The ability of clostridium novyi-NT spores to induce apoptosis via the mitochondrial pathway in mice with HPV-positive cervical cancer tumors derived from the TC-1 cell line

Singh D, Vignat J, Lorenzoni V, Eslahi M, Ginsburg O, Lauby-Secretan B, et al. Global estimates of incidence and mortality of cervical cancer in 2020: a baseline analysis of the WHO Global Cervical Cancer Elimination Initiative. Lancet Global Health. 2023;11(2):e197–206.

Article  CAS  PubMed  Google Scholar 

Haręża DA, Wilczyński JR, Paradowska E. Human papillomaviruses as infectious agents in gynecological cancers. Oncogenic properties of viral proteins. Int J Mol Sci. 2022;23(3):1818.

Article  PubMed  PubMed Central  Google Scholar 

Hull R, Mbele M, Makhafola T, Hicks C, Wang SM, Reis RM, et al. Cervical cancer in low and middle–income countries. Oncol Lett. 2020;20(3):2058–74.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Datta A, West C, O’Connor JP, Choudhury A, Hoskin P. Impact of hypoxia on cervical cancer outcomes. Int J Gynecologic Cancer. 2021;31(11).

Cohen AC, Roane BM, Leath CA. Novel therapeutics for recurrent cervical cancer: moving towards personalized therapy. Drugs. 2020;80:217–27.

Article  PubMed  PubMed Central  Google Scholar 

Narva SI, Seppänen MP, Raiko JR, Forsback SJ, Orte KJ, Virtanen JM, et al. Imaging of tumor hypoxia with 18F-EF5 PET/MRI in cervical cancer. Clin Nucl Med. 2021;46(12):952–7.

Article  PubMed  Google Scholar 

Bossler F, Kuhn BJ, Günther T, Kraemer SJ, Khalkar P, Adrian S, et al. Repression of human papillomavirus oncogene expression under hypoxia is mediated by PI3K/mTORC2/AKT signaling. MBio. 2019;10(1):02323–18. https://doi.org/10.1128/mbio.

Article  Google Scholar 

Hoppe-Seyler K, Mändl J, Adrian S, Kuhn BJ, Hoppe-Seyler F. Virus/host cell crosstalk in hypoxic HPV-positive cancer cells. Viruses. 2017;9(7):174.

Article  PubMed  PubMed Central  Google Scholar 

Hoppe-Seyler K, Bossler F, Lohrey C, Bulkescher J, Rösl F, Jansen L, et al. Induction of dormancy in hypoxic human papillomavirus-positive cancer cells. Proc Natl Acad Sci. 2017;114(6):E990–8.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bossler F, Kuhn B, Günther T, Kraemer S, Khalkar P, Adrian S, et al. Repression of human papillomavirus oncogene expression under hypoxia is mediated by PI3K/mTORC2/AKT signaling. mBio. 2019;10:e02323–18.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kozal K, Krześlak A. The role of hypoxia-inducible factor isoforms in breast cancer and perspectives on their inhibition in therapy. Cancers. 2022;14(18):4518.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hoption Cann S, Van Netten J, Van Netten C. Dr William Coley and tumour regression: a place in history or in the future. Postgrad Med J. 2003;79(938):672–80.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Sharafabad BE, Abdoli A, Abdolmohammadi Khiav L, Meskini M, Jamur P, Dilmaghani A. Therapeutic potential of Clostridium novyi-NT in Cancer: current knowledge and future perspectives. Curr Cancer Drug Targets. 2023;23(9):682–96.

Article  CAS  PubMed  Google Scholar 

Dang LH, Bettegowda C, Huso DL, Kinzler KW, Vogelstein B. Combination bacteriolytic therapy for the treatment of experimental tumors. Proc Natl Acad Sci. 2001;98(26):15155–60.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Krick EL, Sorenmo KU, Rankin SC, Cheong I, Kobrin B, Thornton K, et al. Evaluation of Clostridium novyi–NT spores in dogs with naturally occurring tumors. Am J Vet Res. 2012;73(1):112–8.

Article  PubMed  PubMed Central  Google Scholar 

Roberts NJ, Zhang L, Janku F, Collins A, Bai R-Y, Staedtke V, et al. Intratumoral injection of Clostridium novyi-NT spores induces antitumor responses. Sci Transl Med. 2014;6(249):ra249111–249111.

Article  Google Scholar 

DeClue AE, Axiak-Bechtel SM, Zhang Y, Saha S, Zhang L, Tung D, et al. Immune response to C. novyi-NT immunotherapy. Vet Res. 2018;49:1–11.

Article  Google Scholar 

Janku F, Zhang HH, Pezeshki A, Goel S, Murthy R, Wang-Gillam A, et al. Intratumoral injection of Clostridium novyi-NT spores in patients with treatment-refractory advanced solid tumors. Clin Cancer Res. 2021;27(1):96–106.

Article  CAS  PubMed  Google Scholar 

Feng X, He P, Zeng C, Li Y-H, Das SK, Li B, et al. Novel insights into the role of Clostridium novyi–NT related combination bacteriolytic therapy in solid tumors. Oncol Lett. 2021;21(2):1.

CAS  Google Scholar 

Staedtke V, Roberts NJ, Bai R-Y, Zhou S. Clostridium novyi-NT in cancer therapy. Genes Dis. 2016;3(2):144–52.

Article  PubMed  PubMed Central  Google Scholar 

Jafari FA, Abdoli A, Pilehchian R, Soleimani N, Hosseini SM. The oncolytic activity of Clostridium novyi nontoxic spores in breast cancer. BioImpacts: BI. 2022;12(5):405.

Google Scholar 

Ebadi Sharafabad B, Abdoli A, Panahi M, Abdolmohammadi Khiav L, Jamur P, Abedi Jafari F, et al. Anti-tumor effects of Cisplatin Synergist in Combined Treatment with Clostridium novyi-NT spores against hypoxic microenvironments in a mouse model of Cervical Cancer caused by TC-1 cell line. Adv Pharm Bull. 2023;13(4):817–26.

Article  PubMed  PubMed Central  Google Scholar 

Zhang A, Wu Y, Lai HW, Yew D. Apoptosis–a brief review. Neuroembryology Aging. 2005;3(1):47–59.

Article  CAS  Google Scholar 

Gogvadze V, Orrenius S, Zhivotovsky B. Multiple pathways of cytochrome c release from mitochondria in apoptosis. Biochim et Biophys Acta (BBA)-Bioenergetics. 2006;1757(5–6):639–47.

Article  CAS  Google Scholar 

Hajizadeh F, Okoye I, Esmaily M, Chaleshtari MG, Masjedi A, Azizi G, et al. Hypoxia inducible factors in the tumor microenvironment as therapeutic targets of cancer stem cells. Life Sci. 2019;237:116952.

Article  CAS  PubMed  Google Scholar 

Huang R, Zhou P-K. HIF-1 signaling: a key orchestrator of cancer radioresistance. Radiation Med Prot. 2020;1(1):7–14.

Article  Google Scholar 

Zhang S, Xu H, Zhang L, Qiao Y. Cervical cancer: Epidemiology, risk factors and screening. Chin J Cancer Res. 2020;32(6):720.

Article  PubMed  PubMed Central  Google Scholar 

Buskwofie A, David-West G, Clare CA. A review of cervical cancer: incidence and disparities. J Natl Med Assoc. 2020;112(2):229–32.

PubMed  Google Scholar 

Adiga D, Eswaran S, Pandey D, Sharan K, Kabekkodu SP. Molecular landscape of recurrent cervical cancer. Crit Rev Oncol/Hematol. 2021;157:103178.

Article  PubMed  Google Scholar 

Li Y, Gao X, Huang Y, Zhu X, Chen Y, Xue L, et al. Tumor microenvironment promotes lymphatic metastasis of cervical cancer: its mechanisms and clinical implications. Front Oncol. 2023;13:1114042.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Pietrobon V, Marincola FM. Hypoxia and the phenomenon of immune exclusion. J Translational Med. 2021;19(1):1–26.

Article  Google Scholar 

Abd GM, Laird MC, Ku JC, Li Y. Hypoxia-induced cancer cell reprogramming: a review on how cancer stem cells arise. Front Oncol. 2023;13:1227884.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Huang L, Zhao S, Wu J, Yu L, Singh N, Yang K, et al. Photodynamic therapy for hypoxic tumors: advances and perspectives. Coord Chem Rev. 2021;438:213888.

Article  CAS  Google Scholar 

Shen Z, Ma Q, Zhou X, Zhang G, Hao G, Sun Y, et al. Strategies to improve photodynamic therapy efficacy by relieving the tumor hypoxia environment. NPG Asia Mater. 2021;13(1):39.

Article  CAS 

留言 (0)

沒有登入
gif