An integrated multi-omics analysis of the effects of the food processing-induced contaminant 2-monochloropropane-1,3-diol (2-MCPD) in rat heart

Allen D, Hasanally D, Ravandi A (2013) Role of oxidized phospholipids in cardiovascular pathology. Clin Lipidol 8:205–215. https://doi.org/10.2217/clp.13.13

Article  CAS  Google Scholar 

Andres S, Appel KE, Lampen A (2013) Toxicology, occurrence and risk characterisation of the chloropropanols in food: 2-Monochloro-1,3-propanediol, 1,3-dichloro-2-propanol and 2,3-dichloro-1-propanol. Food Chem Toxicol 58:467–478. https://doi.org/10.1016/j.fct.2013.05.024

Article  CAS  PubMed  Google Scholar 

Aragno M, Mastrocola R, Alloatti G, Vercellinatto I, Bardini P, Geuna S, Catalano MG, Danni O, Boccuzzi G (2008) Oxidative stress triggers cardiac fibrosis in the heart of diabetic rats. Endocrinology 149:380–388. https://doi.org/10.1210/EN.2007-0877

Article  CAS  PubMed  Google Scholar 

Aukema HM, Ravandi A (2023) Factors affecting variability in free oxylipins in mammalian tissues. Curr Opin Clin Nutr Metab Care 26:91–98. https://doi.org/10.1097/MCO.0000000000000892

Article  PubMed  Google Scholar 

Aukema HM, Winter T, Ravandi A, Dalvi S, Miller DW, Hatch GM (2016) Generation of bioactive oxylipins from exogenously added arachidonic, eicosapentaenoic and docosahexaenoic acid in primary human brain microvessel endothelial cells. Lipids 51:591–599. https://doi.org/10.1007/s11745-015-4074-0

Article  CAS  PubMed  Google Scholar 

Bento AF, Claudino RF, Dutra RC, Marcon R, Calixto JB, Dutra C, Marcon R, Calixto JB (2011) Omega-3 fatty acid-derived mediators 17( R )-hydroxy docosahexaenoic acid, aspirin-triggered resolvin D1 and resolvin D2 prevent experimental colitis in mice. J Immunol. https://doi.org/10.4049/jimmunol.1101305

Article  PubMed  Google Scholar 

Berry E, Hernandez-Anzaldo S, Ghomashchi F, Lehner R, Murakami M, Gelb MH, Kassiri Z, Wang X, Fernandez-Patron C (2015) Matrix metalloproteinase-2 negatively regulates cardiac secreted phospholipase A2 to modulate inflammation and fever. J Am Heart Assoc. https://doi.org/10.1161/JAHA.115.001868

Article  PubMed  PubMed Central  Google Scholar 

Buhrke T, Schultrich K, Braeuning A, Lampen A (2017) Comparative analysis of transcriptomic responses to repeated-dose exposure to 2-MCPD and 3-MCPD in rat kidney, liver and testis. Food Chem Toxicol 106:36–46. https://doi.org/10.1016/j.fct.2017.05.028

Article  CAS  PubMed  Google Scholar 

Buhrke T, Voss L, Briese A, Stephanowitz H, Krause E, Braeuning A, Lampen A (2018) Oxidative inactivation of the endogenous antioxidant protein DJ-1 by the food contaminants 3-MCPD and 2-MCPD. Arch Toxicol 92:289–299. https://doi.org/10.1007/s00204-017-2027-5

Article  CAS  PubMed  Google Scholar 

Cayer LGJ, Roberts J, Caldwell D, Ravandi A, Raju J, Aukema HM (2024) Bioactive lipids are altered in the heart, kidney, and serum of male and female F344 rats sub-chronically exposed to dietary 2-MCPD. (Manuscripts submitted together)

Croset M, Sala A, Folco G, Lagarde M (1988) Inhibition by lipoxygenase products of TXA2-like responses of platelets and vascular smooth muscle. Biochem Pharmacol 37:1275–1280. https://doi.org/10.1016/0006-2952(88)90782-4

Article  CAS  PubMed  Google Scholar 

Cui X, Zhang L, Yang D, Li J, Liu Q, Sui H, Liu Z, Zhou P (2021) Occurrence of 3- and 2-monochloropropanediol esters in infant formulas in China and exposure assessment. Food Addit Contamin Part A 38:1470–1480. https://doi.org/10.1080/19440049.2021.1925164

Article  CAS  Google Scholar 

Deems R, Buczynski MW, Bowers-Gentry R, Harkewicz R, Dennis EA (2007) Detection and quantitation of eicosanoids via high performance liquid chromatography-electrospray ionization-mass spectrometry. Methods Enzymol 432:59–82. https://doi.org/10.1016/S0076-6879(07)32003-X

Article  CAS  PubMed  Google Scholar 

Deng B, Wang CW, Arnardottir HH, Li Y, Cheng CYC, Dalli J, Serhan CN (2014) Maresin biosynthesis and identification of maresin 2, a new anti-inflammatory and pro-resolving mediator from human macrophages. PLoS ONE. https://doi.org/10.1371/JOURNAL.PONE.0102362

Article  PubMed  PubMed Central  Google Scholar 

Dobin A, Gingeras TR (2015) Mapping RNA-seq Reads with STAR. Curr Protoc Bioinforma. https://doi.org/10.1002/0471250953.BI1114S51

Article  Google Scholar 

European Food Safety Authority (2016) Risks for human health related to the presence of 3- and 2-monochloropropanediol (MCPD), and their fatty acid esters, and glycidyl fatty acid esters in food. EFSA J. https://doi.org/10.2903/j.efsa.2016.4426

Article  Google Scholar 

Ferdouse A, Leng S, Winter T, Aukema HM (2019) Dietary n-6 and n-3 PUFA alter the free oxylipin profile differently in male and female rat hearts. Br J Nutr 122:252–261. https://doi.org/10.1017/S0007114519001211

Article  CAS  PubMed  Google Scholar 

Festjens N, Vanden Berghe T, Vandenabeele P (2006) Necrosis, a well-orchestrated form of cell demise: Signalling cascades, important mediators and concomitant immune response. Biochim Biophys Acta Bioenerg 1757:1371–1387. https://doi.org/10.1016/J.BBABIO.2006.06.014

Article  CAS  Google Scholar 

Frangogiannis NG (2021) Cardiac fibrosis. Cardiovasc Res 117:1450–1488. https://doi.org/10.1093/CVR/CVAA324

Article  CAS  PubMed  Google Scholar 

Gabbs M, Leng S, Devassy JG, Monirujjaman MM, Aukema HM, Leng S, Gabbs M (2015) Advances in our understanding of oxylipins derived from dietary PUFAs. Adv Nutr an Int Rev J 6:513–540. https://doi.org/10.3945/an.114.007732

Article  CAS  Google Scholar 

González-Périz A, Planagumà A, Gronert K, Miquel R, López-Parra M, Titos E, Horrillo R, Ferré N, Deulofeu R, Arroyo V, Rodés J, Clària J, González-Périz A, Planagumà A, Gronert K, Miquel R, López-Parra M, Titos E, Horrillo R, Ferré N, Deulofeu R, Arroyo V, Rodés J, Clària J (2006) Docosahexaenoic acid (DHA) blunts liver injury by conversion to protective lipid mediators: protectin D1 and 17S-hydroxy-DHA. FASEB J 20:2537–2539. https://doi.org/10.1096/fj.06-6250fje

Article  CAS  PubMed  Google Scholar 

Hernandez-Anzaldo S, Berry E, Brglez V, Leung D, Yun TJ, Lee JS, Filep JG, Kassiri Z, Cheong C, Lambeau G, Lehner R, Fernandez-Patron C (2015) Identification of a novel heart-liver axis: matrix metalloproteinase-2 negatively regulates cardiac secreted phospholipase A2 to modulate lipid metabolism and inflammation in the liver. J Am Heart Assoc. https://doi.org/10.1161/JAHA.115.002553

Article  PubMed  PubMed Central  Google Scholar 

Hodgson E (2004) A textbook of modern toxicology, Third. ed. John Wiley & Sons, Inc., Hoboken, New Jersey. https://doi.org/10.1002/0471646776

International Agency for Research on Cancer (2013) Some chemicals present in industrial and consumer products, food and drinking-water. IARC Monogr Eval Carcinog Risks Hum

Koo MJ, Rooney KT, Choi ME, Ryter SW, Choi AMK, Moon JS (2015) Impaired oxidative phosphorylation regulates necroptosis in human lung epithelial cells. Biochem Biophys Res Commun 464:875. https://doi.org/10.1016/J.BBRC.2015.07.054

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kowalczyk P, Sulejczak D, Kleczkowska P, Bukowska-Ośko I, Kucia M, Popiel M, Wietrak E, Kramkowski K, Wrzosek K, Kaczyńska K (2021) Mitochondrial oxidative stress—a causative factor and therapeutic target in many diseases. Int J Mol Sci 22:22. https://doi.org/10.3390/IJMS222413384

Article  Google Scholar 

Kuhlmann J (2016) Analysis and occurrence of dichloropropanol fatty acid esters and related process-induced contaminants in edible oils and fats. Eur J Lipid Sci Technol 118:382–395. https://doi.org/10.1002/ejlt.201400518

Article  CAS  Google Scholar 

Lagarde M, Guichardant M, Bernoud-Hubac N (2020) Anti-inflammatory and anti-virus potential of poxytrins, especially protectin DX. Biochimie 179:281–284. https://doi.org/10.1016/J.BIOCHI.2020.09.008

Article  CAS  PubMed  PubMed Central  Google Scholar 

Law CW, Chen Y, Shi W, Smyth GK (2014) voom: Precision weights unlock linear model analysis tools for RNA-seq read counts. Genome Biol. https://doi.org/10.1186/GB-2014-15-2-R29

Article  PubMed  PubMed Central  Google Scholar 

Leng S, Winter T, Aukema HM (2017) Dietary LA and sex effects on oxylipin profiles in rat kidney, liver, and serum differ from their effects on PUFAs. J Lipid Res 58:1702–1712. https://doi.org/10.1194/jlr.M078097

Article  CAS  PubMed  PubMed Central  Google Scholar 

Li K, Zhao J, Wang M, Niu L, Wang Y, Li Y, Zheng Y (2021) The roles of various prostaglandins in fibrosis: a review. Biomolecules. https://doi.org/10.3390/biom11060789

Article  PubMed  PubMed Central 

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