Harnessing 3D models to uncover the mechanisms driving infectious and inflammatory disease in the intestine

Huycke TR, Hakkinen TJ, Miyazaki H, Srivastava V, Barruet E, McGinnis CS, et al. Patterning and folding of intestinal villi by active mesenchymal dewetting. Cell. 2024;187(12):3072–89.e20.

Article  PubMed  Google Scholar 

Hansen SL, Larsen HL, Pikkupeura LM, Maciag G, Guiu J, Muller I, et al. An organoid-based CRISPR-Cas9 screen for regulators of intestinal epithelial maturation and cell fate. Sci Adv. 2023;9(28):eadg4055.

Article  PubMed  PubMed Central  Google Scholar 

Guiu J, Jensen KB. From definitive endoderm to gut-a process of growth and maturation. Stem Cells Dev. 2015;24(17):1972–83.

Article  PubMed  Google Scholar 

Zwick RK, Kasparek P, Palikuqi B, Viragova S, Weichselbaum L, McGinnis CS, et al. Epithelial zonation along the mouse and human small intestine defines five discrete metabolic domains. Nat Cell Biol. 2024;26(2):250–62.

Article  PubMed  PubMed Central  Google Scholar 

Barker N, van Es JH, Kuipers J, Kujala P, van den Born M, Cozijnsen M, et al. Identification of stem cells in small intestine and colon by marker gene Lgr5. Nature. 2007;449(7165):1003–7.

Article  PubMed  Google Scholar 

Hageman JH, Heinz MC, Kretzschmar K, van der Vaart J, Clevers H, Snippert HJG. Intestinal regeneration: regulation by the microenvironment. Dev Cell. 2020;54(4):435–46.

Article  PubMed  Google Scholar 

Jarde T, Chan WH, Rossello FJ, Kaur Kahlon T, Theocharous M, Kurian Arackal T, et al. Mesenchymal niche-derived neuregulin-1 drives intestinal stem cell proliferation and regeneration of damaged epithelium. Cell Stem Cell. 2020;27(4):646-62 e7.

Article  PubMed  Google Scholar 

Yu YR, Rodriguez JR. Clinical presentation of Crohn’s, ulcerative colitis, and indeterminate colitis: symptoms, extraintestinal manifestations, and disease phenotypes. Semin Pediatr Surg. 2017;26(6):349–55.

Article  PubMed  Google Scholar 

Dhaliwal J, Walters TD, Mack DR, Huynh HQ, Jacobson K, Otley AR, et al. Phenotypic variation in paediatric inflammatory bowel disease by age: a multicentre prospective inception cohort study of the Canadian children IBD network. J Crohns Colitis. 2020;14(4):445–54.

Article  PubMed  Google Scholar 

Langerholc T, Maragkoudakis PA, Wollgast J, Gradisnik L, Cencic A. Novel and established intestinal cell line models - an indispensable tool in food science and nutrition. Trends Food Sci Technol. 2011;22:S11–20.

Article  PubMed  PubMed Central  Google Scholar 

Zhou A, Yuan Y, Yang M, Huang Y, Li X, Li S, et al. Crosstalk between the gut microbiota and epithelial cells under physiological and infectious conditions. Front Cell Infect Microbiol. 2022;12: 832672.

Article  PubMed  PubMed Central  Google Scholar 

Sato T, Stange DE, Ferrante M, Vries RG, Van Es JH, Van den Brink S, et al. Long-term expansion of epithelial organoids from human colon, adenoma, adenocarcinoma, and Barrett’s epithelium. Gastroenterology. 2011;141(5):1762–72.

Article  PubMed  Google Scholar 

Sato T, Vries RG, Snippert HJ, van de Wetering M, Barker N, Stange DE, et al. Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche. Nature. 2009;459(7244):262–5.

Article  PubMed  Google Scholar 

Serra D, Mayr U, Boni A, Lukonin I, Rempfler M, Challet Meylan L, et al. Self-organization and symmetry breaking in intestinal organoid development. Nature. 2019;569(7754):66–72.

Article  PubMed  PubMed Central  Google Scholar 

Kraiczy J, Nayak KM, Howell KJ, Ross A, Forbester J, Salvestrini C, et al. DNA methylation defines regional identity of human intestinal epithelial organoids and undergoes dynamic changes during development. Gut. 2019;68(1):49–61.

Article  PubMed  Google Scholar 

Fujii M, Matano M, Toshimitsu K, Takano A, Mikami Y, Nishikori S, et al. Human intestinal organoids maintain self-renewal capacity and cellular diversity in niche-inspired culture condition. Cell Stem Cell. 2018;23(6):787-93 e6.

Article  PubMed  Google Scholar 

Oost KC, Kahnwald M, Barbiero S, de Medeiros G, Suppinger S, Kalck V, et al. Dynamics and plasticity of stem cells in the regenerating human colonic epithelium. bioRxiv. 2023.12.18.572103.

Abud HE, Amarasinghe SL, Micati D, Jarde T. Stromal niche signals that orchestrate intestinal regeneration. Cell Mol Gastroenterol Hepatol. 2024;17(5):679–85.

Article  PubMed  PubMed Central  Google Scholar 

Nikolaev M, Mitrofanova O, Broguiere N, Geraldo S, Dutta D, Tabata Y, et al. Homeostatic mini-intestines through scaffold-guided organoid morphogenesis. Nature. 2020;585(7826):574–8.

Article  PubMed  Google Scholar 

Gjorevski N, Nikolaev M, Brown TE, Mitrofanova O, Brandenberg N, DelRio FW, et al. Tissue geometry drives deterministic organoid patterning. Science. 2022;375(6576):eaaw9021.

Article  PubMed  PubMed Central  Google Scholar 

Takashima S, Martin ML, Jansen SA, Fu Y, Bos J, Chandra D, et al. T cell-derived interferon-gamma programs stem cell death in immune-mediated intestinal damage. Sci Immunol. 2019;4(42):eaay8556.

Article  PubMed  PubMed Central  Google Scholar 

Dekkers JF, Alieva M, Cleven A, Keramati F, Wezenaar AKL, van Vliet EJ, et al. Uncovering the mode of action of engineered T cells in patient cancer organoids. Nat Biotechnol. 2023;41(1):60–9.

Article  PubMed  Google Scholar 

Farin HF, Van Es JH, Clevers H. Redundant sources of Wnt regulate intestinal stem cells and promote formation of Paneth cells. Gastroenterology. 2012;143(6):1518-29 e7.

Article  PubMed  Google Scholar 

Greicius G, Kabiri Z, Sigmundsson K, Liang C, Bunte R, Singh MK, et al. PDGFRalpha(+) pericryptal stromal cells are the critical source of Wnts and RSPO3 for murine intestinal stem cells in vivo. Proc Natl Acad Sci U S A. 2018;115(14):E3173–81.

Article  PubMed  PubMed Central  Google Scholar 

Kabiri Z, Greicius G, Madan B, Biechele S, Zhong Z, Zaribafzadeh H, et al. Stroma provides an intestinal stem cell niche in the absence of epithelial Wnts. Development. 2014;141(11):2206–15.

Article  PubMed  Google Scholar 

Staab JF, Lemme-Dumit JM, Latanich R, Pasetti MF, Zachos NC. Co-culture system of human enteroids/colonoids with innate immune cells. Curr Protoc Immunol. 2020;131(1): e113.

Article  PubMed  PubMed Central  Google Scholar 

Neal JT, Li X, Zhu J, Giangarra V, Grzeskowiak CL, Ju J, et al. Organoid modeling of the tumor immune microenvironment. Cell. 2018;175(7):1972-88 e16.

Article  PubMed  PubMed Central  Google Scholar 

Niec RE, Chu T, Schernthanner M, Gur-Cohen S, Hidalgo L, Pasolli HA, et al. Lymphatics act as a signaling hub to regulate intestinal stem cell activity. Cell Stem Cell. 2022;29(7):1067-82 e18.

Article  PubMed  PubMed Central  Google Scholar 

Goto N, Goto S, Imada S, Hosseini S, Deshpande V, Yilmaz OH. Lymphatics and fibroblasts support intestinal stem cells in homeostasis and injury. Cell Stem Cell. 2022;29(8):1246-61 e6.

Article  PubMed  PubMed Central  Google Scholar 

Kraiczy J, McCarthy N, Malagola E, Tie G, Madha S, Boffelli D, et al. Graded BMP signaling within intestinal crypt architecture directs self-organization of the Wnt-secreting stem cell niche. Cell Stem Cell. 2023;30(4):433-49 e8.

Article  PubMed  PubMed Central  Google Scholar 

Clevers H. The intestinal crypt, a prototype stem cell compartment. Cell. 2013;154(2):274–84.

Article  PubMed  Google Scholar 

Barker N, van Oudenaarden A, Clevers H. Identifying the stem cell of the intestinal crypt: strategies and pitfalls. Cell Stem Cell. 2012;11(4):452–60.

Article  PubMed  Google Scholar 

Bowcutt R, Forman R, Glymenaki M, Carding SR, Else KJ, Cruickshank SM. Heterogeneity across the murine small and large intestine. World J Gastroenterol. 2014;20(41):15216–32.

Article  PubMed  PubMed Central  Google Scholar 

Podolsky DK, Fournier DA, Lynch KE. Human colonic goblet cells. Demonstration of distinct subpopulations defined by mucin-specific monoclonal antibodies. J Clin Invest. 1986;77(4):1263–71.

留言 (0)

沒有登入
gif