Freed EO. HIV-1 assembly, release and maturation. Nat Rev Microbiol. 2015;13(8):484–96.
CAS PubMed PubMed Central Google Scholar
2.Sundquist WI, Krausslich HG. HIV-1 assembly, budding, and maturation. Cold Spring Harbor Perspect Med. 2012;2(7):a006924.
3.Pornillos O, Ganser-Pornillos BK. Maturation of retroviruses. Curr Opin Virol. 2019;36:47–55.
CAS PubMed PubMed Central Google Scholar
4.Lesbats P, Engelman AN, Cherepanov P, Retroviral. DNA integration. Chem Rev. 2016;116(20):12730–57.
CAS PubMed PubMed Central Google Scholar
5.Engelman A. In vivo analysis of retroviral integrase structure and function. Adv Virus Res. 1999;52:411–26.
6.Elliott JL, Kutluay SB. Going beyond Integration: the emerging role of HIV-1 integrase in virion morphogenesis. Viruses. 2020;12(9):1005.
CAS PubMed PubMed Central Google Scholar
7.Engelman A, Englund G, Orenstein JM, Martin MA, Craigie R. Multiple effects of mutations in human immunodeficiency virus type 1 integrase on viral replication. J Virol. 1995;69(5):2729–36.
CAS PubMed PubMed Central Google Scholar
8.Jenkins TM, Engelman A, Ghirlando R, Craigie R. A soluble active mutant of HIV-1 integrase: involvement of both the core and carboxyl-terminal domains in multimerization. J Biol Chem. 1996;271(13):7712–8.
9.Nakamura T, Masuda T, Goto T, Sano K, Nakai M, Harada S. Lack of infectivity of HIV-1 integrase zinc finger-like domain mutant with morphologically normal maturation. Biochem Biophys Res Commun. 1997;239(3):715–22.
10.Shin CG, Taddeo B, Haseltine WA, Farnet CM. Genetic analysis of the human immunodeficiency virus type 1 integrase protein. J Virol. 1994;68(3):1633–42.
CAS PubMed PubMed Central Google Scholar
11.Fontana J, Jurado KA, Cheng N, Ly NL, Fuchs JR, Gorelick RJ, et al. Distribution and redistribution of HIV-1 nucleocapsid protein in immature, mature, and integrase-inhibited virions: a role for integrase in maturation. J Virol. 2015;89(19):9765–80.
CAS PubMed PubMed Central Google Scholar
12.Kessl JJ, Kutluay SB, Townsend D, Rebensburg S, Slaughter A, Larue RC, et al. HIV-1 integrase binds the viral RNA genome and is essential during virion morphogenesis. Cell. 2016;166(5):1257-68.e12.
13.Elliott JL, Eschbach JE, Koneru PC, Li W, Puray-Chavez M, Townsend D, et al. Integrase–RNA interactions underscore the critical role of integrase in HIV-1 virion morphogenesis. eLife. 2020;9:e54311.
CAS PubMed PubMed Central Google Scholar
14.Quillent C, Borman AM, Paulous S, Dauguet C, Clavel F. Extensive regions of pol are required for efficient human immunodeficiency virus polyprotein processing and particle maturation. Virology. 1996;219(1):29–36.
15.Le Rouzic E, Bonnard D, Chasset S, Bruneau JM, Chevreuil F, Le Strat F, et al. Dual inhibition of HIV-1 replication by integrase-LEDGF allosteric inhibitors is predominant at the post-integration stage. Retrovirology. 2013;10:144.
PubMed PubMed Central Google Scholar
16.Kessl JJ, Jena N, Koh Y, Taskent-Sezgin H, Slaughter A, Feng L, et al. Multimode, cooperative mechanism of action of allosteric HIV-1 integrase inhibitors. J Biol Chem. 2012;287(20):16801–11.
CAS PubMed PubMed Central Google Scholar
17.Gupta K, Brady T, Dyer BM, Malani N, Hwang Y, Male F, et al. Allosteric inhibition of human immunodeficiency virus integrase: late block during viral replication and abnormal multimerization involving specific protein domains. J Biol Chem. 2014;289(30):20477–88.
CAS PubMed PubMed Central Google Scholar
18.Fader LD, Malenfant E, Parisien M, Carson R, Bilodeau F, Landry S, et al. Discovery of BI 224436, a noncatalytic site integrase inhibitor (NCINI) of HIV-1. ACS Med Chem Lett. 2014;5(4):422–7.
CAS PubMed PubMed Central Google Scholar
19.Christ F, Voet A, Marchand A, Nicolet S, Desimmie BA, Marchand D, et al. Rational design of small-molecule inhibitors of the LEDGF/p75-integrase interaction and HIV replication. Nat Chem Biol. 2010;6(6):442–8.
20.Wilson TA, Koneru PC, Rebensburg SV, Lindenberger JJ, Kobe MJ, Cockroft NT, et al. An isoquinoline scaffold as a novel class of allosteric HIV-1 integrase inhibitors. ACS Med Chem Lett. 2019;10(2):215–20.
CAS PubMed PubMed Central Google Scholar
21.Deng N, Hoyte A, Mansour YE, Mohamed MS, Fuchs JR, Engelman AN, et al. Allosteric HIV-1 integrase inhibitors promote aberrant protein multimerization by directly mediating inter-subunit interactions: structural and thermodynamic modeling studies. Protein Sci. 2016;25(11):1911–7.
CAS PubMed PubMed Central Google Scholar
22.Feng L, Sharma A, Slaughter A, Jena N, Koh Y, Shkriabai N, et al. The A128T resistance mutation reveals aberrant protein multimerization as the primary mechanism of action of allosteric HIV-1 integrase inhibitors. J Biol Chem. 2013;288(22):15813–20.
CAS PubMed PubMed Central Google Scholar
23.Desimmie BA, Schrijvers R, Demeulemeester J, Borrenberghs D, Weydert C, Thys W, et al. LEDGINs inhibit late stage HIV-1 replication by modulating integrase multimerization in the virions. Retrovirology. 2013;10:57.
PubMed PubMed Central Google Scholar
24.Jurado KA, Wang H, Slaughter A, Feng L, Kessl JJ, Koh Y, et al. Allosteric integrase inhibitor potency is determined through the inhibition of HIV-1 particle maturation. Proc Natl Acad Sci USA. 2013;110(21):8690–5.
CAS PubMed PubMed Central Google Scholar
25.Tsiang M, Jones GS, Niedziela-Majka A, Kan E, Lansdon EB, Huang W, et al. New class of HIV-1 integrase (IN) inhibitors with a dual mode of action. J Biol Chem. 2012;287(25):21189–203.
CAS PubMed PubMed Central Google Scholar
26.Sharma A, Slaughter A, Jena N, Feng L, Kessl JJ, Fadel HJ, et al. A new class of multimerization selective inhibitors of HIV-1 integrase. PLoS Pathog. 2014;10(5):e1004171.
PubMed PubMed Central Google Scholar
27.Balakrishnan M, Yant SR, Tsai L, O’Sullivan C, Bam RA, Tsai A, et al. Non-catalytic site HIV-1 integrase inhibitors disrupt core maturation and induce a reverse transcription block in target cells. PLoS ONE. 2013;8(9):e74163.
CAS PubMed PubMed Central Google Scholar
28.Bonnard D, Le Rouzic E, Eiler S, Amadori C, Orlov I, Bruneau JM, et al. Structure-function analyses unravel distinct effects of allosteric inhibitors of HIV-1 integrase on viral maturation and integration. J Biol Chem. 2018;293(16):6172–86.
CAS PubMed PubMed Central Google Scholar
29.Madison MK, Lawson DQ, Elliott J, Ozanturk AN, Koneru PC, Townsend D, et al. Allosteric HIV-1 integrase inhibitors lead to premature degradation of the viral RNA genome and integrase in target cells. J Virol. 2017;91(17):e00821-17.
PubMed PubMed Central Google Scholar
30.Koneru PC, Francis AC, Deng N, Rebensburg SV, Hoyte AC, Lindenberger J, et al. HIV-1 integrase tetramers are the antiviral target of pyridine-based allosteric integrase inhibitors. eLife. 2019;8:e46344.
PubMed PubMed Central Google Scholar
31.Lu K, Heng X, Summers MF. Structural determinants and mechanism of HIV-1 genome packaging. J Mol Biol. 2011;410(4):609–33.
CAS PubMed PubMed Central Google Scholar
32.Kuzembayeva M, Dilley K, Sardo L, Hu WS. Life of psi: how full-length HIV-1 RNAs become packaged genomes in the viral particles. Virology. 2014;454–455:362–70.
33.Abd El-Wahab EW, Smyth RP, Mailler E, Bernacchi S, Vivet-Boudou V, Hijnen M, et al. Specific recognition of the HIV-1 genomic RNA by the Gag precursor. Nat Commun. 2014;5:4304.
34.Webb JA, Jones CP, Parent LJ, Rouzina I, Musier-Forsyth K. Distinct binding interactions of HIV-1 Gag to Psi and non-Psi RNAs: implications for viral genomic RNA packaging. RNA. 2013;19(8):1078–88.
CAS PubMed PubMed Central Google Scholar
35.Sarni S, Biswas B, Liu S, Olson ED, Kitzrow JP, Rein A, et al. HIV-1 Gag protein with or without p6 specifically dimerizes on the viral RNA packaging signal. J Biol Chem. 2020;295(42):14391–401.
CAS PubMed PubMed Central Google Scholar
36.Smyth RP, Smith MR, Jousset AC, Despons L, Laumond G, Decoville T, et al. In cell mutational interference mapping experiment (in cell MIME) identifies the 5′ polyadenylation signal as a dual regulator of HIV-1 genomic RNA production and packaging. Nucleic Acids Res. 2018;46(9):e57.
PubMed PubMed Central Google Scholar
37.Nikolaitchik OA, Somoulay X, Rawson JMO, Yoo JA, Pathak VK, Hu WS. Unpaired guanosines in the 5′ untranslated region of HIV-1 RNA Act synergistically to mediate genome packaging. J Virol. 2020;94(21):e00439-20.
PubMed PubMed Central Google Scholar
38.Wilkinson KA, Gorelick RJ, Vasa SM, Guex N, Rein A, Mathews DH, et al. High-throughput SHAPE analysis reveals structures in HIV-1 genomic RNA strongly conserved across distinct biological states. PLoS Biol. 2008;6(4):e96.
PubMed PubMed Central Google Scholar
39.Kutluay SB, Zang T, Blanco-Melo D, Powell C, Jannain D, Errando M, et al. Global changes in the RNA binding specificity of HIV-1 gag regulate virion genesis. Cell. 2014;159(5):1096–109.
CAS PubMed PubMed Central Google Scholar
40.Kenyon JC, Prestwood LJ, Lever AM. A novel combined RNA-protein interaction analysis distinguishes HIV-1 Gag protein binding sites from structural change in the viral RNA leader. Sci Rep. 2015;5:14369.
CAS PubMed PubMed Central Google Scholar
41.Jones CP, Cantara WA, Olson ED, Musier-Forsyth K. Small-angle X-ray scattering-derived structure of the HIV-1 5′ UTR reveals 3D tRNA mimicry. Proc Natl Acad Sci USA. 2014;111(9):3395–400.
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