Advances in Radiation Therapy for Primary Liver Cancer

Blomgren H. Lax I. Näslund I. et al.

Stereotactic high dose fraction radiation therapy of extracranial tumors using an accelerator. Clinical experience of the first thirty-one patients.

Acta Oncol. 34: 861-870Lax I. Blomgren H. Larson D. et al.

Extracranial stereotactic radiosurgery of localized targets.

J Radiosurg. 1: 135-148

Stereotactic Body Radiation Therapy for Hepatocellular Carcinoma: Current State and Future Opportunities.

Dig Dis Sci. 64: 1008-1015Boda-Heggemann J. Knopf A.C. Simeonova-Chergou A. et al.

Deep Inspiration Breath Hold-Based Radiation Therapy: A Clinical Review.

Int J Radiat Oncol Biol Phys. 94: 478-492Giraud P. Morvan E. Claude L. et al.

Respiratory gating techniques for optimization of lung cancer radiotherapy.

J Thorac Oncol. 6: 2058-2068Ezzell G.A. Galvin J.M. Low D. et al.

Guidance document on delivery, treatment planning, and clinical implementation of IMRT: report of the IMRT Subcommittee of the AAPM Radiation Therapy Committee.

Med Phys. 30: 2089-2115Xing L. Thorndyke B. Schreibmann E. et al.

Overview of image-guided radiation therapy.

Med Dosim. 31: 91-112Bujold A. Massey C.A. Kim J.J. et al.

Sequential phase I and II trials of stereotactic body radiotherapy for locally advanced hepatocellular carcinoma.

J Clin Oncol. 31: 1631-1639Culleton S. Jiang H. Haddad C.R. et al.

Outcomes following definitive stereotactic body radiotherapy for patients with Child-Pugh B or C hepatocellular carcinoma.

Radiother Oncol. 111: 412-417Lasley F.D. Mannina E.M. Johnson C.S. et al.

Treatment variables related to liver toxicity in patients with hepatocellular carcinoma, Child-Pugh class A and B enrolled in a phase 1-2 trial of stereotactic body radiation therapy.

Pract Radiat Oncol. 5: e443-e449Weiner A.A. Olsen J. Ma D. et al.

Stereotactic body radiotherapy for primary hepatic malignancies - Report of a phase I/II institutional study.

Radiother Oncol. 121: 79-85Feng M. Suresh K. Schipper M.J. et al.

Individualized Adaptive Stereotactic Body Radiotherapy for Liver Tumors in Patients at High Risk for Liver Damage: A Phase 2 Clinical Trial.

JAMA Oncol. 4: 40-47Durand-Labrunie J. Baumann A.S. Ayav A. et al.

Curative Irradiation Treatment of Hepatocellular Carcinoma: A Multicenter Phase 2 Trial.

Int J Radiat Oncol Biol Phys. 107: 116-125Yoon S.M. Kim S.Y. Lim Y.S. et al.

Stereotactic body radiation therapy for small (≤5 cm) hepatocellular carcinoma not amenable to curative treatment: Results of a single-arm, phase II clinical trial.

Clin Mol Hepatol. 26: 506-515Wahl D.R. Stenmark M.H. Tao Y. et al.

Outcomes After Stereotactic Body Radiotherapy or Radiofrequency Ablation for Hepatocellular Carcinoma.

J Clin Oncol. 34: 452-459Lee J. Shin I.S. Yoon W.S. et al.

Comparisons between radiofrequency ablation and stereotactic body radiotherapy for liver malignancies: Meta-analyses and a systematic review.

Radiother Oncol. 145: 63-70Cacciola A. Parisi S. Tamburella C. et al.

Stereotactic body radiation therapy and radiofrequency ablation for the treatment of liver metastases: How and when?.

Rep Pract Oncol Radiother. 25: 299-306Eriguchi T. Takeda A. Sanuki N. et al.

Acceptable toxicity after stereotactic body radiation therapy for liver tumors adjacent to the central biliary system.

Int J Radiat Oncol Biol Phys. 85: 1006-1011Barney B.M. Olivier K.R. Macdonald O.K. et al.

Clinical outcomes and dosimetric considerations using stereotactic body radiotherapy for abdominopelvic tumors.

Am J Clin Oncol. 35: 537-542Velec M. Haddad C.R. Craig T. et al.

Predictors of Liver Toxicity Following Stereotactic Body Radiation Therapy for Hepatocellular Carcinoma.

Int J Radiat Oncol Biol Phys. 97: 939-946Pan C.C. Kavanagh B.D. Dawson L.A. et al.

Radiation-associated liver injury.

Int J Radiat Oncol Biol Phys. 76: S94-S100Kavanagh B.D. Pan C.C. Dawson L.A. et al.

Radiation dose-volume effects in the stomach and small bowel.

Int J Radiat Oncol Biol Phys. 76: S101-S107Miften M. Vinogradskiy Y. Moiseenko V. et al.

Radiation Dose-Volume Effects for Liver SBRT.

Int J Radiat Oncol Biol Phys. 110: 196-205Tse R.V. Hawkins M. Lockwood G. et al.

Phase I study of individualized stereotactic body radiotherapy for hepatocellular carcinoma and intrahepatic cholangiocarcinoma.

J Clin Oncol. 26: 657-664Nabavizadeh N. Waller J.G. Fain R. et al.

Safety and Efficacy of Accelerated Hypofractionation and Stereotactic Body Radiation Therapy for Hepatocellular Carcinoma Patients With Varying Degrees of Hepatic Impairment.

Int J Radiat Oncol Biol Phys. 100: 577-585Bush D.A. Kayali Z. Grove R. et al.

The safety and efficacy of high-dose proton beam radiotherapy for hepatocellular carcinoma: a phase 2 prospective trial.

Cancer. 117: 3053-3059Hong T.S. Wo J.Y. Yeap B.Y. et al.

Multi-Institutional Phase II Study of High-Dose Hypofractionated Proton Beam Therapy in Patients With Localized, Unresectable Hepatocellular Carcinoma and Intrahepatic Cholangiocarcinoma.

J Clin Oncol. 34: 460-468Kasuya G. Kato H. Yasuda S. et al.

Progressive hypofractionated carbon-ion radiotherapy for hepatocellular carcinoma: Combined analyses of 2 prospective trials.

Cancer. 123: 3955-3965Fukumitsu N. Sugahara S. Nakayama H. et al.

A prospective study of hypofractionated proton beam therapy for patients with hepatocellular carcinoma.

Int J Radiat Oncol Biol Phys. 74: 831-836Witt J.S. Rosenberg S.A. Bassetti M.F.

MRI-guided adaptive radiotherapy for liver tumours: visualising the future.

Lancet Oncol. 21: e74-e82Bohoudi O. Bruynzeel A.M.E. Senan S. et al.

Fast and robust online adaptive planning in stereotactic MR-guided adaptive radiation therapy (SMART) for pancreatic cancer.

Radiother Oncol. 125: 439-444Green O.L. Henke L.E. Hugo G.D.

Practical Clinical Workflows for Online and Offline Adaptive Radiation Therapy.

Semin Radiat Oncol. 29: 219-227Mittauer K. Paliwal B. Hill P. et al.

A New Era of Image Guidance with Magnetic Resonance-guided Radiation Therapy for Abdominal and Thoracic Malignancies.

Cureus. 10: e2422Rosenberg S.A. Henke L.E. Shaverdian N. et al.

A Multi-Institutional Experience of MR-Guided Liver Stereotactic Body Radiation Therapy.

Adv Radiat Oncol. 4: 142-149Feldman A.M. Modh A. Glide-Hurst C. et al.

Real-time Magnetic Resonance-guided Liver Stereotactic Body Radiation Therapy: An Institutional Report Using a Magnetic Resonance-Linac System.

Cureus. 11: e5774Henke L.E. Olsen J.R. Contreras J.A. et al.

Stereotactic MR-Guided Online Adaptive Radiation Therapy (SMART) for Ultracentral Thorax Malignancies: Results of a Phase 1 Trial.

Adv Radiat Oncol. 4: 201-209Oderinde O.M. Shirvani S.M. Olcott P.D. et al.

The technical design and concept of a PET/CT linac for biology-guided radiotherapy.

Clin Transl Radiat Oncol. 29: 106-112

Cells at intermediate oxygen levels can be more important than the "hypoxic fraction" in determining tumor response to fractionated radiotherapy.

Radiat Res. 147: 541-550

BGRT: biologically guided radiation therapy-the future is fast approaching.

Med Phys. 34: 3739-3751Xiang L. Tang S. Ahmad M. et al.

High Resolution X-ray-Induced Acoustic Tomography.

Sci Rep. 6: 26118Lei H. Zhang W. Oraiqat I. et al.

Toward in vivo dosimetry in external beam radiotherapy using x-ray acoustic computed tomography: A soft-tissue phantom study validation.

Med Phys. https://doi.org/10.1002/mp.13070Oraiqat I. Zhang W. Litzenberg D. et al.

An ionizing radiation acoustic imaging (iRAI) technique for real-time dosimetric measurements for FLASH radiotherapy.

Med Phys. 47: 5090-5101Ba Sunbul N.H. Zhang W. Oraiqat I. et al.

A simulation study of ionizing radiation acoustic imaging (iRAI) as a real-time dosimetric technique for ultra-high dose rate radiotherapy (UHDR-RT).

Med Phys. 48: 6137-6151Hickling S. Leger P. El Naqa I.

On the Detectability of Acoustic Waves Induced Following Irradiation by a Radiotherapy Linear Accelerator.

IEEE Trans Ultrason Ferroelectr Freq Control. 63: 683-690Hickling S. Lei H. Hobson M. et al.

Experimental evaluation of x-ray acoustic computed tomography for radiotherapy dosimetry applications.

Med Phys. 44: 608-617Hickling S. Xiang L. Jones K.C. et al.

Ionizing radiation-induced acoustics for radiotherapy and diagnostic radiology applications.

Med Phys. 45: e707-e721Jackson W.C. Suresh K. Maurino C. et al.

A mid-treatment break and reassessment maintains tumor control and reduces toxicity in patients with hepatocellular carcinoma treated with stereotactic body radiation therapy.

Radiother Oncol. 141: 101-107Jackson W.C. Tang M. Maurino C. et al.

Individualized Adaptive Radiation Therapy Allows for Safe Treatment of Hepatocellular Carcinoma in Patients With Child-Turcotte-Pugh B Liver Disease.

Int J Radiat Oncol Biol Phys. 109: 212-219Baumann B.C. Wei J. Plastaras J.P. et al.

Stereotactic Body Radiation Therapy (SBRT) for Hepatocellular Carcinoma: High Rates of Local Control With Low Toxicity.

Am J Clin Oncol. 41: 1118-1124Jackson W.C. Hartman H.E. Gharzai L.A. et al.

The Potential for Midtreatment Albumin-Bilirubin (ALBI) Score to Individualize Liver Stereotactic Body Radiation Therapy.

Int J Radiat Oncol Biol Phys. 111: 127-134Anscher M.S. Crocker I.R. Jirtle R.L.

Transforming growth factor-beta 1 expression in irradiated liver.

Radiat Res. 122: 77-85Anscher M.S. Peters W.P. Reisenbichler H. et al.

Transforming growth factor beta as a predictor of liver and lung fibrosis after autologous bone marrow transplantation for advanced breast cancer.

N Engl J Med. 328: 1592-1598Hong T.S. Grassberger C. Yeap B.Y. et al.

Pretreatment plasma HGF as potential biomarker for susceptibility to radiation-induced liver dysfunction after radiotherapy.

NPJ Precis Oncol. 2: 22Cuneo K.C. Devasia T. Sun Y. et al.

Serum Levels of Hepatocyte Growth Factor and CD40 Ligand Predict Radiation-Induced Liver Injury.

Transl Oncol. 12: 889-894Küsters S. Tiegs G. Alexopoulou L. et al.

In vivo evidence for a functional role of both tumor necrosis factor (TNF) receptors and transmembrane TNF in experimental hepatitis.

Eur J Immunol. 27: 2870-2875Heyninck K. Wullaert A. Beyaert R.

Nuclear factor-kappa B plays a central role in tumour necrosis factor-mediated liver disease.

Biochem Pharmacol. 66: 1409-1415

TNFα in liver fibrosis.

Curr Pathobiol Rep. 3: 253-261Cope A.P. Aderka D. Doherty M. et al.

Increased levels of soluble tumor necrosis factor receptors in the sera and synovial fluid of patients with rheumatic diseases.

Arthritis Rheum. 35: 1160-1169Aderka D. Wysenbeek A. Engelmann H. et al.

Correlation between serum levels of soluble tumor necrosis factor receptor and disease activity in systemic lupus erythematosus.

Arthritis Rheum. 36: 1111-1120Khoury S.J. Orav E.J. Guttmann C.R. et al.

Changes in serum levels of ICAM and TNF-R correlate with disease activity in multiple sclerosis.

Neurology. 53: 758-764Cousins M.M. Devasia T.P. Maurino C.M. et al.

Pretreatment Levels of Soluble Tumor Necrosis Factor Receptor 1 and Hepatocyte Growth Factor Predict Toxicity and Overall Survival After.

J Nucl Med. 63: 882-889Cousins M.M. Morris E. Maurino C. et al.

TNFR1 and the TNFα axis as a targetable mediator of liver injury from stereotactic body radiation therapy.

Transl Oncol. 14: 100950Bierman H.R. Byron R.L. Kelley K.H. et al.

Studies on the blood supply of tumors in man. III. Vascular patterns of the liver by hepatic arteriography in vivo.

J Natl Cancer Inst. 12: 107-131

The blood supply of neoplasms in the liver.

Am J Pathol. 30: 969-977Garin E. Lenoir L. Rolland Y. et al.

Dosimetry based on 99mTc-macroaggregated albumin SPECT/CT accurately predicts tumor response and survival in hepatocellular carcinoma patients treated with 90Y-loaded glass microspheres: preliminary results.

J Nucl Med. 53: 255-263Salem R. Johnson G.E. Kim E. et al.

Yttrium-90 Radioembolization for the Treatment of Solitary, Unresectable HCC: The LEGACY Study.

Hepatology. 74: 2342-2352Lewandowski R.J. Gabr A. Abouchaleh N. et al.

Radiation Segmentectomy: Potential Curative Therapy for Early Hepatocellular Carcinoma.

Radiology. 287: 1050-1058Vouche M. Habib A. Ward T.J. et al.

Unresectable solitary hepatocellular carcinoma not amenable to radiofrequency ablation: multicenter radiology-pathology correlation and survival of radiation segmentectomy.

Hepatology. 60: 192-201Riaz A. Gates V.L. Atassi B. et al.

Radiation segmentectomy: a novel approach to increase safety and efficacy of radioembolization.

Int J Radiat Oncol Biol Phys. 79: 163-171Biederman D.M. Titano J.J. Korff R.A. et al.

Radiation Segmentectomy versus Selective Chemoembolization in the Treatment of Early-Stage Hepatocellular Carcinoma.

J Vasc Interv Radiol. 29: 30-37.e2Padia S.A. Johnson G.E. Horton K.J. et al.

Segmental Yttrium-90 Radioembolization versus Segmental Chemoembolization for Localized Hepatocellular Carcinoma: Results of a Single-Center, Retrospective, Propensity Score-Matched Study.

J Vasc Interv Radiol. 28: 777-785.e1Dewaraja Y.K. Chun S.Y. Srinivasa R.N. et al.

Improved quantitative.

Med Phys. 44: 6364-6376Garin E. Tselikas L. Guiu B. et al.

Personalised versus standard dosimetry approach of selective internal radiation therapy in patients with locally advanced hepatocellular carcinoma (DOSISPHERE-01): a randomised, multicentre, open-label phase 2 trial.

Lancet Gastroenterol Hepatol. 6: 17-29Kappadath S.C. Mikell J. Balagopal A. et al.

Hepatocellular Carcinoma Tumor Dose Response After.

Int J Radiat Oncol Biol Phys. 102: 451-461Wei L. Cui C. Xu J. et al.

Tumor response prediction in.

EJNMMI Phys. 7: 74Luterstein E. Cao M. Lamb J.M. et al.

Clinical Outcomes Using Magnetic Resonance-Guided Stereotactic Body Radiation Therapy in Patients With Locally Advanced Cholangiocarcinoma.

Adv Radiat Oncol. 5: 189-195Boldrini L. Romano A. Mariani S. et al.

MRI-guided stereotactic radiation therapy for hepatocellular carcinoma: a feasible and safe innovative treatment approach.

J Cancer Res Clin Oncol. 147: 2057-2068

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