Targeting uric acid: a promising intervention against oxidative stress and neuroinflammation in neurodegenerative diseases

Burtscher J, Millet GP, Place N, Kayser B, Zanou N. The muscle-brain Axis and neurodegenerative diseases: the key role of Mitochondria in Exercise-Induced Neuroprotection. Int J Mol Sci. 2021;22(12):6479.

Abramov AY. Redox biology in neurodegenerative disorders. Free Radic Biol Med. 2022;188:24–5.

Article  CAS  PubMed  Google Scholar 

Kwon HS, Koh SH. Neuroinflammation in neurodegenerative disorders: the roles of microglia and astrocytes. Transl Neurodegener. 2020;9(1):42.

Article  PubMed  PubMed Central  Google Scholar 

Singh A, Kukreti R, Saso L, Kukreti S. Oxidative stress: a key modulator in neurodegenerative diseases. Molecules. 2019;24(8):1583.

Morén C, deSouza RM, Giraldo DM, Uff C. Antioxidant therapeutic strategies in neurodegenerative diseases. Int J Mol Sci. 2022;23(16):9328.

Tana C, Ticinesi A, Prati B, Nouvenne A, Meschi T. Uric acid and cognitive function in older individuals. Nutrients. 2018;10(8):975.

Leask MP, Crișan TO, Ji A, Matsuo H, Köttgen A, Merriman TR. The pathogenesis of gout: molecular insights from genetic, epigenomic and transcriptomic studies. Nat Rev Rheumatol. 2024;20(8):510-23.

Nardi V, Franchi F, Prasad M, et al. Uric acid expression in carotid atherosclerotic plaque and serum uric acid are Associated with cerebrovascular events. Hypertension. 2022;79(8):1814–23.

Article  CAS  PubMed  Google Scholar 

Wen S, Arakawa H, Tamai I. Uric acid in health and disease: from physiological functions to pathogenic mechanisms. Pharmacol Ther. 2024;256:108615.

Article  CAS  PubMed  Google Scholar 

Ames BN, Cathcart R, Schwiers E, Hochstein P. Uric acid provides an antioxidant defense in humans against oxidant- and radical-caused aging and cancer: a hypothesis. Proc Natl Acad Sci U S A. 1981;78(11):6858–62.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Furuhashi M. New insights into purine metabolism in metabolic diseases: role of xanthine oxidoreductase activity. Am J Physiol Endocrinol Metab. 2020;319(5):E827–34.

Article  CAS  PubMed  Google Scholar 

Hille R. Molybdenum-containing hydroxylases. Arch Biochem Biophys. 2005;433(1):107–16.

Article  CAS  PubMed  Google Scholar 

Wu XW, Muzny DM, Lee CC, Caskey CT. Two independent mutational events in the loss of urate oxidase during hominoid evolution. J Mol Evol. 1992;34(1):78–84.

Article  CAS  PubMed  Google Scholar 

Adomako EA, Moe OW. Uric acid transport, transporters, and their pharmacological targeting. Acta Physiol (Oxf). 2023;238(2):e13980.

Article  CAS  PubMed  Google Scholar 

Ermakov VS, Granados JC, Nigam SK. Remote effects of kidney drug transporter OAT1 on gut microbiome composition and urate homeostasis. JCI Insight. 2023;8(21):e172341.

Xu YX, Liu LD, Zhu JY, et al. Alistipes indistinctus-derived hippuric acid promotes intestinal urate excretion to alleviate hyperuricemia. Cell Host Microbe. 2024;32(3):366–e3819.

Article  CAS  PubMed  Google Scholar 

Mijailovic NR, Vesic K, Borovcanin MM. The influence of serum uric acid on the brain and cognitive dysfunction. Front Psychiatry. 2022;13:828476.

Article  PubMed  PubMed Central  Google Scholar 

Otani N, Hoshiyama E, Ouchi M, Takekawa H, Suzuki K. Uric acid and neurological disease: a narrative review. Front Neurol. 2023;14:1164756.

Article  PubMed  PubMed Central  Google Scholar 

Kuwabara M, Fukuuchi T, Aoki Y et al. Exploring the multifaceted Nexus of uric acid and health: a review of recent studies on Diverse diseases. Biomolecules. 2023;13(10):1519.

Nyhan WL. Disorders of purine and pyrimidine metabolism. Mol Genet Metab. 2005;86(1–2):25–33.

Article  CAS  PubMed  Google Scholar 

Dinour D, Gray NK, Campbell S, et al. Homozygous SLC2A9 mutations cause severe renal hypouricemia. J Am Soc Nephrol. 2010;21(1):64–72.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Stiburkova B, Pavelcova K, Pavlikova M, Ješina P, Pavelka K. The impact of dysfunctional variants of ABCG2 on hyperuricemia and gout in pediatric-onset patients. Arthritis Res Ther. 2019;21(1):77.

Article  PubMed  PubMed Central  Google Scholar 

González-Aramburu I, Sánchez-Juan P, Jesús S, et al. Genetic variability related to serum uric acid concentration and risk of Parkinson’s disease. Mov Disord. 2013;28(12):1737–40.

Article  PubMed  Google Scholar 

Kang TH, Friedmann T. Alzheimer’s disease shares gene expression aberrations with purinergic dysregulation of HPRT deficiency (Lesch-Nyhan disease). Neurosci Lett. 2015;590:35–9.

Article  CAS  PubMed  Google Scholar 

Matsuo H, Tomiyama H, Satake W, et al. ABCG2 variant has opposing effects on onset ages of Parkinson’s disease and gout. Ann Clin Transl Neurol. 2015;2(3):302–6.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Facheris MF, Hicks AA, Minelli C, et al. Variation in the uric acid transporter gene SLC2A9 and its association with AAO of Parkinson’s disease. J Mol Neurosci. 2011;43(3):246–50.

Article  CAS  PubMed  Google Scholar 

Major TJ, Topless RK, Dalbeth N, Merriman TR. Evaluation of the diet wide contribution to serum urate levels: meta-analysis of population based cohorts. BMJ. 2018;363:k3951.

Article  PubMed  PubMed Central  Google Scholar 

Gao X, Chen H, Choi HK, Curhan G, Schwarzschild MA, Ascherio A. Diet, urate, and Parkinson’s disease risk in men. Am J Epidemiol. 2008;167(7):831–8.

Article  PubMed  Google Scholar 

Veronese N, Nova A, Fazia T, et al. Contribution of Nutritional, Lifestyle, and metabolic risk factors to Parkinson’s Disease. Mov Disord. 2024;39(7):1203–12.

Article  CAS  PubMed  Google Scholar 

Pou MA, Orfila F, Pagonabarraga J, Ferrer-Moret S, Corominas H, Diaz-Torne C. Risk of Parkinson’s disease in a gout Mediterranean population: a case-control study. Joint Bone Spine. 2022;89(6):105402.

Article  PubMed  Google Scholar 

Kimura Y, Tsukui D, Kono H. Uric acid in inflammation and the pathogenesis of atherosclerosis. Int J Mol Sci. 2021. 22(22).

Waring WS, Convery A, Mishra V, Shenkin A, Webb DJ, Maxwell SR. Uric acid reduces exercise-induced oxidative stress in healthy adults. Clin Sci (Lond). 2003;105(4):425–30.

Article  CAS  PubMed  Google Scholar 

Santos CX, Anjos EI, Augusto O. Uric acid oxidation by peroxynitrite: multiple reactions, free radical formation, and amplification of lipid oxidation. Arch Biochem Biophys. 1999;372(2):285–94.

Article  CAS  PubMed  Google Scholar 

Braga TT, Foresto-Neto O, Camara N. The role of uric acid in inflammasome-mediated kidney injury. Curr Opin Nephrol Hypertens. 2020;29(4):423–31.

Article  CAS  PubMed  Google Scholar 

Copur S, Demiray A, Kanbay M. Uric acid in metabolic syndrome: does uric acid have a definitive role. Eur J Intern Med. 2022;103:4–12.

Article  CAS  PubMed  Google Scholar 

Pacher P, Beckman JS, Liaudet L. Nitric oxide and peroxynitrite in health and disease. Physiol Rev. 2007;87(1):315–424.

Article  CAS  PubMed  Google Scholar 

Hink HU, Santanam N, Dikalov S, et al. Peroxidase properties of extracellular superoxide dismutase: role of uric acid in modulating in vivo activity. Arterioscler Thromb Vasc Biol. 2002;22(9):1402–8.

Article  CAS  PubMed  Google Scholar 

Sevanian A, Davies KJ, Hochstein P. Serum urate as an antioxidant for ascorbic acid. Am J Clin Nutr. 1991;54(6 Suppl):S1129–34.

Article  Google Scholar 

Davies KJ, Sevanian A, Muakkassah-Kelly SF, Hochstein P. Uric acid-iron ion complexes. A new aspect of the antioxidant functions of uric acid. Biochem J. 1986;235(3):747–54.

留言 (0)

沒有登入
gif