The link between eye movements and cognitive function in mild to moderate Alzheimer’s disease

Baltaretu BR, Monaco S, Velji-Ibrahim J, Luabeya GN, Crawford JD (2020) Parietal cortex integrates saccade and object orientation signals to update grasp plans. J Neurosci 40:4525–4535. https://doi.org/10.1523/JNEUROSCI.0300-20.2020

Article  PubMed  PubMed Central  CAS  Google Scholar 

Boxer AL, Garbutt S, Rankin KP, Hellmuth J, Neuhaus J, Miller BL, Lisberger SG (2006) Medial versus lateral frontal lobe contributions to voluntary saccade control as revealed by the study of patients with frontal lobe degeneration. J Neurosci 26:6354–6363. https://doi.org/10.1523/JNEUROSCI.0549-06.2006

Article  PubMed  PubMed Central  CAS  Google Scholar 

Bueno APA, Sato JR, Hornberger M (2019) Eye tracking - the overlooked method to measure cognition in neurodegeneration? Neuropsychologia 133:107191. https://doi.org/10.1016/j.neuropsychologia.2019.107191

Article  PubMed  CAS  Google Scholar 

Chehrehnegar N, Nejati V, Shati M, Esmaeili M, Rezvani Z, Haghi M, Foroughan M (2019) Behavioral and cognitive markers of mild cognitive impairment: diagnostic value of saccadic eye movements and Simon task. Aging Clin Exp Res 31:1591–1600. https://doi.org/10.1007/s40520-019-01121-w

Article  PubMed  Google Scholar 

Crawford TJ, Higham S, Mayes J, Dale M, Shaunak S, Lekwuwa G (2013) The role of working memory and attentional disengagement on inhibitory control: effects of aging and Alzheimer’s disease. Age (Dordr) 35:1637–1650. https://doi.org/10.1007/s11357-012-9466-y

Article  PubMed  Google Scholar 

Crawford TJ, Devereaux A, Higham S, Kelly C (2015) The disengagement of visual attention in Alzheimer’s disease: a longitudinal eye-tracking study. Front Aging Neurosci 7:118. https://doi.org/10.3389/fnagi.2015.00118

Article  PubMed  PubMed Central  Google Scholar 

Folstein MF, Folstein SE, McHugh PR (1975) Mini-mental state. A practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res 12:189–198. https://doi.org/10.1016/0022-3956(75)90026-6

Article  PubMed  CAS  Google Scholar 

Garbutt S, Matlin A, Hellmuth J et al (2008) Oculomotor function in frontotemporal lobar degeneration, related disorders and Alzheimer’s disease. Brain 131:1268–1281. https://doi.org/10.1093/brain/awn047

Article  PubMed  PubMed Central  Google Scholar 

Holden JG, Cosnard A, Laurens B et al (2018) Prodromal Alzheimer’s disease demonstrates increased errors at a simple and automated anti-saccade task. J Alzheimers Dis 65:1209–1223. https://doi.org/10.3233/jad-180082

Article  PubMed  Google Scholar 

Kahana Levy N, Lavidor M, Vakil E (2018) Prosaccade and antisaccade paradigms in persons with Alzheimer’s disease: a meta-analytic review. Neuropsychol Rev 28:16–31. https://doi.org/10.1007/s11065-017-9362-4

Article  PubMed  Google Scholar 

Katzman R, Zhang MY, Ouang Ya Q et al (1988) A Chinese version of the mini-mental state examination; impact of illiteracy in a Shanghai dementia survey. J Clin Epidemiol 41:971–978. https://doi.org/10.1016/0895-4356(88)90034-0

Article  PubMed  CAS  Google Scholar 

Kaufman LD, Pratt J, Levine B, Black SE (2012) Executive deficits detected in mild Alzheimer’s disease using the antisaccade task. Brain Behav 2:15–21. https://doi.org/10.1002/brb3.28

Article  PubMed  PubMed Central  Google Scholar 

Koçoğlu K, Hodgson TL, Eraslan Boz H, Akdal G (2021) Deficits in saccadic eye movements differ between subtypes of patients with mild cognitive impairment. J Clin Exp Neuropsychol 43:187–198. https://doi.org/10.1080/13803395.2021.1900077

Article  PubMed  Google Scholar 

Laurens B, Planche V, Cubizolle S et al (2019) A spatial decision eye-tracking task in patients with prodromal and mild Alzheimer’s disease. J Alzheimers Dis 71:613–621. https://doi.org/10.3233/jad-190549

Article  PubMed  CAS  Google Scholar 

Lin J, Xu T, Yang X et al (2024) A detection model of cognitive impairment via the integrated gait and eye movement analysis from a large Chinese community cohort. Alzheimers Dement 20:1089–1101. https://doi.org/10.1002/alz.13517

Article  PubMed  Google Scholar 

McKhann GM, Knopman DS, Chertkow H et al (2011) The diagnosis of dementia due to Alzheimer’s disease: recommendations from the National Institute on Aging-Alzheimer’s Association workgroups on diagnostic guidelines for Alzheimer’s disease. Alzheimers Dement 7:263–269. https://doi.org/10.1016/j.jalz.2011.03.005

Article  PubMed  Google Scholar 

Moser A, Kompf D, Olschinka J (1995) Eye movement dysfunction in dementia of the Alzheimer type. Dementia 6:264–268. https://doi.org/10.1159/000106957

Article  PubMed  CAS  Google Scholar 

Nasreddine ZS, Phillips NA, Bédirian V et al (2005) The Montreal Cognitive Assessment, MoCA: a brief screening tool for mild cognitive impairment. J Am Geriatr Soc 53:695–699. https://doi.org/10.1111/j.1532-5415.2005.53221.x

Article  PubMed  Google Scholar 

Noiret N, Carvalho N, Laurent E et al (2018) Saccadic eye movements and attentional control in Alzheimer’s disease. Arch Clin Neuropsychol 33:1–13. https://doi.org/10.1093/arclin/acx044

Article  PubMed  Google Scholar 

Opwonya J, Doan DNT, Kim SG et al (2022) Saccadic eye movement in mild cognitive impairment and Alzheimer’s disease: a systematic review and meta-analysis. Neuropsychol Rev 32:193–227. https://doi.org/10.1007/s11065-021-09495-3

Article  PubMed  Google Scholar 

Pavisic IM, Firth NC, Parsons S et al (2017) Eyetracking metrics in young onset Alzheimer’s disease: a window into cognitive visual functions. Front Neurol 8:377. https://doi.org/10.3389/fneur.2017.00377

Article  PubMed  PubMed Central  Google Scholar 

Peltsch A, Hemraj A, Garcia A, Munoz DP (2014) Saccade deficits in amnestic mild cognitive impairment resemble mild Alzheimer’s disease. Eur J Neurosci 39:2000–2013. https://doi.org/10.1111/ejn.12617

Article  PubMed  Google Scholar 

Pereira M, Camargo M, Bellan AFR et al (2020) Visual search efficiency in mild cognitive impairment and Alzheimer’s disease: an eye movement study. J Alzheimers Dis 75:261–275. https://doi.org/10.3233/jad-190690

Article  PubMed  Google Scholar 

Pierce JE, Clementz BA, McDowell JE (2019) Saccades: fundamentals and neural mechanisms. In: Klein C, Ettinger U (eds) Eye Movement Research: an introduction to its scientific foundations and applications. Springer International Publishing, Cham, pp 11–71

Chapter  Google Scholar 

Posner MI, Petersen SE (1990) The attention system of the human brain. Annu Rev Neurosci 13:25–42. https://doi.org/10.1146/annurev.ne.13.030190.000325

Article  PubMed  CAS  Google Scholar 

Qiu C, Kivipelto M, von Strauss E (2009) Epidemiology of Alzheimer’s disease: occurrence, determinants, and strategies toward intervention. Dialogues Clin Neurosci 11:111–128. https://doi.org/10.31887/DCNS.2009.11.2/cqiu

Article  PubMed  PubMed Central  Google Scholar 

Ren R, Qi J, Lin S et al (2022) The China Alzheimer Report 2022. Gen Psychiatr 35:e100751. https://doi.org/10.1136/gpsych-2022-100751

Article  PubMed  PubMed Central  Google Scholar 

Shafiq-Antonacci R, Maruff P, Masters C, Currie J (2003) Spectrum of saccade system function in Alzheimer disease. Arch Neurol 60:1272–1278. https://doi.org/10.1001/archneur.60.9.1272

Article  PubMed  Google Scholar 

Shakespeare TJ, Kaski D, Yong KX et al (2015) Abnormalities of fixation, saccade and pursuit in posterior cortical atrophy. Brain 138:1976–1991. https://doi.org/10.1093/brain/awv103

Article  PubMed  PubMed Central  Google Scholar 

Singh T, Perry CM, Fritz SL, Fridriksson J, Herter TM (2018) Eye movements interfere with limb motor control in stroke survivors. Neurorehabil Neural Repair 32:724–734. https://doi.org/10.1177/1545968318790016

Article  PubMed 

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