The influence of metabolic disorders on adaptive immunity

Medzhitov R, Janeway C. Innate immune recognition: Mechanisms and pathways. Immunol Rev. 2000;173:89–97.

Article  CAS  PubMed  Google Scholar 

Abbas AK, Janeway CA. Immunology: Improving on nature in the twenty-first century. Cell. 2000;100:129–38.

Article  CAS  PubMed  Google Scholar 

Morgan PK, Pernes G, Huynh K, Giles C, Paul S, Smith A, et al. A lipid atlas of human and mouse immune cells provides insights into ferroptosis susceptibility. Nat Cell Biol. 2024;26:645–59. https://doi.org/10.1038/s41556-024-01377-z

Article  CAS  PubMed  Google Scholar 

Surls J, Nazarov-Stoica C, Kehl M, Olsen C, Casares S, Brumeanu TD. Increased membrane cholesterol in lymphocytes diverts T-cells toward an inflammatory response. PLoS One. 2012;7:1–13.

Article  Google Scholar 

Nguyen DH, Espinoza JC, Taub DD. Cellular cholesterol enrichment impairs T cell activation and chemotaxis. Mech Ageing Dev. 2004;125:641–50.

Article  CAS  PubMed  Google Scholar 

Nojima I, Eikawa S, Tomonobu N, Hada Y, Kajitani N, Teshigawara S, et al. Dysfunction of CD8 + PD-1 + T cells in type 2 diabetes caused by the impairment of metabolism-immune axis. Sci Rep. 2020;10:1–12.

Article  Google Scholar 

Mailer RKW, Gisterå A, Polyzos KA, Ketelhuth DFJ, Hansson GK. Hypercholesterolemia Enhances T Cell Receptor Signaling and Increases the Regulatory T Cell Population. Sci Rep. 2017;7:1–10.

Article  CAS  Google Scholar 

Bensinger SJ, Bradley MN, Joseph SB, Zelcer N, Janssen EM, Hausner MA, et al. LXR Signaling Couples Sterol Metabolism to Proliferation in the Acquired Immune Response. Cell. 2008;134:97–111.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Huang SC, Everts B, Ivanova Y, O'Sullivan D, Nascimento M, Smith AM, et al. Cell-intrinsic lysosomal lipolysis is essential for alternative activation of macrophages. Nat Immunol. 2014;15:846–55.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lauterbach MA, Hanke JE, Serefidou M, Mangan M, Kolbe CC, Hess T, et al. Toll-like Receptor Signaling Rewires Macrophage Metabolism and Promotes Histone Acetylation via ATP-Citrate Lyase. Immunity. 2019;51:997–1011.e7.

Article  CAS  PubMed  Google Scholar 

Mills EL, O’Neill LA. Reprogramming mitochondrial metabolism in macrophages as an anti-inflammatory signal. Eur J Immunol. 2016;46:13–21.

Article  CAS  PubMed  Google Scholar 

Morgan PK, Huynh K, Pernes G, Miotto PM, Mellett NA, Giles C, et al. Macrophage polarization state affects lipid composition and the channeling of exogenous fatty acids into endogenous lipid pools. J Biol Chem. 2021;297:101341.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Tabas I, Lichtman AH. Monocyte-Macrophages and T Cells in Atherosclerosis. Immunity. 2017;47:621–34.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Young MP, Febbraio M, Silverstein RL. CD36 modulates migration of mouse and human macrophages in response to oxidized LDL and may contribute to macrophage trapping in the arterial intima. J Clin Invest. 2009;119:136–45.

Google Scholar 

Van Gils JM, Derby MC, Fernandes LR, Ramkhelawon B, Ray TD, Rayner KJ, et al. The neuroimmune guidance cue netrin-1 promotes atherosclerosis by inhibiting the emigration of macrophages from plaques. Nat Immunol. 2012;13:136–43.

Article  PubMed  PubMed Central  Google Scholar 

Harayama T, Riezman H. Understanding the diversity of membrane lipid composition. Nat Rev Mol Cell Biol. 2018;19:281–96.

Article  CAS  PubMed  Google Scholar 

Van Meer G, Voelker DR, Feigenson GW. Membrane lipids: Where they are and how they behave. Nat Rev Mol Cell Biol. 2008;9:112–24.

Article  PubMed  PubMed Central  Google Scholar 

Sezgin E, Levental I, Mayor S, Eggeling C. The mystery of membrane organization: Composition, regulation and roles of lipid rafts. Nat Rev Mol Cell Biol. 2017;18:361–74.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Dossett LA, Dageforde LA, Swenson BR, Metzger R, Bonatti H, Sawyer RG, et al. Obesity and site-specific nosocomial infection risk in the intensive care unit. Surg Infect. 2009;10:137–42.

Article  Google Scholar 

Sheridan PA, Paich HA, Handy J, Karlsson EA, Hudgens MG, Sammon AB, et al. Obesity is associated with impaired immune response to influenza vaccination in humans. Int J Obes. 2012;36:1072–7.

Article  CAS  Google Scholar 

Kanda H, Tateya S, Tamori Y, Kotani K, Hiasa K, Kitazawa R, et al. MCP-1 contributes to macrophage infiltration into adipose tissue, insulin resistance, and hepatic steatosis in obesity. J Clin Invest. 2006;116:1494–505.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hotamisligil GS, Shargill NS, Spiegelman BM. Adipose expression of tumor necrosis factor-α: Direct role in obesity-linked insulin resistance. Science. 1993;259:87–91.

Article  CAS  PubMed  Google Scholar 

Jovinge S, Ares MPS, Kallin B, Nilsson J. Human monocytes/macrophages release TNF-α in response to Ox-LDL. Arterioscler Thromb Vasc Biol. 1996;16:1573–9.

Article  CAS  PubMed  Google Scholar 

Weisberg SP, McCann D, Desai M, Rosenbaum M, Leibel RL, Ferrante AW Jr. Obesity is associated with macrophage accumulation in adipose tissue. J Clin Invest. 2003;112:1796–808.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kapinsky M, Torzewski M, Büchler C, Duong CQ, Rothe G, Schmitz G. Enzymatically degraded LDL preferentially binds to CD14high CD16+ monocytes and induces foam cell formation mediated only in part by the class B scavenger-receptor CD36. Arterioscler Thromb Vasc Biol. 2001;21:1004–10.

Article  CAS  PubMed  Google Scholar 

Aqel NM, Ball RY, Waldmann H, Mitchinson MJ. Monocytic origin of foam cells in human atherosclerotic plaques. Atherosclerosis. 1984;53:265–71.

Article  CAS  PubMed  Google Scholar 

Patel KM, Strong A, Tohyama J, Jin X, Morales CR, Billheimer J, et al. Macrophage sortilin promotes LDL uptake, foam cell formation, and atherosclerosis. Circ Res. 2015;116:789–96.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Rahaman SO, Lennon DJ, Febbraio M, Podrez EA, Hazen SL, Silverstein RL. A CD36-dependent signaling cascade is necessary for macrophage foam cell formation. Cell Metab. 2006;4:211–21.

Article  CAS  PubMed  PubMed Central  Google Scholar 

O’Neill LAJ, Kishton RJ, Rathmell J. A guide to immunometabolism for immunologists. Nat Rev Immunol. 2016;16:553–65.

Article  PubMed  PubMed Central  Google Scholar 

Zhu J, Paul WE. Heterogeneity and plasticity of T helper cells. Cell Res. 2010;20:4–12.

Article  PubMed  Google Scholar 

Martínez-Reyes I, Chandel NS. Mitochondrial TCA cycle metabolites control physiology and disease. Nat Commun. 2020;11:1–11.

Article  Google Scholar 

Lim SA, Su W, Chapman NM, Chi H. Lipid metabolism in T cell signaling and function. Nat Chem Biol. 2022;18:470–81.

Article 

留言 (0)

沒有登入
gif