Modern Radiation for Hematologic Stem Cell Transplantation

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Total Body Irradiation or Chemotherapy Conditioning in Childhood ALL: A Multinational, Randomized, Noninferiority Phase III Study.

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Comparison of preparative regimens in transplants for children with acute lymphoblastic leukemia.

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Randomized trial of busulfan vs total body irradiation containing conditioning regimens for children with acute lymphoblastic leukemia: a Pediatric Blood and Marrow Transplant Consortium study.

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Cyclophosphamide plus total body irradiation compared with busulfan plus cyclophosphamide as a conditioning regimen prior to hematopoietic stem cell transplantation in patients with leukemia: a systematic review and meta-analysis, Hematology/Oncology and Stem Cell.

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Long-term Effects of Myeloablative Allogeneic Hematopoietic Stem Cell Transplantation in Pediatric Patients with Acute Lymphoblastic Leukemia.

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Allogeneic Marrow Transplantation in Patients With Acute Myeloid Leukemia in First Remission: A Randomized Trial of Two Irradiation Regimens.

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Pulmonary Toxicity After Total Body Irradiation - Critical Review of the Literature and Recommendations for Toxicity Reporting.

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Higher Reported Lung Dose Received During Total Body Irradiation for Allogeneic Hematopoietic Stem Cell Transplantation in Children With Acute Lymphoblastic Leukemia Is Associated With Inferior Survival: A Report from the Children’s Oncology Group.

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Renal toxicity in children undergoing total body irradiation for bone marrow transplant.

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Role of Radiation Based Conditioning Regimens in Patients With High-Risk AML Undergoing Allogenic Transplantation in Remission or Active Disease and Mechanisms of Post-Transplant Relapse.

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Clinical feasibility of TBI with helical tomotherapy.

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Feasibility study of helical tomotherapy for total body or total marrow irradiation.

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Target Coverage and Normal Organ Sparing in Dose-Escalated Total Marrow and Lymphatic Irradiation: A Single-Institution Experience.

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Linac-based intensity modulated total marrow irradiation (IM-TMI).

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Total marrow irradiation with RapidArc volumetric arc therapy.

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Total marrow and total lymphatic irradiation with helical tomotherapy.

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Image-guided total marrow and total lymphatic irradiation using helical tomotherapy.

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Targeted Total Marrow Irradiation Using Three-Dimensional Image-Guided Tomographic Intensity-Modulated Radiation Therapy: An Alternative to Standard Total Body Irradiation.

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Radiation-Related Toxicities Using Organ Sparing Total Marrow Irradiation Transplant Conditioning Regimens.

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Acute and Late Toxicities with Total Marrow Irradiation.

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Total Marrow and Lymphoid Irradiation with Post-Transplantation Cyclophosphamide for Patients with AML in Remission.

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Long-Term Outcomes of Patients with Acute Myelogenous Leukemia Treated with Myeloablative Fractionated Total Body Irradiation TBI-Based Conditioning with a Tacrolimus- and Sirolimus-Based Graft-versus-Host Disease Prophylaxis Regimen: 6-Year Follow-Up from a Single Center.

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Phase I Trial of Total Marrow and Lymphoid Irradiation Transplantation Conditioning in Patients with Relapsed/Refractory Acute Leukemia.

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Phase II Study of Dose Escalated Total Marrow and Lymphoid Irradiation (TMLI) in Combination with Cyclophosphamide and Etoposide in Patients with Poor-Risk Acute Leukemia.

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Estimation of radiation-induced, organ-specific, secondary solid-tumor occurrence rates with total body irradiation and total marrow irradiation treatments.

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Clinical study of total bone marrow combined with total lymphatic irradiation pretreatment based on tomotherapy in hematopoietic stem cell transplantation of acute leukemia.

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Haraldsson A., Wichert S., Engström P.E., et al., Organ sparing total marrow irradiation compared to total body irradiation prior to allogeneic stem cell transplantation, Eur J Haematol, 107 (4), 2021, 393–407.

Comparing the outcomes between TMLI and non-TMLI conditioning regimens for adult high-risk acute lymphoblastic leukemia patients undergoing allogeneic hematopoietic stem cell transplantation: a single-center experience.

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TBI lung dose comparisons using bilateral and anteroposterior delivery techniques and tissue density corrections.

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Dosimetric study and verification of total body irradiation using helical tomotherapy and its comparison to extended SSD technique.

Med Dosim. 35: 243-249

Total Body Irradiation (TBI) using Helical Tomotherapy in children and young adults undergoing stem cell transplantation.

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Total-body irradiation using linac-based volumetric modulated arc therapy: Its clinical accuracy, feasibility and reliability.

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Image-guided volumetric-modulated arc therapy of total body irradiation: An efficient workflow from simulation to delivery.

J Appl Clin Med Phys. 22: 169-177

Kovalchuk N., Simiele E., Skinner L., et al., The Stanford Volumetric Modulated Arc Therapy Total Body Irradiation Technique, Pract Radiat Oncol, 12 (3), 2022, 245–258.

A Step Toward Making VMAT TBI More Prevalent: Automating the Treatment Planning Process.

Pract Radiat Oncol. 11: 415-423

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Optimized Conformal Total Body Irradiation Among Recipients of TCRαβ/CD19-Depleted Grafts in Pediatric Patients With Hematologic Malignancies: Single-Center Experience.

Front Oncol. 11: 785916

Volumetric Modulated Arc Therapy Enabled Total Body Irradiation (VMAT-TBI): Six-year Clinical Experience and Treatment Outcomes.

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Marquez C., Hui C., Simiele E., et al., Volumetric modulated arc therapy total body irradiation in pediatric and adolescent/young adult patients undergoing stem cell transplantation: Early outcomes and toxicities, Pediatr Blood Cancer, 69 (6), 2022, e29689.

Dose-escalated volumetric modulated arc therapy for total marrow irradiation: A feasibility dosimetric study with 4DCT planning and simultaneous integrated boost.

Phys Med. 78: 123-128

Helical tomotherapy targeting total bone marrow after total body irradiation for patients with relapsed acute leukemia undergoing an allogeneic stem cell transplant.

Radiother Oncol. 98: 382-386

Haploidentical hematopoietic SCT using helical tomotherapy for total-body irradiation and targeted dose boost in patients with high-risk/refractory acute lymphoblastic leukemia.

Bone Marrow Transplant. 53: 438-448

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