Neutralizing chimeric heavy-chain antibody targeting the L-HN domain of Clostridium botulinum neurotoxin type F

Agarwal R, Schmidt JJ, Stafford RG, Swaminathan S (2009) Mode of VAMP substrate recognition and inhibition of Clostridium botulinum neurotoxin F. Nat Struct Mol Biol 16(7):789–794. https://doi.org/10.1038/nsmb.1626

Article  CAS  PubMed  Google Scholar 

Ayyar BV, Aoki KR, Atassi MZ (2015a) The C-terminal heavy-chain domain of botulinum neurotoxin a is not the only site that binds neurons, as the N-terminal heavy-chain domain also plays a very active role in toxin-cell binding and interactions. Infect Immun 83(4):1465–1476. https://doi.org/10.1128/IAI.00063-15

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ayyar BV, Tajhya RB, Beeton C, Atassi MZ (2015b) Antigenic sites on the HN domain of botulinum neurotoxin A stimulate protective antibody responses against active toxin. Sci Rep 5:15776. https://doi.org/10.1038/srep15776

Article  CAS  PubMed  Google Scholar 

Ben David A, Barnea A, Diamant E et al (2021) Small molecule receptor binding inhibitors with in vivo efficacy against botulinum neurotoxin serotypes A and E. Int J Mol Sci 22(16):8577. https://doi.org/10.3390/ijms22168577

Article  CAS  PubMed  PubMed Central  Google Scholar 

Berger T, Eisenkraft A, Bar-Haim E, Kassirer M, Aran AA, Fogel I (2016) Toxins as biological weapons for terror-characteristics, challenges and medical countermeasures: a mini-review. Disaster Mil Med 2:7. https://doi.org/10.1186/s40696-016-0017-4

Article  PubMed  PubMed Central  Google Scholar 

Bomba-Warczak E, Vevea JD, Brittain JM et al (2016) Interneuronal transfer and distal action of tetanus toxin and botulinum neurotoxins A and D in central neurons. Cell Rep 16(7):1974–1987. https://doi.org/10.1016/j.celrep.2016.06.104

Article  CAS  PubMed  PubMed Central  Google Scholar 

Burgin D, Perier C, Hackett G et al (2021) New modified recombinant botulinum neurotoxin type f with enhanced potency. Toxins (Basel) 13(12):834. https://doi.org/10.3390/toxins13120834

Article  CAS  PubMed  Google Scholar 

Chauhan R, Chauhan Kushwah V, Agnihotri S, Vimal M, Saxena N, Dhaked RK (2023) Designing, synthesis and evaluation of derived analogues of selected small molecule non-peptidic inhibitors against serotype BoNT/ F. Toxicon 222:106981. https://doi.org/10.1016/j.toxicon.2022.106981

Article  CAS  PubMed  Google Scholar 

Choudhury S, Baker MR, Chatterjee S, Kumar H (2021) Botulinum toxin: an update on pharmacology and newer products in development. Toxins (Basel) 13(1):58. https://doi.org/10.3390/toxins13010058

Article  CAS  PubMed  Google Scholar 

Dong M, Stenmark P (2021) The structure and classification of botulinum toxins. Handb Exp Pharmacol 263:11–33. https://doi.org/10.1007/164_2019_342

Article  CAS  PubMed  Google Scholar 

Fan Y, Garcia-Rodriguez C, Lou J et al (2017) A three monoclonal antibody combination potently neutralizes multiple botulinum neurotoxin serotype F subtypes. PLoS ONE 12(3):e0174187. https://doi.org/10.1371/journal.pone.0174187

Article  CAS  PubMed  PubMed Central  Google Scholar 

Fischer A, Mushrush DJ, Lacy DB, Montal M (2008) Botulinum neurotoxin devoid of receptor binding domain translocates active protease. PLoS Pathog 4(12):e1000245. https://doi.org/10.1371/journal.ppat.1000245

Article  CAS  PubMed  PubMed Central  Google Scholar 

Gregory KS, Hall PR, Onuh JP, Mojanaga OO, Liu SM, Acharya KR (2023) Crystal structure of the catalytic domain of a botulinum neurotoxin homologue from Enterococcus faecium: potential insights into substrate recognition. Int J Mol Sci 24(16):12721. https://doi.org/10.3390/ijms241612721

Article  CAS  PubMed  PubMed Central  Google Scholar 

Gupta A, Sumner CJ, Castor M, Maslanka S, Sobel J (2005) Adult botulism type F in the United States, 1981–2002. Neurology 65(11):1694–1700. https://doi.org/10.1212/01.wnl.0000187127.92446.4c

Article  CAS  PubMed  Google Scholar 

Hill KK, Xie G, Foley BT, Smith TJ (2015) Genetic diversity within the botulinum neurotoxin-producing bacteria and their neurotoxins. Toxicon 107(Pt A):2–8. https://doi.org/10.1016/j.toxicon.2015.09.011

Article  CAS  PubMed  Google Scholar 

Ibrahim H, Retailleau K, Hornby F, Maignel J, Beard M, Daly DM (2024) A novel catalytically inactive construct of botulinum neurotoxin A (BoNT/A) directly inhibits visceral sensory signalling. Toxins (Basel) 16(1):30. https://doi.org/10.3390/toxins16010030

Article  CAS  PubMed  Google Scholar 

Janik E, Ceremuga M, Saluk-Bijak J, Bijak M (2019) Biological toxins as the potential tools for bioterrorism. Int J Mol Sci 20(5):1181. https://doi.org/10.3390/ijms20051181

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kalb SR, Baudys J, Raphael BH et al (2015) Functional characterization of botulinum neurotoxin serotype H as a hybrid of known serotypes F and A (BoNT F/A). Anal Chem 87(7):3911–3917. https://doi.org/10.1021/ac504716v

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kosenina S, Martinez-Carranza M, Davies JR, Masuyer G, Stenmark P (2021) Structural analysis of botulinum neurotoxins type B and E by Cryo-EM. Toxins (Basel) 14(1):14. https://doi.org/10.3390/toxins14010014

Article  CAS  PubMed  Google Scholar 

Lacy DB, Tepp W, Cohen AC, DasGupta BR, Stevens RC (1998) Crystal structure of botulinum neurotoxin type A and implications for toxicity. Nat Struct Biol 5(10):898–902. https://doi.org/10.1038/2338

Article  CAS  PubMed  Google Scholar 

Li Z, Lu J, Tan X et al (2022) Functional EL-HN fragment as a potent candidate vaccine for the prevention of botulinum neurotoxin serotype E. Toxins (Basel) 14(2):135. https://doi.org/10.3390/toxins14020135

Article  CAS  PubMed  Google Scholar 

Li Z, Li B, Lu J et al (2023) Biological and Immunological Characterization of a Functional L-HN Derivative of Botulinum Neurotoxin Serotype F. Toxins (Basel) 15(3):200. https://doi.org/10.3390/toxins15030200

Article  CAS  PubMed  Google Scholar 

Liu FJ, Shi DY, Mao YY et al (2020) Immunological characterisation and immunoprotective efficacy of functional domain antigens of botulinum neurotoxin serotype A. Vaccine 38(14):2978–2983. https://doi.org/10.1016/j.vaccine.2020.02.060

Article  CAS  PubMed  Google Scholar 

Liu M, Li L, Jin D, Liu Y (2021) Nanobody-A versatile tool for cancer diagnosis and therapeutics. Wiley Interdiscip Rev Nanomed Nanobiotechnol 13(4):e1697. https://doi.org/10.1002/wnan.1697

Article  CAS  PubMed  Google Scholar 

Matsumura T, Amatsu S, Misaki R et al (2020) Fully human monoclonal antibodies effectively neutralizing botulinum neurotoxin serotype B. Toxins (Basel) 12(5):302. https://doi.org/10.3390/toxins12050302

Article  CAS  PubMed  Google Scholar 

Mukherjee J, Ondeck CA, Tremblay JM et al (2022) Intramuscular delivery of formulated RNA encoding six linked nanobodies is highly protective for exposures to three Botulinum neurotoxin serotypes. Sci Rep 12(1):11664. https://doi.org/10.1038/s41598-022-15876-2

Article  CAS  PubMed  PubMed Central  Google Scholar 

Peck MW, Smith TJ, Anniballi F et al (2017) Historical perspectives and guidelines for botulinum neurotoxin subtype nomenclature. Toxins (Basel) 9(1):38. https://doi.org/10.3390/toxins9010038

Article  CAS 

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