Fowler K, Mucha J, Neumann M, Lewandowski W, Kaczanowska M, Grys M, et al. A systematic literature review of the global seroprevalence of cytomegalovirus: possible implications for treatment, screening, and vaccine development. BMC Public Health. 2022;22:1659.

Article  PubMed  PubMed Central  Google Scholar 

Boppana SB, Ross SA, Fowler KB. Congenital cytomegalovirus infection: clinical outcome. Clin Infect Dis. 2013;57:S178–81.

Article  PubMed  PubMed Central  Google Scholar 

Griffiths P, Reeves M. Pathogenesis of human cytomegalovirus in the immunocompromised host. Nat Rev Microbiol. 2021;19:759–73.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Griffiths P. The direct and indirect consequences of cytomegalovirus infection and potential benefits of vaccination. Antivir Res. 2020;176:104732.

Article  CAS  PubMed  Google Scholar 

Staras SA, Flanders WD, Dollard SC, Pass RF, McGowan JE Jr, Cannon MJ. Influence of sexual activity on cytomegalovirus seroprevalence in the United States, 1988-1994. Sex Transm Dis. 2008;35:472–9.

Article  PubMed  Google Scholar 

Azenkot T, Zaniello B, Green ML, Selke S, Huang ML, Magaret A, et al. Cytomegalovirus shedding from breastmilk and mucosal sites in healthy postpartum women: a pilot study. J Med Virol. 2019;91:894–8.

Article  PubMed  PubMed Central  Google Scholar 

Cannon MJ, Stowell JD, Clark R, Dollard PR, Johnson D, Mask K, et al. Repeated measures study of weekly and daily cytomegalovirus shedding patterns in saliva and urine of healthy cytomegalovirus-seropositive children. BMC Infect Dis. 2014;14:569.

Article  PubMed  PubMed Central  Google Scholar 

Sinzger C, Jahn G. Human cytomegalovirus cell tropism and pathogenesis. Intervirology. 1996;39:302–19.

Article  CAS  PubMed  Google Scholar 

Smith MS, Bentz GL, Alexander JS, Yurochko AD. Human cytomegalovirus induces monocyte differentiation and migration as a strategy for dissemination and persistence. J Virol. 2004;78:4444–53.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Sinzger C, Digel M, Jahn G. Cytomegalovirus cell tropism. Curr Top Microbiol Immunol. 2008;325:63–83.

CAS  PubMed  Google Scholar 

Wu Y, Prager A, Boos S, Resch M, Brizic I, Mach M, et al. Human cytomegalovirus glycoprotein complex gH/gL/gO uses PDGFR-α as a key for entry. PLoS Pathog. 2017;13:e1006281.

Article  PubMed  PubMed Central  Google Scholar 

Kabanova A, Marcandalli J, Zhou T, Bianchi S, Baxa U, Tsybovsky Y, et al. Platelet-derived growth factor-alpha receptor is the cellular receptor for human cytomegalovirus gHgLgO trimer. Nat Microbiol. 2016;1:16082.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Martinez-Martin N, Marcandalli J, Huang CS, Arthur CP, Perotti M, Foglierini M, et al. An unbiased screen for human cytomegalovirus identifies Neuropilin-2 as a central viral receptor. Cell. 2018;174:1158–71.e19.

Article  CAS  PubMed  Google Scholar 

Griffiths PD. Burden of disease associated with human cytomegalovirus and prospects for elimination by universal immunisation. Lancet Infect Dis. 2012;12:790–8.

Article  PubMed  Google Scholar 

Schwartz M, Stern-Ginossar N. Rethinking human cytomegalovirus latency reservoir. Ann N. Y Acad Sci. 2023;1524:30–6.

Article  PubMed  Google Scholar 

Goodrum F. Human cytomegalovirus latency: approaching the gordian knot. Annu Rev Virol. 2016;3:333–57.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Berry R, Watson GM, Jonjic S, Degli-Esposti MA, Rossjohn J. Modulation of innate and adaptive immunity by cytomegaloviruses. Nat Rev Immunol. 2020;20:113–27.

Article  CAS  PubMed  Google Scholar 

Piersma SJ, Brizic I. Natural killer cell effector functions in antiviral defense. FEBS J. 2021;289:3982–99.

Garcia-Sastre A, Biron CA. Type 1 interferons and the virus-host relationship: a lesson in detente. Science. 2006;312:879–82.

Article  CAS  PubMed  Google Scholar 

Klenerman P, Oxenius A. T cell responses to cytomegalovirus. Nat Rev Immunol. 2016;16:367–77.

Article  CAS  PubMed  Google Scholar 

Al-Talib M, Dimonte S, Humphreys IR. Mucosal T-cell responses to chronic viral infections: Implications for vaccine design. Cell Mol Immunol. 2024;21:982–98.

Mozzi A, Biolatti M, Cagliani R, Forni D, Dell’Oste V, Pontremoli C, et al. Past and ongoing adaptation of human cytomegalovirus to its host. PLoS Pathog. 2020;16:e1008476.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Gordon CL, Miron M, Thome JJ, Matsuoka N, Weiner J, Rak MA, et al. Tissue reservoirs of antiviral T cell immunity in persistent human CMV infection. J Exp Med. 2017;214:651–67.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Brizic I, Lisnic B, Krstanovic F, Brune W, Hengel H, Jonjic S. Mouse models for cytomegalovirus infections in newborns and adults. Curr Protoc. 2022;2:e537.

Article  PubMed  Google Scholar 

Reddehase MJ, Lemmermann NAW. Mouse model of cytomegalovirus disease and immunotherapy in the immunocompromised host: predictions for medical translation that survived the “Test of Time”. Viruses. 2018;10:693.

Fisher MA, Lloyd ML. A review of murine cytomegalovirus as a model for human cytomegalovirus disease-do mice lie? Int J Mol Sci. 2020;22:214.

Reddehase M, Lemmermann N. Mouse model of cytomegalovirus disease and immunotherapy in the immunocompromised host: predictions for medical translation that survived the “Test of Time. Viruses. 2018;10:693.

Article  CAS  PubMed  PubMed Central  Google Scholar 

McGeoch DJ, Cook S, Dolan A, Jamieson FE, Telford EA. Molecular phylogeny and evolutionary timescale for the family of mammalian herpesviruses. J Mol Biol. 1995;247:443–58.

Article  CAS  PubMed  Google Scholar 

Nguyen CC, Kamil JP. Pathogen at the gates: human cytomegalovirus entry and cell tropism. Viruses. 2018;10:704.

Scrivano L, Esterlechner J, Muhlbach H, Ettischer N, Hagen C, Grunewald K, et al. The m74 gene product of murine cytomegalovirus (MCMV) is a functional homolog of human CMV gO and determines the entry pathway of MCMV. J Virol. 2010;84:4469–80.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wagner FM, Brizic I, Prager A, Trsan T, Arapovic M, Lemmermann NA, et al. The viral chemokine MCK-2 of murine cytomegalovirus promotes infection as part of a gH/gL/MCK-2 complex. PLoS Pathog. 2013;9:e1003493.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lemmermann NA, Krmpotic A, Podlech J, Brizic I, Prager A, Adler H, et al. Non-redundant and redundant roles of cytomegalovirus gH/gL complexes in host organ entry and intra-tissue spread. PLoS Pathog. 2015;11:e1004640.

Article  PubMed  PubMed Central  Google Scholar 

Ruzic T, Juranic Lisnic V, Mahmutefendic Lucin H, Lenac Rovis T, Zeleznjak J, Cokaric Brdovcak M, et al. Characterization of M116.1p, a murine cytomegalovirus protein required for efficient infection of mononuclear phagocytes. J Virol. 2022;96:e0087621.

Article  PubMed  Google Scholar 

Caló S, Cortese M, Ciferri C, Bruno L, Gerrein R, Benucci B, et al. The human CytomegalovirusUL116Gene encodes an envelope glycoprotein forming a complex with gH independently from gL. J Virol. 2016;90:4926–38.

Article  PubMed  PubMed Central  Google Scholar 

Vezzani G, Amendola D, Yu D, Chandramouli S, Frigimelica E, Maione D, et al. The human cytomegalovirus UL116 glycoprotein is a chaperone to control gH-based complexes levels on virions. Front Microbiol. 2021;12:630121.

Bosnjak B, Henze E, Lueder Y, Do KTH, Rezalotfi A, Cuvalo B, et al. MCK2-mediated MCMV infection of macrophages and virus dissemination to the s