Synergistic ferroptosis in triple-negative breast cancer cells: Paclitaxel in combination with Erastin induced oxidative stress and Ferroportin-1 modulation in MDA-MB-231 cells

Bachegowda LS, Makower DF, Sparano JA (2014) Taxanes: impact on breast cancer therapy. Anticancer Drugs 25(5):512–521. https://doi.org/10.1097/CAD.0000000000000090

Article  PubMed  CAS  Google Scholar 

Bindokas V, Jordan J, Lee C, Miller R (1996) Superoxide production in rat hippocampal neurons: selective imaging with hydroethidine. J Neurosci 16(4):1324–1336. https://doi.org/10.1523/JNEUROSCI.16-04-01324.1996

Article  PubMed  PubMed Central  CAS  Google Scholar 

Boshuizen J, Peeper DS (2020) Rational Cancer Treatment combinations: an Urgent Clinical need. Mol Cell 78(6):1002–1018. https://doi.org/10.1016/j.molcel.2020.05.031

Article  PubMed  CAS  Google Scholar 

Cao JY, Dixon SJ (2016) Mechanisms of ferroptosis. Cell Mol Life Sci 73(11–12):2195–2209. https://doi.org/10.1007/s00018-016-2194-1

Article  PubMed  PubMed Central  CAS  Google Scholar 

Chen JG, Horwitz SB (2002) Differential mitotic responses to microtubule-stabilizing and -destabilizing drugs. Cancer Res 62(7):1935–1938

PubMed  CAS  Google Scholar 

Chen Z, Wang W, Abdul Razak SR et al (2023) Ferroptosis as a potential target for cancer therapy. Cell Death Dis 14:460. https://doi.org/10.1038/s41419-023-05930-w

Article  PubMed  PubMed Central  Google Scholar 

Cheng Q, Bao L, Li M, Chang K, Yi X (2021) Erastin synergizes with cisplatin via ferroptosis to inhibit ovarian cancer growth in vitro and in vivo. J Obstet Gynaecol Res 47(7):2481–2491. https://doi.org/10.1111/jog.14779

Article  PubMed  CAS  Google Scholar 

Chou T-C, Talalay P (1984) Quantitative analysis of dose-effect relationships: the combined effects of multiple drugs or enzyme inhibitors. Adv Enzyme Regul 22:27–55. https://doi.org/10.1016/0065-2571(84)90007-4

Article  PubMed  CAS  Google Scholar 

Dixon SJ, Stockwell BR (2019) The Hallmarks of Ferroptosis. Annu Rev Cancer Biol 3(1):35–54. https://doi.org/10.1146/annurev-cancerbio-030518-055844

Article  Google Scholar 

Dixon SJ, Lemberg KM, Lamprecht MR et al (2012) Ferroptosis: An Iron-Dependent form of non-apoptotic cell death. Cell 149(5):1060–1072. https://doi.org/10.1016/j.cell.2012.03.042

Article  PubMed  PubMed Central  CAS  Google Scholar 

Eliyatkin N, Yalcin E, Zengel B, Aktaş S, Vardar E (2015) Molecular classification of breast carcinoma: from traditional, old-fashioned way to a New Age, and a New Way. J Breast Heal 11(2):59–66. https://doi.org/10.5152/tjbh.2015.1669

Article  Google Scholar 

Endale HT, Tesfaye W, Mengstie TA (2023) ROS induced lipid peroxidation and their role in ferroptosis. Front Cell Dev Biol 11:1226044. https://doi.org/10.3389/fcell.2023.1226044

Article  PubMed  PubMed Central  Google Scholar 

Henry NL, Shah PD, Haider I, Freer PE, Jagsi R, Sabel MS (2020) Abeloff’s Clinical Oncology. Elsevier, pp 1560–1603. https://doi.org/10.1016/B978-0-323-47674-4.00088-8

Book  Google Scholar 

Karki R, Seagle B-LL, Nieves-Neira W, Shahabi S (2014) Taxanes in combination with biologic agents for ovarian and breast cancers. Anticancer Drugs 25(5):536–554. https://doi.org/10.1097/CAD.0000000000000056

Article  PubMed  CAS  Google Scholar 

Kumar P, Aggarwal R (2016) An overview of triple-negative breast cancer. Arch Gynecol Obstet 293(2):247–269. https://doi.org/10.1007/s00404-015-3859-y

Article  PubMed  CAS  Google Scholar 

Lee J, Roh JL (2022) SLC7A11 as a gateway of metabolic perturbation and ferroptosis vulnerability in Cancer. Antioxid (Basel) 11(12):2444. https://doi.org/10.3390/antiox11122444

Article  CAS  Google Scholar 

Louandre C, Ezzoukhry Z, Godin C, Barbare JC, Mazière JC, Chauffert B, Galmiche A (2013) Iron-dependent cell death of hepatocellular carcinoma cells exposed to sorafenib. Int J Cancer 133(7):1732–1742. https://doi.org/10.1002/ijc.28159

Article  PubMed  CAS  Google Scholar 

Molassiotis A, Cheng HL, Leung KT et al (2019) Risk factors for chemotherapy-induced peripheral neuropathy in patients receiving taxane‐ and platinum‐based chemotherapy. Brain Behav 9(6):1–10. https://doi.org/10.1002/brb3.1312

Article  Google Scholar 

Ozkan E, Bakar-Ates F (2023) Etoposide in combination with erastin synergistically altered iron homeostasis and induced ferroptotic cell death through regulating IREB2/FPN1 expression in estrogen receptor positive-breast cancer cells. Life Sci 312:121222. https://doi.org/10.1016/j.lfs.2022.121222

Article  PubMed  CAS  Google Scholar 

Sato M, Kusumi R, Hamashima S et al (2018) The ferroptosis inducer erastin irreversibly inhibits system xc- and synergizes with cisplatin to increase cisplatin’s cytotoxicity in cancer cells. Sci Rep 8(1):1–9. https://doi.org/10.1038/s41598-018-19213-4

Article  CAS  Google Scholar 

Schmid I, Krall WJ, Uittenbogaart CH, Braun J, Giorgi JV (1992) Dead cell discrimination with 7-amino-actinomcin D in combination with dual color immunofluorescence in single laser flow cytometry. Cytometry 13(2):204–208. https://doi.org/10.1002/cyto.990130216

Article  PubMed  CAS  Google Scholar 

Stockwell BR, Friedmann Angeli JP, Bayir H et al (2017) Ferroptosis: a regulated cell death Nexus linking metabolism, Redox Biology, and Disease. Cell 171(2):273–285. https://doi.org/10.1016/j.cell.2017.09.021

Article  PubMed  PubMed Central  CAS  Google Scholar 

Sung H, Ferlay J, Siegel RL et al (2021) Global Cancer statistics 2020: GLOBOCAN estimates of incidence and Mortality Worldwide for 36 cancers in 185 countries. CA Cancer J Clin 71(3):209–249. https://doi.org/10.3322/caac.21660

Article  PubMed  CAS  Google Scholar 

Tang H, Chen D, Li C et al (2019) Dual GSH-exhausting sorafenib loaded manganese-silica nanodrugs for inducing the ferroptosis of hepatocellular carcinoma cells. Int J Pharm 572:118782. https://doi.org/10.1016/j.ijpharm.2019.118782

Article  PubMed  CAS  Google Scholar 

Weaver BA (2014) How Taxol/paclitaxel kills cancer cells. Mol Biol Cell 25(18):2677–2681. https://doi.org/10.1091/mbc.E14-04-0916

Article  PubMed  PubMed Central  CAS  Google Scholar 

Wen Y, Li K, Ni M, Jiang H, Wu H, Yu Q, Li J, Li X, Wei J, Wu W, Xu H (2024) Dendritic polylysine with paclitaxel and triptolide codelivery for enhanced Cancer ferroptosis through the Accumulation of ROS. ACS Appl Mater Interfaces 16:20143–20156. https://doi.org/10.1021/acsami.4c00558

Article  CAS  Google Scholar 

Xie Y, Hou W, Song X, Yu Y, Huang J, Sun X, Kang R, Tang D (2016) Ferroptosis: process and function. Cell Death Differ 23(3):369–379. https://doi.org/10.1038/cdd.2015.158

Article  PubMed  PubMed Central  CAS  Google Scholar 

Yanatori I, Richardson DR, Imada K, Kishi F (2016) Iron Export through the Transporter Ferroportin 1 is modulated by the Iron Chaperone PCBP2. J Biol Chem 291(33):17303–17318. https://doi.org/10.1074/jbc.M116.721936

Article  PubMed  PubMed Central  CAS  Google Scholar 

Zhang W, Liu Y, Liao Y, Zhu C, Zou Z (2024) GPX4, ferroptosis, and diseases. Biomed Pharmacother 174:116512. https://doi.org/10.1016/j.biopha.2024.116512

Article  PubMed  CAS  Google Scholar 

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