Ripperger TJ, Bhattacharya D. Transcriptional and metabolic control of memory B cells and plasma cells. Annu Rev Immunol. 2021;39:345–68.
Article PubMed CAS Google Scholar
Bassing CH, Swat W, Alt FW. The mechanism and regulation of chromosomal V(D)J recombination. Cell. 2002;109:S45–55.
Article PubMed CAS Google Scholar
Berland R, Wortis HH. Origins and functions of B-1 cells with notes on the role of CD5. Annu Rev Immunol. 2002;20:253–300.
Article PubMed CAS Google Scholar
Cerutti A, Cols M, Puga I. Marginal zone B cells: virtues of innate-like antibody-producing lymphocytes. Nat Rev Immunol. 2013;13:118–32.
Article PubMed PubMed Central CAS Google Scholar
Victora GD, Nussenzweig MC. Germinal centers. Annu Rev Immunol. 2012;30:429–57.
Article PubMed CAS Google Scholar
Nutt SL, Hodgkin PD, Tarlinton DM, Corcoran LM. The generation of antibody-secreting plasma cells. Nat Rev Immunol. 2015;15:160–71.
Article PubMed CAS Google Scholar
Nutt SL, Heavy B, Rolink AG, Busslinger M. Commitment to the B-lymphoid lineage depends on the transcription factor Pax5. Nature. 1999;401:556–62.
Article PubMed CAS Google Scholar
Horcher M, Souabni A, Busslinger M. Pax5/BSAP maintains the identity of B cells in late B lymphopoiesis. Immunity. 2001;14:779–90.
Article PubMed CAS Google Scholar
Calderón L, Schindler K, Malin SG, Schebesta A, Sun Q, Schwickert T, et al. Pax5 regulates B-cell immunity by promoting PI3K signaling via PTEN downregulation. Sci Immunol. 2021;6:eabg5003.
Article PubMed PubMed Central Google Scholar
Kaiser FMP, Gruenbacher S, Oyaga MR, Nio E, Jaritz M, Sun Q, et al. Biallelic PAX5 mutations cause hypogammaglobulinemia, sensorimotor deficits, and autism spectrum disorder. J Exp Med. 2022;219:e20220498.
Article PubMed PubMed Central CAS Google Scholar
Fuxa M, Busslinger M. Reporter gene insertions reveal a strictly B lymphoid-specific expression pattern of Pax5 in support of its B-cell identity function. J Immunol. 2007;178:3031–7.
Article PubMed CAS Google Scholar
Delogu A, Schebesta A, Sun Q, Aschenbrenner K, Perlot T, Busslinger M. Gene repression by Pax5 in B cells is essential for blood cell homeostasis and is reversed in plasma cells. Immunity. 2006;24:269–81.
Article PubMed CAS Google Scholar
Revilla-i-Domingo R, Bilic I, Vilagos B, Tahoh H, Ebert A, Tamir IM, et al. The B-cell identity factor Pax5 regulates distinct transcriptional programs in early and late B lymphopoiesis. EMBO J. 2012;31:3130–46.
Article PubMed PubMed Central CAS Google Scholar
Schebesta A, McManus S, Salvagiotto G, Delogu A, Busslinger GA, Busslinger M. Transcription factor Pax5 activates the chromatin of key genes involved in B-cell signaling, adhesion, migration, and immune function. Immunity. 2007;27:49–63.
Article PubMed CAS Google Scholar
Nutt SL, Morrison AM, Dörfler P, Rolink A, Busslinger M. Identification of BSAP (Pax-5) target genes in early B-cell development by loss- and gain-of-function experiments. EMBO J. 1998;17:2319–33.
Article PubMed PubMed Central CAS Google Scholar
Pasqualucci L, Neumeister P, Goossens T, Nanjangud G, Chaganti RS, Küppers R, Dalla-Favera R. Hypermutation of multiple proto-oncogenes in B-cell diffuse large-cell lymphomas. Nature. 2001;412:341–6.
Article PubMed CAS Google Scholar
Busslinger M, Klix N, Pfeffer P, Graninger PG, Kozmik Z. Deregulation of PAX-5 by translocation of the Eµ enhancer of the IgH locus adjacent to two alternative PAX-5 promoters in a diffuse large-cell lymphoma. Proc Natl Acad Sci USA. 1996;93:6129–34.
Article PubMed PubMed Central CAS Google Scholar
Lida S, Rao PH, Nallasivam P, Hibshoosh H, Butler M, Louie DC, et al. The t(9;14)(p13;q32) chromosomal translocation associated with lymphoplasmacytoid lymphoma involves the PAX-5 gene. Blood. 1996;88:4110–7.
Morrison AM, Jäger U, Chott A, Schebesta M, Haas OA, Busslinger M. Deregulated PAX-5 transcription from a translocated IgH promoter in marginal zone lymphoma. Blood. 1998;92:3865–78.
Article PubMed CAS Google Scholar
Cozma D, Yu D, Hodawadekar S, Azvolinsky A, Grande S, Tobias JW, et al. B-cell activator PAX5 promotes lymphomagenesis through stimulation of B-cell receptor signaling. J Clin Invest. 2007;117:2602–10.
Article PubMed PubMed Central CAS Google Scholar
Usacheva A, Smith R, Minshall R, Baida G, Seng S, Croze E, et al. The WD motif-containing protein receptor for activated protein kinase C (RACK1) is required for recruitment and activation of signal transducer and activator of transcription 1 through the type I interferon receptor. J Biol Chem. 2001;276:22948–53.
Article PubMed CAS Google Scholar
Zhang W, Zong CS, Hermanto U, Lopez-Bergami P, Ronai Z, Wang LH. RACK1 recruits STAT3 specifically to insulin and insulin-like growth factor 1 receptors for activation, which is important for regulating anchorage-independent growth. Mol Cell Biol. 2006;26:413–24.
Article PubMed PubMed Central CAS Google Scholar
Okano K, Schnaper HW, Bomsztyk K, Hayashida T. RACK1 binds to Smad3 to modulate transforming growth factor-β-stimulated α2(I) collagen transcription in renal tubular epithelial cells. J Biol Chem. 2006;281:26196–204.
Article PubMed CAS Google Scholar
Zhu Q, Chen L, Li Y, Huang M, Shao J, Li S, et al. Rack1 is essential for corticogenesis by preventing p21-dependent senescence in neural stem cells. Cell Rep. 2021;36:109639.
Article PubMed CAS Google Scholar
Liu YV, Baek JH, Zhang H, Diez R, Cole RN, Semenza GL. RACK1 competes with HSP90 for binding to HIF-1α and is required for O2-independent and HSP90 inhibitor-induced degradation of HIF-1α. Mol Cell. 2007;25:207–17.
Article PubMed PubMed Central Google Scholar
Wang J, Chen X, Hu H, Yao M, Song Y, Yang A, et al. PCAT-1 facilitates breast cancer progression by binding to RACK1 and enhancing oxygen-independent stability of HIF-1α. Mol Ther Nucleic Acids. 2021;24:310–24.
Article PubMed PubMed Central Google Scholar
Cao J, Zhao M, Liu J, Zhang X, Pei Y, Wang J, et al. RACK1 promotes self-renewal and chemoresistance of cancer stem cells in human hepatocellular carcinoma through stabilizing Nanog. Theranostics. 2019;9:811–28.
Article PubMed PubMed Central CAS Google Scholar
Oien DB, Sharma S, Hattersley MM, DuPont M, Criscione SW, Prickett L, et al. BET inhibition targets ABC-DLBCL constitutive B-cell receptor signaling through PAX5. Blood Adv. 2023;7:5108–21.
Article PubMed PubMed Central CAS Google Scholar
Schmidt-Supprian M, Rajewsky K. Vagaries of conditional gene targeting. Nat Immunol. 2007;8:665–8.
留言 (0)