We gratefully acknowledge the originating laboratories responsible for obtaining the specimens, as well as the submitting laboratories where the genome data were generated and shared via GISAID, on which this research is based. We thank all study participants for their support and Janine Topal, Luis Manthey and Noemí Calderón Hampel for technical and logistical help. We further thank Stephan Ludwig, Andrea Maisner, Thomas Pietschmann and Gert Zimmer for providing reagents. SP acknowledges funding by the EU project UNDINE (grant agreement number 101057100), the Ministry for Science and Culture of Lower Saxony (Niedersächsisches Ministerium für Wissenschaft und Kultur; 14-76103-184, COFONI Network, including projects 7FF22, 6FF22, 10FF22) and the German Research Foundation (Deutsche Forschungsgemeinschaft, DFG; PO 716/11-1). H-MJ received funding from BMBF (01KI2043, NaFoUniMedCovid19-COVIM: 01KX2021), Bavarian State Ministry for Science and the Arts (Bayerisches Staatsministerium für Wissenschaft und Kunst) and DFG through the research training groups RTG1660 and TRR130, the Bayerische Forschungsstiftung (Project CORAd) and the Kastner Foundation. GMNB acknowledges funding by the German Centre for Infection Research (Deutsches Zentrum für Infektionsforschung, DZIF; grant no 80018019238). Further, GMNB and AD-J acknowledge funding by a European Regional Development Fund (Defeat Corona, ZW7-8515131). The funding sources had no role in the design and execution of the study, the writing of the manuscript and the decision to submit the manuscript for publication.