Singer M, Deutschman CS, Seymour CW, Shankar-Hari M, Annane D, Bauer M, Bellomo R, Bernard GR, Chiche JD, Coopersmith CM, Hotchkiss RS, Levy MM, Marshall JC, Martin GS, Opal SM, Rubenfeld GD, van der Poll T, Vincent JL, Angus DC. The third international consensus definitions for sepsis and septic shock (Sepsis-3). JAMA. 2016;315(8):801–10. https://doi.org/10.1001/jama.2016.0287.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Vincent JL, van der Poll T, Marshall JC. The end of “one size fits all” sepsis therapies: toward an individualized approach. Biomedicines. 2022;10(9):2260. https://doi.org/10.3390/biomedicines10092260.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Daniel M, Bedoui Y, Vagner D, Raffray L, Ah-Pine F, Doray B, Gasque P. Pathophysiology of Sepsis and genesis of septic shock: the critical role of mesenchymal stem cells (MSCs). Int J Mol Sci. 2022;23(16):9274. https://doi.org/10.3390/ijms23169274.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ranieri VM, Thompson BT, Barie PS, Dhainaut JF, Douglas IS, Finfer S, Gårdlund B, Marshall JC, Rhodes A, Artigas A, Payen D, Tenhunen J, Al-Khalidi HR, Thompson V, Janes J, Macias WL, Vangerow B, Williams MD, PROWESS-SHOCK Study Group. Drotrecogin alfa (activated) in adults with septic shock. N Engl J Med. 2012;366(22):2055–64. https://doi.org/10.1056/NEJMoa1202290.

Article  CAS  PubMed  Google Scholar 

Abraham E, Wunderink R, Silverman H, et al. Efficacy and safety of monoclonal antibody to human tumor necrosis factor alpha in patients with sepsis syndrome. A randomized, controlled, double-blind, multicenter clinical trial TNF-alpha Mab Sepsis Study Group. JAMA. 1995;273:934–41.

Article  CAS  PubMed  Google Scholar 

Opal SM, Fisher CJ Jr, Dhainaut JF, et al. Confirmatory interleukin-1 receptor antagonist trial in severe sepsis: a phase III, randomized, double-blind, placebo-controlled, multicenter trial. The Interleukin-1 Receptor Antagonist Sepsis Investigator Group. Crit Care Med. 1997;25:1115–24.

Article  CAS  PubMed  Google Scholar 

Cavaillon JM, Adrie C, Fitting C, Adib-Conquy M. Reprogramming of circulatory cells in sepsis and SIRS. J Endotoxin Res. 2005;11:311–20.

Article  CAS  PubMed  Google Scholar 

Ronco C, Brendolan A, Lonnemann G, Bellomo R, Piccinni P, Digito A, Dan M, Irone M, La Greca G, Inguaggiato P, Maggiore U, De Nitti C, Wratten ML, Ricci Z, Tetta C. A pilot study of coupled plasma filtration with adsorption in septic shock. Crit Care Med. 2002;30(6):1250–5. https://doi.org/10.1097/00003246-200206000-00015.

Article  PubMed  Google Scholar 

Mehta Y, Paul R, Ansari AS, Banerjee T, Gunaydin S, Nassiri AA, Pappalardo F, Premužić V, Sathe P, Singh V, Vela ER. Extracorporeal blood purification strategies in sepsis and septic shock: an insight into recent advancements. World J Crit Care Med. 2023;12(2):71–88. https://doi.org/10.5492/wjccm.v12.i2.71.

Article  PubMed  PubMed Central  Google Scholar 

Hellman T, Uusalo P, Järvisalo MJ. Renal replacement techniques in septic shock. Int J Mol Sci. 2021;22(19):10238. https://doi.org/10.3390/ijms221910238.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ronco C, Tetta C, Mariano F, Wratten ML, Bonello M, Bordoni V, et al. Interpreting the mechanisms of continuous renal replacement therapy in sepsis: the peak concentration hypothesis. Artif Organs. 2003;27(9):792–801.

Article  PubMed  Google Scholar 

Ronco C, Bellomo R. Acute renal failure and multiple organ dysfunction in the ICU: from renal replacement therapy (RRT) to multiple organ support therapy (MOST). Int J Artif Organs. 2002;25(8):733–47. https://doi.org/10.1177/039139880202500801.

Article  CAS  PubMed  Google Scholar 

Ricci Z, Romagnoli S, Ronco C, La Manna G. From continuous renal replacement therapies to multiple organ support therapy. Contrib Nephrol. 2018;194:155–69. https://doi.org/10.1159/000485634.

Article  PubMed  Google Scholar 

Ranieri VM, Brodie D, Vincent JL. Extracorporeal organ support: from technological tool to clinical strategy supporting severe organ failure. JAMA. 2017;318(12):1105–6. https://doi.org/10.1001/jama.2017.10108.

Article  PubMed  Google Scholar 

Husain-Syed F, Ricci Z, Brodie D, Vincent JL, Ranieri VM, Slutsky AS, Taccone FS, Gattinoni L, Ronco C. Extracorporeal organ support (ECOS) in critical illness and acute kidney injury: from native to artificial organ crosstalk. Intensive Care Med. 2018;44(9):1447–59. https://doi.org/10.1007/s00134-018-5329-z.

Article  PubMed  Google Scholar 

Ratanarat R, Brendolan A, Piccinni P, Dan M, Salvatori G, Ricci Z, Ronco C. Pulse high-volume haemofiltration for treatment of severe sepsis: effects on hemodynamics and survival. Crit Care. 2005;9(4):R294-302. https://doi.org/10.1186/cc3529.

Article  PubMed  PubMed Central  Google Scholar 

Tapia P, Chinchón E, Morales D, Stehberg J, Simon F. Effectiveness of short-term 6-hour high-volume hemofiltration during refractory severe septic shock. J Trauma Acute Care Surg. 2012;72(5):1228–37. https://doi.org/10.1097/TA.0b013e318248bc6c.

Article  PubMed  Google Scholar 

Palevsky PM, Zhang JH, O’Connor TZ, Chertow GM, Crowley ST, Choudhury D, et al. Intensity of renal support in critically ill patients with acute kidney injury. N Engl Med. 2008;359(1):7–20.

Article  CAS  Google Scholar 

Bellomo R, Cass A, Cole L, Finfer S, Gallagher M, Lo S, et al. Intensity of conitnuous renal replacement therapy in critically ill patients. N Engl Med. 2009;361:1627–38.

Article  Google Scholar 

Joannes-Boyau O, Honorè PM, Perez P, Bagshaw SM, Grand H, Canivet JL, et al. High-volume versus standard-volume haemofiltration for septic shock patients with acute kidney injury (IVOIRE study): a multicentre randomized controlled trial. Intensive Care Med. 2013;39:1535–46.

Article  PubMed  Google Scholar 

Lehner GF, Wiedermann CJ, Joannidis M. High-volume hemofiltration in critically ill patients: a systematic review and meta-analysis. Minerva Anestesiol. 2014;80(5):595–609.

CAS  PubMed  Google Scholar 

Nguyen TC, Han YY, Kiss JE, Hall MW, Hassett AC, Jaffe R, Orr RA, Janosky J, Carcillo JA. Intensive plasma exchange increases a disintegrin and metalloprotease with thrombospondin motifs-13 activity and reverses organ dysfunction in children with thrombocytopenia-associated multiple organ failure. Crit Care Med. 2008;36(10):2878–87. https://doi.org/10.1097/ccm.0b013e318186aa49.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Long EJ, Taylor A, Delzoppo C, Shann F, Pearson G, Buckley D, Butt W. A randomised controlled trial of plasma filtration in severe paediatric sepsis. Crit Care Resusc. 2013 Sep;15(3):198-204. Erratum in: Crit Care Resusc. 2016 Dec;18(4):289. PMID: 23944206

Stahl K, Schmidt JJ, Seeliger B, Schmidt BMW, Welte T, Haller H, Hoeper MM, Budde U, Bode C, David S. Effect of therapeutic plasma exchange on endothelial activation and coagulation-related parameters in septic shock. Crit Care. 2020;24(1):71. https://doi.org/10.1186/s13054-020-2799-5.

Article  PubMed  PubMed Central  Google Scholar 

David S, Bode C, Putensen C, Welte T, Stahl K, EXCHANGE study group. Adjuvant therapeutic plasma exchange in septic shock. Intensive Care Med. 2021;47(3):352–4. https://doi.org/10.1007/s00134-020-06339-1.

Article  PubMed  PubMed Central  Google Scholar 

Connelly-Smith L, Alquist CR, Aqui NA, Hofmann JC, Klingel R, Onwuemene OA, Patriquin CJ, Pham HP, Sanchez AP, Schneiderman J, Witt V, Zantek ND, Dunbar NM. Guidelines on the use of therapeutic apheresis in clinical practice—evidence-based approach from the writing Committee of the American Society for Apheresis: the ninth special issue. Intensive Care Med. 2023;38(2):77–278. https://doi.org/10.1002/jca.22043.

Article  Google Scholar 

Livigni S, Bertolini G, Rossi C, Ferrari F, Giardino M, Pozzato M, Remuzzi G. GiViTI: Gruppo Italiano per la Valutazione degli interventi in terapia intensiva (Italian Group for the Evaluation of Interventions in Intensive Care Medicine) is an independent collaboration network of Italian intensive care units. Efficacy of coupled plasma filtration adsorption (CPFA) in patients with septic shock: a multicenter randomised controlled clinical trial. BMJ Open. 2014;4(1):e003536. https://doi.org/10.1136/bmjopen-2013-003536.

Article  PubMed  PubMed Central  Google Scholar 

Garbero E, Livigni S, Ferrari F, Finazzi S, Langer M, Malacarne P, Meca MCC, Mosca S, Olivieri C, Pozzato M, Rossi C, Tavola M, Terzitta M, Viaggi B, Bertolini G. GiViTI. High dose coupled plasma filtration and adsorption in septic shock patients Results of the COMPACT-2 a multicentre, adaptive, randomised clinical trial. Intensive Care Med. 2021;47(11):1303–11. https://doi.org/10.1007/s00134-021-06501-3.

Article  CAS  PubMed  Google Scholar 

Mehta Y, Mehta C, Kumar A,