Khoury, P., Grayson, P. C. & Klion, A. D. Eosinophils in vasculitis: characteristics and roles in pathogenesis. Nat. Rev. Rheumatol. 10, 474–483 (2014).
Article CAS PubMed PubMed Central Google Scholar
Wen, T. & Rothenberg, M. E. The regulatory function of eosinophils. Microbiol. Spectr. https://doi.org/10.1128/microbiolspec.MCHD-0020-2015 (2016).
Takatsu, K. Interleukin-5 and IL-5 receptor in health and diseases. Proc. Jpn Acad. Ser. B Phys. Biol. Sci. 87, 463–485 (2011).
Article CAS PubMed PubMed Central Google Scholar
Takatsu, K. & Nakajima, H. IL-5 and eosinophilia. Curr. Opin. Immunol. 20, 288–294 (2008).
Article CAS PubMed Google Scholar
Kouro, T. & Takatsu, K. IL-5- and eosinophil-mediated inflammation: from discovery to therapy. Int. Immunol. 21, 1303–1309 (2009).
Article CAS PubMed Google Scholar
Ramirez, G. A. et al. Eosinophils from physiology to disease: a comprehensive review. Biomed. Res. Int. 2018, 9095275 (2018).
Article PubMed PubMed Central Google Scholar
Wu, D. et al. Eosinophils sustain adipose alternatively activated macrophages associated with glucose homeostasis. Science 332, 243–247 (2011).
Article CAS PubMed PubMed Central Google Scholar
Molofsky, A. B. et al. Innate lymphoid type 2 cells sustain visceral adipose tissue eosinophils and alternatively activated macrophages. J. Exp. Med. 210, 535–549 (2013).
Article CAS PubMed PubMed Central Google Scholar
Lee, E. H. et al. Eosinophils support adipocyte maturation and promote glucose tolerance in obesity. Sci. Rep. 8, 9894 (2018).
Article PubMed PubMed Central Google Scholar
Davoine, F. & Lacy, P. Eosinophil cytokines, chemokines, and growth factors: emerging roles in immunity. Front. Immunol. 5, 570 (2014).
Article PubMed PubMed Central Google Scholar
Hams, E., Locksley, R. M., McKenzie, A. N. & Fallon, P. G. Cutting edge: IL-25 elicits innate lymphoid type 2 and type II NKT cells that regulate obesity in mice. J. Immunol. 191, 5349–5353 (2013).
Article CAS PubMed Google Scholar
Mesnil, C. et al. Lung-resident eosinophils represent a distinct regulatory eosinophil subset. J. Clin. Invest. 126, 3279–3295 (2016).
Article PubMed PubMed Central Google Scholar
Bousquet, J. et al. Eosinophilic inflammation in asthma. N. Engl. J. Med. 323, 1033–1039 (1990).
Article CAS PubMed Google Scholar
McBrien, C. N. & Menzies-Gow, A. The biology of eosinophils and their role in asthma. Front. Med. 4, 93 (2017).
Hartl, S. et al. Blood eosinophil count in the general population: typical values and potential confounders. Eur. Respir. J. 55, 1901874 (2020).
Article CAS PubMed Google Scholar
Liu, C. L. et al. Allergic lung inflammation aggravates angiotensin II-induced abdominal aortic aneurysms in mice. Arterioscler. Thromb. Vasc. Biol. 36, 69–77 (2016).
Liu, C. L. et al. Allergic lung inflammation promotes atherosclerosis in apolipoprotein E-deficient mice. Transl. Res. 171, 1–16 (2016).
Article PubMed PubMed Central Google Scholar
Liu, C. L. et al. Asthma associates with human abdominal aortic aneurysm and rupture. Arterioscler. Thromb. Vasc. Biol. 36, 570–578 (2016).
Article CAS PubMed PubMed Central Google Scholar
Guo, J. et al. Allergic asthma is a risk factor for human cardiovascular diseases. Nat. Cardiovasc. Res. 1, 417–430 (2022).
Liu, C. L. et al. Eosinophils protect mice from angiotensin-II perfusion-induced abdominal aortic aneurysm. Circ. Res. 128, 188–202 (2021).
Article CAS PubMed Google Scholar
Meng, Z. et al. Cationic proteins from eosinophils bind bone morphogenetic protein receptors promoting vascular calcification and atherogenesis. Eur. Heart J. 44, 2763–2783 (2023).
Article CAS PubMed PubMed Central Google Scholar
Welsh, C. et al. Association of total and differential leukocyte counts with cardiovascular disease and mortality in the UK Biobank. Arterioscler. Thromb. Vasc. Biol. 38, 1415–1423 (2018).
Article CAS PubMed Google Scholar
Groot, H. E., van Blokland, I. V., Lipsic, E., Karper, J. C. & van der Harst, P. Leukocyte profiles across the cardiovascular disease continuum: a population-based cohort study. J. Mol. Cell. Cardiol. 138, 158–164 (2020).
Article CAS PubMed Google Scholar
Nadimi, A. E., Ahmadi, J. & Mehrabian, M. Peripheral eosinophil count and allergy in patients with coronary artery disease. Acta Med. Indones. 40, 74–77 (2008).
Pongdee, T. et al. Rethinking blood eosinophil counts: epidemiology, associated chronic diseases, and increased risks of cardiovascular disease. J. Allergy Clin. Immunol. Glob. 1, 233–240 (2022).
Article PubMed PubMed Central Google Scholar
Niccoli, G. et al. Pre-intervention eosinophil cationic protein serum levels predict clinical outcomes following implantation of drug-eluting stents. Eur. Heart J. 30, 1340–1347 (2009).
Article CAS PubMed Google Scholar
Quinta, J. B. et al. Cardiovascular adverse effects of anti-IL-5/IL-5Ralpha therapies: a real-world study. J. Allergy Clin. Immunol. Pract. 9, 1411–1413 (2021).
Article CAS PubMed Google Scholar
Verdoia, M. et al. Absolute eosinophils count and the extent of coronary artery disease: a single centre cohort study. J. Thromb. Thrombolysis 39, 459–466 (2015).
Shah, A. D., Denaxas, S., Nicholas, O., Hingorani, A. D. & Hemingway, H. Low eosinophil and low lymphocyte counts and the incidence of 12 cardiovascular diseases: a CALIBER cohort study. Open Heart 3, e000477 (2016).
Article PubMed PubMed Central Google Scholar
Gao, S. et al. Eosinophils count in peripheral circulation is associated with coronary artery disease. Atherosclerosis 286, 128–134 (2019).
Article CAS PubMed Google Scholar
Liu, T. et al. Group 2 innate lymphoid cells protect mouse heart from myocardial infarction injury via interleukin 5, eosinophils, and dendritic cells. Cardiovasc. Res. 119, 1046–1061 (2023).
Article CAS PubMed Google Scholar
Zhang, Y. et al. Group 2 innate lymphoid cells protect mice from abdominal aortic aneurysm formation via IL5 and eosinophils. Adv. Sci. 10, e2206958 (2023).
Yang, C. et al. Eosinophils protect pressure overload- and beta-adrenoreceptor agonist-induced cardiac hypertrophy. Cardiovasc. Res. 119, 195–212 (2023).
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