Nicolau, J., Lequerre, T., Bacquet, H. & Vittecoq, O. Rheumatoid arthritis, insulin resistance, and diabetes. Joint Bone Spine 84, 411–416 (2017).
Article CAS PubMed Google Scholar
Spies, C. M., Straub, R. H. & Buttgereit, F. Energy metabolism and rheumatic diseases: from cell to organism. Arthritis Res. Ther. 14, 216 (2012).
Francisco, V. et al. A new immunometabolic perspective of intervertebral disc degeneration. Nat. Rev. Rheumatol. 18, 47–60 (2022).
Article CAS PubMed Google Scholar
Mobasheri, A. et al. The role of metabolism in the pathogenesis of osteoarthritis. Nat. Rev. Rheumatol. 13, 302–311 (2017).
Article CAS PubMed Google Scholar
Abella, V. et al. Leptin in the interplay of inflammation, metabolism and immune system disorders. Nat. Rev. Rheumatol. 13, 100–109 (2017).
Article CAS PubMed Google Scholar
Huang, Z. & Kraus, V. B. Does lipopolysaccharide-mediated inflammation have a role in OA? Nat. Rev. Rheumatol. 12, 123–129 (2016).
Article CAS PubMed Google Scholar
Lackey, D. E. & Olefsky, J. M. Regulation of metabolism by the innate immune system. Nat. Rev. Endocrinol. 12, 15–28 (2016).
Article CAS PubMed Google Scholar
Kerekes, G. et al. Rheumatoid arthritis and metabolic syndrome. Nat. Rev. Rheumatol. 10, 691–696 (2014).
Article CAS PubMed Google Scholar
Zhuo, Q., Yang, W., Chen, J. & Wang, Y. Metabolic syndrome meets osteoarthritis. Nat. Rev. Rheumatol. 8, 729–737 (2012).
Article CAS PubMed Google Scholar
Straub, R. H. Insulin resistance, selfish brain, and selfish immune system: an evolutionarily positively selected program used in chronic inflammatory diseases. Arthritis Res. Ther. 16 (Suppl. 2), S4 (2014).
Lopez, M., Nogueiras, R., Tena-Sempere, M. & Dieguez, C. Hypothalamic AMPK: a canonical regulator of whole-body energy balance. Nat. Rev. Endocrinol. 12, 421–432 (2016).
Article CAS PubMed Google Scholar
Jais, A. & Bruning, J. C. Arcuate nucleus-dependent regulation of metabolism-pathways to obesity and diabetes mellitus. Endocr. Rev. 43, 314–328 (2022).
Quarta, C. et al. POMC neuronal heterogeneity in energy balance and beyond: an integrated view. Nat. Metab. 3, 299–308 (2021).
Lopez, M. Hypothalamic AMPK as a possible target for energy balance-related diseases. Trends Pharmacol. Sci. 43, 546–556 (2022).
Article CAS PubMed Google Scholar
Lopez, M., Tena-Sempere, M. & Dieguez, C. Cross-talk between orexins (hypocretins) and the neuroendocrine axes (hypothalamic-pituitary axes). Front. Neuroendocrinol. 31, 113–127 (2010).
Article CAS PubMed Google Scholar
Loos, R. J. F. & Yeo, G. S. H. The genetics of obesity: from discovery to biology. Nat. Rev. Genet. 23, 120–133 (2022).
Article CAS PubMed Google Scholar
Muller, T. D., Bluher, M., Tschop, M. H. & DiMarchi, R. D. Anti-obesity drug discovery: advances and challenges. Nat. Rev. Drug. Discov. 21, 201–223 (2022).
Bruning, J. C. & Fenselau, H. Integrative neurocircuits that control metabolism and food intake. Science 381, eabl7398 (2023).
Levine, J. D., Goetzl, E. J. & Basbaum, A. I. Contribution of the nervous system to the pathophysiology of rheumatoid arthritis and other polyarthritides. Rheum. Dis. Clin. North. Am. 13, 369–383 (1987).
Article CAS PubMed Google Scholar
Levine, J. D., Collier, D. H., Basbaum, A. I., Moskowitz, M. A. & Helms, C. A. Hypothesis: the nervous system may contribute to the pathophysiology of rheumatoid arthritis. J. Rheumatol. 12, 406–411 (1985).
Seoane-Collazo, P. et al. Activation of hypothalamic AMP-activated protein kinase ameliorates metabolic complications of experimental arthritis. Arthritis Rheumatol. 74, 212–222 (2022).
Article CAS PubMed Google Scholar
Kelly, M. The neurogenic factor in rheumatic inflammation. Med. J. Aust. 1, 859–864 (1951).
Article CAS PubMed Google Scholar
Taylor, C. T. & Colgan, S. P. Hypoxia and gastrointestinal disease. J. Mol. Med. 85, 1295–1300 (2007).
Lewis, J. S., Lee, J. A., Underwood, J. C., Harris, A. L. & Lewis, C. E. Macrophage responses to hypoxia: relevance to disease mechanisms. J. Leukoc. Biol. 66, 889–900 (1999).
Article CAS PubMed Google Scholar
Pirzgalska, R. M. & Domingos, A. I. Macrophages in obesity. Cell. Immunol. 330, 183–187 (2018).
Article CAS PubMed Google Scholar
Procaccini, C., Pucino, V., Mantzoros, C. S. & Matarese, G. Leptin in autoimmune diseases. Metabolism 64, 92–104 (2015).
Article CAS PubMed Google Scholar
La Cava, A. Leptin in inflammation and autoimmunity. Cytokine 98, 51–58 (2017).
Carobbio, S., Pellegrinelli, V. & Vidal-Puig, A. Adipose tissue function and expandability as determinants of lipotoxicity and the metabolic syndrome. Adv. Exp. Med. Biol. 960, 161–196 (2017).
Article CAS PubMed Google Scholar
Francisco, V. et al. Adipokines and inflammation: is it a question of weight? Br. J. Pharmacol. 175, 1569–1579 (2018).
Article CAS PubMed Google Scholar
Rohm, T. V., Meier, D. T., Olefsky, J. M. & Donath, M. Y. Inflammation in obesity, diabetes, and related disorders. Immunity 55, 31–55 (2022).
Article CAS PubMed PubMed Central Google Scholar
Larabee, C. M., Neely, O. C. & Domingos, A. I. Obesity: a neuroimmunometabolic perspective. Nat. Rev. Endocrinol. 16, 30–43 (2020).
Martinez-Sanchez, N. et al. The sympathetic nervous system in the 21st century: neuroimmune interactions in metabolic homeostasis and obesity. Neuron 110, 3597–3626 (2022).
Article CAS PubMed Google Scholar
O’Brien, C. J. O., Haberman, E. R. & Domingos, A. I. A tale of three systems: toward a neuroimmunoendocrine model of obesity. Annu. Rev. Cell Dev. Biol. 37, 549–573 (2021).
Straub, R. H. The brain and immune system prompt energy shortage in chronic inflammation and ageing. Nat. Rev. Rheumatol. 13, 743–751 (2017).
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