Perivascular adipose tissue: a central player in the triad of diabetes, obesity, and cardiovascular health

Szasz T, Webb RC. Perivascular adipose tissue: more than just structural support. Clin Sci (Lond). 2012;122:1–12.

Article  CAS  PubMed  Google Scholar 

Qi X-Y, Qu S-L, Xiong W-H, Rom O, Chang L, Jiang Z-S. Perivascular adipose tissue (PVAT) in atherosclerosis: a double-edged sword. Cardiovasc Diabetol. 2018;17:134.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Adachi Y, Ueda K, Nomura S, et al. Beiging of perivascular adipose tissue regulates its inflammation and vascular remodeling. Nat Commun. 2022;13:5117.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wang Z, Lu H, Garcia-Barrio M, Guo Y, Zhang J, Chen YE, Chang L. RNA sequencing reveals perivascular adipose tissue plasticity in response to angiotensin II. Pharmacol Res. 2022;178:106183.

Article  CAS  PubMed  Google Scholar 

Mu W, Qian S, Song Y, et al. BMP4-mediated browning of perivascular adipose tissue governs an anti-inflammatory program and prevents atherosclerosis. Redox Biol. 2021;43:101979.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hu H, Garcia-Barrio M, Jiang ZS, Chen YE, Chang L. Roles of Perivascular Adipose tissue in hypertension and atherosclerosis. Antioxid Redox Signal. 2021;34:736–49.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Gálvez-Prieto B, Somoza B, Gil-Ortega M, et al. Anticontractile Effect of Perivascular Adipose Tissue and leptin are reduced in hypertension. Front Pharmacol. 2012. https://doi.org/10.3389/fphar.2012.00103.

Article  PubMed  PubMed Central  Google Scholar 

Azul L, Leandro A, Boroumand P, Klip A, Seiça R, Sena CM. Increased inflammation, oxidative stress and a reduction in antioxidant defense enzymes in perivascular adipose tissue contribute to vascular dysfunction in type 2 diabetes. Free Radic Biol Med. 2020;146:264–74.

Article  CAS  PubMed  Google Scholar 

Meijer RI, Serne EH, Smulders YM, Van Hinsbergh VWM, Yudkin JS, Eringa EC. Perivascular adipose tissue and its role in type 2 diabetes and cardiovascular disease. Curr Diab Rep. 2011;11:211–7.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Antoniades C, Tousoulis D, Vavlukis M, et al. Perivascular adipose tissue as a source of therapeutic targets and clinical biomarkers. Eur Heart J. 2023;44:3827–44.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Antonopoulos AS, Sanna F, Sabharwal N, et al. Detecting human coronary inflammation by imaging perivascular fat. Sci Transl Med. 2017. https://doi.org/10.1126/scitranslmed.aal2658.

Article  PubMed  Google Scholar 

Stanek E, Pacia MZ, Kaczor A, Czamara K. The distinct phenotype of primary adipocytes and adipocytes derived from stem cells of white adipose tissue as assessed by Raman and fluorescence imaging. Cell Mol Life Sci. 2022;79:383.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Maniyadath B, Zhang Q, Gupta RK, Mandrup S. Adipose tissue at single-cell resolution. Cell Metab. 2023;35:386–413.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Saxton SN, Clark BJ, Withers SB, Eringa EC, Heagerty AM. Mechanistic links between obesity, diabetes, and blood pressure: role of Perivascular Adipose tissue. Physiol Rev. 2019;99:1701–63.

Article  CAS  PubMed  Google Scholar 

Jin Y, Liu S, Guzmán KE, et al. PVAT-conditioned media from Dahl S rats on high fat diet promotes inflammatory cytokine secretion by activated T cells prior to the development of hypertension. PLoS ONE. 2024;19:e0302503.

Article  PubMed  PubMed Central  Google Scholar 

Tai G-J, Ma Y-J, Feng J-L, et al. NLRP3 inflammasome-mediated premature immunosenescence drives diabetic vascular aging dependent on the induction of perivascular adipose tissue dysfunction. Cardiovasc Res. 2024. https://doi.org/10.1093/cvr/cvae079.

Article  PubMed  Google Scholar 

Hillock-Watling C, Gotlieb AI. The pathobiology of perivascular adipose tissue (PVAT), the fourth layer of the blood vessel wall. Cardiovasc Pathol. 2022;61:107459.

Article  CAS  PubMed  Google Scholar 

Corselli M, Crisan M, Murray IR, West CC, Scholes J, Codrea F, Khan N, Péault B. Identification of perivascular mesenchymal stromal/stem cells by flow cytometry. Cytometry A. 2013;83:714–20.

Article  PubMed  Google Scholar 

Police SB, Thatcher SE, Charnigo R, Daugherty A, Cassis LA. Obesity promotes inflammation in periaortic adipose tissue and angiotensin II-induced abdominal aortic aneurysm formation. Arterioscler Thromb Vasc Biol. 2009;29:1458–64.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Padilla J, Jenkins NT, Vieira-Potter VJ, Laughlin MH. Divergent phenotype of rat thoracic and abdominal perivascular adipose tissues. Am J Physiology-Regulatory Integr Comp Physiol. 2013;304:R543–52.

Article  CAS  Google Scholar 

Kwok KHM, Lam KSL, Xu A. Heterogeneity of white adipose tissue: molecular basis and clinical implications. Exp Mol Med. 2016;48:e215–215.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Waldén TB, Hansen IR, Timmons JA, Cannon B, Nedergaard J. Recruited vs. nonrecruited molecular signatures of brown, brite, and white adipose tissues. Am J Physiology-Endocrinology Metabolism. 2012;302:E19–31.

Article  Google Scholar 

Gálvez-Prieto B, Bolbrinker J, Stucchi P, et al. Comparative expression analysis of the renin-angiotensin system components between white and brown perivascular adipose tissue. J Endocrinol. 2008;197:55–64.

Article  PubMed  Google Scholar 

Chang L, Villacorta L, Li R, Hamblin M, Xu W, Dou C, Zhang J, Wu J, Zeng R, Chen YE. Loss of perivascular adipose tissue on peroxisome proliferator-activated receptor-γ deletion in smooth muscle cells impairs intravascular thermoregulation and enhances atherosclerosis. Circulation. 2012;126:1067–78.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Henrichot E, Juge-Aubry CE, Pernin A, Pache JC, Velebit V, Dayer JM, Meda P, Chizzolini C, Meier CA. Production of chemokines by perivascular adipose tissue: a role in the pathogenesis of atherosclerosis? Arterioscler Thromb Vasc Biol. 2005;25:2594–9.

Article  CAS  PubMed  Google Scholar 

Fitzgibbons TP, Kogan S, Aouadi M, Hendricks GM, Straubhaar J, Czech MP. Similarity of mouse perivascular and brown adipose tissues and their resistance to diet-induced inflammation. Am J Physiol Heart Circ Physiol. 2011;301:H1425–37.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Nedergaard J, Bengtsson T, Cannon B. Unexpected evidence for active brown adipose tissue in adult humans. Am J Physiology-Endocrinology Metabolism. 2007;293:E444–52.

Article  CAS  Google Scholar 

Efremova A, Senzacqua M, Venema W, Isakov E, Di Vincenzo A, Zingaretti MC, Protasoni M, Thomski M, Giordano A, Cinti S. A large proportion of mediastinal and perirenal visceral fat of siberian adult people is formed by UCP1 immunoreactive multilocular and paucilocular adipocytes. J Physiol Biochem. 2020;76:185–92.

Article  CAS  PubMed  Google Scholar 

Iacobellis G. Epicardial adipose tissue in contemporary cardiology. Nat Rev Cardiol. 2022;19:593–606.

Article  CAS  PubMed  PubMed Central  Google Scholar 

留言 (0)

沒有登入
gif