Xie Y, Kang R, Klionsky DJ, Tang D. GPX4 in cell death, autophagy, and disease. Autophagy. 2023;19:2621–38.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Brütsch SH, Wang CC, Li L, Stender H, Neziroglu N, Richter C, et al. Expression of inactive glutathione peroxidase 4 leads to embryonic lethality, and inactivation of the Alox15 gene does not rescue such knock-in mice. Antioxid Redox Signal. 2015;22:281–93.

Article  PubMed  Google Scholar 

Yant LJ, Ran Q, Rao L, Van Remmen H, Shibatani T, Belter JG, et al. The selenoprotein GPX4 is essential for mouse development and protects from radiation and oxidative damage insults. Free Radic Biol Med. 2003;34:496–502.

Article  CAS  PubMed  Google Scholar 

Muller FL, Lustgarten MS, Jang Y, Richardson A, Van Remmen H. Trends in oxidative aging theories. Free Radic Biol Med. 2007;43:477–503.

Article  CAS  PubMed  Google Scholar 

Liang H, Yoo S-E, Na R, Walter CA, Richardson A, Ran Q. Short form glutathione peroxidase 4 is the essential isoform required for survival and somatic mitochondrial functions. J Biol Chem. 2009;284:30836–44.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Seiler A, Schneider M, Förster H, Roth S, Wirth EK, Culmsee C, et al. Glutathione peroxidase 4 senses and translates oxidative stress into 12/15-lipoxygenase dependent- and AIF-mediated cell death. Cell Metab. 2008;8:237–48.

Article  CAS  PubMed  Google Scholar 

Liu Y, Wan Y, Jiang Y, Zhang L, Cheng W. GPX4: The hub of lipid oxidation, ferroptosis, disease and treatment. Biochimica et Biophysica Acta (BBA). 2023;1878: 188890.

CAS  Google Scholar 

Yang WS, Stockwell BR. Synthetic lethal screening identifies compounds activating iron-dependent, nonapoptotic cell death in oncogenic-RAS-harboring cancer cells. Chem Biol. 2008;15:234–45.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Dixon SJ, Lemberg KM, Lamprecht MR, Skouta R, Zaitsev EM, Gleason CE, et al. Ferroptosis: an iron-dependent form of nonapoptotic cell death. Cell. 2012;149:1060–72.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ingold I, Berndt C, Schmitt S, Doll S, Poschmann G, Buday K, et al. Selenium UTILIZATION by GPX4 is required to prevent hydroperoxide-induced ferroptosis. Cell. 2018;172:409-422.e21.

Article  CAS  PubMed  Google Scholar 

Forcina GC, Dixon SJ. GPX4 at the crossroads of lipid homeostasis and ferroptosis. Proteomics. 2019;19: e1800311.

Article  PubMed  Google Scholar 

Ursini F, Maiorino M. Lipid peroxidation and ferroptosis: the role of GSH and GPx4. Free Radic Biol Med. 2020;152:175–85.

Article  CAS  PubMed  Google Scholar 

Stockwell BR, Friedmann Angeli JP, Bayir H, Bush AI, Conrad M, Dixon SJ, et al. Ferroptosis: a regulated cell death nexus linking metabolism, redox biology, and disease. Cell. 2017;171:273–85.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Dixon SJ, Patel DN, Welsch M, Skouta R, Lee ED, Hayano M, et al. Pharmacological inhibition of cystine–glutamate exchange induces endoplasmic reticulum stress and ferroptosis. Elife. 2014;3: e02523.

Article  PubMed  PubMed Central  Google Scholar 

Chen X, Yu C, Kang R, Tang D. Iron metabolism in ferroptosis. Front Cell Dev Biol. 2020. https://doi.org/10.3389/fcell.2020.590226.

Article  PubMed  PubMed Central  Google Scholar 

Bang S, Park S, Lee Y-M, Hong S, Cho K-B, Nam W. Demonstration of the heterolytic O-O bond cleavage of putative nonheme iron(II)-OOH(R) complexes for Fenton and enzymatic reactions. Angew Chem Int Ed Engl. 2014;53:7843–7.

Article  CAS  PubMed  Google Scholar 

Su L-J, Zhang J-H, Gomez H, Murugan R, Hong X, Xu D, et al. Reactive oxygen species-induced lipid peroxidation in apoptosis, autophagy, and ferroptosis. Oxid Med Cell Longev. 2019;2019:5080843.

Article  PubMed  PubMed Central  Google Scholar 

Angeli JPF, Schneider M, Proneth B, Tyurina YY, Tyurin VA, Hammond VJ, et al. Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice. Nat Cell Biol. 2014;16:1180–91.

Article  PubMed Central  Google Scholar 

Schieber M, Chandel NS. ROS function in redox signaling and oxidative stress. Curr Biol. 2014;24:R453–62.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Henry E, Picou F, Barroca V, Dechamps N, Sobrino S, Six E, et al. The antioxidant TEMPOL protects human hematopoietic stem cells from culture-mediated loss of functions. Stem Cells Transl Med. 2023;12:676–88.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Barroca V, Henry E, Dechamps N, Renou L, Chaintreuil P, Kulkarni R, et al. REDD1 is a gatekeeper of murine hematopoietic stem cell functions during stress responses. Leukemia. 2022;36:2140–3.

Article  PubMed  Google Scholar 

Hu Q, Zhang Y, Lou H, Ou Z, Liu J, Duan W, et al. GPX4 and vitamin E cooperatively protect hematopoietic stem and progenitor cells from lipid peroxidation and ferroptosis. Cell Death Dis. 2021;12:706.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Altamura S, Vegi NM, Hoppe PS, Schroeder T, Aichler M, Walch A, et al. Glutathione peroxidase 4 and vitamin E control reticulocyte maturation, stress erythropoiesis and iron homeostasis. Haematologica. 2020;105:937–50.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yang Y, Wang Y, Guo L, Gao W, Tang T-L, Yan M. Interaction between macrophages and ferroptosis. Cell Death Dis. 2022;13:1–10.

CAS  Google Scholar 

Handa P, Thomas S, Morgan-Stevenson V, Maliken BD, Gochanour E, Boukhar S, et al. Iron alters macrophage polarization status and leads to steatohepatitis and fibrogenesis. J Leukoc Biol. 2019;105:1015–26.

Article  CAS  PubMed  Google Scholar 

Zhou Y, Que K-T, Zhang Z, Yi ZJ, Zhao PX, You Y, et al. Iron overloaded polarizes macrophage to proinflammation phenotype through ROS/acetyl-p53 pathway. Cancer Med. 2018;7:4012–22.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Piattini F, Matsushita M, Muri J, Bretscher P, Feng X, Freigang S, et al. Differential sensitivity of inflammatory macrophages and alternatively activated macrophages to ferroptosis. Eur J Immunol. 2021;51:2417–29.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chaintreuil P, Kerreneur E, Bourgoin M, Savy C, Favreau C, Robert G, et al. The generation, activation, and polarization of monocyte-derived macrophages in human malignancies. Front Immunol. 2023;14:1178337.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Tothova Z, Kollipara R, Huntly BJ, Lee BH, Castrillon DH, Cullen DE, et al. FoxOs are critical mediators of hematopoietic stem cell resistance to physiologic oxidative stress. Cell. 2007;128:325–39.

Article  CAS  PubMed  Google Scholar 

Miyamoto K, Araki KY, Naka K, Arai F, Takubo K, Yamazaki S, et al. Foxo3a is essential for maintenance of the hematopoietic stem cell pool. Cell Stem Cell. 2007;1:101–12.

Article