Liwei Lu dedicates this work to his mentor Dr Dennis G. Osmond at McGill University for his pioneering work in B cell immunology. This work was supported by the National Natural Science Foundation of China (82071817), the Hong Kong Research Grants Council (17113319, 17103821, 17111222), the RGC Theme-based Research Scheme (TRS) (T12-703/19-R) and the Centre for Oncology and Immunology under the Health@InnoHK Initiative funded by the Innovation and Technology Commission, The Government of Hong Kong SAR, China. The figure was created with BioRender.com with the permission of the publication license.