  CAS  PubMed  Google Scholar 

Singh KD, Karnik SS. Angiotensin receptors: structure, function, signaling and clinical applications. J Cell Signal. 2016;1(2).

Royea J, et al. Angiotensin IV receptors mediate the cognitive and cerebrovascular benefits of losartan in a mouse model of Alzheimer’s disease. J Neurosci. 2017;37(22):5562–73.

Santos RAS, et al. The ACE2/angiotensin-(1–7)/MAS axis of the renin-angiotensin system: focus on angiotensin-(1–7). Physiol Rev. 2017.

•• Masenga SK, et al. Hypertension and metabolic syndrome in persons with HIV. Curr Hypertens Rep. 2020;22:1–8. A comprehensive review that describes the mechanisms that trigger Metabolic syndrome and hypertension in people living with HIV.

Article  Google Scholar 

•• Chandel N, et al. Renin modulates HIV replication in T cells. J Leukoc Biol. 2014;96(4):601–9. This research article encapsulates the role of renin in the modulation of HIV replication in T cells.

Article  PubMed  PubMed Central  Google Scholar 

Ouellette DR, Kelly JW, Anders GT. Serum angiotensin-converting enzyme level is elevated in patients with human immunodeficiency virus infection. Arch Intern Med. 1992;152(2):321–4.

Article  CAS  PubMed  Google Scholar 

Sikhosana ML, et al. Association between preeclampsia and HIV: a case-control study in urban South Africa. AJOG Glob Rep. 2022;2(3):100056.

Machado ES, et al. Hypertension, preeclampsia and eclampsia among HIV-infected pregnant women from Latin America and Caribbean countries. J Infect. 2014;68(6):572–80.

Article  PubMed  PubMed Central  Google Scholar 

Mattar R, et al. Preeclampsia and HIV infection. Eur J Obstet Gynecol Reprod Biol. 2004;117(2):240–1.

Crane HM, et al. Lipoatrophy and lipohypertrophy are independently associated with hypertension. HIV Med. 2009;10(8):496–503.

Article  PubMed  PubMed Central  Google Scholar 

Phoswa WN, et al. Pre-eclampsia: the role of highly active antiretroviral therapy and immune markers. Inflamm Res. 2019;68:47–57.

Article  CAS  PubMed  Google Scholar 

Sonalkar S, et al. Comparison of complications associated with induction by misoprostol versus dilation and evacuation for second-trimester abortion. Int J Gynecol Obstet. 2017;138(3):272–5.

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