Huo JL, Feng Q, Pan S, Fu WJ, Liu Z, Liu Z. Diabetic cardiomyopathy: early diagnostic biomarkers, pathogenetic mechanisms, and therapeutic interventions. Cell Death Discov. 2023;9(1):256.
Article CAS PubMed PubMed Central Google Scholar
Grubic Rotkvic P, Planinic Z, Liberati Prso AM, Sikic J, Galic E, Rotkvic L. The Mystery of Diabetic Cardiomyopathy: from early concepts and underlying mechanisms to novel therapeutic possibilities. Int J Mol Sci 2021;22(11).
Yin L, Sun Z, Ren Q, Su X, Zhang D. Long non-coding RNA BANCR is overexpressed in patients with diabetic retinopathy and promotes apoptosis of retinal pigment epithelial cells. Med Sci Monit. 2019;25:2845–51.
Article CAS PubMed PubMed Central Google Scholar
Duncan JG, Fong JL, Medeiros DM, Finck BN, Kelly DP. Insulin-resistant heart exhibits a mitochondrial biogenic response driven by the peroxisome proliferator-activated receptor-alpha/PGC-1alpha gene regulatory pathway. Circulation. 2007;115(7):909–17.
Article CAS PubMed PubMed Central Google Scholar
Flarsheim CE, Grupp IL, Matlib MA. Mitochondrial dysfunction accompanies diastolic dysfunction in diabetic rat heart. Am J Physiol. 1996;271(1 Pt 2):H192–202.
Zhang GQ, Wang SQ, Chen Y, Fu LY, Xu YN, Li L, Tao L, Shen XC. MicroRNAs regulating mitochondrial function in cardiac diseases. Front Pharmacol. 2021;12:663322.
Article CAS PubMed PubMed Central Google Scholar
Hong H, Tao T, Chen S, Liang C, Qiu Y, Zhou Y, Zhang R. MicroRNA-143 promotes cardiac ischemia-mediated mitochondrial impairment by the inhibition of protein kinase Cepsilon. Basic Res Cardiol. 2017;112(6):60.
Zhu H, Leung SW. MicroRNA biomarkers of type 2 diabetes: evidence synthesis from meta-analyses and pathway modelling. Diabetologia. 2023;66(2):288–99.
Article CAS PubMed Google Scholar
Gambardella J, Fiordelisi A, Spigno L, Boldrini L, Lungonelli G, Di Vaia E, Santulli G, Sorriento D, Cerasuolo FA, Trimarco V et al. Effects of chronic supplementation of L-Arginine on physical fitness in water polo players. Oxid Med Cell Longev. 2021;2021:6684568.
Article PubMed PubMed Central Google Scholar
Gambardella J, Khondkar W, Morelli MB, Wang X, Santulli G, Trimarco V. Arginine and endothelial function. Biomedicines. 2020;8(8).
Hristina K, Langerholc T, Trapecar M. Novel metabolic roles of L-Arginine in body energy metabolism and possible clinical applications. J Nutr Health Aging. 2014;18(2):213–8.
Article CAS PubMed Google Scholar
Matsuoka H, Nakata M, Kohno K, Koga Y, Nomura G, Toshima H, Imaizumi T. Chronic L-Arginine administration attenuates cardiac hypertrophy in spontaneously hypertensive rats. Hypertension. 1996;27(1):14–8.
Article CAS PubMed Google Scholar
Alex L, Russo I, Holoborodko V, Frangogiannis NG. Characterization of a mouse model of obesity-related fibrotic cardiomyopathy that recapitulates features of human heart failure with preserved ejection fraction. Am J Physiol Heart Circ Physiol. 2018;315(4):H934–49.
Article CAS PubMed PubMed Central Google Scholar
Myers J, Prakash M, Froelicher V, Do D, Partington S, Atwood JE. Exercise capacity and mortality among men referred for exercise testing. N Engl J Med. 2002;346(11):793–801.
Mancuso M, Angelini C, Bertini E, Carelli V, Comi GP, Minetti C, Moggio M, Mongini T, Servidei S, Tonin P, et al. Fatigue and exercise intolerance in mitochondrial diseases. Literature revision and experience of the Italian Network of mitochondrial diseases. Neuromuscul Disord. 2012;22(Suppl):S226–229.
Article PubMed PubMed Central Google Scholar
McCandless MG, Altara R, Booz GW, Kurdi M. What role do mitochondria have in diastolic dysfunction? Implications for diabetic cardiomyopathy and heart failure with preserved ejection function. J Cardiovasc Pharmacol. 2022;79(4):399–406.
Article CAS PubMed Google Scholar
Chen X, Luo X, Chen D, Yu B, He J, Huang Z. Arginine promotes porcine type I muscle fibres formation through improvement of mitochondrial biogenesis. Br J Nutr. 2020;123(5):499–507.
Article CAS PubMed Google Scholar
Zhang H, Zheng P, Chen D, Yu B, He J, Mao X, Yu J, Luo Y, Luo J, Huang Z et al. Dietary arginine supplementation improves intestinal mitochondrial functions in low-birth-weight piglets but not in normal-birth-weight piglets. Antioxid (Basel). 2021;10(12).
Halling JF, Pilegaard H. PGC-1alpha-mediated regulation of mitochondrial function and physiological implications. Appl Physiol Nutr Metab. 2020;45(9):927–36.
Article CAS PubMed Google Scholar
Jager S, Handschin C, St-Pierre J, Spiegelman BM. AMP-activated protein kinase (AMPK) action in skeletal muscle via direct phosphorylation of PGC-1alpha. Proc Natl Acad Sci U S A. 2007;104(29):12017–22.
Article PubMed PubMed Central Google Scholar
Rohas LM, St-Pierre J, Uldry M, Jager S, Handschin C, Spiegelman BM. A fundamental system of cellular energy homeostasis regulated by PGC-1alpha. Proc Natl Acad Sci U S A. 2007;104(19):7933–8.
Article CAS PubMed PubMed Central Google Scholar
Chidnok W, Fulford J, Bailey SJ, Dimenna FJ, Skiba PF, Vanhatalo A, Jones AM. Muscle metabolic determinants of exercise tolerance following exhaustion: relationship to the critical power. J Appl Physiol (1985). 2013;115(2):243–50.
Rowe GC, Jiang A, Arany Z. PGC-1 coactivators in cardiac development and disease. Circ Res. 2010;107(7):825–38.
Article CAS PubMed PubMed Central Google Scholar
Xihua L, Shengjie T, Weiwei G, Matro E, Tingting T, Lin L, Fang W, Jiaqiang Z, Fenping Z, Hong L. Circulating miR-143-3p inhibition protects against insulin resistance in metabolic syndrome via targeting of the insulin-like growth factor 2 receptor. Transl Res. 2019;205:33–43.
Muralimanoharan S, Maloyan A, Myatt L. Mitochondrial function and glucose metabolism in the placenta with gestational diabetes mellitus: role of miR-143. Clin Sci (Lond). 2016;130(11):931–41.
Article CAS PubMed Google Scholar
Lu CH, Chen DX, Dong K, Wu YJ, Na N, Wen H, Hu YS, Liang YY, Wu SY, Lin BY, et al. Inhibition of miR-143-3p alleviates myocardial ischemia reperfusion injury via limiting mitochondria-mediated apoptosis. Biol Chem. 2023;404(6):619–31.
Article CAS PubMed Google Scholar
Zurkan D, Edelmann F. Diagnosis of heart failure with preserved ejection fraction. Dtsch Med Wochenschr. 2024;149(4):151–6.
Jankauskas SS, Kansakar U, Varzideh F, Wilson S, Mone P, Lombardi A, Gambardella J, Santulli G. Heart failure in diabetes. Metabolism. 2021;125:154910.
Article CAS PubMed PubMed Central Google Scholar
Jankauskas SS, Mone P, Avvisato R, Varzideh F, De Gennaro S, Salemme L, Macina G, Kansakar U, Cioppa A, Frullone S, et al. miR-181c targets Parkin and SMAD7 in human cardiac fibroblasts: validation of differential microRNA expression in patients with diabetes and heart failure with preserved ejection fraction. Mech Ageing Dev. 2023;212:111818.
Article CAS PubMed PubMed Central Google Scholar
Mone P, Lombardi A, Kansakar U, Varzideh F, Jankauskas SS, Pansini A, Marzocco S, De Gennaro S, Famiglietti M, Macina G, et al. Empagliflozin improves the MicroRNA signature of endothelial dysfunction in patients with heart failure with preserved ejection fraction and diabetes. J Pharmacol Exp Ther. 2023;384(1):116–22.
Article CAS PubMed PubMed Central Google Scholar
Sacre JW, Jellis CL, Haluska BA, Jenkins C, Coombes JS, Marwick TH, Keske MA. Association of exercise intolerance in type 2 diabetes with skeletal muscle blood flow reserve. JACC Cardiovasc Imaging. 2015;8(8):913–21.
Nesti L, Pugliese NR, Sciuto P, Natali A. Type 2 diabetes and reduced exercise tolerance: a review of the literature through an integrated physiology approach. Cardiovasc Diabetol. 2020;19(1):134.
留言 (0)