Members of the TDM study group are: Arnim Geise, Department for Respiratory Medicine; Golo-Sung Haarmeyer, Department for Respiratory Medicine; Matthias Baumgärtel, Department for Respiratory Medicine; Jens Nentwich, Department of Cardiology, Intensive Care Medicine; Axel von Fragstein, Department of Anaesthesiology and Operative Intensive Medicine, Anke Jensen, Department of Anaesthesiology and Operative Intensive Medicine (all from Klinikum Nürnberg, Paracelsus Medical University, Nuremberg, Germany).