The Evolving Landscape of Neuroendocrine Tumors

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Surgical treatment of neuroendocrine metastases to the liver: a plea for resection to increase survival.

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The palliative benefit of aggressive surgical intervention for both hepatic and mesenteric metastases from neuroendocrine tumors.

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A novel stratification of mesenteric mass involvement as a predictor of challenging mesenteric lymph node dissection by minimally invasive approach for ileal neuroendocrine tumors.

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Resection of at-risk mesenteric lymph nodes is associated with improved survival in patients with small bowel neuroendocrine tumors.

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Association of a prophylactic surgical approach to stage iv small intestinal neuroendocrine tumors with survival.

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Impact of tumor size and nodal status on recurrence of nonfunctional pancreatic neuroendocrine tumors </=2 cm after curative resection: A multi-institutional study of 392 cases.

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Observation versus resection for small asymptomatic pancreatic neuroendocrine tumors: a matched case-control study.

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Small, nonfunctioning, asymptomatic pancreatic neuroendocrine tumors (PNETs): role for nonoperative management.

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Comparison of prognosis between observation and surgical resection groups with small sporadic non-functional pancreatic neuroendocrine neoplasms without distant metastasis.

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A novel validated recurrence risk score to guide a pragmatic surveillance strategy after resection of pancreatic neuroendocrine tumors: an international study of 1006 patients.

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A systematic review of localization, surgical treatment options, and outcome of insulinoma.

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Resection of primary tumor site is associated with prolonged survival in metastatic nonfunctioning pancreatic neuroendocrine tumors.

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Comparative study of lung and extrapulmonary poorly differentiated neuroendocrine carcinomas: A SEER database analysis of 162,983 cases.

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A Phase II Basket Trial of Dual Anti-CTLA-4 and Anti-PD-1 Blockade in Rare Tumors (DART SWOG 1609) in Patients with Nonpancreatic Neuroendocrine Tumors.

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Neuroendocrine liver metastasis: The chance to be cured after liver surgery.

J Surg Oncol. 115: 687-695Graff-Baker A.N. Sauer D.A. Pommier S.J. et al.

Expanded criteria for carcinoid liver debulking: maintaining survival and increasing the number of eligible patients.

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Effective cytoreduction can be achieved in patients with numerous neuroendocrine tumor liver metastases (NETLMs).

Surgery. 165: 166-175

The Landmark Series: Neuroendocrine Tumor Liver Metastases.

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Randomized Embolization Trial for NeuroEndocrine Tumor Metastases to the Liver (RETNET): study protocol for a randomized controlled trial.

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Surgery versus intra-arterial therapy for neuroendocrine liver metastasis: a multicenter international analysis.

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Everolimus for the Treatment of Advanced Pancreatic Neuroendocrine Tumors: Overall Survival and Circulating Biomarkers From the Randomized, Phase III RADIANT-3 Study.

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Placebo-Controlled, Double-Blind, Prospective, Randomized Study on the Effect of Octreotide LAR in the Control of Tumor Growth in Patients with Metastatic Neuroendocrine Midgut Tumors (PROMID): Results of Long-Term Survival.

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Everolimus for the treatment of advanced, non-functional neuroendocrine tumours of the lung or gastrointestinal tract (RADIANT-4): a randomised, placebo-controlled, phase 3 study.

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Sunitinib malate for the treatment of pancreatic neuroendocrine tumors.

N Engl J Med. 364: 501-513Kunz P.L. Catalano P.J. Nimeiri H. et al.

A randomized study of temozolomide or temozolomide and capecitabine in patients with advanced pancreatic neuroendocrine tumors: A trial of the ECOG-ACRIN Cancer Research Group (E2211).

J Clin Oncol. 36: 4004

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