Boers E, et al. Global Burden of Chronic Obstructive Pulmonary Disease Through 2050. JAMA Netw Open. 2023;6(12):e2346598.

Article  PubMed  PubMed Central  Google Scholar 

Lin S, et al. PM(2.5) and its components and respiratory disease healthcare encounters - unanticipated increased exposure-response relationships in recent years after environmental policies. Environ Pollut. 2024;360:124585.

Article  CAS  PubMed  Google Scholar 

Ono SJ, et al. Chemokines: roles in leukocyte development, trafficking, and effector function. J Allergy Clin Immunol. 2003;111(6):1185–99 quiz 1200.

Article  CAS  PubMed  Google Scholar 

Ranasinghe R, Eri R. Modulation of the CCR6-CCL20 axis: a potential therapeutic target in inflammation and cancer. Medicina (Kaunas). 2018;54(5):88.

Reibman J, et al. Airway epithelial cells release MIP-3alpha/CCL20 in response to cytokines and ambient particulate matter. Am J Respir Cell Mol Biol. 2003;28(6):648–54.

Article  CAS  PubMed  Google Scholar 

Nakayama WL, et al. Fine particulate matter from urban ambient and wildfire sources from California’s San Joaquin Valley initiate differential inflammatory, oxidative stress, and xenobiotic responses in human bronchial epithelial cells. Toxicol In Vitro. 2011;25(8):1895–905.

Article  Google Scholar 

Furue K, et al. The CCL20 and CCR6 axis in psoriasis. Scand J Immunol. 2020;91(3):e12846.

Article  PubMed  Google Scholar 

Brand S. Crohn’s disease: Th1, Th17 or both? The change of a paradigm: new immunological and genetic insights implicate Th17 cells in the pathogenesis of Crohn’s disease. Gut. 2009;58(8):1152–67.

Article  CAS  PubMed  Google Scholar 

Elnabawi YA, et al. CCL20 in psoriasis: a potential biomarker of disease severity, inflammation, and impaired vascular health. J Am Acad Dermatol. 2021;84(4):913–20.

Article  CAS  PubMed  Google Scholar 

Harper EG, et al. Th17 cytokines stimulate CCL20 expression in keratinocytes in vitro and in vivo: implications for psoriasis pathogenesis. J Invest Dermatol. 2009;129(9):2175–83.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ariza ME, Williams MV. A human endogenous retrovirus K dUTPase triggers a TH1, TH17 cytokine response: does it have a role in psoriasis? J Invest Dermatol. 2011;131(12):2419–27.

Article  CAS  PubMed  Google Scholar 

Nishimura M, et al. Chemokines as novel therapeutic targets for inflammatory bowel disease. Ann N Y Acad Sci. 2009;1173:350–6.

Article  CAS  PubMed  Google Scholar 

Calderón-Gómez E, et al. Commensal-Specific CD4(+) cells from patients with Crohn’s Disease Have a T-Helper 17 inflammatory profile. Gastroenterology. 2016;151(3):489–500.e3.

Article  PubMed  Google Scholar 

He H, et al. Mild atopic dermatitis lacks systemic inflammation and shows reduced nonlesional skin abnormalities. J Allergy Clin Immunol. 2021;147(4):1369–80.

Article  CAS  PubMed  Google Scholar 

Koga T, et al. Calcium/Calmodulin-Dependent Kinase IV Facilitates the Recruitment of Interleukin-17-Producing Cells to Target Organs Through the CCR6/CCL20 Axis in Th17 Cell-Driven Inflammatory Diseases. Arthritis Rheumatol. 2016;68(8):1981–8.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhang L, et al. Circulating CCL20: a potential biomarker for active vitiligo together with the number of Th1/17 cells. J Dermatol Sci. 2019;93(2):92–100.

Article  CAS  PubMed  Google Scholar 

Korbecki J, et al. CC Chemokines in a tumor: a review of pro-cancer and anti-cancer properties of receptors CCR5, CCR6, CCR7, CCR8, CCR9, and CCR10 Ligands. Int J Mol Sci. 2020;21(20):7619.

Liu Y, et al. PPARδ dysregulation of CCL20/CCR6 axis promotes gastric adenocarcinoma carcinogenesis by remodeling gastric tumor microenvironment. Gastric Cancer. 2023;26(6):904–17.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wang Y, et al. Lipid droplet accumulation mediates macrophage survival and Treg recruitment via the CCL20/CCR6 axis in human hepatocellular carcinoma. Cell Mol Immunol. 2024;21(10):1120–30.

Article  CAS  PubMed  Google Scholar 

Barnes PJ, et al. Barriers to new drug development in respiratory disease. Eur Respir J. 2015;45(5):1197–207.

Article  PubMed  Google Scholar 

Sallusto F, Baggiolini M. Chemokines and leukocyte traffic. Nat Immunol. 2008;9(9):949–52.

Article  CAS  PubMed  Google Scholar 

Rossi DL, et al. Identification through bioinformatics of two new macrophage proinflammatory human chemokines: MIP-3alpha and MIP-3beta. J Immunol. 1997;158(3):1033–6.

Article  CAS  PubMed  Google Scholar 

Hieshima K, et al. Molecular cloning of a novel human CC chemokine liver and activation-regulated chemokine (LARC) expressed in liver. Chemotactic activity for lymphocytes and gene localization on chromosome 2. J Biol Chem. 1997;272(9):5846–53.

Article  CAS  PubMed  Google Scholar 

Charbonnier A, et al. Macrophage Inflammatory protein 3α is involved in the constitutive trafficking of epidermal langerhans cells. J Exp Med. 1999;190(12):1755–68.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Tanaka Y, et al. Selective expression of liver and activation-regulated chemokine (LARC) in intestinal epithelium in mice and humans. Eur J Immunol. 1999;29(2):633–42.

Article  CAS  PubMed  Google Scholar 

Nakayama T, et al. Inducible expression of a CC chemokine liver- and activation-regulated chemokine (LARC)/macrophage inflammatory protein (MIP)-3 alpha/CCL20 by epidermal keratinocytes and its role in atopic dermatitis. Int Immunol. 2001;13(1):95–103.

Article  CAS  PubMed  Google Scholar 

Thorley AJ, et al. Primary human alveolar type II epithelial cell CCL20 (macrophage inflammatory protein-3alpha)-induced dendritic cell migration. Am J Respir Cell Mol Biol. 2005;32(4):262–7.

Article  CAS  PubMed  Google Scholar 

Yoshie O, Imai T, Nomiyama H. Novel lymphocyte-specific CC chemokines and their receptors. J Leukoc Biol. 1997;62(5):634–44.

Article  CAS  PubMed  Google Scholar 

Varona R, et al. Molecular cloning, functional characterization and mRNA expression analysis of the murine chemokine receptor CCR6 and its specific ligand MIP-3alpha. FEBS Lett. 1998;440(1–2):188–94.

Article  CAS  PubMed  Google Scholar 

Proudfoot A, et al. Glycosaminoglycan interactions with chemokines add complexity to a complex system. Pharmaceuticals. (Basel). 2017;10(3):70.

Wasilko DJ, et al. Structural basis for chemokine receptor CCR6 activation by the endogenous protein ligand CCL20. Nat Commun. 2020;11(1):3031.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Baba M, et al. Identification of CCR6, the specific receptor for a novel lymphocyte-directed CC Chemokine LARC*. J Biol Chem. 1997;272(23):14893–8.

Article  CAS  PubMed  Google Scholar 

Liao F, et al. STRL22 is a receptor for the CC chemokine MIP-3alpha. Biochem Biophys Res Commun. 1997;236(1):212–7.

Article  CAS  PubMed  Google Scholar 

Matti C, et al. CCL20 is a novel ligand for the scavenging atypical chemokine receptor 4. J Leukoc Biol. 2020;107(6):1137–54.

Article  CAS