1. Freedman, L. P., Cockburn, I. M., Simcoe, T. S. The Economics of Reproducibility in Preclinical Research. PLoS Biol. 2015, 13, e1002165.
Google Scholar | Crossref | Medline2. Coussens, N. P., Sittampalam, G. S., Guha, R., et al. Assay Guidance Manual: Quantitative Biology and Pharmacology in Preclinical Drug Discovery. Clin. Transl. Sci. 2018, 11, 461–470.
Google Scholar | Crossref | Medline3. Assay Guidance Manual, ; Markossian, S., Grossman, A., Brimacombe, K., et al., Eds. Eli Lilly & Company and the National Center for Advancing Translational Sciences: Bethesda, MD, 2004.
Google Scholar4. Born, J. R., Chenniappan, V. K., Davis, D. P., et al. The Impact of Assay Design on Medicinal Chemistry: Case Studies. SLAS Discov. 2021, 1243–1255.
Google Scholar5. Riss, T. L., Moravec, R. A., Duellman, S. J., et al. Treating Cells as Reagents to Design Reproducible Assays. SLAS Discov. 2021, 1256–1267.
Google Scholar | Medline6. Korch, C. T., Capes-Davis, A. The Extensive and Expensive Impacts of HEp-2 [HeLa], Intestine 407 [HeLa], and Other False Cell Lines in Journal Publications. SLAS Discov. 2021, 1268–1279.
Google Scholar | Medline7. Coussens, N. P., Auld, D. S., Thielman, J. R., et al. Addressing Compound Reactivity and Aggregation Assay Interferences: Case Studies of Biochemical High-Throughput Screening Campaigns Benefiting from the National Institutes of Health Assay Guidance Manual Guidelines. SLAS Discov. 2021, 1280–1290.
Google Scholar8. Haelewyn, J., Iversen, P. W., Weidner, J. R. Addressing Unusual Assay Variability with Robust Statistics. SLAS Discov. 2021, 1291–1297.
Google Scholar9. Kaur, G., Evans, D. M., Teicher, B. A., et al. Complex Tumor Spheroids, a Tissue Mimicking Tumor Model, for Drug Discovery and Precision Medicine. SLAS Discov. 2021, 1298–1314.
Google Scholar | Medline10. Wen, K. K., Roy, S., Grumbach, I. M., et al. A “Failed” Assay Development for the Discovery of Rescuing Small Molecules from the Radiation Damage. SLAS Discov. 2021, 1315–1325.
Google Scholar11. Siramshetty, V., Williams, J., Nguyen Eth, T., et al. Validating ADME QSAR Models Using Marketed Drugs. SLAS Discov. 2021, 1326–1336.
Google Scholar12. Lowell, J. A., O’Neill, N., Danzi, M. C., et al. Phenotypic Screening Following Transcriptomic Deconvolution to Identify Transcription Factors Mediating Axon Growth Induced by a Kinase Inhibitor. SLAS Discov. 2021, 1337–1354.
Google Scholar13. Li, S., Li, A. J., Travers, J., et al. Identification of Compounds for Butyrylcholinesterase Inhibition. SLAS Discov. 2021, 1355–1364.
Google Scholar