O’Brien K, Breyne K, Ughetto S, Laurent LC, Breakefield XO. RNA delivery by extracellular vesicles in mammalian cells and its applications. Nat Rev Mol Cell Biol. 2020;21(10):585–606.

Article  PubMed  PubMed Central  Google Scholar 

Sadovska L, Zayakin P, Eglitis K, Endzelins E, Radovica-Spalvina I, Avotina E, et al. Comprehensive characterization of RNA cargo of extracellular vesicles in breast cancer patients undergoing neoadjuvant chemotherapy. Front Oncol. 2022;12:1005812.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Liu QW, He Y, Xu WW. Molecular functions and therapeutic applications of exosomal noncoding RNAs in cancer. Exp Mol Med. 2022;54(3):216–25.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Boguslawska J, Poplawski P, Alseekh S, Koblowska M, Iwanicka-Nowicka R, Rybicka B et al. MicroRNA-Mediated metabolic reprograming in Renal Cancer. Cancers (Basel). 2019;11(12).

Boguslawska J, Rodzik K, Poplawski P, Kedzierska H, Rybicka B, Sokol E, et al. TGF-beta1 targets a microRNA network that regulates cellular adhesion and migration in renal cancer. Cancer Lett. 2018;412:155–69.

Article  CAS  PubMed  Google Scholar 

Boguslawska J, Kryst P, Poletajew S, Piekielko-Witkowska A. TGF-beta and microRNA interplay in Genitourinary Cancers. Cells. 2019;8(12).

Mokarram P, Niknam M, Sadeghdoust M, Aligolighasemabadi F, Siri M, Dastghaib S, et al. PIWI interacting RNAs perspectives: a new avenues in future cancer investigations. Bioengineered. 2021;12(2):10401–19.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Su JF, Concilla A, Zhang DZ, Zhao F, Shen FF, Zhang H, et al. PIWI-interacting RNAs: Mitochondria-based biogenesis and functions in cancer. Genes Dis. 2021;8(5):603–22.

Article  CAS  PubMed  Google Scholar 

Pinzaru AM, Tavazoie SF. Transfer RNAs as dynamic and critical regulators of cancer progression. Nat Rev Cancer. 2023;23(11):746–61.

Article  CAS  PubMed  Google Scholar 

Huang SQ, Sun B, Xiong ZP, Shu Y, Zhou HH, Zhang W, et al. The dysregulation of tRNAs and tRNA derivatives in cancer. J Exp Clin Cancer Res. 2018;37(1):101.

Article  PubMed  PubMed Central  Google Scholar 

Padala SA, Barsouk A, Thandra KC, Saginala K, Mohammed A, Vakiti A, et al. Epidemiology of renal cell carcinoma. World J Oncol. 2020;11(3):79–87.

Article  PubMed  PubMed Central  Google Scholar 

Powles T, Staehler M, Ljungberg B, Bensalah K, Canfield SE, Dabestani S, et al. Updated EAU guidelines for Clear Cell Renal Cancer patients who fail VEGF targeted therapy. Eur Urol. 2016;69(1):4–6.

Article  PubMed  Google Scholar 

Li JH, Fan WS, Wang MM, Wang YH, Ren ZG. Effects of mesenchymal stem cells on solid tumor metastasis in experimental cancer models: a systematic review and meta-analysis. J Transl Med. 2018;16(1):113.

Article  PubMed  PubMed Central  Google Scholar 

Yang Y, Chen QH, Liu AR, Xu XP, Han JB, Qiu HB. Synergism of MSC-secreted HGF and VEGF in stabilising endothelial barrier function upon lipopolysaccharide stimulation via the Rac1 pathway. Stem Cell Res Ther. 2015;6:250.

Article  PubMed  PubMed Central  Google Scholar 

Dvorak HF. Tumors: wounds that do not heal. Similarities between tumor stroma generation and wound healing. N Engl J Med. 1986;315(26):1650–9.

Article  CAS  PubMed  Google Scholar 

Lazennec G, Lam PY. Recent discoveries concerning the tumor - mesenchymal stem cell interactions. Biochim Biophys Acta. 2016;1866(2):290–9.

PubMed  Google Scholar 

Galie M, Konstantinidou G, Peroni D, Scambi I, Marchini C, Lisi V, et al. Mesenchymal stem cells share molecular signature with mesenchymal tumor cells and favor early tumor growth in syngeneic mice. Oncogene. 2008;27(18):2542–51.

Article  CAS  PubMed  Google Scholar 

Bartosh TJ, Ullah M, Zeitouni S, Beaver J, Prockop DJ. Cancer cells enter dormancy after cannibalizing mesenchymal stem/stromal cells (MSCs). Proc Natl Acad Sci U S A. 2016;113(42):E6447–56.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Du T, Ju G, Wu S, Cheng Z, Cheng J, Zou X, et al. Microvesicles derived from human Wharton’s jelly mesenchymal stem cells promote human renal cancer cell growth and aggressiveness through induction of hepatocyte growth factor. PLoS ONE. 2014;9(5):e96836.

Article  PubMed  PubMed Central  Google Scholar 

Hsiao WC, Sung SY, Liao CH, Wu HC, Hsieh CL. Vitamin D3-inducible mesenchymal stem cell-based delivery of conditionally replicating adenoviruses effectively targets renal cell carcinoma and inhibits tumor growth. Mol Pharm. 2012;9(5):1396–408.

Article  CAS  PubMed  Google Scholar 

Poplawski P, Zarychta-Wisniewska W, Burdzinska A, Boguslawska J, Adamiok-Ostrowska A, Hanusek K, et al. Renal cancer secretome induces migration of mesenchymal stromal cells. Stem Cell Res Ther. 2023;14(1):200.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Poplawski P, Alseekh S, Jankowska U, Skupien-Rabian B, Iwanicka-Nowicka R, Kossowska H, et al. Coordinated reprogramming of renal cancer transcriptome, metabolome and secretome associates with immune tumor infiltration. Cancer Cell Int. 2023;23(1):2.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Robinson MD, Oshlack A. A scaling normalization method for differential expression analysis of RNA-seq data. Genome Biol. 2010;11(3):R25.

Article  PubMed  PubMed Central  Google Scholar 

Benjamini Y, Hochberg Y. Controlling the false Discovery Rate - a practical and powerful Approach to multiple testing. J R Stat Soc B. 1995;57(1):289–300.

Article  Google Scholar 

Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 2001;25(4):402–8.

Article  CAS  PubMed  Google Scholar 

Schmittgen TD, Livak KJ. Analyzing real-time PCR data by the comparative C(T) method. Nat Protoc. 2008;3(6):1101–8.

Article  CAS  PubMed  Google Scholar 

Piuco R, Galante PAF, piRNAdb. A piwi-interacting RNA database. bioRxiv. 2021:2021.09.21.461238.

Strober W. Trypan Blue Exclusion Test of cell viability. Curr Protoc Immunol. 2015;111:A3. B 1-A3 B.

Article  PubMed Central  Google Scholar 

Li JH, Liu S, Zhou H, Qu LH, Yang JH. starBase v2.0: decoding miRNA-ceRNA, miRNA-ncRNA and protein-RNA interaction networks from large-scale CLIP-Seq data. Nucleic Acids Res. 2014;42(Database issue):D92–7.

Article  CAS  PubMed  Google Scholar 

Chang L, Zhou G, Soufan O, Xia J. miRNet 2.0: network-based visual analytics for miRNA functional analysis and systems biology. Nucleic Acids Res. 2020;48(W1):W244–51.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ge SX, Jung D, Yao R. ShinyGO: a graphical gene-set enrichment tool for animals and plants. Bioinformatics. 2020;36(8):2628–9.

Article  CAS  PubMed  Google Scholar 

Yao D, Sun X, Zhou L, Amanullah M, Pan X, Liu Y, et al. OncotRF: an online resource for exploration of tRNA-derived fragments in human cancers. RNA Biol. 2020;17(8):1081–91.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhang Z, Ye Y, Gong J, Ruan H, Liu CJ, Xiang Y, et al. Global analysis of tRNA and translation factor expression reveals a dynamic landscape of translational regulation in human cancers. Commun Biol. 2018;1:234.

Article  PubMed  PubMed Central