TLE4 is a repressor of the oncogenic activity of TLX3 in T-cell acute lymphoblastic leukemia

Girardi T, Vicente C, Cools J, De Keersmaecker K. The genetics and molecular biology of T-ALL. Blood. 2017;129:1113–23. Mar 2

Article  CAS  PubMed  Google Scholar 

MacLeod RAF, Nagel S, Kaufmann M, Janssen JWG, Drexler HG. Activation of HOX11L2 by juxtaposition with 3’-BCL11B in an acute lymphoblastic leukemia cell line (HPB-ALL) with t(5;14)(q35;q32.2). Genes Chromosomes Cancer. 2003;37:84–91. May 1

Article  CAS  PubMed  Google Scholar 

Cheng L, Samad OA, Xu Y, Mizuguchi R, Luo P, Shirasawa S, et al. Lbx1 and Tlx3 are opposing switches in determining GABAergic versus glutamatergic transmitter phenotypes. Nat Neurosci. 2005;8:1510–5. Nov

Article  CAS  PubMed  Google Scholar 

Smits WK, Vermeulen C, Hagelaar R, Kimura S, Vroegindeweij EM, Buijs-Gladdines JGCAM, et al. Elevated enhancer-oncogene contacts and higher oncogene expression levels by recurrent CTCF inactivating mutations in acute T cell leukemia. Cell Rep. 2023;42:112373.

Botten GA, Zhang Y, Dudnyk K, Kim YJ, Liu X, Sanders JT, et al. Structural variation cooperates with permissive chromatin to control enhancer hijacking-mediated oncogenic transcription. Blood. 2023;142:336–51.

CAS  PubMed  PubMed Central  Google Scholar 

Göös H, Kinnunen M, Salokas K, Tan Z, Liu X, Yadav L, et al. Human transcription factor protein interaction networks. Nat Commun. 2022;13:766.

Dadi S, Le Noir S, Payet-Bornet D, Lhermitte L, Zacarias-Cabeza J, Bergeron J, et al. TLX homeodomain oncogenes mediate T cell maturation arrest in T-ALL via interaction with ETS1 and suppression of TCRα gene expression. Cancer Cell. 2012;21:563–76.

Article  CAS  PubMed  Google Scholar 

Shimomura A, Patel D, Wilson SM, Koehler KR, Khanna R, Hashino E. Tlx3 promotes glutamatergic neuronal subtype specification through direct interactions with the chromatin modifier CBP. PLoS ONE. 2015;10:10.

Article  Google Scholar 

Renou L, Boelle P, Deswarte C, Spicuglia S, Benyoucef A, Calvo J, et al. Homeobox protein TLX3 activates miR-125b expression to promote T-cell acute lymphoblastic leukemia. Blood Adv. 2017;1:733–47.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Jennings BH, Ish-Horowicz D. The Groucho/TLE/Grg family of transcriptional co-repressors. Genome Biol. 2008;9:205.

Article  PubMed  PubMed Central  Google Scholar 

Palaparti A, Baratz A, Stifani S. The Groucho/transducin-like enhancer of split transcriptional repressors interact with the genetically defined amino-terminal silencing domain of histone H3. J Biol Chem. 1997;272:26604–10.

Article  CAS  PubMed  Google Scholar 

Chen G, Fernandez J, Mische S, Courey AJ. A functional interaction between the histone deacetylase Rpd3 and the corepressor groucho in Drosophila development. Genes Dev. 1999;13:2218–30.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yu X, Li P, Roeder RG, Wang Z. Inhibition of androgen receptor-mediated transcription by amino-terminal enhancer of split. Mol Cell Biol. 2001;21:4614–25.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Daniels DL, Weis WI. Beta-catenin directly displaces Groucho/TLE repressors from Tcf/Lef in Wnt-mediated transcription activation. Nat Struct Mol Biol. 2005;12:364–71.

Article  CAS  PubMed  Google Scholar 

Cai Y, Brophy PD, Levitan I, Stifani S, Dressler GR. Groucho suppresses Pax2 transactivation by inhibition of JNK-mediated phosphorylation. EMBO J. 2003;22:5522–9. Oct 15

Article  CAS  PubMed  PubMed Central  Google Scholar 

Riz I, Lee HJ, Baxter KK, Behnam R, Hawley TS, Hawley RG. Transcriptional activation by TLX1/HOX11 involves Gro/TLE corepressors. Biochem Biophys Res Commun. 2009;380:361. Mar 6

Article  CAS  PubMed  PubMed Central  Google Scholar 

Liu Y, Easton J, Shao Y, Maciaszek J, Wang Z, Wilkinson MR, et al. The genomic landscape of pediatric and young adult T-lineage acute lymphoblastic leukemia. Nat Genet. 2017;49:1211–8.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Touzart A, Mayakonda A, Smith C, Hey J, Toth R, Cieslak A, et al. Epigenetic analysis of patients with T-ALL identifies poor outcomes and a hypomethylating agent-responsive subgroup. Sci Transl Med. 2021;13:eabc4834.

Bornschein S, Demeyer S, Stirparo R, Gielen O, Vicente C, Geerdens E, et al. Defining the molecular basis of oncogenic cooperation between TAL1 expression and Pten deletion in T-ALL using a novel pro-T-cell model system. Leukemia. 2018;32:941.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Palomero T, Wei KL, Odom DT, Sulis ML, Real PJ, Margolin A, et al. NOTCH1 directly regulates c-MYC and activates a feed-forward-loop transcriptional network promoting leukemic cell growth. Proc Natl Acad Sci USA. 2006;103:18261–6.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bonnet M, Loosveld M, Montpellier B, Navarro JM, Quilichini B, Picard C, et al. Posttranscriptional deregulation of MYC via PTEN constitutes a major alternative pathway of MYC activation in T-cell acute lymphoblastic leukemia. Blood. 2011;117:6650–9.

Article  CAS  PubMed  Google Scholar 

Herranz D, Ambesi-Impiombato A, Palomero T, Schnell SA, Belver L, Wendorff AA, et al. A NOTCH1-driven MYC enhancer promotes T cell development, transformation and acute lymphoblastic leukemia. Nat Med. 2014;20:1130–7.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Staal FJT, Weerkamp F, Langerak AW, Hendriks RW, Clevers HC. Transcriptional control of t lymphocyte differentiation. Stem Cells. 2001;19:165–79.

Article  CAS  PubMed  Google Scholar 

Zhang Y, Qian JJ, Zhou YL, Huang X, Li JH, Li XY, et al. Comparison of early T-cell precursor and non-ETP subtypes among 122 Chinese adults with acute lymphoblastic leukemia. Front Oncol. 2020;10:1423.

Article  PubMed  PubMed Central  Google Scholar 

Van Thillo Q, De Bie J, Seneviratne JA, Demeyer S, Omari S, Balachandran A, et al. Oncogenic cooperation between TCF7-SPI1 and NRAS(G12D) requires β-catenin activity to drive T-cell acute lymphoblastic leukemia. Nat Commun. 2021;12:4164.

Brady SW, Roberts KG, Gu Z, Shi L, Pounds S, Pei D, et al. The genomic landscape of pediatric acute lymphoblastic leukemia. Nat Genet. 2022;54:1376–89.

Article  CAS  PubMed  PubMed Central  Google Scholar 

de Bock CE, Demeyer S, Degryse S, Verbeke D, Sweron B, Gielen O, et al. HOXA9 cooperates with activated JAK/STAT signaling to drive leukemia development. Cancer Discov. 2018;8:616–31.

Article  PubMed  Google Scholar 

Thielemans N, Demeyer S, Mentens N, Gielen O, Provost S, Cools J. TAL1 cooperates with PI3K/AKT pathway activation in T-cell acute lymphoblastic leukemia. Haematologica. 2022;107:2304–17.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Tsherniak A, Vazquez F, Montgomery PG, Weir BA, Kryukov G, Cowley GS, et al. Defining a cancer dependency map. Cell. 2017;170:564–576.e16.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Coustan-Smith E, Mullighan CG, Onciu M, Behm FG, Raimondi SC, Pei D, et al. Early T-cell precursor leukaemia: a subtype of very high-risk acute lymphoblastic leukaemia. Lancet Oncol. 2009;10:147–56.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Copley RR. The EH1 motif in metazoan transcription factors. BMC Genom. 2005;6:169.

Article  Google Scholar 

Shimeld SM. A transcriptional modification motif encoded by homeobox and fork head genes. FEBS Lett. 1997;410:124–5.

Article  CAS  PubMed  Google Scholar 

Gehre N, Nusser A, von Muenchow L, Tussiwand R, Engdahl C, Capoferri G, et al. A stromal cell free culture system generates mouse pro-T cells that can reconstitute T-cell compartments in vivo. Eur J Immunol. 2015;45:932–42.

Article  CAS  PubMed 

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