Andersen ML (2016) Guia brasileiro de produção, manutenção ou utilização de animais em atividade de ensino ou pesquisa cientifica, Conselho nacional de controle de experimentação animal. Brasília: Ministério da Ciência, Tecnologia e Inovação. 11.794/2008, art 22, inciso II

Britto-Júnior J, de Oliveira MG, Dos Reis Gati C, Campos R, Moraes MO, Moraes MEA, Mónica FZ, Antunes E, De Nucci G (2022) 6-NitroDopamine is an endogenous modulator of rat heart chronotropism. Life Sci 15(307):120879. https://doi.org/10.1016/j.lfs.2022.120879

Article  CAS  Google Scholar 

Britto-Júnior J, Pereira do Prado GL, Chiavegatto S, Cunha F, Moraes O, Moraes E, Monica FZ, Antunes E, De Nucci G (2023a) The importance of the endothelial nitric oxide synthase on the release of 6-nitrodopamine from mouse isolated atria and ventricles and their role on chronotropism. Nitric Oxide 1(138–139):26–33. https://doi.org/10.1016/j.niox.2023.06.001

Article  CAS  Google Scholar 

Britto-Júnior J, Lima AT, Fuguhara V, Monica FZ, Antunes E, De Nucci G (2023b) Investigation on the positive chronotropic action of 6-nitrodopamine in the rat isolated atria. Naunyn Schmiedebergs Arch Pharmacol 396:1279–1290. https://doi.org/10.1007/s00210-023-02394-9

Article  CAS  PubMed  Google Scholar 

Britto-Júnior J, Medeiros-Teixeira LR, Lima AT, Dassow LC, Lopes-Martins RÁB, Campos R, Moraes MO, Moraes MEA, Antunes E, De Nucci G (2023c) 6-Nitrodopamine is the most potent endogenous positive inotropic agent in the isolated rat heart. Life (Basel) 4(13):2012. https://doi.org/10.3390/life13102012

Article  CAS  Google Scholar 

Brodde OE (1991) Pathophysiology of the beta-adrenoceptor system in chronic heart failure: consequences for treatment with agonists, partial agonists or antagonists? Eur Heart J 12:54–62. https://doi.org/10.1093/eurheartj/12.suppl_f.54

Article  PubMed  Google Scholar 

Chatterjee S, Biondi-Zoccai G, Abbate A, D’Ascenzo F, Castagno D, Van Tassell B, Mukherjee D, Lichstein E (2013) Benefits of β blockers in patients with heart failure and reduced ejection fraction: network meta-analysis. BMJ 16(346):f55. https://doi.org/10.1136/bmj.f55.Erratum.In:BMJ.2013;346:f596

Article  Google Scholar 

Coltart DJ, Shand DG (1970) Plasma propranolol levels in the quantitative assessment of beta-adrenergic blockade in man. Br Med J 26(3):731–734. https://doi.org/10.1136/bmj.3.5725.731

Article  Google Scholar 

Coltart J, Alderman EL, Robison SC, Harrison DC (1975) Effect of propranolol on left ventricular function, segmental wall motion, and diastolic pressure-volume relation in man. Br Heart J 1(37):357–364. https://doi.org/10.1136/hrt.37.4.357

Article  Google Scholar 

Desai SP, Marsh JD, Allen PD (1989) Contractility effects of local anesthetics in the presence of sodium channel blockade. Reg Anesth 14(2):58–62

CAS  PubMed  Google Scholar 

Frishman WH, Saunders E (2011) β-Adrenergic blockers. J Clin Hypertens 13:649–653. https://doi.org/10.1111/j.1751-7176.2011.00515.x

Article  CAS  Google Scholar 

Hasking GJ, Esler MD, Jennings GL, Burton D, Johns JA, Korner PI (1986) Norepinephrine spillover to plasma in patients with congestive heart failure: evidence of increased overall and cardiorenal sympathetic nervous activity. Circulation 73(4):615–621. https://doi.org/10.1161/01.cir.73.4.615

Article  CAS  PubMed  Google Scholar 

Hirano A, Hashimoto H, Nakashima M (1982) Influence of hypothyroid status on dopamine-induced positive chronotropic and inotropic effects on isolated rat atria. Japan J Pharmacol 1(32):221–230. https://doi.org/10.1254/jjp.32.221

Article  Google Scholar 

Kamisaki Y, Wada K, Bian K, Balabanli B, Davis K, Martin E, Behbod F, Lee YC, Murad F (1998) An activity in rat tissues that modifies nitrotyrosine-containing proteins. Proc Natl Acad Sci U S A 95(20):11584–11589. https://doi.org/10.1073/pnas.95.20.11584

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kavanagh T, Yacoub MH, Mertens DJ, Kennedy J, Campbell RB, Sawyer P (1988) Cardiorespiratory responses to exercise training after orthotopic cardiac transplantation. Circulation 77:162–171. https://doi.org/10.1161/01.cir.77.1.162

Article  CAS  PubMed  Google Scholar 

Lewis MJ, Grey AC, Henderson AH (1983) Inotropic β-blocking potency (pA2) and partial agonist activity of propranolol, practolol, sotalol and acebutolol. Eur J Pharmacol 86:71–76

Article  Google Scholar 

Marques F, Castro RB, Nobre F, Pintya AO, Gallo L Jr, Maciel BC, Simões MV (2010) Replacement of carvedilol for propranolol in patients with heart failure. Arq Bras Cardiol 95(1):107–114. https://doi.org/10.1590/s0066-782x2010005000062

Article  PubMed  Google Scholar 

Matthews JC, Baker JK (1982) Effects of propranolol and a number of its analogues on sodium channels. Biochem Pharmacol 1(31):1681–1685. https://doi.org/10.1016/0006-2952(82)90668-2

Article  Google Scholar 

Mehvar R, Brocks DR (2001) Stereospecific pharmacokinetics and pharmacodynamics of beta-adrenergic blockers in humans. J Pharm Pharm Sci 4:185–200

CAS  PubMed  Google Scholar 

Michel MC, Murphy TJ, Motulsky HJ (2020) New author guidelines for displaying data and reporting data analysis and statistical methods in experimental biology. Mol Pharmacol 97:49–60. https://doi.org/10.1124/mol.119.118927

Article  PubMed  Google Scholar 

Motulsky HJ (2014) Common misconceptions about data analysis and statistics. Naunyn Schmiedebergs Arch Pharmacol 387:1017–1023. https://doi.org/10.1007/s00210-014-1037-6

Article  CAS  PubMed  PubMed Central  Google Scholar 

O’Donnell SR, Wanstall JC (1979) The importance of choice of agonist in studies designed to predict beta 2: beta 1 adrenoceptor selectivity of antagonists from pA2 values on guinea-pig trachea and atria. Naunyn Schmiedebergs Arch Pharmacol 308:183–190. https://doi.org/10.1007/BF00501381

Article  CAS  PubMed  Google Scholar 

Percie du Sert N, Hurst V, Ahluwalia A, Alam S, Avey MT, Baker M, Browne WJ, Clark A, Cuthill IC, Dirnagl U, Emerson M, Garner P, Holgate ST, Howells DW, Karp NA, Lazic SE, Lidster K, MacCallum CJ, Macleod M, Pearl EJ, Petersen OH, Rawle F, Reynolds P, Rooney K, Sena ES, Silberberg SD, Steckler T, Würbel H (2020) The ARRIVE guidelines 2.0: updated guidelines for reporting animal research. PLoS Biol 14(18):e3000410. https://doi.org/10.1371/journal.pbio.3000410

Article  CAS  Google Scholar 

Quirino-Junior GQ, Britto-Júnior J, Magalhaes TB, Campos R, Nyamkondiwa KL, Klugh KL, Peterson LW, Corvino A, Sparaco R, Frecentese F, Caliendo G, De Nucci G (2023) Measurement of 6-cyanodopamine, 6-nitrodopa, 6-nitrodopamine and 6-nitroadrenaline by LC-MS/MS in Krebs-Henseleit solution. Assessment of basal release from rabbit isolated right atrium and ventricles. Biomed Chromatogr 37:e5691. https://doi.org/10.1002/bmc.5691

Article  CAS  Google Scholar 

Sparaco R, Scognamiglio A, Corvino A, Caliendo G, Fiorino F, Magli E, Perissutti E, Santagada V, Severino B, Luciano P, Caserta M, Aiello A, De Nucci G, Frecentese F (2023) Synthesis, Chiral resolution and enantiomers absolute configuration of 4-nitropropranolol and 7-nitropropranolol. Molecules 28(1):57. https://doi.org/10.3390/molecules28010057

Article  CAS  Google Scholar 

Venugopalan P, Agarwal AK (2003) Plasma catecholamine levels parallel severity of heart failure and have prognostic value in children with dilated cardiomyopathy. Eur J Heart Fail 5(5):655–658. https://doi.org/10.1016/s1388-9842(03)00109-0

Article  CAS  PubMed  Google Scholar 

Wang DW, Mistry AM, Kahlig KM, Kearney JA, Xiang J, George AL Jr (2010) Propranolol blocks cardiac and neuronal voltage-gated sodium channels. Front Pharmacol 31(1):144. https://doi.org/10.3389/fphar.2010.00144.PMID:21833183

Article  Google Scholar 

Welson WL, Burke TR (1978) Absolute configuration of glycerol derivatives. 5. Oxprenolol enantiomers. J Org Chem 43:3641–3645. https://doi.org/10.1021/jo00413a002

Article  Google Scholar 

Wu JR, Chang HR, Chen SS, Huang TY (1996) Circulating noradrenaline and beta-adrenergic receptors in children with congestive heart failure. Acta Paediatr 85(8):923–927. https://doi.org/10.1111/j.1651-2227.1996.tb14187.x

Article  CAS  PubMed  Google Scholar 

Zatz R, De Nucci G (2024) Endothelium-derived dopamine and 6-nitrodopamine in the cardiovascular system. Physiology 39:44–59. https://doi.org/10.1152/physiol.00020.2023

Article  CAS  PubMed  Google Scholar