Nurmohamed MT, Heslinga M, Kitas GD. Cardiovascular comorbidity in rheumatic diseases. Nat Rev Rheumatol. 2015;11(12):693–704. https://doi.org/10.1038/nrrheum.2015.112. Epub 2015 Aug 18 PMID: 26282082.
Article PubMed CAS Google Scholar
Weber BN, Giles JT, Liao KP. Shared inflammatory pathways of rheumatoid arthritis and atherosclerotic cardiovascular disease. Nat Rev Rheumatol. 2023;19(7):417–28. https://doi.org/10.1038/s41584-023-00969-7. Epub 2023 May 25 PMID: 37231248.
Article PubMed PubMed Central Google Scholar
Ruscitti P, Cipriani P, Liakouli V, Iacono D, Pantano I, Margiotta DPE, Navarini L, Destro Castaniti GM, Maruotti N, Di Scala G, Caso F, Bongiovanni S, Grembiale RD, Atzeni F, Scarpa R, Perosa F, Emmi G, Cantatore FP, Guggino G, Afeltra A, Ciccia F, Giacomelli R. Occurrence and predictive factors of high blood pressure, type 2 diabetes, and metabolic syndrome in rheumatoid arthritis: findings from a 3-year, multicentre, prospective, observational study. Clin Exp Rheumatol. 2021;39(5):995–1002 Epub 2020 Dec 4. PMID: 33337994.
Donath MY. Targeting inflammation in the treatment of type 2 diabetes: time to start. Nat Rev Drug Discov. 2014;13(6):465–76. https://doi.org/10.1038/nrd4275. Epub 2014 May 23 PMID: 24854413.
Article PubMed CAS Google Scholar
Giacomelli R, Ruscitti P, Alvaro S, Ciccia F, Liakouli V, Di Benedetto P, Guggino G, Berardicurti O, Carubbi F, Triolo G, Cipriani P. IL-1β at the crossroad between rheumatoid arthritis and type 2 diabetes: may we kill two birds with one stone? Expert Rev Clin Immunol. 2016;12(8):849–55. https://doi.org/10.1586/1744666X.2016.1168293. Epub 2016 Apr 12 PMID: 26999417.
Article PubMed CAS Google Scholar
Larsen CM, Faulenbach M, Vaag A, Vølund A, Ehses JA, Seifert B, Mandrup-Poulsen T, Donath MY. Interleukin-1-receptor antagonist in type 2 diabetes mellitus. N Engl J Med. 2007;356(15):1517–26. https://doi.org/10.1056/NEJMoa065213. PMID: 17429083.
Article PubMed CAS Google Scholar
Ruscitti P, Masedu F, Alvaro S, Airò P, Battafarano N, Cantarini L, Cantatore FP, Carlino G, D’Abrosca V, Frassi M, Frediani B, Iacono D, Liakouli V, Maggio R, Mulè R, Pantano I, Prevete I, Sinigaglia L, Valenti M, Viapiana O, Cipriani P, Giacomelli R. Anti-interleukin-1 treatment in patients with rheumatoid arthritis and type 2 diabetes (TRACK): A multicentre, open-label, randomised controlled trial. PLoS Med. 2019;16(9):e1002901. https://doi.org/10.1371/journal.pmed.1002901. PMID: 31513665; PMCID: PMC6742232.
Article PubMed PubMed Central CAS Google Scholar
Ruscitti P, Ursini F, Cipriani P, Greco M, Alvaro S, Vasiliki L, Di Benedetto P, Carubbi F, Berardicurti O, Gulletta E, De Sarro G, Giacomelli R. IL-1 inhibition improves insulin resistance and adipokines in rheumatoid arthritis patients with comorbid type 2 diabetes: an observational study. Medicine (Baltimore). 2019;98(7):e14587. https://doi.org/10.1097/MD.0000000000014587. PMID: 30762811; PMCID: PMC6408058.
Article PubMed CAS Google Scholar
Ruscitti P, Berardicurti O, Cipriani P, Giacomelli R, TRACK study group. Benefits of anakinra versus TNF inhibitors in rheumatoid arthritis and type 2 diabetes: long-term findings from participants furtherly followed-up in the TRACK study, a multicentre, open-label, randomised, controlled trial. Clin Exp Rheumatol. 2021;39(2):403–6. https://doi.org/10.55563/clinexprheumatol/phsqg7. Epub 2021 Mar 3. PMID: 33666156.
Dinarello CA. The IL-1 family of cytokines and receptors in rheumatic diseases. Nat Rev Rheumatol. 2019;15(10):612–32. https://doi.org/10.1038/s41584-019-0277-8. Epub 2019 Sep 12 PMID: 31515542.
Article PubMed CAS Google Scholar
Ciechanover A. The unravelling of the ubiquitin system. Nat Rev Mol Cell Biol. 2015;16(5):322–4. https://doi.org/10.1038/nrm3982. PMID: 25907614.
Article PubMed CAS Google Scholar
Lopez-Castejon G. Control of the inflammasome by the ubiquitin system. FEBS J. 2020;287(1):11–26. https://doi.org/10.1111/febs.15118. Epub 2019 Nov 20. PMID: 31679183; PMCID: PMC7138099.
Article PubMed CAS Google Scholar
Kattah MG, Malynn BA, Ma A. Ubiquitin-Modifying Enzymes and Regulation of the Inflammasome. J Mol Biol. 2017;429(22):3471–85. https://doi.org/10.1016/j.jmb.2017.10.001. Epub 2017 Oct 13. PMID: 29031697; PMCID: PMC5675782.
Article PubMed PubMed Central CAS Google Scholar
Lewis MJ, Barnes MR, Blighe K, Goldmann K, Rana S, Hackney JA, Ramamoorthi N, John CR, Watson DS, Kummerfeld SK, Hands R, Riahi S, Rocher-Ros V, Rivellese F, Humby F, Kelly S, Bombardieri M, Ng N, DiCicco M, van der Heijde D, Landewé R, van der Helm-van MA, Cauli A, McInnes IB, Buckley CD, Choy E, Taylor PC, Townsend MJ, Pitzalis C. Molecular portraits of early rheumatoid arthritis identify clinical and treatment response phenotypes. Cell Rep. 2019;28(9):2455–2470.e5. https://doi.org/10.1016/j.celrep.2019.07.091. PMID: 31461658; PMCID: PMC6718830.
Article PubMed PubMed Central CAS Google Scholar
Humby F, Lewis M, Ramamoorthi N, Hackney JA, Barnes MR, Bombardieri M, Setiadi AF, Kelly S, Bene F, DiCicco M, Riahi S, Rocher V, Ng N, Lazarou I, Hands R, van der Heijde D, Landewé RBM, van der Helm-van Mil A, Cauli A, McInnes I, Buckley CD, Choy EH, Taylor PC, Townsend MJ, Pitzalis C. Synovial cellular and molecular signatures stratify clinical response to csDMARD therapy and predict radiographic progression in early rheumatoid arthritis patients. Ann Rheum Dis. 2019;78(6):761–72. https://doi.org/10.1136/annrheumdis-2018-214539. Epub 2019 Mar 16. PMID: 30878974; PMCID: PMC6579551.
Article PubMed CAS Google Scholar
Lliso-Ribera G, Humby F, Lewis M, Nerviani A, Mauro D, Rivellese F, Kelly S, Hands R, Bene F, Ramamoorthi N, Hackney JA, Cauli A, Choy EH, Filer A, Taylor PC, McInnes I, Townsend MJ, Pitzalis C. Synovial tissue signatures enhance clinical classification and prognostic/treatment response algorithms in early inflammatory arthritis and predict requirement for subsequent biological therapy: results from the pathobiology of early arthritis cohort (PEAC). Ann Rheum Dis. 2019;78(12):1642–52. https://doi.org/10.1136/annrheumdis-2019-215751.
Article PubMed CAS Google Scholar
Fève B, Bastard JP. The role of interleukins in insulin resistance and type 2 diabetes mellitus. Nat Rev Endocrinol. 2009;5(6):305–11. https://doi.org/10.1038/nrendo.2009.62. PMID: 19399017.
Article PubMed CAS Google Scholar
Donath MY, Shoelson SE. Type 2 diabetes as an inflammatory disease. Nat Rev Immunol. 2011;11(2):98–107. https://doi.org/10.1038/nri2925. Epub 2011 Jan 14 PMID: 21233852.
Article PubMed CAS Google Scholar
McInnes IB, Schett G. Pathogenetic insights from the treatment of rheumatoid arthritis. Lancet. 2017;389(10086):2328–37. https://doi.org/10.1016/S0140-6736(17)31472-1. PMID: 28612747.
Article PubMed CAS Google Scholar
Tripolino C, Ciaffi J, Pucino V, Ruscitti P, van Leeuwen N, Borghi C, Giacomelli R, Meliconi R, Ursini F. Insulin signaling in arthritis. Front Immunol. 2021;30(12):672519. https://doi.org/10.3389/fimmu.2021.672519. PMID: 33995414; PMCID: PMC8119635.
Rivellese F, Humby F, Bugatti S, Fossati-Jimack L, Rizvi H, Lucchesi D, Lliso-Ribera G, Nerviani A, Hands RE, Giorli G, Frias B, Thorborn G, Jaworska E, John C, Goldmann K, Lewis MJ, Manzo A, Bombardieri M, Pitzalis C, PEAC-R4RA Investigators. B cell synovitis and clinical phenotypes in rheumatoid arthritis: relationship to disease stages and drug exposure. Arthritis Rheumatol. 2020;72(5):714–25. https://doi.org/10.1002/art.41184.
Article PubMed PubMed Central CAS Google Scholar
Humby F, Durez P, Buch MH, Lewis MJ, Rizvi H, Rivellese F, Nerviani A, Giorli G, Mahto A, Montecucco C, Lauwerys B, Ng N, Ho P, Bombardieri M, Romão VC, Verschueren P, Kelly S, Sainaghi PP, Gendi N, Dasgupta B, Cauli A, Reynolds P, Cañete JD, Moots R, Taylor PC, Edwards CJ, Isaacs J, Sasieni P, Choy E, Pitzalis C, R4RA collaborative group. Rituximab versus tocilizumab in anti-TNF inadequate responder patients with rheumatoid arthritis (R4RA): 16-week outcomes of a stratified, biopsy-driven, multicentre, open-label, phase 4 randomised controlled trial. Lancet. 2021;397(10271):305–17. https://doi.org/10.1016/S0140-6736(20)32341-2. PMID: 33485455; PMCID: PMC7829614.
Article PubMed PubMed Central CAS Google Scholar
Rivellese F, Surace AEA, Goldmann K, Sciacca E, Çubuk C, Giorli G, John CR, Nerviani A, Fossati-Jimack L, Thorborn G, Ahmed M, Prediletto E, Church SE, Hudson BM, Warren SE, McKeigue PM, Humby F, Bombardieri M, Barnes MR, Lewis MJ, Pitzalis C, R4RA collaborative group. Rituximab versus tocilizumab in rheumatoid arthritis: synovial biopsy-based biomarker analysis of the phase 4 R4RA randomized trial. Nat Med. 2022;28(6):1256–68. https://doi.org/10.1038/s41591-022-01789-0. Epub 2022 May 19. PMID: 35589854; PMCID: PMC9205785.
Article PubMed PubMed Central CAS Google Scholar
Giacomelli R, Afeltra A, Bartoloni E, Berardicurti O, Bombardieri M, Bortoluzzi A, Carubbi F, Caso F, Cervera R, Ciccia F, Cipriani P, Coloma-Bazán E, Conti F, Costa L, D’Angelo S, Distler O, Feist E, Foulquier N, Gabini M, Gerber V, Gerli R, Grembiale RD, Guggino G, Hoxha A, Iagnocco A, Jordan S, Kahaleh B, Lauper K, Liakouli V, Lubrano E, Margiotta D, Naty S, Navarini L, Perosa F, Perricone C, Perricone R, Prete M, Pers JO, Pitzalis C, Priori R, Rivellese F, Ruffatti A, Ruscitti P, Scarpa R, Shoenfeld Y, Triolo G, Tzioufas A. The growing role of precision medicine for the treatment of autoimmune diseases; results of a systematic review of literature and Experts’ Consensus. Autoimmun Rev. 2021;20(2):102738. https://doi.org/10.1016/j.autrev.2020.102738. Epub 2020 Dec 14. PMID: 33326854.
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